Presentation on theme: "The NIH Roadmap for Medical Research"— Presentation transcript:
1 The NIH Roadmap for Medical Research Elias A. Zerhouni, M.D.February 27, 2004
2 Questions, questions and more questions How and why was the NIH Roadmap developed?How is it being implemented?What are the initiatives?How will the Roadmap benefit my research area?
3 Challenges for NIH Revolutionary and rapid changes in Science Increasing breadth of mission and growthComplex organization with many units (27 institutes and centers, multiple program offices, e.g., OWHR, OAR, ORD, ...)Structured by Disease, Organ, Life stage, Disciplines ….Rapid Convergence of Science
4 Evolving Public Health Challenges Acute to chronic conditionsAging PopulationHealth DisparitiesEmerging DiseasesBiodefense
5 U.S. Health Expenditures (Percentage of GDP)18ActualProjected16Percent14121019851987198919911993199519971999200120032005200720092011Year
6 Imperatives for NIH Accelerate pace of discoveries in life sciences Translate research more rapidly from laboratories to patients and backExplore novel approaches orders of magnitude more effective than currentDevelop new strategies: NIH Roadmap
7 How was the Roadmap developed? Extensive consultations with stakeholders, scientists, health care providersWhat are today’s scientific challenges?What are the roadblocks to progress?What do we need to do to overcome roadblocks?
8 What is the NIH Roadmap?A framework of priorities the NIH as a whole must address in order to optimize its entire research portfolio.A vision for a more efficient, innovative and productive system of biomedical and behavioral research.A set of initiatives that are central to extending the quality of healthy life for people in this country and around the world.
11 Need to understand biological systems Brent Cell, 2000
12 The Biological Data of the Future DestructiveQualitativeUni-dimensionalLow temporal resolutionLow data densityVariable standardsNon cumulativeNon-destructiveQuantitativeMulti-dimensional and spatially resolvedHigh Temporal resolutionHigh data densityStricter standardsCumulative
13 Multi- and Interdisciplinary Research will be Required to Solve the “Puzzle” of Complex Diseases and ConditionsGenesBehaviorDiet/NutritionInfectious agentsEnvironmentSociety???
14 NIH Roadmap Research Teams of the Future Scale and complexity of 21st C research requirenew organizational models for scientific teamsMulti-disciplinary and Inter-disciplinary TeamsLarger, coordinated, resource sharing TeamsPreserve the investigator(s)-initiated strategy
15 Translational Research For historical reasons, clinical research has evolved haphazardlyStarted as cottage industry and select centersNow has more complex requirements: regulation, technology, speed, efficiencyGreater links to basic scienceNeed transformation to move into the 21st CenturyIndividual apprenticeship discipline of clinical researchUniform gauge harmonize rules, build infrastructure and create networksFocus on mentoring multidisciplinary teamsThe key value is access to well characterized cohorts of patients and biological samples
16 NIH Roadmap Strategy Bench Bedside Practice Interdisciplinary Research Building Blocks PathwaysMolecular LibrariesBioinformatics andComputationalBiologyStructural BiologyNanomedicineTranslationalResearchInitiativesClinicalInformaticsIntegrated ResearchNetworksClinical outcomesTrainingNational Clinical Research AssociatesInterdisciplinary ResearchPioneer AwardPublic PrivatePartnerships
17 ClinicalEnterpriseNew Pathways to DiscoveryResearch Teams
18 Key elements of Roadmap funding and management All Institutes:Participate with their scientific community in defining all components of the RoadmapContribute equally and proportionatelyParticipate directly in decision making and have a direct liaison to the RoadmapAll Roadmap initiatives are offered for competition to researchers from all fieldsAll research communities can compete for all initiativesThe peer-review process will ensure appropriate expertise
19 Roadmap Funding dollars in millions FY 2004 Funding = $128.3 (dollars in millions)NIH$64.1$26.6$37.6
20 Roadmap Funding dollars in millions FY04FY05FY06FY07FY08FY09TotalPathways toDiscovery64137169182209188948ResearchTeams273944929693390Clinical38611201742142278331282373324485205072,172~0.9%0.34% %To be competed for in a common poolof initiatives by all researchers from every discipline
21 NIH Roadmap GoalAccelerate basic research discoveries and speed translation of those discoveries into clinical practiceExplicitly address roadblocks that slow the pace of medical research in improving the health of the American people
22 “How does the NIH Roadmap benefit my research area?” Speeding removal of major and fundamental roadblocks common to all diseasesNo Institute can solve these issues aloneTHIS IS A COMMON TRANS-NIH POOL OF TRANSFORMING INVESTMENTS OPEN TO ALL DISEASE AREAS FOR COMPETITION
23 “Yes, but we’re already doing those things. What’s new?” THE NIH ROADMAP POOLS RESOURCES FOR SPECIFIC ENABLING INVESTMENTS THAT INDIVIDUAL INSTITUTES COULD NOT UNDERTAKEExpanding molecular probe libraries publicly available to researchers by a factor of 7Increasing the number of publicly available molecular probes from less than 100,000 to over 500,000Developing a common national research informatics platform allowing interoperability for data for all patients whether seen at a research hospital or in their own community (NECTAR)Improving the implementation of Breakthrough research trials through the creation of INTEGRATED research partnershipsMORE RAPID DIFFUSION OF BEST PRACTICES TO PATIENTS