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Regenerative Medicine Anita Mol, Carlijn Bouten, Simon Hoerstrup, Frank Baaijens Laboratory for Tissue Biomechanics and Tissue Engineering, Department.

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Presentation on theme: "Regenerative Medicine Anita Mol, Carlijn Bouten, Simon Hoerstrup, Frank Baaijens Laboratory for Tissue Biomechanics and Tissue Engineering, Department."— Presentation transcript:

1 Regenerative Medicine Anita Mol, Carlijn Bouten, Simon Hoerstrup, Frank Baaijens Laboratory for Tissue Biomechanics and Tissue Engineering, Department of Biomedical Engineering, Eindhoven University of Technology

2 Healthcare-transforming technologies Imaging Earlier diagnosis saves lives and reduces costs Minimally Invasive surgery Reducing patient trauma and reduces costs Adapted from: Russ Coile, Futurescan 2003, SG-2 Clinical IT Right Information at the right time enables best treatment and reduces costs Molecular Medicine Preventing disease from happening and reduces costs Regenerative medicine Implants taking over vital bodily functions, improving quality of life

3 Heart valves

4 Valve replacements 300.000 replacements / year Main drawback: no growth, repair and adaptation

5 Tissue Engineering Paradigm CellsScaffold (Mechanical) preconditioning Tissue formation, matrix remodelling Implantation/ Model system Implantation Isolation of cells from vessels Seeding in scaffoldCulture, conditioning Tissue formation vsmc endothelial cells

6 Proof-of-concept: sheep cells 6 weeks 16 weeks 20 weeks Hoerstrup et al. Circulation 2000 Not sufficient load-bearing properties to serve as aortic valve replacement Implanted as pulmonary heart valve replacement

7 Challenge Develop a living, autologous valve replacement, able to grow, repair and adapt to changing environment using human cells Sufficiently strong for aortic (high pressure) side

8 Strong, functional human valves! Effective orifice area: 1.52  0.21 cm 2 Mean systolic gradient: 11.5  3.1 mm Hg Regurgitation: 18.2  4.2 % Dynamically conditioned tissue engineered human heart valve Mol et al. Circulation 2006

9 Discussion Tissue engineered human heart valves show promising features as aortic valve replacements Functional parameters are in the range of those reported for commonly used bioprostheses Upcoming animal studies will elucidate short- and long- term functionality of tissue-engineered heart valves in aortic position and the capability of growth and remodeling

10 Engineered tissues (In-vitro)

11 Acknowledgements Eindhoven, BMT, TBME Dr. Anita Mol Drs. Marjolein van Lieshout Ir. Niels Driessen Ir. Ralf Boerboom Ir. Angelique Balguid Ir. Rolf Pullens Ir. Martijn Cox Ir. Mirjam Rubbens Christa Dam Katy Krahn Dr. Carlijn Bouten Dr. Marcel Rutten Dr. Claudia Vaz Dr. Gerrit Peeters Prof. Bas de Mol Prof. Frank Baaijens Eindhoven, BMT / ST, SMO Ir. Eva Wisse Drs. Patricia Dankers Dr. Nico Sommerdijk Dr. Maarten Merkx Prof. Bert Meijer Eindhoven, BMT, BEMI Prof. Klaas Nicolaij Dr. Gustav Strijkers Zürich Dr. Stephan Neuenschwander Dörthe Schmidt, MSc. Prof. Simon Hoerstrup Leiden, TNO TPG Dr. Ruud Bank Rotterdam, Dutch Heart Valve Bank Dr. J. van Kats, prof. A. Bogers Grants Bio-Initiative, Eindhoven University of Technology Vici grant, Netherlands Organisation for Scientific Research BioPolymers program, Dutch Polymer Institute

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