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Cytidine analogue ALL, AMLcytarabine (araC) Cytidine analogue ALL, AML
Guanine analogue AML Watch myelosuppression and GI perforationthioguanine Guanine analogue AML Watch myelosuppression and GI perforation
cyclophosphamide Alkylating agent (binds DNA)Autoimmune diseases, leukemias/lymphomas Beware hemorrhagic cystitis
vinblastine Prevents microtubule polymerizationMetastatic testicular cancer and lymphoma Marrow suppression is dose-limiting
Alkylating agent Hodgkin’s diseasedacarbazine Alkylating agent Hodgkin’s disease
irinotecan Topoisomerase I inhibitor Colorectal cancerBeware life-threatening diarrhea
Alkylating agent Hodgkin’s diseaseprocarbazine Alkylating agent Hodgkin’s disease
Thymidylate synthase inhibitor Breast, GI, and skin cancer (topical)5-FluoroUracil Thymidylate synthase inhibitor Breast, GI, and skin cancer (topical)
bleomycin Breaks DNA via oxidative intermediariesTesticular cancer and hodgkin’s disease Pulmonary fibrosis is dose-limiting
Alkylating agent gastric and pancreatic cancermitomycin Alkylating agent gastric and pancreatic cancer
Thymidylate synthase inhibitor Metastatic colorectal and breast cancercapecitabine Thymidylate synthase inhibitor Metastatic colorectal and breast cancer
Topoisomerase II inhibitor Leukemias and lymphomas Watch heart failuredoxorubicin Topoisomerase II inhibitor Leukemias and lymphomas Watch heart failure
hydroxyurea Inhibits ribonucleotide reductaseHematologic malignancies, head & neck cancers, sickle cell (increases HbF) Watch out for secondary leukemia
Alkylating agent Brain cancercarmustine Alkylating agent Brain cancer
6-MercaptoPurine Inhibitor of IMP dehydrogenase (purine construction)ALL, AML Allopurinol potentiates effectiveness and pancreatic/marrow toxicity
azathioprine Inhibitor of IMP dehydrogenase (purine construction)Immunosuppression in renal transplants, RA Allopurinol potentiates effectiveness and toxicity
etoposide Topoisomerase II inhibitor Testicular and lung cancerWatch myelosuppression
Alkylating agent Ovarian canceraltretamine Alkylating agent Ovarian cancer
Alkylating agent Bladder cancer (instilled directly into bladder)thiopeta Alkylating agent Bladder cancer (instilled directly into bladder)
vincristine Prevents microtubule polymerizationLeukemias and Hodgkin’s disease Peripheral neuropathy is dose-limiting
Adenosine analogue Hairy cell leukemia, MScladribine Adenosine analogue Hairy cell leukemia, MS
Cross-links guanines Genitourinary & lung cancercarboplatin Cross-links guanines Genitourinary & lung cancer
Inhibits microtubule depolymerization Ovarian and NSC lung cancerpaclitaxel Inhibits microtubule depolymerization Ovarian and NSC lung cancer
topotecan Topoisomerase I inhibitorSmall cell lung cancer and cervical carcinoma Beware life-threatening diarrhea
cisplatin Cross-links guanines Genitourinary & lung cancerWatch nephrotoxicity; co-admin amifostine
Inhibits microtubule depolymerization Breast and gastric cancerdocetaxel Inhibits microtubule depolymerization Breast and gastric cancer
Therapy of cancer disease This study material is recommended specifically for practical courses from Pharmacology II for students of general medicine and.
Antineoplastics 1 February :08 AM.
Anticancer Drugs. Introduction Cancer refers to a malignant neoplasm or new growth. Cancer cells manifest uncontrolled proliferation, loss of function.
Cancer Drug Classes The classes of drugs currently used in the cancer clinic are 1. DNA Binding Agents (intercalating and alkylating.
Joseph A. De Soto M.D., Ph.D., F.A.I.C.
Clinical Division of Oncology Department of Medicine I Medical University of Vienna, Austria Cytotoxic Agents.
Anticancer & Immunosupressants Q.. Questions 1-3. For each of the following statements, select the most appropriate drug which is BEST characterized by.
CANCER CHEMOTHERAPY. General Principles of Action of Anticancer Drugs A. Treatment strategies B. Treatment regimens and scheduling C. Problems associated.
