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Career Opportunities in the Life Sciences

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1 Career Opportunities in the Life Sciences
Career Opportunities in Biotechnology and Drug Development Career Opportunities in the Life Sciences Toby Beth Freedman, Ph.D. SEBA, October 12th, 2012 10-11 am Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved.

2 Transitioning from Academia to Industry Job search strategies
Today’s Talk Career overview Transitioning from Academia to Industry Job search strategies If there is time, current economy Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 2 2

3 Definitions “Pharmaceuticals” Chemical synthesis “Small molecule drugs” Pfizer, BMS, Merck Aspirin, statins, Viagra, antibiotics, taxol, Prozac, antihistamines, anti-inflammatories

4 Definitions “Biotechnology”
Biologics: DNA, RNA, protein, viruses, antibodies, hormones “Large molecule drugs” Genentech, Amgen, Genzyme, Gilead, Biogen Rituxan, EPO, Enbrel, Gleevec, Herceptin, insulin, HGF

5 Definitions: Biotechnology Also
Biotools, Reagents & Services Instruments and tools, enabling technology, services Microscopes, reagents, software, services Affymetrix, Zeiss, Promega, Covance, BCG

6 Definitions “Medical Devices” Instrument or software for diagnosis or therapeutic purposes J&J, GE, Medtronic, Tyco, Philips, Boston Scientific, Abbott Stents, MRI, surgical equipment, defibrillators, wheelchairs

7 Biofuels Each box is many Ph.D.s of information Biotech versus pharma
Teams Cost of developing products, high attrition rate

8 Definitions “Healthcare” Hospitals/HMOs, Insurance companies Kaiser, Sutter Health

9 Three Main Career Paths for Students
Academia Government, Research Institutes, Non-Profits Industry CEO VP Tenured Professor Director or Other Dean Director Fellow or Principal Scientist Track Advocate Scientist or Other Manager Tenure track Educator Science and Business Student Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 9 9 9 9

10 Career choices for science and medical backgrounds
My Experiment A comprehensive, systematic assessment of careers for life science professionals Not hypothesis driven Career choices for science and medical backgrounds Resource guide for career planning—so much information that readers identify a career that suits their skills, interests, goals and personality attributes Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 10 10

11 Goals: Be Sure To Enjoy a Job
“If you are doing what you love, then it’s not really ‘work’” Peter David

12 Goals: Get on the Right Track

13 1 hour telephone informational interviews Mostly VPs, Ph.D.s or MDs
Methods 200+ interviews 1 hour telephone informational interviews Mostly VPs, Ph.D.s or MDs 10 interviews per chapter Compiled, analyzed and summarized Took three years Published by Cold Spring Harbor Laboratory Press and is on Amazon Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 13 13

14 Results: So Many Careers To Choose!
Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 14 14

15 Product Development Overview
Preclinical Studies Commercial Operations and Sales Preclinical Studies Lead Optimization of Drug Candidates Clinical Trials NDA or BLA filing Discovery Research IND filing FDA review Product Launch! Bio/Chemical Process Development Scale-Up / Manufacturing Phase IIIB/IV Trials Discovery Research Clinical Development and Regulatory Affairs Medical Affairs Commercial Operations: Marketing, Sales, and Technical Support Chemical and Biological Development, Operations and Manufacturing, Quality Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 15 15 15 15

16 Careers for Engineers: Medical Device and Biotech Tools Companies
Discovery Research Preclinical Research Recruiting Venture Capital & Banking Law Product Development Management Consulting Project Management Bio IT Services R&D Clinical Development Quality Operations Operations & Manufacturing Commercial Operations Regulatory Affairs Business Development Medical Affairs Corporate Communications Marketing Sales Product Support

17 Careers in Research www.careersbiotech.com 17
Discovery Research Preclinical Research Recruiting Venture Capital & Banking Law Bio/Pharmaceutical Product Development Management Consulting Project Management Bio IT Services R&D Clinical Development Quality Operations Commercial Operations Regulatory Affairs Operations & Manufacturing Business Development Medical Affairs Corporate Communications Marketing Sales Product Support Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 17 17

