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Contact Dermatitis. Pathogenesis of Dermatitis Endogenous factors Allergens type 1&4 IrritantsInfection.

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Presentation on theme: "Contact Dermatitis. Pathogenesis of Dermatitis Endogenous factors Allergens type 1&4 IrritantsInfection."— Presentation transcript:

1 Contact Dermatitis

2 Pathogenesis of Dermatitis Endogenous factors Allergens type 1&4 IrritantsInfection

3 Contact Dermatitis Acute -redness, itching, vesiculation Acute -redness, itching, vesiculation Chronic - scaly desquamation Chronic - scaly desquamation Site and morphology determined by causative exposure Site and morphology determined by causative exposure Irritant - caustic agents or detergents -hands Irritant - caustic agents or detergents -hands Allergic - rash 6-12 hours peaking at hours Allergic - rash 6-12 hours peaking at hours

4 Irritant contact dermatitis Skin damaged directly by the irritant Skin damaged directly by the irritant soaps, detergents, water, solvents, dry atmosphere etc soaps, detergents, water, solvents, dry atmosphere etc very, very common very, very common at least 5% of the population suffer from hand dermatitis at least 5% of the population suffer from hand dermatitis Treat with emollients/moisturisers Treat with emollients/moisturisers

5 Delayed allergy Takes the immune system a few hours to react Takes the immune system a few hours to react Allergic contact dermatitis (ACD) Allergic contact dermatitis (ACD) Common causes: Common causes: nickel nickel fragrances fragrances rubber additives rubber additives preservatives preservatives plants plants medicaments etc medicaments etc

6 Sensitizers Nickel - wear >18 carat gold Nickel - wear >18 carat gold Rubber accelerators in elastic, gloves, shoes Rubber accelerators in elastic, gloves, shoes Permanent hair dyes -paraphenylenediamine Permanent hair dyes -paraphenylenediamine Fragrances eg Balsam of Peru and cinnamic aldehyde present in cosmetics, soaps, perfumes and toothpastes - use fragrance free products not just unscented. Fragrances eg Balsam of Peru and cinnamic aldehyde present in cosmetics, soaps, perfumes and toothpastes - use fragrance free products not just unscented. Adhesives and Varnishes Adhesives and Varnishes Latex, Formaldehyde and Chromates Latex, Formaldehyde and Chromates Benzocaine and neomycin in topical medications Benzocaine and neomycin in topical medications

7 ACD Nickel allergy involves ears, skin under buckles and often the hands; accidental spread from the hands can affect the face Nickel allergy involves ears, skin under buckles and often the hands; accidental spread from the hands can affect the face Hair products - dyes and sprays - affect the face, neck and ears. Hair products - dyes and sprays - affect the face, neck and ears. Dyes in socks and shoes affect the feet. Dyes in socks and shoes affect the feet. Medications for the treatment of leg ulcers can cause dermatitis of the legs Medications for the treatment of leg ulcers can cause dermatitis of the legs


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