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New Frontier in Personal Care. Aluminum Sources Over the Counter: Deodorants, antiperspirants, baby wipes, skin creams, suntan lotions, toothpaste, buffered.

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Presentation on theme: "New Frontier in Personal Care. Aluminum Sources Over the Counter: Deodorants, antiperspirants, baby wipes, skin creams, suntan lotions, toothpaste, buffered."— Presentation transcript:

1 New Frontier in Personal Care

2 Aluminum Sources Over the Counter: Deodorants, antiperspirants, baby wipes, skin creams, suntan lotions, toothpaste, buffered asprin. Medical: Vaccinations, intervenous solutions, wound and antacid irrigation, ulcer treatment, blood oxygenization, bone or joint replacement and burn treatments. Foods: Aluminum cans, foils, containers, baking powder, cake mixes, frozen dough, pancake mixes, self-rising flour, grains, processed cheese.

3 STUDIES OF ALUMINUM TOXICITY

4 Aluminum Toxicity 1 Aluminum, a contaminant of commercial intravenous– feeding solutions, is potentially neurotoxic. We investigated the effect of perinatal exposure to intravenous aluminum on the neurologic development of infants born prematurely. RESULTS: For all 157 infants without neuromotor impairment, increasing aluminum exposure was associated with a reduction in the Mental Development Index (P=0.03), with an adjusted loss of one point per day of intravenous feeding for infants receiving the standard solutions. In preterm infants, prolonged intravenous feeding with solutions containing aluminum is associated with impaired neurologic development. –NJ Bishop Medical Research Council (MRC), Cambridge, United Kingdom (N Engl J Med 1997 May 29) 336(22).

5 Aluminum Toxicity 2 Mental status changes in an immunosuppressed child can be due to a variety of causes; aluminum toxicity is rarely considered. We report a teenage girl with acute lymphoblastic leukemia who developed mental status changes, speech disturbance, coarse tremor, and abnormal EEG findings following intravesical 1% alum irrigation and administration of aluminum-containing antacids. All abnormalities resolved after a nine- week course of intravenous deferoxamine. –VS Kanwar, Department of Hematology Oncology, St. Jude Children's Research Hospital, Mcmphis (Med Pediatr Oncol 1996 Jul)

6 Aluminum Toxicity 3 Regardless of the host, the route of administration, or the speciation, aluminum is a potent neurotoxicant. –MJ Strong, Department of Clinical Neurological Sciences, University of Western Ontario, Canada Aluminium is acutely toxic to fish in acid waters. The gill is the principal target organ and death is due to a combination of ionoregulatory, osmoregulatory and respiratory dysfunction. The mechanism of epithelial cell death is proposed as a general mechanism of aluminium-induced accelerated cell death. –C Exley, University of Stirling, Scotland

7 Aluminum Toxicity 4 Aluminum chloride induces aggregates of phosphorylated neurofilament that mimics the intraneuronal inclusions of amyotrophic lateral sclerosis (ALS or Lou Gehrigs Disease). –MJ Strong and RM Garruto, National Institutes of Health, Bethesda, Maryland (Can J Neurol Sci 1991 Aug) The bone fractures had occurred suddenly while the patients were going about their daily work. These observations indicate that aluminum- or iron- related bone disease with secondary hyperparathyroidism can induce bone fracture by only slight stress in patients maintained on hemodialysis. –F Marumo et al., Transverse fractures of the spinous process of the 7th cervical vertebra in RDT patients: an aluminum-related disease? Int J Artif Organs 1987 Mar)

8 Aluminum Toxicity 5 In the present study, an attempt has been made to investigate the distribution of aluminum in different regions of brain and body organs of male albino rats, following subacute and acute aluminum exposure. Aluminum was observed to accumulate in all regions of the brain with maximum accumulation in the hippocampus. Aluminum was also seen to compartmentalize in almost all the tissues of the body to varying extents, and the highest accumulation was in the spleen. –RK Vasishta and KD Gill, Distribution of aluminum in different brain regions and body organs of rat. Biol Trace Elem Res (1996 May) 52(2): Experimental evidence is summarized to support the hypothesis that chronic exposure to low levels of aluminum may lead to neurological disorders. –JG Joshi, Aluminum, a neurotoxin which affects diverse metabolic reactions. Biofactors (1990 Jul) 2(3):163-9