18 Having a business background is an advantage
Discovery Research Preclinical Research Recruiting Law Venture Capital & Banking Bio/Pharmaceutical Product Development Management Consulting Project Management Bio IT Services R&D Clinical Development Quality Operations Operations & Manufacturing Commercial Operations Regulatory Affairs Business Development Medical Affairs Corporate Communications Marketing Sales Product Support Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 18 18

19 Do you want to be a CEO one day?
Discovery Research Preclinical Research Recruiting Venture Capital & Banking Law Bio/Pharmaceutical Product Development Management Consulting Project Management Bio IT Services R&D Clinical Development Quality Operations Operations & Manufacturing Commercial Operations Regulatory Affairs Business Development Medical Affairs Corporate Communications Marketing Sales Product Support Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 19 19

20 Careers where you can earn the most money
Discovery Research Preclinical Research Recruiting Venture Capital & Banking Law Bio/Pharmaceutical Product Development Management Consulting Project Management Bio IT Services R&D Clinical Development Quality Operations Commercial Operations Regulatory Affairs Operations & Manufacturing Business Development Medical Affairs Corporate Communications Marketing Sales Product Support Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 20 20

21 Hot Jobs www.careersbiotech.com 21
Discovery Research Preclinical Research Recruiting Venture Capital & Banking Law Bio/Pharmaceutical Product Development Management Consulting Project Management Bio-IT Services R&D Clinical Development Quality Operations Operations & Manufacturing Commercial Operations Regulatory Affairs Business Development Medical Affairs Corporate Communications Marketing Sales Product Support Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 21 21

22 Positions for students
Analysts/Assoc Kauffman Fellow Portfolio, SRA Consultant Project coordinator Analyst Budget, strategy Quality systems Many Liaison --what’s hot what’s not -PM is a good career --most will go into DR and move around, most people will find that your interests change over time and you will want to explore new career areas --business interest? --interested in writing? Having children? Whatever your passion, there is hopefully something for you Analyst Marketing Marcom, AAAS Fellow Marketing, MR Tech Support, FAS Sales reps, trainers, managers Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 22 22

23 Positions for PhDs/Postdocs
Patent agent, advisor, USPTO Scientist I Research Analysts/Assoc Kauffman Fellow Consultant Project coordinator Bioinformatics Medical writer, IT QC chemist Startups FDA, Liaison --what’s hot what’s not -PM is a good career --most will go into DR and move around, most people will find that your interests change over time and you will want to explore new career areas --business interest? --interested in writing? Having children? Whatever your passion, there is hopefully something for you OTT, Portfolio MSL, Scientific affairs Marcom, AAAS Fellow Market research Tech Support, FAS, Trainer Technical sales rep, FAS Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 23 23

24 So Many Careers To Choose!
--what’s hot what’s not -PM is a good career --most will go into DR and move around, most people will find that your interests change over time and you will want to explore new career areas --business interest? --interested in writing? Having children? Whatever your passion, there is hopefully something for you Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 24 24

25 Many areas to consider Table 6-1: Biotechnology and Drug Development Overview... Where the Jobs Are Drug Discovery & Development Biotechnology “Tools” Biotechnology Services Other Pharma/ Biotech Areas Government Institutions Medical Devices Academia Pharmaceutical companies Biotechnology therapeutic Vaccines Drug delivery Molecular Diagnostics Reagents and Chemical suppliers Instruments (e.g., microscopes) Platform companies (e.g., genomics, proteomics, nanotechnology) Bio-IT Software and hardware diagnostics Management consulting and accounting firms Law firms Venture capital and investment banking Recruiting firms Contract research organizations (CROs) Contract manufacturers (CMOs) Research and clinical testing: clinical labs, customized antibodies Other agencies and niche providers: PR, advertising, market research, medical communications Consultants Agricultural Industrial biotechnology Molecular diagnostics Veterinary companies Foundations, non-profits, social philanthropy Clean tech/energy Nanotech Journalism Viticulture Food and Drug Administration (FDA) and CBER Centers for Disease Control (CDC) National Institutes of Health (NIH) US Patent and Trademark Office (USPTO) Research institutes and government labs Homeland security & defense CIA, FBI, and NASA Trade commissions Crime labs forensics Medical devices Diagnostic companies eHealth HC Informatics Telemedicine Tech transfer Industry-supported labs and institutes Education Program management Incubators Miscellaneous includes veterinary, industrial biotechnology, molecular dx, ab-bio Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 25 25

