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Immunity to Infectious Diseases BIOS 486A/586A K.J.Goodrum 2005.

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Presentation on theme: "Immunity to Infectious Diseases BIOS 486A/586A K.J.Goodrum 2005."— Presentation transcript:

1 Immunity to Infectious Diseases BIOS 486A/586A K.J.Goodrum 2005

2 Topic Outline Routes and sites of infection Mechanisms of tissue injury in infection Timing of immune responses to infection Regulation of cell-mediated (T H 1) vs. humoral immunity (T H 2) in infections Effector mechanisms for immunity to different pathogens Microbial evasion of immune responses Immunizations/vaccines

3 Primary Route of Infection: Microbial Adherence and Invasion of epithelial tissues (lung, gut, other) Janeway, Fig. 10.2

4 Primary Route of Infection: Microbial Adherence and Invasion of epithelial tissues (continued). Janeway, Fig. 10.2

5 Janeway. Fig Infection compartments

6 Janeway. Fig Mechanisms of Pathogen- induced tissue Damage

7 Janeway. Fig Mechanisms of Pathogen- induced tissue Damage (continued)

8 Janeway. Fig Time course of immune response to acute infection.

9 Janeway. Fig Infection induced Th1 vs. Th2 responses.

10 Janeway. Fig Protective Effector Mechanisms against various infectious microbes

11 Janeway. Fig Protective Effector Mechanisms against various infectious microbes (continued)

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13 Janeway. Fig Mucosal  T cell function.

14 Janeway. Fig Mucosal Secretory IgA function

15 Janeway. Fig Recognition of intracellular infection by Nod1.

16 Janeway. Fig Recognition of intracellular infection by Nod1.(continued)

17 Janeway. Fig Innate recognition of microbes and phagocytosis by macrophages

18 Janeway. Fig Microbial activation of complement pathways for inflammation.

19 Janeway. Fig Protective effector mechanisms of antibody.

20 Janeway. Fig Protective effector mechanisms of antibody.

21 Janeway. Fig Effector T cell populations and effector mechanisms.

22 Janeway. Fig Immune evasion via multiple antigenic variants of microbes (serotypes).

23 Fig.11.1 continued

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25 Janeway. Fig Immune Evasion via antigen drift/shift.

26 Janeway. Fig Immune Evasion via antigen drift/shift. (continued)

27 Janeway. Fig Immune evasion via sequential DNA rearrangements of microbial antigens.

28 Janeway. Fig Immune evasion via sequential DNA rearrangements of microbial antigens. (continued)

29 Janeway. Fig Immune evasion mechanisms of herpes viruses.

30 Janeway. Fig Immune evasion mechanisms of herpes viruses. (continued)

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32 Janeway. Fig The effect of T helper subpopulations on leprosy outcome.

33 Janeway. Fig The effect of T helper subpopulations on leprosy outcome. (continued)

34 Janeway. Fig Childhood vaccination schedule in USA.

35 Janeway. Fig

36 Janeway. Fig continued.

37 Summary Immunity to infection depends on a combination of innate mechanisms (phagocytosis, complement, etc.) and antigen specific adaptive responses (antibody, effector T lymphocytes). The immune system regulates which specific responses predominate (humoral vs. cell- mediated) based on the body compartment infected (intracellular vs. extracellular) and on cytokine signals present at initial antigen contact (Th1 vs. Th2 responses).

38 Summary-continued Disease-causing microbes have virulence mechanisms that resist or evade innate and/or specific immune effector functions. Recovery from natural infection or artificial immunization promote specific longterm immunity to re-infection (immunological memory).


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