9 Aluminum Toxicity 6 Aluminum intoxicated rabbits did not acquire the conditioned response over the 4 days of testing. This disruption of conditioning in aluminum-treated rabbits could not be attributed to deficits in sensory or motor processes or to illness. Neuropathological analysis revealed widespread neurofibrillary tangle formation in aluminum-treated animals. –WW Pendlebury, University of Vermont College of Medicine (Behav Neurosci 1988 Oct)

10 Aluminum Toxicity 7 This data defines a new model in which aluminum kills liver cells by mechanisms distinct from previously recognized pathways of lethal cell injury. It is hypothesized that aluminum binds to cytoskeletal proteins intimately associated with the plasma membrane. This interaction eventually disrupts the permeability barrier function of the cell membrane, an event that heralds the death of the hepatocyte. –JW Snyder et al., Department of Pathology, Thomas Jefferson University, Philadelphia, Pennsylvania (Arch Biochem Biophys 1995) Epidemiological studies from Norway and England suggest a relation between the frequency of Alzheimer's disease and the concentration of aluminum in the drinking water. Estimates, made in this study, show that the role of aluminum from tooth pastes may be even more important than that from the drinking water. For that reason we determined in samples of tooth pastes taken from the BENELUX market which brands contained aluminum. This appeared to be the case for about 22% of the brands which according to the manufacturers cover about 60% of the market. –RM Verbeeck, Laboratory for Analytical Chemistry, State University, Gent, Belgium (Acta Stomatol Belg 1990 Jun)

11 Aluminum Toxicity 8 We report six cases of patients with renal failure and exposure to aluminum who developed septicemia. In all cases the serum aluminum increased markedly. This may have contributed to the neurological dysfunction seen in five, and the deaths of four of the patients. We suggest that the rise in serum aluminum was due to the release of tissue-bound aluminum, resulting in an increase in free, diffusable aluminum and that this jeopardized both neurological function and immunocompetence. –A Davenport et al. Renal Unit, Royal Liverpool Hospital, England Attention was first drawn to the potential role of aluminum as a toxic metal over 50 years ago… the accumulation of aluminum is associated with the development of toxic phenomena; dialysis encephalopathy, osteomalacic dialysis osteodystrophy, and an anemia. Aluminum has also been implicated as a toxic agent in the etiology of Alzheimer's disease, Guamiam amyotrophic lateral sclerosis, and parkinsonism- dementia. –CD Hewitt et al., University of Virginia Health Sciences Center, Charlottesville

12 Aluminum Toxicity 9 It has been a dozen years since aluminum was first shown to contaminate parenteral nutrition solutions and to be a contributing factor in the pathogenesis of metabolic bone disease in parenteral nutrition patients as well as in uremic patients. –GL Klein, Department of Pediatrics, University of Texas Medical Branch, Galveston. Aluminum related osteodystrophy is the most important manifestation of trace metal toxicity related to degenerative diseases of the skeleton. –J Savory et al., Acta Pharmacol Toxicol (Copenhagen, 1986)

13 Aluminum Toxicity 10 Three patients had subcutaneous nodules at the sites of previous injections of vaccine containing tetanus toxoid. Biopsy and microscopic findings in all three cases showed foci of granulomatous inflammation, consisting of lymphoid follicles, in the deep dermis and subcutaneous tissues and a surrounding infiltrate of lymphocytes, histiocytes, plasma cells, and eosinophils. Occasional zones of eosinophilic necrosis were seen within the inflammatory foci, and surrounding dense fibrous bands were present in some areas. A solochrome-azurin stain showed aluminum crystals in the nodules from two patients. From the evidence available, we believe that these nodules are a complication of inoculations with aluminum-containing vaccines. –H Fawcett and N Smith, Arch Dermatol. 1984: Injection-site granuloma due to aluminum.

