Presentation on theme: "Preliminary Results and Research Design and Methods George Leikauf University of Cincinnati OR THE TRUTH HURTS WHAT THE EXECUTIVE SECRETARY WON’T TELL."— Presentation transcript:
Preliminary Results and Research Design and Methods George Leikauf University of Cincinnati OR THE TRUTH HURTS WHAT THE EXECUTIVE SECRETARY WON’T TELL YOU YOU CAN TRY IT YOUR OWN WAY BUT THE REVEIWERS PROBABLY WON’T LIKE IT LIFE OR DEATH ON THE TENURE TRACK
Preliminary Results The overall purpose of the research plan is to describe the what, when, why, and how of the proposal Preliminary Results contributes to both the why and how IT IS ALL ABOUT YOU, YOUR WORK, YOUR JUDGEMENT, and HOW YOU INTERPRET DATA
Preliminary Results This section is not mandatory for new applications BUT IT IS VIRTUALLY IMPOSSIBLE TO OBTAIN A FAVORABLE REVIEW WITHOUT STRONG PRELIMINARY RESULTS In a competing renewal application, this section becomes a progress report describing studies performed during the last grant period UNLESS YOU HAVE OUTSTANDING PROGRESS CONSIDER A NEW PROPOSAL
Preliminary Results Content: In a new application, the preliminary results contributes to why of the proposal: Provide experimental support for the hypothesis and the research design Brief description of older published studies by the applicant that provide important background information relevant to the proposed project
Preliminary Results Content: In a new application, the preliminary results contributes to how of the proposal: Present unpublished studies by the applicants to establish: the feasibility and importance of the project the applicants’ competence and experience with the experimental techniques to be used in the project
Preliminary Results Content: May also include: Results of previous studies by the applicant not directly relevant to the proposed project that demonstrated the applicants’ competence and experience with the experimental techniques to be used in the project CLEARLY IDENTIFIED AS SUCH. PUBLISH IN RIGOROUS JOURNALS BETTER PLACED IN BACKGROUND?
Preliminary Results Suggestions Organization: Link directly with Specific Aims (i.e. Use headings “Preliminary Data Supporting Aim 1: To determine…”) SUPPORT EACH AND EVERY AIM! Include all Tables and Figures necessary for the presentation of preliminary results TYPICALLY ORDINATE (Y AXIS) IS THE INDEPENDENT VARIABLE.
Preliminary Results Suggestions Full-size glossy photographs of materials such as electron micrographs, gels, etc. may be included in the appendix, but only if a photocopy (reduced in size, as appropriate) is included in the body of the Research Plan DON’T EXPECT APPENDICIES TO BE READ
Preliminary Results Suggestions Figures and Figure legends must be legible. Observe limits on type size given in the application instructions, but beyond this rule, the critical factor is whether the data are legible and convincing to the reviewers REVIEWERS ARE NOT IMPRESSED BY SMALL DIFFERENCES
Preliminary Results Suggestions All data must be analyzed with proper statistical methods STATISTICAL VS. MEDICAL SIGNIFICANCE Don't show raw data or data you have not fully analyzed
Preliminary Results Suggestions Don’t dwell on results already published PUBLISHED RESULTS CAN PROVE COMPENDENCE BUT PUBLISHED RESULTS REDUCE INNOVATION
Preliminary Results Suggestions Present result objectively USE SUPERLATIVES SPARINGLY “DRAMATIC” “ABSOLUTELY” “CRITICAL” “IMPRESSIVE” Don’t be overly impressed by your own findings HAVE CONFIDENCE IN YOUR REVIEWER
Preliminary Results Suggestions Make sure you are ready Collect at least 1-2 years of preliminary data Consider publishing 2 manuscripts in the area to make your research questions more robust
Preliminary Results Editing Consider including mainly data that demonstrate expertise with the more difficult methods Combine figures into multiple panels Place Tables into text (present data parenthetically)
Preliminary Results Editing Eliminate any figure that will initiate a debate in the mind of the reviewer Don’t ignore different possible interpretations Be as cautious as is prudent
Preliminary Results Editing Word choice: Our findings “suggest”, “imply”, “support ”, or “indicate” Present your results (even if they are preliminary) in as professional a manner as possible, with clear and complete figure/table legends, calibrations, statistical analysis, etc.