26 Careers in Healthcare www.careersbiotech.com
Healthcare Practitioners Nursing Associated Careers and Therapists Technologists and Technicians Rehab Therapists Healthcare Administration Insurance Industry Physicians Chiropractors Dentists Optometrists Podiatrists Veterinarians Licensed nurses Registered nurses Nurse anesthetists Nurse midwives Nurse practitioners Home health aides Surgeon assistants Nurse’s aides Acupuncturists Audiologists Dental hygienists Dietitians and nutritionists Genetic counselors Pharmacists Psychologists Occupational therapists Opticians Orthotists and prosthetists Physical therapists Recreational therapists Respiratory therapists Pediatric occupational therapists Biomedical engineers Biomedical equipment techs Biomedical photographers Biomedical writers Child life specialists Dietary managers Geriatric social workers Anesthesiologists Blood bank techs Cardiovascular techs Radiology techs Clinical lab techs Cytotechnologists Cardiovascular Nuclear medicine Dental assistants Dental lab techs Diagnostic medical sonographers Diagnostic imaging Dietetic techs Electroencephalograph Emergency techs Paramedics Food techs Histology techs Ophthalmic techs Optometric techs Perfusionists Phlebotomists Pulmonary techs Radiation therapy techs Surgical techs Veterinary assistants Art therapists Certified athletic trainers Dance movement Music therapists Patient reps Psychiatric aides Rehab counselors Social services aides Speech language pathologists Substance abuse counselors Admitting officers Accounting and finance Coordinators of health wellness Environmental health and safety Food service Health education Health information technologists Human resources Librarians Public relations Nursing home directors QA directors Geriatric care managers Medical records Medical billing, claims, patient accounting Medical secretaries Mental health workers Administration Actuaries Agents and brokers Claims adjusters Loss control specialists Medical insurance billing and coding reps Medical claims reviewers Service reps Sales and marketing Underwriters Miscellaneous includes veterinary, industrial biotechnology, molecular dx, ab-bio Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 26 26

27 Values/Goals$$$/Market
Ideal Job Skills Interests Ideal Job Values/Goals$$$/Market Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 27 27

28 About the Life Sciences Industry
In 1982, Synthetic Insulin, produced by Eli Lilly and Genentech. This was the first ever approved genetically engineered human therapeutic. Image: Wikipedia Commons Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 28 28

29 Drug Development: A Risky Endeavor
Commercial Operations and Sales Preclinical Studies Lead Optimization of Drug Candidates Clinical Trials NDA or BLA filing Discovery Research IND filing FDA review Product Launch! Bio/Chemical Process Development Scale-Up / Manufacturing Phase IIIB/IV Trials Discovery Research Preclinical Studies Clinical Development and Regulatory Affairs Millions of compounds 71-2 1 in 10 About 15 years and > $1B!

30 Career Paths in the Life Sciences
Photo: Wikipedia Commons Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 30 30 30 30

31 Career Ladder in Discovery Research for Research Associates
SRA SRA SRA SRA Research Associate Student Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 31 31

32 Career Ladder in Discovery Research: Ph.D.s are not technicians
CEO VP R&D VP Research or CSO Director Fellow or Principal Scientist Track Group Leader Scientist I - III Postdoc Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 32 32

33 Career Potential in Discovery Research
CEO Consultant Venture Capital Patent Law VP R&D or CSO Project Management Preclinical Research Regulatory or Clinical Affairs Quality Discovery Research Other Areas: Operations, Business Development, Marketing, Sales, Tech Support, Product Development Academia Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 33 33

34 Going from Academia to Industry
Image: Wikipedia Commons

35 What you can do now to make yourself more marketable
Human disease rather than basic research Hot therapeutic areas of interest to industry “Unmet medical needs” Same techniques, drug screens, applied science Patent your work Gain business understanding Gain understanding of clinical development Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 35 35

36 What you can do now -- continued
Collaborate with industry cohorts Informational interviews Industry postdoc Follow biotech news Publish, publish, publish (but don’t perish) Presentations and attend conferences and become a perceived expert (get visibility) Consider FAS, MSL, Tech Support, Trainer Attend industry events, network and start early Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 36 36

