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BioASP Roadshow Maastricht; May 19 2004 Brought to you by: BioASP and BiGCaT Bioinformatics

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10.00 - 10.10 Welcome and Introduction 10.10 - 10.35 From genes to pathways; data mining to couple microarray reporter info with protein functions (Dr. R. van Haaften) 10.35 - 11.00 Around the triangle; combination of expression data with known quantitative trade loci and pathways (Dr.Ir. C. Evelo) 11.00 - 12.00 BioASP Road Show (Dr. K. van Haren) 12.00 - 12.30 BioASP tools; Rosetta resolver and Spotfire Decisionsite powerful tools for biomedical research (Dr. A.P. Bijnens) 12.30 - 12.40 BOS2; Getting Bioinformatics On Speed (Prof. Dr. E. Mariman). 12.40 - 13.00 Concluding remarks and discussion Program

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BiGCaT Bioinformatics Where the cat hunts

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BiGCaT Bioinformatics, bridge between two universities Universiteit Maastricht Patients, Experiments, Arrays and Loads of Data TU/e Ideas & Experience in Data Handling BiGCaT LUC Diepenbeek Statistical Foundations

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BiGCaT Bioinformatics, between two research fields Cardiovascular Research Nutritional & Environmental Research BiGCaT

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Systems Biology Transcriptomics Metabolomics Proteomics microarrays, 20 k (available) Large scale analytical chemistry (developing outside) 2D-gels, antibody techniques (developing inside)

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Our usual prey: gene expression arrays Microarrays: relative fluorescense signals. Identification. Classic treatment Look at 20 or so most changed genes Look at your own favorites Look at large tissue chunks

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What can we do to increase understanding? Look at functional pathway info – Dr. Rachel van Haaften Combine with known info – Dr. Chris Evelo Use the BioASP portal and data - Dr. Karin van Haren Use major bioinformatics tools – Dr. Anne Pascale Bijnens Look into the future - Prof. Edwin Mariman

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