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Elias A. Zerhouni, M.D. February 27, 2004 The NIH Roadmap for Medical Research.

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Presentation on theme: "Elias A. Zerhouni, M.D. February 27, 2004 The NIH Roadmap for Medical Research."— Presentation transcript:

1 Elias A. Zerhouni, M.D. February 27, 2004 The NIH Roadmap for Medical Research

2 Questions, questions and more questions How and why was the NIH Roadmap developed? How is it being implemented? What are the initiatives? How will the Roadmap benefit my research area?

3 Challenges for NIH Revolutionary and rapid changes in Science Increasing breadth of mission and growth Complex organization with many units (27 institutes and centers, multiple program offices, e.g., OWHR, OAR, ORD,...) Structured by Disease, Organ, Life stage, Disciplines …. Rapid Convergence of Science

4 Acute to chronic conditions Evolving Public Health Challenges Health Disparities Emerging Diseases Aging Population Biodefense

5 U.S. Health Expenditures (Percentage of GDP) Year Percent Actual Projected

6 Imperatives for NIH Accelerate pace of discoveries in life sciences Translate research more rapidly from laboratories to patients and back Explore novel approaches orders of magnitude more effective than current Develop new strategies: NIH Roadmap

7 How was the Roadmap developed? Extensive consultations with stakeholders, scientists, health care providers –What are todays scientific challenges? –What are the roadblocks to progress? –What do we need to do to overcome roadblocks?

8 What is the NIH Roadmap? A framework of priorities the NIH as a whole must address in order to optimize its entire research portfolio. A vision for a more efficient, innovative and productive system of biomedical and behavioral research. A set of initiatives that are central to extending the quality of healthy life for people in this country and around the world.

9 NIH Roadmap for Medical Research New Pathways to Discovery Re-engineering the Clinical Research Enterprise Research Teams of the Future NIH

10 Emerging Complexity of Biology

11 Need to understand biological systems Brent Cell, 2000

12 The Biological Data of the Future Destructive Qualitative Uni-dimensional Low temporal resolution Low data density Variable standards Non cumulative Non-destructive Quantitative Multi-dimensional and spatially resolved High Temporal resolution High data density Stricter standards Cumulative

13 Multi- and Interdisciplinary Research will be Required to Solve the Puzzle of Complex Diseases and Conditions Genes Behavior Diet/Nutrition Infectious agents Environment Society ???

14 NIH Roadmap Research Teams of the Future Scale and complexity of 21 st C research require new organizational models for scientific teams Multi-disciplinary and Inter-disciplinary Teams Larger, coordinated, resource sharing Teams Preserve the investigator(s)-initiated strategy

15 Translational Research For historical reasons, clinical research has evolved haphazardly –Started as cottage industry and select centers –Now has more complex requirements: regulation, technology, speed, efficiency –Greater links to basic science Need transformation to move into the 21 st Century –Individual apprenticeship discipline of clinical research –Uniform gauge harmonize rules, build infrastructure and create networks –Focus on mentoring multidisciplinary teams The key value is access to well characterized cohorts of patients and biological samples

16 BenchBedsidePractice Building Blocks Pathways Molecular Libraries Bioinformatics and Computational Biology Structural Biology Nanomedicine Translational Research Initiatives Clinical Research Informatics Integrated Research Networks Clinical outcomes Training National Clinical Research Associates Interdisciplinary Research Pioneer Award Nanomedicine Public Private Partnerships NIH Roadmap Strategy

17 ImplementationGroups Molecular Libraries and Imaging Building Blocks, Biological Pathways and Networks Structural Biology Bioinformatics and Computational Biology Nanomedicine Interdisciplinary Research High-risk Research Public-Private Partnerships Re-engineering the Clinical Research Enterprise New Pathways to Discovery Research Teams Clinical Enterprise

18 Key elements of Roadmap funding and management All Institutes: –Participate with their scientific community in defining all components of the Roadmap –Contribute equally and proportionately –Participate directly in decision making and have a direct liaison to the Roadmap All Roadmap initiatives are offered for competition to researchers from all fields All research communities can compete for all initiatives The peer-review process will ensure appropriate expertise

19 Roadmap Funding dollars in millions NIH $64.1 $26.6$37.6 FY 2004 Funding = $128.3 (dollars in millions)

20 Roadmap Funding dollars in millions FY04FY05FY06FY07FY08FY09Total Pathways to Discovery Research Teams Clinical Research Total ,172 To be competed for in a common pool of initiatives by all researchers from every discipline 0.34% 0.63% ~0.9%

21 NIH Roadmap Goal Accelerate basic research discoveries and speed translation of those discoveries into clinical practice Explicitly address roadblocks that slow the pace of medical research in improving the health of the American people

22 How does the NIH Roadmap benefit my research area? Speeding removal of major and fundamental roadblocks common to all diseases No Institute can solve these issues alone THIS IS A COMMON TRANS-NIH POOL OF TRANSFORMING INVESTMENTS OPEN TO ALL DISEASE AREAS FOR COMPETITION

23 Yes, but were already doing those things. Whats new? THE NIH ROADMAP POOLS RESOURCES FOR SPECIFIC ENABLING INVESTMENTS THAT INDIVIDUAL INSTITUTES COULD NOT UNDERTAKE Expanding molecular probe libraries publicly available to researchers by a factor of 7 Increasing the number of publicly available molecular probes from less than 100,000 to over 500,000 Developing a common national research informatics platform allowing interoperability for data for all patients whether seen at a research hospital or in their own community (NECTAR) Improving the implementation of Breakthrough research trials through the creation of INTEGRATED research partnerships MORE RAPID DIFFUSION OF BEST PRACTICES TO PATIENTS

24 There is no wrong time to do the right thing.

25 Ideas People Resources Leadership NIH

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