2 Blood Cell Antigens A, B, O blood type Rh factor Blood types are the result of the presence (or absence) of antigens (molecules) on the surface of the individual’s red blood cells. These fall into two groups:A, B, O blood typeRh factor
3 CodominanceThe gene for antigen A and the gene for antigen B are CODOMINANT.Both traits are expressed completely when the gene for A is inherited from one parent and the gene for B is inherited from the other parent.
5 A, B, O Inheritance Allele from Parent 1 Allele from Parent 2 Child’s genotypeChild’sphenotypeAAAOAOBABBBBOOO
6 Blood Type ProblemThree children recently born in a hospital were accidently mixed up. The blood types of the parents involved are given along with the blood types of the infants. Determine which baby belongs with which parents, and explain your reasoning for the decisions you made.Mother and Father_____ _____Babies_______Parents #1 Type A & Type B Child x Type AParents #2 Type O & Type AB Child y Type OParents #3 Type B & Type O Child z Type AB
7 Rh Inheritance Rh inheritance is independent of A, B, O blood type. Rh factorPossible genotypesRh+Rh+/Rh+ OR Rh+/Rh-Rh-Rh-/Rh-Parent 1Rh alleleParent 2Child’sphenotypeRh+Rh-
8 ABO and Rh blood type distribution by nation (population averages) Country O+ A+ B+ AB+ O− A− B− AB− Australia40%31%8%2%9%7%1%Austria30%33%12%6%3%Belgium38.1%34%8.5%4.1%1.5%0.8%Canada39%36%7.6%2.5%1.4%0.5%Denmark35%37%4%Finland27%38%15%FranceGermanyHong Kong, China26%<0.3%Ireland47%5%South Korea35.2%28.1%26.1%11.3%0.1%0.05%Netherlands39.5%6.7%7.5%1.3%New Zealand32%Norway42.5%6.8%3.4%1.2%0.6%PolandSweden10%Turkey29.8%37.8%14.2%7.2%3.9%4.7%1.6%UKUSA37.4%35.7%6.6%6.3%
9 Blood Type ProblemA man whose alleles for blood type are A/O and Rh+/Rh- marries a woman whose alleles are B/O and Rh+/Rh-.What are the phenotypes of the parents with respect to blood type?What are the possible genotypes for their offspring with respect to blood type?What are the possible phenotypes for their offspring with respect to blood type?
10 What are the phenotypes of the parents with respect to blood type? Father:AO is expressed as type ARh+/Rh- is expressed as Rh+Father’s phenotype is A+Mother:BO is expressed as type BRh+/Rh- is expressed as Rh+Mother’s phenotype is B+
11 What are the possible genotypes for their offspring with respect to blood type? Paternal gametesA/Rh+A/Rh-O/Rh+O/Rh-ABRh+Rh+ABRh+Rh-BORh+Rh+BORh+Rh-B/Rh+ABRh+Rh-ABRh-Rh-BORh+Rh-BORh-Rh-B/Rh-MaternalgametesAORh+Rh+AORh+Rh-OORh+Rh+OORh+Rh-O/Rh+AORh+Rh-AORh-Rh-OORh+Rh-OORh-Rh-O/Rh-
12 What are the possible phenotypes for their offspring with respect to blood type? AB+ = /16AB- = /16A+ = /16A- = /16B+ = /16B- = /16O+ = /16O- = /163ABRh+Rh+ABRh+Rh-BORh+Rh+BORh+Rh-13ABRh+Rh-ABRh-Rh-BORh+Rh-BORh-Rh-1AORh+Rh+AORh+Rh-OORh+Rh+OORh+Rh-31AORh+Rh-AORh-Rh-OORh+Rh-OORh-Rh-31