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Cytarabine (araC) Cytidine analogue ALL, AML. thioguanine Guanine analogue AML Watch myelosuppression and GI perforation.

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Presentation on theme: "Cytarabine (araC) Cytidine analogue ALL, AML. thioguanine Guanine analogue AML Watch myelosuppression and GI perforation."— Presentation transcript:

1 cytarabine (araC) Cytidine analogue ALL, AML

2 thioguanine Guanine analogue AML Watch myelosuppression and GI perforation

3 cyclophosphamide Alkylating agent (binds DNA) Autoimmune diseases, leukemias/lymphomas Beware hemorrhagic cystitis

4 vinblastine Prevents microtubule polymerization Metastatic testicular cancer and lymphoma Marrow suppression is dose-limiting

5 dacarbazine Alkylating agent Hodgkin’s disease

6 irinotecan Topoisomerase I inhibitor Colorectal cancer Beware life-threatening diarrhea

7 procarbazine Alkylating agent Hodgkin’s disease

8 5-FluoroUracil Thymidylate synthase inhibitor Breast, GI, and skin cancer (topical)

9 bleomycin Breaks DNA via oxidative intermediaries Testicular cancer and hodgkin’s disease Pulmonary fibrosis is dose-limiting

10 mitomycin Alkylating agent gastric and pancreatic cancer

11 capecitabine Thymidylate synthase inhibitor Metastatic colorectal and breast cancer

12 doxorubicin Topoisomerase II inhibitor Leukemias and lymphomas Watch heart failure

13 hydroxyurea Inhibits ribonucleotide reductase Hematologic malignancies, head & neck cancers, sickle cell (increases HbF) Watch out for secondary leukemia

14 carmustine Alkylating agent Brain cancer

15 6-MercaptoPurine Inhibitor of IMP dehydrogenase (purine construction) ALL, AML Allopurinol potentiates effectiveness and pancreatic/marrow toxicity

16 azathioprine Inhibitor of IMP dehydrogenase (purine construction) Immunosuppression in renal transplants, RA Allopurinol potentiates effectiveness and toxicity

17 etoposide Topoisomerase II inhibitor Testicular and lung cancer Watch myelosuppression

18 altretamine Alkylating agent Ovarian cancer

19 thiopeta Alkylating agent Bladder cancer (instilled directly into bladder)

20 vincristine Prevents microtubule polymerization Leukemias and Hodgkin’s disease Peripheral neuropathy is dose-limiting

21 cladribine Adenosine analogue Hairy cell leukemia, MS

22 carboplatin Cross-links guanines Genitourinary & lung cancer

23 paclitaxel Inhibits microtubule depolymerization Ovarian and NSC lung cancer

24 topotecan Topoisomerase I inhibitor Small cell lung cancer and cervical carcinoma Beware life-threatening diarrhea

25 cisplatin Cross-links guanines Genitourinary & lung cancer Watch nephrotoxicity; co-admin amifostine

26 docetaxel Inhibits microtubule depolymerization Breast and gastric cancer


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