1. Transformation of the ppCRRT to the ppAKI-RG Stuart L. Goldstein, MD Founder and Principal Investigator The Prospective Pediatric CRRT Registry Group The Prospective Pediatric Acute Kidney Injury Research Group

2. The Center for Acute Care Nephrology The ppCRRT Registry 13 US Centers Prospective observational CRRT cohort registry 2001 to 2005 370 patients entered Patients aged 1 day to 25 years Unrestricted industry funding –Gambro, Dialysis Solutions Inc, Baxter, B Braun Jordan Symons, MD – Resident Artist

3. The Center for Acute Care Nephrology Bunchman Brophy Goldstein SymonsSomers The Founding Five

4. The Center for Acute Care Nephrology Askenazi D et al: PCRRT in Children < 10 kg (J Peds)

5. The Center for Acute Care Nephrology The ppCRRT Registry Co-Investigators/Authors Michael Somers Michelle Baum Pat Brophy Jordan Symons Tim Bunchman Rick Hackbarth Mark Benfield David Askenazi Michael Zappitelli Geoffrey Fleming James Fortenberry John Mahan Deepa Chand Francisco Flores Kevin McBryde Steven Alexander Annabelle Chua Douglas Blowey Scott Sutherland

6. The Center for Acute Care Nephrology The ppAKI-RG Multi-national research collaborative Web-based registry under development Interventional trials/FDA 510K planned AKI studies, not limited to CRRT (no ECMO) The Center for Acute Care Nephrology manages contracts with sponsors and registry Sites receive PI, patient care and indirect costs Jordan Symons, MD, Resident Artist

7. The Center for Acute Care Nephrology

8. Admission and Structure Signed consortium agreement: –contact S. Goldstein (stuart.goldstein@cchmc.org)stuart.goldstein@cchmc.org Each site with a signed agreement has a seat on the research committee Anyone can bring a project to the ppAKI-RG and they serve as overall project PI if approved by the steering and research committees

9. The Center for Acute Care Nephrology Current ppAKI-RG Sites CenterPI AlabamaAskenazi Ann ArborSelewski AtlantaPaden BostonSomers CincinnatiGoldstein Grand RapidsHackbarth Iowa CityBrophy Kansas CityChadha Kings, LondonDeep MontrealZappitelli NashvilleFleming Palo AltoSutherland RichmondBunchman RomePicca SeattleSymons SingaporePeilin St. Petersburg, FLFlores SydneyKennedy