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Original Article Evidence for Human Lung Stem Cells Jan Kajstura, Ph.D., Marcello Rota, Ph.D., Sean R. Hall, Ph.D., Toru Hosoda, M.D., Ph.D., Domenico.

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Presentation on theme: "Original Article Evidence for Human Lung Stem Cells Jan Kajstura, Ph.D., Marcello Rota, Ph.D., Sean R. Hall, Ph.D., Toru Hosoda, M.D., Ph.D., Domenico."— Presentation transcript:

1 Original Article Evidence for Human Lung Stem Cells Jan Kajstura, Ph.D., Marcello Rota, Ph.D., Sean R. Hall, Ph.D., Toru Hosoda, M.D., Ph.D., Domenico D'Amario, M.D., Fumihiro Sanada, M.D., Hanqiao Zheng, M.D., Barbara Ogórek, Ph.D., Carlos Rondon-Clavo, M.D., João Ferreira-Martins, M.D., Alex Matsuda, M.D., Christian Arranto, M.D., Polina Goichberg, Ph.D., Giovanna Giordano, M.D., Kathleen J. Haley, M.D., Silvana Bardelli, Ph.D., Hussein Rayatzadeh, M.D., Xiaoli Liu, M.D., Ph.D., Federico Quaini, M.D., Ronglih Liao, Ph.D., Annarosa Leri, M.D., Mark A. Perrella, M.D., Joseph Loscalzo, M.D., Ph.D., and Piero Anversa, M.D. N Engl J Med Volume 364(19): May 12, 2011

2 Study Overview Cells in certain niches of the lower airways that express c-kit appear to be capable of self-renewal, clonogenicity, and differentiation into various lung-tissue components (including alveoli, muscle cells, and vessels) in vitro and may regenerate mouse lung tissue in vivo.

3 Clonogenicity and Pluripotency of Human Lung Stem Cells (hLSCs). Kajstura J et al. N Engl J Med 2011;364:

4 Lung Regeneration by Clonal and Nonclonal Human Lung Stem Cells. Kajstura J et al. N Engl J Med 2011;364:

5 Human Lung Stem Cells in the Serial Transplantation Assay. Kajstura J et al. N Engl J Med 2011;364:

6 Integration of Human Pulmonary Structures. Kajstura J et al. N Engl J Med 2011;364:

7 Localization of Human Lung Stem Cells. Kajstura J et al. N Engl J Med 2011;364:

8 Conclusions Human lungs contain identifiable stem cells. In animal models, these cells participate in tissue homeostasis and regeneration. They have the undemonstrated potential to promote tissue restoration in patients with lung disease.


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