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Lannate® Insecticide Registration Attributes Lannate® compared to OPs products Reversibility Studies in Rat Mexican worker exposure DuPont Safe Use Measures.

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Presentation on theme: "Lannate® Insecticide Registration Attributes Lannate® compared to OPs products Reversibility Studies in Rat Mexican worker exposure DuPont Safe Use Measures."— Presentation transcript:

1 Lannate® Insecticide Registration Attributes Lannate® compared to OPs products Reversibility Studies in Rat Mexican worker exposure DuPont Safe Use Measures & Proposal SNCOSNCO

2 Methomyl Registration çLannate has been commercialized since 1968 (USA) çWidely registered ç80 countries çapproximately 190 crops (vegetables, fruits, fibers, and plantation crops) çVariety of formulations available to meet local needs çNo severe restrictions or bans based on risk assessment çIs not PIC listed

3 Insecticidal Attributes çLannate is anti-acetyl cholinesterase, inhibiting nerve function çBroad spectrum of activity; controls >140 insect species çFast acting, effective by contact & ingestion; also ovicidal activity çNot phytotoxic, systemic, translaminar çExcellent compatibility with commonly used pesticides çResistance management tool and fits with IPM

4 Toxicology Attributes çAcute dermal toxicity is extremely low çone of the primary attributes of methomyl ç95% of worker exposure is potentially dermal çAcute oral and inhalation toxicity is high çexposure can be mitigated (masks) çToxicity (acetyl cholinesterase inhibition) is quickly reversible without treatment çcarbamate insecticide property çno delayed neurotoxicity in long term çEffective antidote is available (atropine) çToxicology studies have shown that methomyl does not cause: developmental toxicity, reproductive toxicity, mutations, chronic toxicity, delayed neurotoxicity, carcinogenicity

5 Environmental Attributes çRapid decomposition to natural molecules, no potential to bioaccumulate çRapid degradation çsoil: 90% loss in 35 days, low mobility çwater: half life very short, hours to <7 days çRapid metabolism çplants: half life <3-5 days, short residual on crops, safe for harvesters (PHIs 1-7 days) and consumers çanimals: >50% metabolized or excreted in 24 hrs çAquatic toxicity çacutely toxic to invertebrates but exposure mitigated by label precautions (no aquatic uses) çlow potential for chronic toxicity due to rapid degradation

6 Lannate® Vs. commonly used OPs çDermal and dietary safety in comparison to some OP insecticides: Dermal LD50ADI* (mg/kg) (ug/kg/day) methomyl 5880 (rabbit) 30 methamidophos 118 (rabbit) 0.6 monocrotophos 354 (rabbit); 120 (rat) 0.6 demeton S methyl 30 (rat) 0.3 oxydemeton methyl 130 (rat) 0.3 mevinphos (rabbit); 4-90 (rat) 1.3 *ADI = Acceptable Daily Intake values determined by JMPR

7 Lannate®: Rat Reversibility Study Results

8 Mexican Worker Exposure Study çDetermine potential dermal and respiratory exposure to mixers, loaders, and applicators during use with backpack sprayers çlow (cauliflower) and medium (tomato) height crops ç15 replicates (5 operators spraying on 3 separate occasions) çGIFAP recommended clothing worn çouter cotton tunic and trousers with inner cotton underwear (dosimeter f/dermal exposure) çwaterproof gloves with cotton undergloves (dosimeter f/hand exposure) çrubber boots, baseball caps & dust masks (dosimeter f/respiratory exposure)

9 Mexican Worker Exposure Study : Summary of Findings çOuter clothing provides a high degree of protection from dermal exposure intercepting 83-93% of total methomyl residue çRespiratory exposure is very low (<0.1%)[dust mask] çMargins of safety for workers applying methomyl to a medium height crop (tomato) with appropriate PPE are: ç206 for dermal exposure ç3316 for respiratory exposure

10 Mexican Worker Exposure Study: Results

11 Methomyl residues Mexican Worker Exposure Study: Results

12 Mexican Worker Exposure Study: Tomato Results RouteExposure*NOELMOS**** Dermal0.437 mg/kg90 mg/kg**206 (sum of deposits on inner suit and gloves, face, and neck) Respiratory mg/kg12.6 mg/kg***3316 (deposit on respirator) *based on a 70 kg person and adjusted to 6 and 4 hrs exposure for dermal and respiratory routes, respectively ** 21-day dermal study in rabbits (exposure 6 hrs/day) *** rat inhalation LC50 study (exposure 4 hrs; no mortality at 1.8 mg/L); assumes 100% absorption by a 0.25 kg rat with a respiration rate of 73 mL/min **** Margin of Safety = NOEL divided by exposure

13 DuPont Safe Use Measures çUse of dye (color) çNew formulations with bittering agents (mal sabor) to prevent accidental ingestion çUse of constant flow valve for backpack sprays çLabelling with precautions and pictograms çAvailability of atropine whenever needed çSafe use training programs çPackaging in water soluble bags for solids and high density plastic bottles for liquids; no large containers

14 DuPonts proposal to authorities çDiscontinue commercialization of liquid Lannate® çNew 1 oz presentation on WSB to avoid handling çTraining to medical department, to be able to tell difference between acetyl cholinesterase symptoms and other (heat) çContinue training efforts on good use and Lannate ® management çOn the last 3 years, 430 people were trained in El Salvador çAgricultores, cooperativas, çDistribuidores: çdependientes de mostrador, çArea de ventas, servicio tecnico, bodegueros.


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