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The Cell Cycle 10-2. Process by which a cell grows, prepares for division and divides Process by which a cell grows, prepares for division and divides.

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Presentation on theme: "The Cell Cycle 10-2. Process by which a cell grows, prepares for division and divides Process by which a cell grows, prepares for division and divides."— Presentation transcript:

1 The Cell Cycle 10-2

2 Process by which a cell grows, prepares for division and divides Process by which a cell grows, prepares for division and divides

3 The Cell Cycle Four phases Four phases 1.G 1 (Gap 1) – Cell grows, generates organelles, etc. – 40% of a cells life – If a cells life were a day it would last from midnight to 9:36 am

4 The Cell Cycle 2.S (Synthesis) –All of a cells DNA is copied –39% of a cells life –If a cells life were a day it would last from 9:36 am to 6:47 pm

5 The Cell Cycle 3.G 2 (Gap 2) –Final preparation for cell division –19% of a cells life –If a cells life were a day it would last from 6:47 pm to 11:21 pm

6 The Cell Cycle 4.M (Mitosis) –Cell division –2% of a cells life –If a cells life were a day it would last from 11:21 pm to midnight

7 The Cell Cycle Interphase Interphase –G 1, S and G 2 phases –Business as usual for a cell –98% of a cells life –Basically the time a cell spends not dividing

8 Cell Division Ends with two genetically identical daughter cells Ends with two genetically identical daughter cells

9 Cell Division Before a cell divides: Before a cell divides: –An exact copy of the cells DNA is made S phase of the cell cycle S phase of the cell cycle

10 Cell Division –DNA condenses into chromosomes Most of the time DNA is in a loose jumbled mess called chromatin Most of the time DNA is in a loose jumbled mess called chromatin –Resembles Ramen soup

11 Cell Division Chromatin Chromatin nucleus cell membrane chromatin

12 Cell Division If a cell divided before condensing there is no way to ensure each new cell received equal amounts of DNA If a cell divided before condensing there is no way to ensure each new cell received equal amounts of DNA

13 Cell Division Chromosomes Chromosomes –Made of two exact copies of the same section of DNA –Two copies are attached to one another –DNA is very tightly packed

14 Cell Division Chromosome structure Chromosome structure DNA strand wound around proteins identical strands attach DNA condenses

15 Cell Division Chromosome structure Chromosome structure Centromere: attachment point Tightly packed DNA Sister chromatids: two copies of the same DNA

16 BREAK

17 Cell Division Two Phases: Two Phases: 1.Mitosis: division of the nucleus 2.Cytokinesis: division of the cytoplasm

18 Cell Division 1. Mitosis –Division of the nucleus –If something goes wrong here the daughter cells may not function properly or they may die –If something goes wrong here the daughter cells may not function properly or they may die

19 Cell Division machinery machinery Chromosomes Chromosomes Spindles: protein fibers that form then pull the chromosomes apart at the end of mitosis Spindles: protein fibers that form then pull the chromosomes apart at the end of mitosis Centroles: structures that help organize the spindles Centroles: structures that help organize the spindles

20 Cell Division –4 Phases: Prophase Prophase Metaphase Metaphase Anaphase Anaphase Telophase Telophase = PMAT

21 Cell Division –Prophase Chromatin (DNA soup) condenses into chromosomes (X-shaped structures) Chromatin (DNA soup) condenses into chromosomes (X-shaped structures) Centrioles move to opposite ends of the cells Centrioles move to opposite ends of the cells Spindle begins to form Spindle begins to form Nuclear envelope breaks down Nuclear envelope breaks down

22 Cell Division –Prophase

23 Cell Division –Metaphase Chromosomes line up down the center of the cell Chromosomes line up down the center of the cell Spindles attach to the chromosomes Spindles attach to the chromosomes Nucleus has completely dissolved Nucleus has completely dissolved

24 Cell Division –Metaphase

25 Cell Division –Anaphase Sister chromatids (each half of the X- shaped chromosome) separate Sister chromatids (each half of the X- shaped chromosome) separate Spindles pull sister chromatids apart Spindles pull sister chromatids apart

