Presentation on theme: "Jiangsu Institute of Nuclear Medicine Contact:"— Presentation transcript:
1Jiangsu Institute of Nuclear Medicine Contact: firstname.lastname@example.org 10th AOTA CongressBALI, INDONESIA, 2012Curcumin Induces both Apoptosis and Autophagy in Human Papillary Thyroid Carcinoma BCPAP CellsZhang LiJiangsu Institute of Nuclear MedicineWuxi, Jiangsu, ChinaContact:
2Curcumin ? An acitve polyphenol derived from the plant turmeric low toxicityanti-inflammatoryantioxidantantiangiogenicantitumourCurcuminThyroid cancer?Chemical structure of curcumin
3Apoptosis and Autophagy Apoptosis –type I programmed cell deathAutophagy- type II programmed cell death- a self-degradative process- cope with stresses- required in apoptotic-deficient cellsThree types of autophgay:MicroautophagyChaperone-mediated autophagyMacroautopahgy
21Conclusions Curcumin induces cytotoxicity of BCPAP cells. Induction of apoptosis and autophagy as the likely underlying mechanism that is responsible for the cytotoxicity of curcumin .Curcumin inhibited AKT pathway and activated mitogen-activated protein kinase (MAPK) signaling thereby inducing autophagy.
22Thank you for your attention! AcknowledgementsJiangsu Institute of Nuclear MedicineGrantsBao JiandongYu HuixinZhang ChiyuWu JingZheng JieSun WeiChina Medical UniversityGuan HaixiaNangjing UniversitySun YangNational Natural Science Foundation of China (No )Natural Science Foundation of Jiangsu Province (No. BK )Science and Research Foundation of Health Bureau of Jiangsu Province (No. H )Thank you for your attention!