Presentation on theme: "Ahmed El-Sohemy Department of Nutritional Sciences University of Toronto Coffee, Caffeine and Cardiovascular Disease Canada Research Chair in Nutrigenomics."— Presentation transcript:
Ahmed El-Sohemy Department of Nutritional Sciences University of Toronto Coffee, Caffeine and Cardiovascular Disease Canada Research Chair in Nutrigenomics
DietGenes Nutrigenomics: Using genomic information and techniques in molecular genetics & genomics to address issues important to nutrition and health. Food preferences
Confounding (residual) Measurement error Recall Bias (case-control) Why bother with genetics/genomics? Challenges for Nutritional Epidemiology
Risk No Effect Is Coffee associated with CVD?
Coffee or associated lifestyle? Are coffee abstainers at risk? Does risk depend on age? Which component of coffee? Is Coffee associated with CVD?
Costa Rica Study 2013 cases (myocardial infarction) 2013 population-based controls - matched (age, sex, area of residence) Data collection: - food frequency questionnaire - health and lifestyle questionnaire - fasting blood sample (DNA)
Increase Decrease No effect Genes Genotype A Genotype C Genotype B Health Outcome Coffee
Caffeine Consumption Habits Study Healthy Men and Women aged years (n=940) Food Frequency Questionnaire - Caffeine consumption Caffeine Consumption Habits Questionnaire - Acute effects of caffeine - Caffeine withdrawal symptoms - Limiting or avoiding caffeine
* P<0.05 ** * ** P<0.005 DRD2 C957T Genotype and Elevated Mood Among Men and Women
* P<0.05 * DRD2 C957T Genotype and Caffeine Intake Among Men and Women
ACKNOWLEDGMENTS Marilyn Cornelis Leah Cahill Karen Eny Bénédicte Fontaine-Bisson Ilana Platt Stephen Ozsungur Clare Toguri Canada Research Chairs Canadian Institutes of Health Research Natural Sciences and Engineering Research Council Advanced Foods and Materials Network Centres of Excellence Hyeon-Joo Lee Lindsay Stewart Daiva Nielsen Alejandra Navarro-Allende Susana Huang Sarah Herd Darren Brenner Bibiana Garcia-Bailo Hannia Campos Edmond Kabagambe Tom Wolever CCD Investigators Paul Corey David Jenkins