14 FDA Warns Against Aluminum In response complaints by Glen Scott, MD, of Cincinnati and Patricia Saunders, a government microbiologist, warning of aluminum neurotoxicity, the FDA is now requiring aluminum-bearing antiperspirants to carry a renal dysfunction warning (June 9, 2003). According the Antiperspirant Products Final Monograph, the FDA is –concerned that people with renal dysfunction may not be aware that the daily use of antiperspirant drug products containing aluminum may put them at higher risk because of exposure to aluminum in the product. Young children are –at higher risk resulting from exposure to aluminum. Parents and others –must keep these products away from children, and to seek professional assistance if accidental ingestion occurs.

15 Common Chemicals YL surveyed over 30 different brands of stick deodorant from main- stream retailers, health food stores, and other MLMs. Every one either contained aluminum, propylene glycol, or synthetic petrochemicalseven so-called premium-priced natural brands. Many contain stearatesa product of the animal rendering industry which utilizes a "witch's brew" of animal parts: spinal cords, brains, eyeballs, and intestines. 250 rendering plants in the US produce 100 million pounds DAILY of slaughtered animal remains such as bones, blood, hides, offal, feathers, as well as road kill, spoiled grocery meat, and euthanized dogs, cats, and horses. This material is the raw material from which tallow, lard, protein meal, and cosmetics are made. The National Renderer's Association says rendered waste is used in: –1. Ingredients in livestock and pet rations –2. Ingredients in industrial processes –3. The manufacture of soaps and personal care products –4. Edible products for the food industry

16 Stearates Are Suspect Almost all stearates found in personal hygiene and cosmetic products are animal-derived, usually from rendered cattle or animal parts C11-15 Pareth-12 Stearate Aluminum Stearates/Distearates/Isostearates Calcium Stearate Cetyl Stearate Diethylaminoethyl Stearate Diglyceryl Stearate Malate Ethyl Stearate Glyceryl stearate/Distearate/Isostearate Glyceryl Monostearate Glycol Stearate Glycyrrhetinyl Stearate Hydroxyoctacosanyl Hydroxyastearate Hexanediol Distearate Isocetyl Stearate Isobutyl Stearate Isocetyl Stearoyl Stearate Isoceteth-10 Stearate Isodecyl hydroxystearate Isopropyl Isostearate/Stearate Isostearyl Isostearate Isostearyl Stearoyl Stearate Stearmidoethyl Diethylamine Stearoamphoacetate Stearoamphohydroxypropysulfonate Stearoamphopropionate Stearone Stearoxy Dimethicone Stearoxytrimethylsilane Stearoyl Lactylic Acid Steartrimonium Chloride Stearyl Acetate Stearyl Alcohol Stearyl Betaine Stearyl Caprylate Stearyl Citrate Stearyl Erucamide Stearyl Erucate Stearyl Ghycyrrhetinate Stearyl Heptanoate Stearyl Hydroxyethyl Imidazoline Stearyl Lactate Stearyl Octanoate Stearyl Stearate Stearyldimethyl Amine Lauryl Isostearate Lauryl Stearate Lithium Stearate Magnesium Stearate Methyl Glucose Sesquistearate PEG-2 through -175 Distearate PEG-5 through -120 Glyceryl Stearate PEG-6 or -12 Isostearate PEG-20 Methyl Glucose Sesquistearate PEG-25 through -125 Propylene Glycol Stearate PEG-5 or -20 Sorbitan Isostearate PEG-3 or -40 Sorbitan Stearate Sodium stearate Stearalkonium Bentonite/Chloride Stearamide Stearamide Diethanolamide Stearmidopropalkonium Chloride Stearamidopropyl Dimethylamine Stearamine Stearates Steareth-4 through -100 Stearic Acid

17 Many Cosmetic Ingredients Are Animal-Derived

18 Many Other Cosmetic Ingredients Are Animal-Derived

19 Warnings Cosmetics industry expert, Steve Hazell of Gillette Management Inc. says: –Increasing concern over bovine spongiform encephalopathy (BSE) and its link with new variant Creutzfeldt-Jakob disease (nvCJD) has prompted a move toward specifying plant-derived rather than animal derived stearate. But can industry afford it? Vegetable stearates are scarce and very expensiveover triple the cost of rendered-animal stearates. Which one is in your cosmetic?