37 Land a job on the business side
Work at the OTTBD Visit Haas MBA program—management consulting firms, career coaching Business classes Join a startup at QB3 Entrepreneurial classes—CBE, QB3 series Entrepreneur chapter Talk to profs who consult or founders Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 37 37

38 What you can do now to land a job on the business side--continued
Follow the biotech stock Invest in public companies—demonstrate financial acumen Show leadership—start something, run a program, be a President Pubs not needed in business Read WSJ, follow biotech business news Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 38 38

39 Making the Leap to Industry
Industry postdoc MBT programs, KGI, JHU, SJSU Keck Institute’s Postdoc Professional Master’s Program (PPM) Certificates, UC Berkeley X and UCSC X Additional degrees: MBA, MPH, JD Volunteer/intern Network Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 39 39

40 Jobs in Industry

41 Looking for a job can be a full time job
Job search strategies Looking for a job can be a full time job Apply to jobs that interest you Apply to jobs that will get you in the door The more you interview, the more likely you will find the most appealing job Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 41 41

42 Genentech Scientist I requirements
Jobs in Industry Difficult job market--large numbers of industry professionals seeking employment Genentech Scientist I requirements Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 42 42

43 Build Your Network! www.careersbiotech.com 43
Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 43 43

44 Why networking is so effective
Someone that you know refers you to a job opportunity The more people you know, the greater your chances of being contacted or finding out about an opportunity Personally-vouched for candidates Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 44 44

45 Local places to network
Local and national conferences Local biopharma societies, trade associations AWIS WIB ACRP AAAS You name it, there is a society Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 45 45

46 Networking Photo from Wikipedia www.careersbiotech.com 46
Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 46 46

47 The Art of Networking It’s a two-way street. Be helpful, ask questions about the other person, ask “what can I do for you?” Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 47 47

48 Scanning the audience looking for other people to talk to
Networking No-No’s Can you get me a job? Are there any job openings in your company? (what can you say instead?) Scanning the audience looking for other people to talk to Ask a question and then walk away Looking desperate “I have to get a drink—I’ll be right back” ditch Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 48 48

49 Using LinkedIn LinkedIn.com: recruiters use it
The greater your LinkedIn network, the more access you have LinkIn with LIONs and power users Join LinkedIn groups, alumni organizations Include key words, therapeutic areas to interest recruiters address or way to be contacted Keep professional Jobs are on site and groups MySpace, Facebook: set on private Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 49 49

50 Networking on the Internet
Google “therapeutic area conference” Contact speakers, authors Search LinkedIn in specific companies that interest you for people that you might know Professors who consult/founders Contact alumni Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 50 50

51 “Shop” for a Job on the Internet
Job posting sites Professional societies Therapeutic areas and functional areas, i.e. immunology, neurosciences, oncology, marketing, business development Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 51 51

52 Let the jobs find you Resume posting sites www.biospace.com
Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 52 52

53 BioSpace, www.biospace.com Campus Career Fairs
Society meetings, i.e. ASCB, AAAS, Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 53 53

54 Trade Shows at Scientific Conferences
BIO, the biggest InformEx, Chemistry ASCB, Interphex, manufacturing, Tri-Molecular, Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 54 54

55 Career counselors and services
On campus, medical schools, business, law programs Alumni school counselors usually free Off campus NOVA, ProMatch, Peninsula Works, EastBay Works, free interview coaching and resume preparation Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 55 55

56 Free Biotechnology News
BioSpace Biospace careers insider BayBiotechReview FierceBiotech FierceBioResearch OnBioVC The IN VIVO Blog Nature Biotechnology The Scientist Biotechnology Industry Organization Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 56 56

57 Resumes Image: Wikipedia
As a team you are able to accomplish more than an individual researcher Image: Wikipedia

58 Resumes: how to stand out
Prepare for the 5 second scan Align skills with the position specs Highlight and show how you fit the position Add key words, therapeutic areas Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 58 58

59 Tips for submitting your resume to large companies
Job requisition number Career objective Apply directly on the company’s website Network, network, network! Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 59 59

