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Blood-Type Genetics. Blood Cell Antigens Blood types are the result of the presence (or absence) of antigens (molecules) on the surface of the individual’s.

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Presentation on theme: "Blood-Type Genetics. Blood Cell Antigens Blood types are the result of the presence (or absence) of antigens (molecules) on the surface of the individual’s."— Presentation transcript:

1 Blood-Type Genetics

2 Blood Cell Antigens Blood types are the result of the presence (or absence) of antigens (molecules) on the surface of the individual’s red blood cells. These fall into two groups:  ABO  A, B, O blood type  Rh  Rh factor

3 Codominance A BCODOMINANT The gene for antigen A and the gene for antigen B are CODOMINANT. A B Both traits are expressed completely when the gene for A is inherited from one parent and the gene for B is inherited from the other parent.

4 Bloodtype antigens and antibodies

5 A, B, O Inheritance

6 Blood Type Problem Three children recently born in a hospital were accidently mixed up. The blood types of the parents involved are given along with the blood types of the infants. Determine which baby belongs with which parents, and explain your reasoning for the decisions you made. Mother and Father__________Babies _______ Parents #1Type A & Type BChild x Type A Parents #2Type O & Type ABChild y Type O Parents #3Type B & Type OChild z Type AB

7 Rh Inheritance Parent 1 Rh allele Parent 2 Rh allele Child’s phenotype Rh+ Rh-Rh+ Rh- Rh factorPossible genotypes Rh + Rh + /Rh + OR Rh + /Rh - Rh - Rh - /Rh - Rh inheritance is independent of A, B, O blood type.

8 ABO and Rh blood type distribution by nation (population averages) Country O+ A+ B+ AB+ O− A− B− AB− Australia40%31%8%2%9%7%2%1% Austria30%33%12%6%7%8%3%1% Belgium38.1%34%8.5%4.1%7%6%1.5%0.8% Canada39%36%7.6%2.5%7%6%1.4%0.5% Denmark35%37%8%4%6%7%2%1% Finland27%38%15%7%4%6%2%1% France36%37%9%3%6%7%1% Germany35%37%9%4%6% 2%1% Hong Kong, China 40%26%27%7%<0.3% Ireland47%26%9%2%8%5%2%1% South Korea35.2%28.1%26.1%11.3%0.1% 0.05% Netherlands39.5%35%6.7%2.5%7.5%7%1.3%0.5% New Zealand38%32%9%3%9%6%2%1% Norway34%42.5%6.8%3.4%6%7.5%1.2%0.6% Poland31%32%15%7%6% 2%1% Sweden32%37%10%5%6%7%2%1% Turkey29.8%37.8%14.2%7.2%3.9%4.7%1.6%0.8% UK37%35%8%3%7% 2%1% USA37.4%35.7%8.5%3.4%6.6%6.3%1.5%0.6%

9 Blood Type Problem A man whose alleles for blood type are A/O and Rh+/Rh- marries a woman whose alleles are B/O and Rh+/Rh-. a)What are the phenotypes of the parents with respect to blood type? b)What are the possible genotypes for their offspring with respect to blood type? c)What are the possible phenotypes for their offspring with respect to blood type?

10 What are the phenotypes of the parents with respect to blood type? Father:  AO is expressed as type A  Rh+/Rh- is expressed as Rh+  Father’s phenotype is A+ Mother:  BO is expressed as type B  Rh+/Rh- is expressed as Rh+  Mother’s phenotype is B+

11 What are the possible genotypes for their offspring with respect to blood type? A/Rh+A/Rh-O/Rh+O/Rh- Paternal gametes B/Rh+ B/Rh- O/Rh+ O/Rh- Maternal gametes AB Rh+Rh+ AB Rh-Rh- BO Rh+Rh- OO Rh+Rh- BO Rh-Rh- BO Rh+Rh+ BO Rh+Rh- OO Rh-Rh- AO Rh+Rh- AO Rh-Rh- AO Rh+Rh- OO Rh+Rh+ OO Rh+Rh- AB Rh+Rh- AO Rh+Rh+ AB Rh+Rh-

12 What are the possible phenotypes for their offspring with respect to blood type? AB Rh+Rh+ AB Rh-Rh- BO Rh+Rh- OO Rh+Rh- BO Rh-Rh- BO Rh+Rh+ BO Rh+Rh- OO Rh-Rh- AO Rh+Rh- AO Rh-Rh- AO Rh+Rh- OO Rh+Rh+ OO Rh+Rh- AB Rh+Rh- AO Rh+Rh+ AB Rh+Rh- AB+ = /16 AB- = /16 A+ = /16 A- = /16 B+ = /16 B- = /16 O+ = /16 O- = /


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