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1Presentation Title DATE HERE A Developmental-Neurobiological Model for Treatment of Substance Abuse in Emerging AdultsThe Neuro-biological Wisdom of the 12 Step ModelJesse Viner, MDFounder & Executive Medical Director, YellowbrickAsst. Professor Psychiatry,Northwestern Feinberg School of MedicineFaculty, Chicago Institute for PsychoanalysisPresentation Title DATE HERE
2Yellowbrick Find Your Way Home Disclosures- As a matter of policy, Yellowbrick and its employees are prohibited from accepting gifts from any corporations, including pharmaceutical companies- The three psychiatrists at Yellowbrick, Drs. Viner, Hamilton and Baron , have never accepted gifts, grants, or any other funds from the Pharmaceutical Industry, at any point in their careers.In short, there are no disclosures to make!22
3Minding the Brain Emerging Adulthood as a phase of development Mind, Self, BrainBrain maturation in emerging adulthoodRisk factors for substance abuseSubstance abuse and brain maturationPsycho-neurobiology & intervention
4Emerging AdulthoodArnett & Tanner: “Emerging Adulthood: Coming of Age in the 21st Century”Ages 18 – 295 Primary Features
5Emerging Adulthood: Primary Features Arnett & Tanner Identity explorationGeneralized instability and change: Education, Location, Jobs, RelationshipsAge of “in between”; $, responsibility, brainAutonomy> Community> SpiritualityAge of possibilities as well as risks
6The Developing Mind Daniel Siegel, M.D. Research on the purpose of the brain.Evolve the Self as a brain representation for survival and adaptation.Emerging adulthood is pivotal in the maturation of attachment patterns which affect self integration & emotional regulation.“Human connections shape neural connections.”
7Emerging Adult Brain Maturation Prefrontal-Thalamic-Cerebellar Cortex Necessary for higher order cognitive functions including: set shifting, behavioral inhibition, decision-making, cognitive inhibition, and working memory (Braver et al., 2002).Prefrontal cortex is the “convergence zone” between the cortex and subcortex. It is the “hierarchical apex” of the limbic system and is responsible for the mechanisms of reward-excitation and aversion-inhibition in emotion regulation (Schore, 2003).
8Emerging Adult Brain Maturation Orbital Pre-frontal Cortex Social and emotional processing(e.g., facial cues)Self-regulation(e.g., tension and vitalization states)Homeostatic regulation of the body (sympathetic and parasympathetic ANS)Behavior (e.g., reward gratification)Attachment patterns (SAO); Secure, Anxious –Avoidant, Ambivalent, Disorganized (e.g., Steklis & Kling, 1985).
9Emerging Adult Brain Maturation (Giedd, 2008;Steinberg 2009): Sprouting and pruning of synapses; information processing & logic (Keating 2004)Proliferation in reward system networks; limbic-PFC (Chambers 2003)Myelination- Structural and functional increases in connectivity, efficiency of integrative processing & executive functioning (Lenroot 2007)Subcortical – Cortical projections & corpus collosum; Socio-emotional processing and emotional regulation (Eluvathingal et al, 2007)
10Normal Brain Maturation : The Frontal Lobes mature later into emerging adulthood We know that executive functions continue to mature into early adulthood, up to age 25.I guess the car rental companies figured that out without needing brain scan evidence, but the important point to be made here is to stress the late maturity of the frontal lobes and I will stress how important that is in understanding the neurobiology of ADHD and even comorbid BD and SUDs.Gogtay, N., et al (2004). Dynamic mapping of human cortical development during childhood through early adulthood. Proc Natl Acad Sci U S A, 101(21):8174–8179.10
11Factors Affecting Emerging Adult Brain Development (Giedd, 2008): Maturational timetable for networking of information processing, motivation & risk-reward centers, executive functioning, emotional regulation.Cross-species maturation of risk taking and exploration in service of separation. Risk and identity formation (Baumrind 1987)Maturation affected by genetics, hyper-hypo arousal, substances, socio-emotional context.75% of psychiatric illnesses manifest ages15-30
12Yellowbrick Find Your Way Home Imaging The Depressed BrainMaybe “Imaging the depressed brain” or something…? Just b/c there is a control there and the labels in the pic may or may not be visible to the audience1212
13Socio-emotional Context: Developmental Risk Factors Loss of secure, structuring contexts: family, friends, school, community.Search for motivation and direction; brain correlationProvocative triggering factors increase personal vulnerability and associated neural activation.Increasingly responsible for life competence; threats to self worth.Neuroplastic substrate of attachment patterns in exploring mode, in search of peer community and love partner; anxiety, aloneness, identification.
