2 Can you define accuracy and precision based on the graphics above? Can you hit the bull's-eye?Three shooters with three arrows each to shoot.How do they compare?Both accurate and precisePrecise but not accurateNeither accurate nor preciseCan you define accuracy and precision based on the graphics above?
3 Some terminologyTrue value – standard or reference of known value or a theoretical valueAccuracy – closeness to the true valuePrecision – reproducibility or agreement with each other for multiple trials
4 Can all errors be controlled? What are some possible things that can be done to minimize errors?
5 Types of Errors Determinate (or Systematic) Sometimes called bias due to error in one direction- high or lowKnown causeOperatorCalibration of glassware, sensor, or instrumentWhen determined can be correctedMay be of a constant or proportional naturePGCC CHM 103 Sinex
6 constant or proportional error… Proportional error influences the slope.Constant error influences the intercept.
7 Types of Errors continued Indeterminate (or Random)Cannot be determined (no control over)Random nature causes both high and low values which will average outMultiple trials help to minimize
8 Sources of Error sampling preparation analysis Representative sample homogeneousvs.heterogeneouspreparationLossContamination(unwanted addition)analysisMeasurementof AnalyteCalibration ofInstrument orStandardsolutionsHow about sampling a chocolate chip cookie?
9 How do you assess the total error? One way to assess total error is to treat a reference standard as a sample.The reference standard would be carried through the entire process to see how close the results are to the reference value.
10 Expressing accuracy and precision Mean (average)Percent errorRangeDeviationStandard deviationPercent coefficient of variationaccuracyprecision
11 Accuracy and Precision The center ofthe target isthe true value.Nature of accuracy and precisionBoth accurate and precisePrecise onlyNeither accurate nor preciseTarget shooters commentsGreat shooting!Gun barrel must be bent!Can’t hit the broad side of a barn!
12 Scientific comments Very small error in measurement Both a & pP onlyNeither a nor pScientific commentsVery small error in measurementAll cluster the true valueRemember a standard or true value is neededClustered multiple measurements but consistently off from true valueCalibration of probe or other measuring device is off or unknown systematic errorThe shot-gun effectGet a new measurement system or operator
13 Mathematical comments Both a & pP onlyNeither a nor pMathematical commentsSmall standard deviation or %CVSmall %errorLarge %errorLargestandard deviation or %CVStatus/rankHighly desiredAcceptable, the best that can be done without a true valueUnacceptable
14 How would practice in target shooting or making a measurement influence the results? To judge the accuracy of an analysis, what is required?
16 Most accurate and precise Graphical methodsScatter plotsMost accurate and preciseSystematic error?Worst precision
17 Let’s examine some results for two students analyzing two different CaCO3 antacid tablets True valueStudent 1Student 2Label value500 mg750 mgMean463 mg761 mgStd. dev.20 mg28 mgWhich student has the more accurate results?Which student has the greater precision?
18 How are we going to address these questions? quantityStudent 1Student 2%CV%ErrorWhat does the sign of the percent error tell you about the error?
19 and always remember to… Make all measurements carefully and check your results or readings a second time.Read all devices to as many places as possible (significant figures):calibration marks + one more placeA buret, which is calibrated to 0.1 mL, can be read to 0.01 mL.A thermometer marked every degree can be read to 0.1 degree