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cytarabine (araC) Cytidine analogue ALL, AML
thioguanine Guanine analogue AML Watch myelosuppression and GI perforation
cyclophosphamide Alkylating agent (binds DNA) Autoimmune diseases, leukemias/lymphomas Beware hemorrhagic cystitis
vinblastine Prevents microtubule polymerization Metastatic testicular cancer and lymphoma Marrow suppression is dose-limiting
dacarbazine Alkylating agent Hodgkin’s disease
irinotecan Topoisomerase I inhibitor Colorectal cancer Beware life-threatening diarrhea
procarbazine Alkylating agent Hodgkin’s disease
5-FluoroUracil Thymidylate synthase inhibitor Breast, GI, and skin cancer (topical)
bleomycin Breaks DNA via oxidative intermediaries Testicular cancer and hodgkin’s disease Pulmonary fibrosis is dose-limiting
mitomycin Alkylating agent gastric and pancreatic cancer
capecitabine Thymidylate synthase inhibitor Metastatic colorectal and breast cancer
doxorubicin Topoisomerase II inhibitor Leukemias and lymphomas Watch heart failure
hydroxyurea Inhibits ribonucleotide reductase Hematologic malignancies, head & neck cancers, sickle cell (increases HbF) Watch out for secondary leukemia
carmustine Alkylating agent Brain cancer
6-MercaptoPurine Inhibitor of IMP dehydrogenase (purine construction) ALL, AML Allopurinol potentiates effectiveness and pancreatic/marrow toxicity
azathioprine Inhibitor of IMP dehydrogenase (purine construction) Immunosuppression in renal transplants, RA Allopurinol potentiates effectiveness and toxicity
etoposide Topoisomerase II inhibitor Testicular and lung cancer Watch myelosuppression
altretamine Alkylating agent Ovarian cancer
thiopeta Alkylating agent Bladder cancer (instilled directly into bladder)
vincristine Prevents microtubule polymerization Leukemias and Hodgkin’s disease Peripheral neuropathy is dose-limiting
cladribine Adenosine analogue Hairy cell leukemia, MS
carboplatin Cross-links guanines Genitourinary & lung cancer
paclitaxel Inhibits microtubule depolymerization Ovarian and NSC lung cancer
topotecan Topoisomerase I inhibitor Small cell lung cancer and cervical carcinoma Beware life-threatening diarrhea
cisplatin Cross-links guanines Genitourinary & lung cancer Watch nephrotoxicity; co-admin amifostine
docetaxel Inhibits microtubule depolymerization Breast and gastric cancer
Prof J.E.Brown Password: CCL.
PHARMACOLOGY REVIEW. No antiviral drugs Know both mechanisms and clinical uses Good Review Sources: First Aid, Hi-Yield Pharm, Katzung Review (drug list.
IMMUNOMODULATORS Dr. Manjunath. The Immune Response - why and how ? Discriminate: Self / Non self Destroy: Infectious invaders Dysregulated self (cancers)
Oncology / Chemotherapy NAPLEX PG 121. What is Cancer? Group of over 100 different diseases Group of over 100 different diseases Characterized by uncontrolled.
Complications of the Systemic Treatment of Cancer Introduction to Acute Oncology – October 2013 Dr Lucy Walkington.
George Segall, M.D. Stanford University PET/CT in Oncology.
Leicester Warwick Medical School Neoplasia II Invasion, Metastasis and Effects of Tumours Professor Rosemary A Walker Department of Pathology.
1 NUCLEOTIDE METABOLISM Metabolism of pyrimidine nucleotides NUCLEOTIDE METABOLISM Metabolism of pyrimidine nucleotides Prof. Mária Sasvári Gergely Keszler.
1 Nursing Care & Interventions in Managing Those with Cancer Keith Rischer RN, MA, CEN.
Care of Patients Undergoing Chemotherapy MMC-ONCOLOGY CLINIC BONE MARROW TRANSPLANT UNIT CES PAJE, BSN, R.N.
HODGKIN LYMPHOMA IN CHILDREN Dr.M.Shamvil Ashraf Children Cancer Hospital, Karachi.
Michael Weintraub, M.D. Hadassah University Hospital Jerusalem, Israel Pediatric Soft Tissue Sarcomas.
Neurological Emergencies in Cancer Patients Pete Kang.
Chemotherapeutic Treatment Options for Triple Negative Breast Cancer Lauren Barney April 17, 2013.
Chemotherapy of Tuberculosis. Tuberculosis Chronic granulomatous disease. Usually affects the lungs, up to one third of cases, other organs are involved.
Principles of Cancer Treatment Authors: Edward A. Sausville, Dan L. Longo (Harrisons) Edward A. SausvilleDan L. Longo The goal of cancer treatment is first.
Lymphoma Dr.Usha Dorairajan MS,FRCSEd Professor of Surgery Kilpauk Medical College Brevity in writing is the best insurance for its perusal. Rudolf Virchow.
Drug Interaction with Immunosuppressants A Case Report and Review.
Neoplasms. Definitions: Neoplasm New growth No new purpose Tumor Swelling, enlargement, mass.
Pharmacological Interactions with Antiretroviral Drugs Gilles PEYTAVIN PharmD, PhD GHU X Bichat-Cl Bernard - APHP Paris - France.
Oncology Understanding Medical Surgical Nursing 4th ed., Ch 11 OBJECTIVES: 1. Explain the differences between benign & malignant tumors. 2. List risk factors.
Jamie Manuell Year 2 Pharmacology & Therapeutics.
IV Training Practice Review Questions. USP/NF 797 requires that air sampling for high risk level areas be performed at least: Daily Weekly Monthly Annually.
Treatment of Major Rheumatic Diseases Dr Tanya Potter Consultant Rheumatologist.
Oncology Update in GI Cancer Tiffany Sipe FNP-BC, MSN,OCN Oncology Nurse Practitioner Tennova Physicians Services.
Mostafa El- Haddad. Blood Supply? Lns distribution: Cross over from Rt to Lt but not from Lt. to Rt. Scrotal Lymphatic's disruption.
Part B vs. Part D Drug Coverage Issues Babette Edgar, Pharm.D., MBA, Senior Vice President, Strategic Business Solutions Sept. 11, 2006 Health Care Compliance.
Treatment. Summary of Treatment Approach to Patients with Lung Cancer Harrison’s Principle of Internal Medicine 17 th Edition p558.
Non Hodgkin’s lymphoma Rakesh Biswas MD, Professor, Department of Medicine, People's College of Medical Sciences, Bhanpur, Bhopal, India.
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