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Blood-Type Genetics.

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Presentation on theme: "Blood-Type Genetics."— Presentation transcript:

1 Blood-Type Genetics

2 Blood Cell Antigens A, B, O blood type Rh factor
Blood types are the result of the presence (or absence) of antigens (molecules) on the surface of the individual’s red blood cells. These fall into two groups: A, B, O blood type Rh factor

3 Codominance The gene for antigen A and the gene for antigen B are CODOMINANT. Both traits are expressed completely when the gene for A is inherited from one parent and the gene for B is inherited from the other parent.

4 Bloodtype antigens and antibodies

5 A, B, O Inheritance Allele from Parent 1 Allele from Parent 2
Child’s genotype Child’s phenotype A AA O AO B AB BB BO OO

6 Blood Type Problem Three children recently born in a hospital were accidently mixed up. The blood types of the parents involved are given along with the blood types of the infants. Determine which baby belongs with which parents, and explain your reasoning for the decisions you made. Mother and Father_____ _____Babies_______ Parents #1 Type A & Type B Child x Type A Parents #2 Type O & Type AB Child y Type O Parents #3 Type B & Type O Child z Type AB

7 Rh Inheritance Rh inheritance is independent of A, B, O blood type.
Rh factor Possible genotypes Rh+ Rh+/Rh+ OR Rh+/Rh- Rh- Rh-/Rh- Parent 1 Rh allele Parent 2 Child’s phenotype Rh+ Rh-

8 ABO and Rh blood type distribution by nation (population averages)
Country   O+   A+   B+   AB+    O−    A−    B−   AB−   Australia 40% 31% 8% 2% 9% 7% 1% Austria 30% 33% 12% 6% 3% Belgium 38.1% 34% 8.5% 4.1% 1.5% 0.8% Canada 39% 36% 7.6% 2.5% 1.4% 0.5% Denmark 35% 37% 4% Finland 27% 38% 15% France Germany Hong Kong, China 26% <0.3% Ireland 47% 5% South Korea 35.2% 28.1% 26.1% 11.3% 0.1% 0.05% Netherlands 39.5% 6.7% 7.5% 1.3% New Zealand 32% Norway 42.5% 6.8% 3.4% 1.2% 0.6% Poland Sweden 10% Turkey 29.8% 37.8% 14.2% 7.2% 3.9% 4.7% 1.6% UK USA 37.4% 35.7% 6.6% 6.3%

9 Blood Type Problem A man whose alleles for blood type are A/O and Rh+/Rh- marries a woman whose alleles are B/O and Rh+/Rh-. What are the phenotypes of the parents with respect to blood type? What are the possible genotypes for their offspring with respect to blood type? What are the possible phenotypes for their offspring with respect to blood type?

10 What are the phenotypes of the parents with respect to blood type?
Father: AO is expressed as type A Rh+/Rh- is expressed as Rh+ Father’s phenotype is A+ Mother: BO is expressed as type B Rh+/Rh- is expressed as Rh+ Mother’s phenotype is B+

11 What are the possible genotypes for their offspring with respect to blood type?
Paternal gametes A/Rh+ A/Rh- O/Rh+ O/Rh- AB Rh+Rh+ AB Rh+Rh- BO Rh+Rh+ BO Rh+Rh- B/Rh+ AB Rh+Rh- AB Rh-Rh- BO Rh+Rh- BO Rh-Rh- B/Rh- Maternal gametes AO Rh+Rh+ AO Rh+Rh- OO Rh+Rh+ OO Rh+Rh- O/Rh+ AO Rh+Rh- AO Rh-Rh- OO Rh+Rh- OO Rh-Rh- O/Rh-

12 What are the possible phenotypes for their offspring with respect to blood type?
AB+ = /16 AB- = /16 A+ = /16 A- = /16 B+ = /16 B- = /16 O+ = /16 O- = /16 3 AB Rh+Rh+ AB Rh+Rh- BO Rh+Rh+ BO Rh+Rh- 1 3 AB Rh+Rh- AB Rh-Rh- BO Rh+Rh- BO Rh-Rh- 1 AO Rh+Rh+ AO Rh+Rh- OO Rh+Rh+ OO Rh+Rh- 3 1 AO Rh+Rh- AO Rh-Rh- OO Rh+Rh- OO Rh-Rh- 3 1


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