Presentation on theme: "RV function Prognostic implications in heart failure Efthimios Anagnostou M.D."— Presentation transcript:
RV function Prognostic implications in heart failure Efthimios Anagnostou M.D.
After AMI Congestive HF Valvular HD Congenital HD After HT Pulmonary Embolism Pulmonary HTN HFpEF The prognostic value of RV function in cardiovascular disease.
Courtesy C.Celton-Saty reduced RVEF. reduced RVEF is an independent prognostic factor in moderate to severe CHF.
RVEF predicts prognosis in CHF
Larose 147Pts, late after MI, RVEF<40% CMR RVEF and 17 months Larose JACC 2007 RVEF: Prognostic impact late after AMI RVEF<40% RVEF≥40%
Better survival & Better exercise capacity
RV function + PH predict survival in CHF Ghio, JACC CHF pts, LVEF<35%,DCM & IHD, optimized Rx RHC with thermodilution RVEF Normal PAP +Normal RVEF High PAP +Low RVEF
RV dilatation predicts survival in CHF 380 CHF pts, LVEF<45% VS controls DILATED RV IN 25% of pts RVESVi: independent predictor of mortality Bourantas EJHF 2011
RV dysfunction portends an inferior survival. variations in study populations, severity and substrates of disease, methodologies of assessment. Despite…
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distribution of RVEF in CHF 2008 pts, from the BEST study, LVEF<35%,NYHA III/IV Radionuclide RVEF and 24 months Meyer et al, Circulation 2012 Mortality 47% Mortality 27% =63% =37%
What is RV failure ? Inability of the RV to maintain cardiac output through the pulmonary vascular bed at normal central venous pressures. an Increased Preload (RA pressure) is required to maintain adequate CO
The commonest cause of RV Dysfunction is Left Heart Disease LV Systolic Dysfunction CAD Valve Disease LV Diastolic Dysfunction Hypertension Restrictive Cardiomyopathy HCM HFrEF HFpEF
HTN HFpEF HFrEF MV disease AoV disease LA pressure CHF causes Pulmonary Hypertension leading to Right Ventricular Failure PCWP Group 2 PH mPA>25mmHg PCWP >15mmHg CO normal or low PAPPAP
1000 CHF pts undergoing transplant evaluation Correlation nice and straight and fairly tight indicating therefore that PAP is driven passively by PCWP Mechanism of PH in CHF Drazner J Heart Lung Transplant 1999
PAPPAP PCWP intimal Fibrosis This may or may not result in rise in the PAP with a consequent rise in the TPG or PVR Mechanism of PH in CHF
Different Hemodynamic Stages in GROUP 2 PH
Drazner J Heart Lung Transplant CHF pts undergoing transplant evaluation Mechanism of PH in CHF because of vascular changes in the arterial side of pulmonary circulation Out of proportion PH
CHF, PH - CHF, PH+ Marked medial hypertrophy of a muscular pulmonary artery in a patient with CHF, compared to another of similar size with minimal medial thickening in a patient with CHF but not pulmonary hypertension This is NOT, however, idiopathic PAH (a vascular proliferative disease) but rather a secondary medial hypertrophy of the pulmonary arteries A RESPONSE TO PREVENT ALVEOLAR EDEMA FROM HAPPENING
PAPPAP PCWP As a consequence of rise in PAP, PVR and PVH, the RV runs into trouble Mechanism of PH in CHF
PH and impaired Exercise capacity in CHF Di Salvo JACC pts a consequence of rise in PVR is the dramatic decrease in CO both at rest and during exercise
This is the end, my friendThis is the beginning The shrinking LV…
PASP estimates are a risk factor for death.
Markers of RV Dysfunction associated with clinical status and prognosis Systolic Performance RVEF RVFAC TAPSE RV MPI Hemodynamics RA pressure CI Maximal dP/dT Pressure–volume Measurements Ventricular elastance Preload recruitable stroke work Diastolic Filling Tissue Doppler indices Isovolumic acceleration Syst/Diast myocardial velocities Right-sided Dilation RV dilation absolute/ relative to LV RA size TR W h i c h ?
We would be poorly served by buying into the concept that an RVEF is the only ‘‘reference standard,’’ without recognition of its shortcomings.
Sugeng, J A C C i m g Multimodality Comparison of Quantitative Volumetric Analysis of the Right Ventricle However, our results also showed that RV volume measurements are not interchangeable between modalities and, therefore, serial evaluations should be performed using the same modality.
When grappling with what measure should be adopted to evaluate RV systolic function, we are left with the classic answer: it depends!
RV dysfunction is a strong parameter of functional capacity RV dysfunction is prognostically superior to LV parameters of systolic/diastolic function RV dysfunction is present in about two-thirds of patients with CCF and doubles mortality RV dilatation has the worst prognosis RV assessment is a must of the diagnostic work-up in CCF patients Conclusions
The myocardium of the entire heart is now known to be a single sheet of muscle rolled into different chambers