14Predisposing Neurobiological Factors for Substance Abuse Genetic (Kendler 1997, Kendler & Prescott 1998, Tsuang 1996).Ex: Bingeing > Serotonin Transport (Herman 2003); < Asians ALDH (Wall 2001)Temperament (Anxious; Stimulus Seeking).Disorders of attachment and self-regulation (trauma, abuse, loss, neglect).Chronic pain & medical illnessChronic effects of substance dependence (withdrawal; cravings).Pre-existing Psychiatric or Processing Disorder (Khantzian & Albanese 2008).
15Earlier Onset of Substance Abuse in ADHD : 1020304050600.00.20.40.60.81.0ADHD**p<.05 vs controlProbabilityControl1: It happens EARLIER: The average age of ADHD patients at onset of substance abuse was found to be 19 years compared to non-ADHD controls (age 22).2. The SUD becomes SEVERE MORE QUICKLY [abuse dependence] (1.2 years in ADHD versus 3 years in non-ADHD controls)Age of OnsetWilens TE, et al. J Nerv Ment Dis. 1997;185(8):15
16Prevalence of Substance Abuse (NSDUH 2008, CDC, National College Study)Total US: 95 million (38%) Illicit, Binge/Heavy ETOHUse by age 18ETOH Past month 45%; Lifetime 73%SA Past month 22%; Lifetime 48%By age 2023% meet criteria for ETOH/SA abuse or dependenceCollege students45% have met criteria for binge drinking1825 alcohol related deaths annually600,000 injuries, 700,000 assaults97,000 rapes
17Causes of Death-College Students (Turner & Kelter 2011; CDC)(per 100,000)Prescription Drug OD 8.4Suicide 6.18Non alcohol vehicular 3.51Alcohol related vehicular 3.37Non alcohol, non traffic injury 2.39Cancer 1.94Alcohol related non-traffic 1.49Homicide 1.53Total MH+SA: 19.44/ 9.37
21Substance Abuse Derails Brain Development Limits brain growth (Volkow, Ma & Zhu et al., 2008) and differentiation (De Bellis, 2005). Decreased PF(Debellis (2005) & hippocampal volume-ETOH; reduced grey matter-MJ (Nagel, 2005)Disrupts development of executive functions: attention, decision-making, planning, conceptualization (Thorberg & Lyvers, 2006; Crean et al 2011).Distorts Reward-Risk Decision-Making (Hanson, Luciana & Sullwold, 2006). Motivational systems become organized around danger of withdrawal, cravings, distress avoidance.Dysregulates HPA axis(Sher 2007)biorhythms, emotional engagement and feedback networks, judgment and resultant behavior.
22Derailed Brain Development (cont’d) Substance becomes primary attachment relationship.Heavy use (MJ) or binging (ETOH) before 17 worsens effects; earlier is worseEarlier (2.7+ yrs) onset of psychosis in heavy marijuana use (Gonzalez, Pinto-Vega & Ibanez, 2008; Large 2010).Higher Rate (4x) of depression with heavy marijuana use (Bovasso, 2003). 7-12x rate of relapse if use.
