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Separation Science – Uppsala University RESEARCH In the Border Between Analytical Chemistry, Physical Chemistry and Chemical Engineering PhD Students:

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Presentation on theme: "Separation Science – Uppsala University RESEARCH In the Border Between Analytical Chemistry, Physical Chemistry and Chemical Engineering PhD Students:"— Presentation transcript:

1 Separation Science – Uppsala University RESEARCH In the Border Between Analytical Chemistry, Physical Chemistry and Chemical Engineering PhD Students: Robert Arnell Jörgen Samuelsson Group Leader: Torgny Fornstedt Torgny.Fornstedt@ytbioteknik.uu.se 070-425 06 83

2 Research Profile  Preparative LC Theory  Computer Simulations  New Methods for Determination of Adsorption Isotherms  Characterization of New Columns (Adsorption Energy Distribution calculations)  Preparative CSPs  HPLC Phases for Alkaline Conditions  Tuning of Band Shapes for Increased Production (Chirobiotic T, CHI-TBB?) 

3 1. Analytical Reason: A. Column Characterization Capacity, Selectivity Surface Heterogeneity B. Detailed Characterization of Drug-Protein Interactions using Immobilized Protein Stationary Phases Affinity, Enantioselectivity Displacement Studies Multi-Site Interaction Why measure Adsorption Isotherms?

4 Adsorption Isotherms Known Chromatography Simulation Numerical Process Optimization (SMB) Why measure Adsorption Isotherms? 2. Process Related Reason:

5 Publications 2006 1.An Improved Algorithm for Solving Inverse Problems in Liquid Chromatography. P. Forssén, R. Arnell and T. Fornstedt. Computers & Chemical Engineering (2006) 30, 1381-1391. 2. Discovery of invisible extra fronts in single-component frontal analysis in liquid chromatography by J. Samuelsson and T. Fornstedt. Journal of Chromatography A (2006) 1114, 53-61. 3. Analytical Characterization of Chiral Drug-Protein Interactions: Comparison between an SPR Assay and the HPLC Perturbation Method. R. Arnell, N, Ferraz and T. Fornstedt. Analytical Chemistry (2006) 78 1682-1689. 4. Invisible Analyte Peak Deformations in Single-Component Liquid Chromatography” by J. Samuelsson, R. Arnell and T. Fornstedt. Analytical Chemistry (2006) 78 2765-2771. 5. Validation of the Tracer Pulse Method for Multi Component Liquid Chromatography- a Classical Paradox Revisited. R. Arnell and T. Fornstedt. Analytical Chemistry (2006) 78, 4615-4623. 6. General theory of indirect detection in chromatography. P. Forssén and T. Fornstedt. Journal of Chromatography A (2006) 1126, 268-275.

6 OUR GROUP! From left: Robert Arnell, Jörgen Samuelsson and T. Fornstedt Patrik Forssén Dept. Of Scientific Computing Se vår kurs industrin: HPLC teori för praktiskt bruk, Flera tillfällen tidigt i vår, kommer upp snart på: http://www.kemi.uu.se/industrikurser/LC-teori/index.shtm


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