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21 Made from animal tallow: source of irreversible brain-damaging prions (Cruetzfeld-Jakob Disease). Cosmetic stearates are produced by animal rendering plants from spinal cords and brains of diseased animals. An aliphatic polyester compound made synthetically. Industrial chemical used as antifreeze Synthetic silicone oil known to be toxic and reasonably anticipated to be toxic to humans according to the NHSC (National Health and Safety Council). Regarded as potentially environmentally hazardous by Danish Environmental Protection Agency. Aluminum is a potent neurotoxin implicated in dementia, neurological impairment, ALS, Parkinsons Disease, and Alzheimers Disease (Joshi, 1990; Strong 1991; Kanwar 1996). Chemically treated and altered transfatty acid. $1.50

22 Made from animal tallow: source of irreversible brain-damaging prions (Creutzfeld-Jakob Disease). Cosmetic stearates are produced by animal rendering plants from spinal cords and brains of diseased animals. Industrial chemical used as antifreeze Synthetic coal tar (azo) dye shown to cause liver cancer in animals; known carcinogen according to the International Agency for Research on Cancer (IARC) EPA registered pesticide chemically related to dioxin; Impurities formed during Triclosan's manufacture (dioxins and dibenzofurans) are some of the most hazardous chemicals on earth are have shown to cause birth defects, genetic mutations, and cancer. $1.74 Synthetic fragrance of unknown origin and toxicity.

23 Aluminum is a potent neurotoxin implicated in dementia, neurological impairment, ALS (Lou Gehrigs Disease), Parkinsons Disease, and Alzheimers Disease (Joshi, 1990; Strong 1991; Kanwar 1996). $2.06

24 Comedogenic (acne-causing) corn oil Synthetic fragrance of unknown origin and toxicity. aka Ammonium iron hexacyanoferrate or Prussian Blue Dye. Contains toxic cyanide. Harmful if swallowed, inhaled or absorbed through skin (MSDS sheet). Extremely toxic, lethal dose (LD50) >5 gm/kg. Made from animal tallow: source of irreversible brain- damaging prions (Creutzfeld-Jakob Disease). Cosmetic stearates are produced by animal rendering plants from spinal cords and brains of diseased animals. Synthetic silicone oil known to be toxic and reasonably anticipated to be toxic to humans according to the NHSC (National Health and Safety Council). Regarded as potentially environmentally hazardous by Danish Environmental Protection Agency. Aluminum is a potent neurotoxin implicated in dementia, neurological impairment, ALS (Lou Gehrigs Disease), Parkinsons Disease, and Alzheimers Disease (Joshi, 1990; Strong 1991; Kanwar 1996). Chemically treated and altered transfatty acid. A synthetic compound related to silicone. aka Butoxy polypropylene glycol, on a high priority for review by the Cosmetics Review Committee; Probable lethal dose for humans: 500 mg/K body weight. $2.39

25 Most extracts are created using industrial-grade propylene glycol or synthetic solvents. Industrial chemical used as antifreeze Ineffective preservative often adulterated with synthetic Benzethonium Chloride, according to USDA research. Cationic ammonium compound created from soy and petrochemicals; also known as Quaternium 2 or Atlas G271. Registered as a pesticide. No safety studies conducted. New chemical with no history. Made from animal tallow: source of irreversible brain- damaging prions (Creutzfeld-Jakob Disease). Cosmetic stearates are produced by animal rendering plants from spinal cords and brains of diseased animals. $3.99

26 Industrial chemical used as antifreeze Ineffective preservative often adulterated with Benzethonium Chloride, according to USDA research. Made from animal tallow: source of irreversible brain-damaging prions (Creutzfeld- Jakob Disease). Cosmetic stearates are produced by animal rendering plants from spinal cords and brains of diseased animals. $4.75 No mention of how this was distilled; Almost all extracts sold in the botanical industry use propylene glycol and chemical preservatives like Phenonip.