60 Working with Recruiters
They know about positions that may not be posted on the Internet—the “hidden” job market They will get your resume in front of the hiring manager Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 60 60

61 Working with Recruiters
Recruiters are paid by the company You are your own best job agent Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 61 61

62 Interviewing www.careersbiotech.com 62
Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 62 62

63 The Art of Interviewing
You’ve already pass the technical test—corporate match Research the company Don’t interview like a postdoc! Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 63 63

64 Good Interviewing Books
Knock em dead 101 Great Answers to the Toughest Interview Questions 301 Smart Answers to Tough Interview Questions And by the way, you should do the same thing. Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 64 64

65 The Current Economy Each box is many Ph.D.s of information
Biotech versus pharma Teams Cost of developing products, high attrition rate

66 The current economy: “The Times, They are a Changin’”
2008 was a bad year 2009 was a *terrible* year It’s a little better now 3 IPOs in 2009, 13 IPOs in 2010, 10 IPOs in 2011, lackluster receptions Overall biotech sector was down Social media hot, 3.3% unemployment Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 66 66 66 66

67 Monster Report on Biotech Jobs 2011
Job postings in biotech positive expansion 2011 Hottest area: clinical lab techs and technicians 40% Areas hiring most (volume posting): Texas, NC, Kentucky, Michigan, NJ, RH Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 67 67 67 67

68 In High Demand Regulatory affairs Sales CLIA-certification Bioreactors
QA and QC Rare skills, i.e. ephiz Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 68 68 68 68

69 Successful biopharmas Service companies, i.e. CROs and CMOs
Where are the jobs? Academia Successful biopharmas Service companies, i.e. CROs and CMOs Biofuels (bioreactors, fermentation, microbiology, plant genetics (agbio)) Small venture-backed companies Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 69 69

70 43,000 layoffs in big pharma in 2010
Top 5 lay-offs in 2011 Pfizer – 4,220 Novartis – 2,000 Abbott Labs – 1,900 AstraZeneca – 1,550 Sanofi – 700+ 43,000 layoffs in big pharma in 2010 Source: December 9, 2011 Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 70 70 70 70

71 Merck/Schering Plough – 16,000 J&J – 8,900 Astra Zeneca – 7,400
Top 5 lay-offs in 2009 Pfizer/Wyeth – 19,500 Merck/Schering Plough – 16,000 J&J – 8,900 Astra Zeneca – 7,400 GlaxoSmithKline – 6,000 Source: December 9, 2009 Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 71 71 71 71

72 Venture capital and capital markets
ROI for LS VCs was -1.5% in 2010 Less VCs, less money, smaller investments Difficult for startups to raise money Public markets less interested in LS, IPO window lackluster VCs investing in later stage deals Corporate venture, academia-industry partnerships Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 72 72 72 72

73 M&As are bad for industry
30 mergers over last 60 years didn’t boost productivity More companies = more successful drugs New areas of pharmacology most successful 25% fewer public biotechs in 2010 than 3 years ago Bernard Munos/Forbes 2011 Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 73 73 73 73

74 The FDA… Overburdened with added responsibilities
Increasingly focused less on benefits and more on possible risks Average review times increasing Regulatory environment raises “serious barriers to innovation” CHI Report, 2011 CHI 2011 Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 74 74 74 74

75 Consequences of the FDA…
Difficult to raise money—regulatory risks and uncertainty Dramatic shift in clinical trials US to Europe Rise in number of drugs approved in EU first EU Docs learn new tech first Costs of RA and consultants going up Operations, experts move overseas CHI Report, 2011 CHI 2011 Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 75 75 75 75

76 The Scenario at Big Pharma…
Dismal internal R&D returns Cost per successful drug has risen (cost of R&D has gone up, shorter periods of economic returns due to generics and patent life span, declining productivity) Regulatory hurdles higher Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 76 76

77 Big pharma solution: outsource R&D to biotech
“Externalize” small mol discovery research, pre-Phase III compounds, particularly for riskier therapeutic areas (NR, COPD, Cardio) Reduction in R&D research and reallocating resources to in-license deals with biotechs Move from R&D to “Search & Development” orgs Reduces investment risk Biotechs expected to become pharma’s main R&D engine Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 77 77

