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Neoadjuvante chemoradiatie: surgery when needed (preSANO) Neoadjuvante chemoradiatie: targeted treatment (TRAP) Neoadjuvante/definitieve chemoradiatie:

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Presentation on theme: "Neoadjuvante chemoradiatie: surgery when needed (preSANO) Neoadjuvante chemoradiatie: targeted treatment (TRAP) Neoadjuvante/definitieve chemoradiatie:"— Presentation transcript:

1 Neoadjuvante chemoradiatie: surgery when needed (preSANO) Neoadjuvante chemoradiatie: targeted treatment (TRAP) Neoadjuvante/definitieve chemoradiatie: surgery if possible (TOR) Definitieve chemoradiatie: dosisintensificatie (ART-DECO) Dataregistratie (POCOP) Blik op de toekomst: lopende en geplande DOCG studies Dr. Hanneke W.M. van Laarhoven Medische Oncologie Academisch Medische Centrum

2 preSANO pre- Surgery As Needed for Oesophageal carcinoma A single-arm feasibility trial Primary endpoint Correlation between the clinical response during CRE-I and CRE-II and the final pathological response in the resection specimen Secondary endpoints Serious complications during endoscopic and endosonographic tissue sampling R 0 -resection rates for all included patients that undergo resection

3 TRAP Chemoradiation, TRAstuzumab and Pertuzumab in resectable HER2+ esophageal carcinoma A single arm feasibility study Primary endpoint Withdrawal rate from surgery Secondary endpoints pCR Toxicity Post-operative complications

4 TOR Chemoradiotherapy followed by resection for patients with gevolgd a T4b oesofagus carcinoma Primary endpoint R0 resection (≥ 80% ) Secondary endpoints Post-operative complications Mortality Quality of life

5 ART-DECO A Randomized Trial of Dose Escalation in definitive Chemoradiotherapy for patients with Oesophageal cancer Landelijk Platform Radiotherapie voor Gastro Enterologische tumoren Primary endpoint Local recurrence rate (≥ 15% difference) Secondary endpoints Grade 3-4 toxicity Survival

6 POCOP Prospective Observational Cohort Study of Oesophageal-gastric cancer Patients Acknowledgments Joel Shapiro, Bas Wijnhoven, Jan van Lanschot (preSANO) Maarten Anderegg, Mark van Berge Henegouwen (TOR) Maarten Hulshof (ART-DECO) Leonie Haverkamp, Jelle Ruurda (Oesofagus/maag parel)


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