27 GSE (Grapefruit Seed Extract)

28 Made from animal tallow: source of irreversible brain- damaging prions (Creutzfeld-Jakob Disease). Cosmetic stearates are produced by animal rendering plants from spinal cords and brains of diseased animals. Industrial chemical used as antifreeze Synthetic preservative (Sodium Propyl 4- Hydroxybenzoate) that disrupts endocrine hormones (Oishi, 2001, Tokyo Metropolitan Research Laboratory of Public Health; Routledge et al., 1998, Department of Biology & Biochemistry, Brunel University, UK.) Synthetic cationic ammonium compound; also known as Quaternium 2 or Atlas G271. Registered as a pesticide. No safety studies conducted. New chemical with no history. $4.99

29 Industrial chemical used as antifreeze Most natural fragrances are synthetic Made from animal tallow: source of irreversible brain-damaging prions (Creutzfeld- Jakob Disease). Cosmetic stearates are produced by animal rendering plants from spinal cords and brains of diseased animals. $5.59 No mention of how this was extracted; Almost all extracts sold in the botanical industry use propylene glycol and powerful chemical preservatives like Phenonip.

30 AromaGuard Stick Deodorant MEADOW MIST Distilled Coconut Oil (Cocos nucifera) Pure Beeswax (Cera alba) Vegetable Esters (from Elaeis guineensis) Therapeutic-grade Essential Oil Blend –Lemon EO (Citrus limon) –Geranium EO (Pelargonium graveolens) –Rosemary EO (Rosmarinus officinalis CT 1,8 Cineol) –Rosewood EO (Aniba rosaeodora) –Lavender EO (Lavandula angustifolia) –Melaleuca alternifolia EO –Melaleuca quinquenervia EO –Clove EO (Syzygium aromaticum) Zinc Oxide Natural Vitamin E (alpha, beta, gamma, and delta tocopherols derived from Elaeis guineensis) *with Autoship + Web discount. Wholesale price $7.00. $6.65 *

31 AromaGuard Stick Deodorant MOUNTAIN MINT Distilled Coconut Oil (Cocos nucifera) Pure Beeswax (Cera alba) Vegetable Esters (from Elaeis guineensis) Essential Oil Blend –Clove EO (Syzygium aromaticum) –Lemon EO (Citrus limon) –Peppermint EO (Mentha piperita) –Rosemary EO (Rosmarinus officinalis ct 1,8 Cineol) –Eucalyptus radiata EO (Eucalyptus radiata) –Juniper EO (Juniperus osteosperma/scopulorum) Zinc Oxide Natural Vitamin E (alpha, beta, gamma, and delta tocopherols) derived from Elaeis guineensis

32 Progessence Plus Copaifera Reticulata (Copaiba) Oil Boswellia Carterii (Frankincense) Oil Cedrus Atlantica (Cedar) Bark Oil Capric/Caprylic Triglycerides Vitamin E Citrus Aurantium Bergamia (Furanocoumarin free Bergamot) Peel Oil Mentha Piperita (Peppermint) Oil USP Progesterone (from Wild Yam Extract) Aniba Rosaeodora (Rosewood) Oil Eugenia Caryophyllus (Clove) Bud Oil Formulated by D. Gary Young 100% pure YLTG quality essential oil

33 Australian Blue Blue Cypress EO –(Callitris intratropica) Ylang Ylang EO –(Cananga odorata) Cedarwood EO –(Cedrus atlantica) Tansy, Blue EO –(Tanacetum annuum)

34 AnimalScents OINTMENT Mink Oil Lecithin Bees Wax (Cera flava) Lanolin Sesame Seed Oil (Sesamum indicum) Wheat Germ Oil (Triticum asestivum) Rosewood EO (Aniba rosaeodora) Palmarosa EO (Cymopogon martinii) Patchouly EO (Pogostemon cablin) Myrrh EO (Commiphora myrrha) Carrot seed oil (Daucus carota) Melaleuca Alternifolia EO Rose Hip Seed Oil (organic, Chile) Geranium EO (Pelargonium graveolens) Balsam Fir EO (Abies concolor)

35 AnimalScents SHAMPOO Bath gel base (saponified coconut and olive oil) –Demineralized Water –Saponified Coconut & Olive Oil –Aloe Vera (Aloe barbadensis) –Rosemary Extract (Rosmarinus officinalis) Citronella EO (Cymbopogon nardus) Lavandin EO (Lavandula x hydrida) Lemon EO (Citrus limon) Geranium EO (Pelargonium graveolens) Spikenard EO (Nardostachys jatamansi)

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