23SPECT Scan – brain function in an 18 y. o SPECT Scan – brain function in an 18 y.o. woman with ADHD, Conduct Disorder and Polysubstance Dependence IMPULSE DYSCONTROL Sx Note the hypofunction = “hole” in left inferior cortex (OFC)23
24Psycho-Neurobiology of Intervention: Guiding Models Quieting the limbic systemSafety, Attachment, Self-Regulation,Re-network meso-limbic motivationCompetence(van der Kolk2005)self-efficacySelf-in-relation; Psycho-neurobiology of self cohesion and regulation (Schore, Siegel)Neuro-cognitive Model of Decision Making (Noel, 2006); Reaction-Reflection-Relation (Viner et al)
25Psycho-Neurobiology of Intervention: Components of the Models Abstinence/12 Step Recovery CommtyPsychiatryIn-depth PsychotherapyExecutive Function & Role CompetenceRole of the Body & Physical Self
26Psycho-Neurobiology of Intervention: Resistance to Recovery Brain wired for exploration, novelty, stimulationAutonomy-self empowered-invulnerable-denial vsPowerlessness, limits, support, risk assessmentSA provides actual/illusory relief/control/separatenessSmith (2010) Quitting ETOH in EA & “loss of control”Anxiety & affect/anger management; traumaEF impairment, shame, avoidanceSecrets/separateness(authority)/ peer membershipNarcissism vs affecting others, low transcendenceBelonging & being normal within SA peer culture
27Psycho-Neurobiology of Intervention: Abstinence Abstinence opens neural pathways for emotional and cognitive processing.Abstinence resets the reward motivational systems via self-efficacy; highest correlation with recovery.Abstinence interferes with the primary attachment to substances.Supportive treatment of withdrawal and cravings (medical and interpersonal) facilitates abstinence, resets reward system.
28Psycho-Neurobiology of Intervention: The 12-Step Recovery Model Reassures danger systems by providing ever-present safe places.Relieves distressing emotions of aloneness and shame through group membership.Sponsor and members provide organizing relationships to replace substances at times of distress.
29Psycho-Neurobiology of Intervention The 12-Step Recovery Model Confronts denial and rationalization while providing acknowledgment of the difficulties maintaining sobriety.Supports self worth, hope and motivation through acceptance and praise for realizable actions supporting sobriety in self/ others.12 Steps provide a guide towards self-efficacy, empowerment and governance in connection to others.
30Psycho-Neurobiology of Intervention: Psychiatry Effective treatment of psychiatric diagnosis reduces distress and supports abstinence.Reduction of cravings and resetting reward systems.Supervised withdrawal from prescribed medications that promote relapse.Reframing of substance abuse as disease to reduce self-criticism, shame and sense of failure.
31Psycho-Neurobiology of Intervention: Psychotherapy Attuned Attachment; safety & self regulationMirroring, validation, mentalizationMotivational Interviewing;Collaboration, autonomy, efficacyArousal-Affect immersion interferes with dissociation;“Limbic dialogue”(Schore,2001)Here-and-now issue of the moment, in andoutside the Rx relationship; self disclosure
32Psycho-Neurobiology of Intervention: Psychotherapy Targeting maturing brain systems linked with researched protective factors:Emotional regulation & motivational systems (trauma, abuse, neglect)Identity integration and coherence; neg risk correlation (Schwartz 2010)Attachment patterns; peer & familyExecutive function/competence-rehabilitationShame-self-judgment-avoidance patternsverbal-social mask
33Psycho-Neurobiology of Intervention: Support for Executive Functioning EF Predicts relapse on fMRI (Paulus 2005)Brief Action Planning; interest, next steps, confidence, commitmentAction analysis,problem solving,strategic planRisk-reward recognition and consequencesRelapse prevention and harm reductionResistance to negative peer influenceSober community
34Psycho-Neurobiology of Intervention: The Body & Physical Self Action & experience; mode of learningEmotional pathways to the body selfDistress tolerance (DBT).ExerciseYogaMeditation & mindful practicesHeartmath, neuro-feedbackGratitude, compassion & forgiveness
35Psycho-Neurobiology of Intervention: High relapse ratesHarm reduction: abstinence in EA“Though none among us may complete the task, none among us is exempt from contributing our unique part” (Talmud)
36Minding the Brain Emerging Adulthood as a phase of development Mind, Self, BrainBrain maturation in emerging adulthoodRisk factors for substance abuseSubstance abuse and brain maturationPsycho-Neurobiology of intervention
37Presentation Title DATE HERE “Minding the Brain”The ResidenceLife Strategies ProgramCenter for Clinical NeuroscienceAddictions ServiceEating Disorder ServiceTrauma Recovery ProgramCareerDevelopment