Presentation on theme: "Citric Acid Cycle 1 C483 Spring 2013. 1. The net effect of the eight steps of the citric acid cycle is to A) completely oxidize an acetyl group to carbon."— Presentation transcript:
1. The net effect of the eight steps of the citric acid cycle is to A) completely oxidize an acetyl group to carbon dioxide. B) convert pyruvate to Acetyl CoA. C) produce a citrate molecule D) produce 8 ATP for every pass through the cycle. E) More than one of the above 2. The order of prosthetic groups as they act in the three proteins of the PDH(pyruvate dehydrogenase) complex is: A) FAD → thiamine pyrophosphate → NAD+ B) FAD → thiamine pyrophosphate → dihydrolipoamide C) thiamine pyrophosphate → dihydrolipoamide → FAD D) NAD+ → FAD → dihydrolipoamide 3. Which might you expect to have a higher than normal blood concentration in an individual with thiamine deficiency? A) Isocitrate. B) Pyruvate. C) Oxaloacetate. D) Acetyl CoA.
4. About how many total ATP equivalents are generated by the complete oxidation of one molecule of acetyl CoA? A) 1.5 B) 2.5 C) 3 D) 10 E) 30 5. Which product of the citric acid cycle produces the most ATP equivalents? A) NADH. B) QH2. C) GTP. D) CO2.
Net ATP Harvest from Glucose Glycolysis = 2 ATP – Plus 3 or 5 ATP from NADH – In humans, cytosolic NADH leads to production of 3 ATP Pyruvate DH = 5 ATP Citric Acid Cycle = 20 ATP Total: 30 ATP/glucose in humans