Anticancer Agents Antibiotics Classification of Antibiotics:
Prof J.E.Brown Password: CCL.
ONCOLOGY Cytotoxic Agents. ONCOLOGY Cytotoxic agents Selective toxicity based on characteristics that distinguish malignant cells from normal cells Antineoplastic.
Cancer therapeutic drugs
Zenaida N. Maglaya, MD, FPSECP
1 By: Abdulaziz bin Saeedan P h.D. Department of Pharmacology E mail: P harmacology – IV PHL-425 Chapter 3: CANCER CHEMOTHERAPY.
Elsevier Inc. items and derived items © 2010 by Saunders, an imprint of Elsevier Inc. Chapter 101 Anticancer Drugs I: Cytotoxic Agents.
Alkylating agents: Platinum analogs Nitrogen Mustards Carboplatin
ANTICANCER DRUGS DR FATAI OLUYADI USMLEINCLINED.COM 1.
Chapter 45 Antineoplastic drugs.
Nitrogen mustards: mustard gas used first during WWI. Leukopenia and GI ulceration noted in survivors Bondage: crosslinking agents.
Chapter 49 Antineoplastic Drugs Department of pharmacology Liu xiaokang( 刘小康） 2010,3.
Antineoplastics W hat is Cancer ? Cancer is a disorder of cell division (leading cause of death). C C ancers most commonly occur in: breast (♀) -
CHEMOTHERAPY Dr.M.Torfehnezhad Pediatrician Definition: Chemotherapy The treatment of cancer using specific chemical agents or drugs that are destructive.
Cancer Chemotherapy Dr.Azarm. The goal of cancer treatment is eradication of cancer If not possible shifts to palliation,amelioration and preservation.
Understanding the cell cycle - chemotherapy and beyond
Cancer therapy - conventional Surgery Radiotherapy Chemotherapy Adjuvant therapies.
Antineoplastics Pharmacology III Practical Sessions Cairo University
I. Alkylating Agents & Related Compounds
Anti Kanker. Cancer is the second leading cause of death Each year there are 2,300,000 deaths in the US: ◦ Heart disease 730,000 ◦ Cancer 530,000 ◦ Cerebrovascular.
Principles of Chemotherapy and Chemotherapy Complications Özlem Sönmez, MD Yeditepe University Hospital Section of Medical Oncology.
Chapter 54 Cancer Chemotherapy
Application of Chemotherapy in Hematology Malignancies 林建廷 Dec 4, 2007.
Wednesday, February 15th Seth Wander
Antineoplastic Agents Cell Cycle Specific (CCS) AgentsCell Cycle Non-Specific (CCNS) Agents Plant alkaloids and antimetabolites Alkylating agents and some.
Cancer Chemotherapy Topics
Daniela Katz M.D. Sharett Institute of Oncology Chemotherapy.
Clinical Division of Oncology Department of Medicine I Mediacal University of Vienna, Austria Principles of chemotherapy.
PBL 6 – Lymphoma and leukemia
Principles of Chemotherapy. Objectives At the completion of this session the participant will be able to: ◦ Define combination chemotherapy ◦ Recognize.
Anticancer and Chemotherapy By: Mohamed Fahad Al-Ajmi.
Patients on Chemotherapy Dr. Feras FARARJEH. General Concepts The purpose of treating cancer with chemotherapeutic agents is to prevent cancer cells from.
Pharmacology of Chemotherapy
ANTI CANCER DRUGS.
Indications: MANY: Malignant lymphomas, mycosis fungoides and leukemias; several non-malignant diseases: severe rheumatoid arthritis and systemic lupus.
Cancer Detection and Diagnosis Early Cancer May Not Have Any symptoms Pap Test Mammograms Blood tests Prostate-specific antigen (PSA) Carcinoembryonic.
Feb. 17, 2014 Phase II, Foundation BlockAntineoplastics Faculty of Medicine, Kuwait University Prof. Saghir Akhtar RM 327, Phone: 6342
Encompass how some hormones and antihormones are utilized as anticancer therapy Identify concept of immunomodulation as an anticancer treatment modality.
Cancer Chemotherapy: Development of Drug Resistance.
Shanghai, China March 24 th 2001 Xeloda Future Developments Mr. John Collins.
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