Research Design and Methods The overall purpose of the research plan is to describe the what, when, why, and how of the proposal Research Design and Methods contributes to what, when, why, and how APPROACH > SIGNIFICANCE > INNOVATION
Research Design and Methods Recommended length: 20 pages TOTAL LIMIT IS 25 PAGES SO, YOU CAN NOT GIVE EVERY LITTLE DETAIL IN METHODS SECTION SOME REVIEWERS ARE TECHIQUE DRIVEN AND MAY MAKE MOUNTAINS OUT OF MOLE HILLS
Research Design and Methods Content: Research Design and Methods contributes to what, when, why, and how: What? Experimental Model and Specific Aims REAGENTS IN HAND AND EXPERIENCE When? Sequence of Specific Aims INTERACTING BUT INDEPENDENT Why? Meaningfulness of results, and their relationship to hypothesis HUMAN HEALTH SIGNIFICANCE How? Experimental Design and Methods STATISTICAL APPROACH
Research Design and Methods Content: Description of any new methodology used and why it represents an improvement over the existing ones Detailed description of specific methods to be employed Projected sequence of Specific Aims and timetable
Research Design and Methods Content: Experimental design (how the research will be carried out) Detailed discussion of the way in which the results will be collected, analyzed, and interpreted
Research Design and Methods Content: Detailed discussion of the way in which the results will be collected, analyzed, and interpreted : Expected results, and alternative approaches that will be used if unexpected results are found Discussion of potential difficulties and limitations and how these will be overcome or mitigated DON’T SAY THERE WON’T BE ANY
Research Design and Methods Suggestions Organize the sections in this part of the application to correspond to the numbers of the Specific Aims Give sufficient detail DON’T ASSUME THE REVIEWER WILL KNOW HOW YOU INTEND TO PROCEED
Research Design and Methods Suggestions Avoid excessive experimental detail by referring to publications that describe the methods to be employed MIXING LEVEL OF DETAIL CAN BE CONFUSING Pull all the details on Methods together in the end of the proposal
Research Design and Methods Suggestions Publications cited should be by the applicants, when reasonable Citing publication by others establishes that you know what method to use, but citing your own (or collaborator) establishes that the applicant personnel are experienced with the necessary techniques
Research Design and Methods Suggestions If relevant, explain why one approach or method will be used in preference to others. This establishes that the alternatives were not simply overlooked Give not only the "how" but the "why"
Research Design and Methods Suggestions When employing a complex technology for the first time, take extra care to demonstrate familiarity with the experimental details and potential pitfalls What have you (and your collaborators) done to establish the feasibility of what you are proposing to do?
Research Design and Methods Suggestions. Add a co-investigator or consultant experienced with the technology if necessary Document proposed collaborations and offers of materials or reagents of restricted availability with letters from the individual involved
Research Design and Methods Suggestions. Use reagents in hand, proposing to generate a reagent (e.g., knockout mouse lines) is dangerous
Research Design and Methods Suggestions. Be sure to explain how the results to be obtained will be used to test the hypothesis Discovery science (genomics/proteomics) is harder than “Hypothesis-driven” science to support: Complete an initial discovery phase should lead to hypothesis.
Research Design and Methods Suggestions. Include Timeline to demonstrate the objectives are attainable within the stated time frame Don't bite off more than you can chew. A small, focused project is generally better received than a diffuse, multifaceted project
Summary You have succeeded if you demonstrate to the reviewer that YOU: Can design logical, well-controlled experiments Present your results in a clear and thoughtful manner
Summary You have succeeded if you demonstrate to the reviewer that YOU: That you demonstrate what you (and your collaborators) have done to establish the feasibility of any new methods you are proposing to do in the proposal
Summary You have succeeded if you demonstrate to the reviewer that YOU: Are experienced (hopefully published) with most of the experimental techniques proposed in the application
Summary You have succeeded if you demonstrate to the reviewer that YOU: Have you clearly described how will the research be accomplished? Describe Who? What? When? Where? Why?
Conclusions The assessment of the Preliminary Results and the Research Design and Methods will largely determine whether or not the proposal is favorably recommended for funding. APPROACH > SIGNIFICANCE > INNOVATION
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