26 Cell Division –Anaphase

27 Cell Division –Telophase Chromosomes gather at opposite ends of the cell and begin to unravel into chromatin Chromosomes gather at opposite ends of the cell and begin to unravel into chromatin Two new nuclear envelopes form Two new nuclear envelopes form

28 Cell Division –Telophase

29 Cell Division –Ends with one giant cell with two nuclei

30 Cell Division 2.Cytokinesis –In animal cells: Cell membrane pinches inward between the two nuclei Cell membrane pinches inward between the two nuclei Continues pinching until two nuclei are separated Continues pinching until two nuclei are separated End up with about half the organelles and cytoplasm in each cell End up with about half the organelles and cytoplasm in each cell

31 Cell Division –In animal cells:

32 Cell Division –In plant cells: A cell plate forms between the two nuclei A cell plate forms between the two nuclei Cell plate turns into the new cell membrane Cell plate turns into the new cell membrane New cell wall forms around the cell membrane New cell wall forms around the cell membrane

33 Cell Division –In plant cells: Cell plate

34 Cell Division Cell division movie Cell division movie Cell division movie Cell division movie

35 BREAK

36 Control of the Cell Cycle 10-3

37 Enzymes that Control the Cell Cycle Controlled in large part by a group of enzymes called cyclins Cyclins: levels rise and fall during cycle causing numerous different actions Other enzymes regulate specific phases of the cell cycle Still more enzymes: respond to events outside the cell and adjust the cell cycle

38 Enzymes that Control the Cell Cycle Production of these enzymes is directed by DNA When DNA is damaged, production of enzymes goes all wrong: Complete lack of production of a enzyme Overproduction of a enzyme Without the proper amount of specific enzymes the cell cycle will either stop (resulting in cell death) or cells will divide uncontrollably (resulting in cancer)

39 Contact Inhibition Some cells will only divide if they are not in direct contact with one another When skin cells contact one another, cell division slows to rates just fast enough to replace cells that die due to normal wear and tear Skin cells sense contact through chemical signals, which are controlled by DNA Damage to the DNA that controls these signals can also result in cancer

40 Cancer: a disease where cells lose the ability to control the cell cycle Caused by changes to the DNA that controls enzymes that regulate the cell cycle Can begin in any cells of the body and then spread through the body in the bloodstream or lymphatic system (glands) Most small changes are fixed by the body, those that are not can become cancer Cancer

41 A quote from the American Cancer Society website: Cancer is the second leading cause of death in the United States. Nearly half of all men and a little over one-third of all women in the US will develop cancer during their lifetimes. Today, millions of people are living with cancer or have had cancer. The risk of developing most types of cancer can be reduced by changes in a person's lifestyle, for example, by quitting smoking and eating a better diet. The sooner a cancer is found and treatment begins, the better are the chances for living for many years.

42 Causes of Cancer The well-known factors that increase risk: Overexposure to UV radiation (THE SUN & SUN LAMPS!!) Smoking Over consumption of alcohol Other forms of radiation Contaminants in water Viruses!

43 Scare the Girls Slides Cervical Cancer Rates of cervical cancer have risen dramatically in young (16- to 30-year-olds) girls recently Infection with human papilloma virus (HPV) is found in nearly 80% of all cases of cervical cancer HPV is a sexually-transmitted disease!!! There are 3,700 fatalities in the U.S. each year due to cervical cancer

44 Scare the Girls Slides Cervical Cancer Routine screening (yearly gynecological exam) is the best way to catch the disease early. Vaccines are now available (Gardasil and Cervarix) to protect against HPV but it must be administered before a girl becomes sexually active There is no way to vaccinate or test males (who are carriers) and there is almost no way to tell whether a male is infected

45 Scare the Guys Slide Testicular Cancer (aka What Lance Armstrong had) Testicular cancer is the most common cancer in American men between the ages of 15 and 40 (YOUR AGE GROUP!). 7,600 men receive a diagnosis of testicular cancer each year in the US men die When diagnosed early, testicular cancer is highly treatable Regular testicular self-examinations can help identify dangerous growths early, when the chance for successful treatment is highest


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