Presentation on theme: "Lannate® Insecticide Registration Attributes"— Presentation transcript:
1Lannate® Insecticide Registration Attributes Lannate® compared to OP’s productsReversibility Studies in RatMexican worker exposureDuPont Safe Use Measures & ProposalSNCO
2Methomyl Registration Lannate has been commercialized since 1968 (USA)Widely registered80 countriesapproximately 190 crops (vegetables, fruits, fibers, and plantation crops)Variety of formulations available to meet local needsNo severe restrictions or bans based on risk assessmentIs not PIC listedAsk Patrick was Pic listed means (ezplanation)
3Insecticidal Attributes Lannate is anti-acetyl cholinesterase, inhibiting nerve functionBroad spectrum of activity; controls >140 insect speciesFast acting, effective by contact & ingestion; also ovicidal activityNot phytotoxic, systemic, translaminarExcellent compatibility with commonly used pesticidesResistance management tool and fits with IPM
4Toxicology Attributes Acute dermal toxicity is extremely lowone of the primary attributes of methomyl95% of worker exposure is potentially dermalAcute oral and inhalation toxicity is highexposure can be mitigated (masks)Toxicity (acetyl cholinesterase inhibition) is quickly reversible without treatmentcarbamate insecticide propertyno delayed neurotoxicity in long termEffective antidote is available (atropine)Toxicology studies have shown that methomyl does not cause: developmental toxicity, reproductive toxicity, mutations, chronic toxicity, delayed neurotoxicity, carcinogenicityLow demal toxicity due to break down, when penetrating through skin.No allergiesToxicity (acetyl cholinesterase inhibition) is quickly reversible without treatment compared with OP’s- carbamate attribute
5Environmental Attributes Rapid decomposition to natural molecules, no potential to bioaccumulateRapid degradationsoil: 90% loss in 35 days, low mobilitywater: half life very short, hours to <7 daysRapid metabolismplants: half life <3-5 days, short residual on crops, safe for harvesters (PHI’s 1-7 days) and consumersanimals: >50% metabolized or excreted in 24 hrsAquatic toxicityacutely toxic to invertebrates but exposure mitigated by label precautions (no aquatic uses)low potential for chronic toxicity due to rapid degradationLannate does not accumulate in body and any adverse effect is rapidly reversible.Metabolites (acetonitrile & CO2) are eliminate primarily by respiration and urine.
6Lannate® Vs. commonly used OP’s Dermal and dietary safety in comparison to some OP insecticides:Dermal LD50 ADI*(mg/kg) (ug/kg/day)methomyl (rabbit) 30methamidophos (rabbit) 0.6monocrotophos (rabbit); 120 (rat) 0.6demeton S methyl 30 (rat) 0.3oxydemeton methyl 130 (rat) 0.3mevinphos (rabbit); 4-90 (rat) 1.3*ADI = Acceptable Daily Intake values determined by JMPRUAE-united arab emirats banned products, very strictDo these products are still sold? Even in banned?
8Mexican Worker Exposure Study Determine potential dermal and respiratory exposure to mixers, loaders, and applicators during use with backpack sprayerslow (cauliflower) and medium (tomato) height crops15 replicates (5 operators spraying on 3 separate occasions)GIFAP recommended clothing wornouter cotton tunic and trousers with inner cotton underwear (dosimeter f/dermal exposure)waterproof gloves with cotton undergloves (dosimeter f/hand exposure)rubber boots, baseball caps & dust masks (dosimeter f/respiratory exposure)Patrick:Do Knapsack is the same as backpack sprayers?
9Mexican Worker Exposure Study : Summary of Findings Outer clothing provides a high degree of protection from dermal exposure intercepting 83-93% of total methomyl residueRespiratory exposure is very low (<0.1%)[dust mask]Margins of safety for workers applying methomyl to a medium height crop (tomato) with appropriate PPE are:206 for dermal exposure3316 for respiratory exposure
12Mexican Worker Exposure Study: Tomato Results Route Exposure* NOEL MOS****Dermal mg/kg 90 mg/kg** 206(sum of depositson inner suit and gloves,face, and neck)Respiratory mg/kg 12.6 mg/kg*** 3316(deposit on respirator)*based on a 70 kg person and adjusted to 6 and 4 hrs exposure for dermal and respiratory routes,respectively** 21-day dermal study in rabbits (exposure 6 hrs/day)*** rat inhalation LC50 study (exposure 4 hrs; no mortality at 1.8 mg/L); assumes 100% absorption bya 0.25 kg rat with a respiration rate of 73 mL/min**** Margin of Safety = NOEL divided by exposure
13DuPont Safe Use Measures Use of dye (color)New formulations with bittering agents (mal sabor) to prevent accidental ingestionUse of constant flow valve for backpack spraysLabelling with precautions and pictogramsAvailability of atropine whenever neededSafe use training programsPackaging in water soluble bags for solids and high density plastic bottles for liquids; no large containersconstant flow valve? Is that used in CA?
14DuPont’s proposal to authorities Discontinue commercialization of liquid Lannate®New 1 oz presentation on WSB to avoid handlingTraining to medical department, to be able to tell difference between acetyl cholinesterase symptoms and other (heat)Continue training efforts on good use and Lannate ® managementOn the last 3 years, 430 people were trained in El SalvadorAgricultores, cooperativas,Distribuidores:dependientes de mostrador,Area de ventas, servicio tecnico, bodegueros.