78 Reason for biopharma to outsource: develop presence overseas
Pursue a market presence China expected to be third largest Rx market by 2013, number two in 2020 Growing markets Australia, S. Korea, India, Vietnam, Japan, Russia Cost of dev is 1/5 to 1/3rd, labor costs are rapidly rising Serendipity lost Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 78 78

79 Outsourcing and impact on jobs
Chemistry and manufacturing overseas Small molecule, devices, large mol safer Clinical trials, preclinical, research and IT Virtual companies= growth in services and consultants Still need quality and PM Global leadership Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 79 79 79 79

80 Biotech and medical devices better than other industries
Not so bad off… Biotech and medical devices better than other industries Big biotech is doing well Big pharma is cash rich, patents expiring, need to fill pipelines Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 80 80 80 80

81 VCs are Funding Biotech and Medical Device Companies
Source: PricewaterhouseCoopers, Money Tree Report,

82 Northwest Funding Source: PricewaterhouseCoopers, Money Tree Report,

83 History of VC Funding in Biotech
Source: PricewaterhouseCoopers, Money Tree Report,

84 Hot growth potential sectors: new and emerging areas
Healthcare, surgery centers Generics and biosimilars Biofuels and green/clean tech, grey water, energy Personalized medicine/companion Dx Combination therapies HC IT, telemedicine, mobile HC apps, “doc-in-the-box” Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 84 84 84 84

85 Healthcare informatics (i.e. electronic health records)
Trend to transition to electronic data capture in just about every job function Healthcare informatics (i.e. electronic health records) Laboratory automation Bioinformatics (personalized medicine) Data management, bio-IT Regulatory affairs, i.e. electronic filing Discovery research, i.e. eNotebooks Intersection of life and computer sciences training Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 85 85 85 85

86 The Future of the Life Sciences Remains Promising
Significant unmet medical needs remain—neurological disorders, cancer, infectious diseases, diabetes, obesity, cardiovascular diseases People are living longer, aging population all over the world Tremendous market opportunity in China, India and other emerging countries Energy Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 86 86 86 86

87 Recommendations for job search during difficult economic times
Non-glamorous jobs Temp-to-hire/contract ops Safety in biotech hubs: SF, SD, Boston, Seattle Good time to start a company Start networking early Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 87 87

88 Conclusions Over >100 different careers in academia, industry and government Many different industries in which to work Find the vocation that best suits your interests, skills and goals Do what you love Not money or a fad Be flexible about job search--your first job will not be your last

89 Find your niche

90 Recommended Academia Career Books
At the Bench and At the Helm, Kathy Barker, CSHLP Advice for New Faculty Members, Robert Boice Making the Right Moves: A Practical Guide to Scientific Management for Postdocs and New Faculty, Burroughs Wellcome Fund, HHMI, Lab Dynamics: Management Skills for Scientists, Carl and Suzanne Cohen, CSHLP Managing Scientists, Alice Sapienza Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 90 90 90 90

91 Recommended Industry Books
Science Lessons, Gordon Binder, Former CEO of Amgen Emperor of All Maladies, Siddhartha Mukherjee Put Your Science to Work, Peter Fiske Career Opportunities in Clinical Drug Research, Rebecca Anderson Nontraditional Careers for Chemists, Lisa Balbes Alternative Careers in Science, Cynthia Robbins-Roth Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 91 91 91 91

92 Book Information Careers in Biotechnology and Drug Development
Published by Cold Spring Harbor Laboratory Press Books available on Amazon and Paperbacks selling for $35 Hard covers selling for $47 Available in German Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 92 92

93 Additional Information
Free sample chapter on Careers in Project Management, List of job posting sites under career resources at Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 93 93 93 93

94 President, Synapsis Search
Contact Information Toby Freedman, Ph.D. President, Synapsis Search Recruiting in the life sciences: Biotechnology, Biofuels, Services, Non-Profits Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 94 94 94 94

95 Acknowledgments Over 200+ industry professionals Special Thanks to:
Molly Schmid, Joseph Carlino, Betsy Alberty, Angelie Agarwal, Bill Lindstaedt Even More Special Thanks to: My father, Bill Freedman, who edited the chapters multiple times and Peter Symonds Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 95 95 95 95

96 Thank you! Start companies, be successful, and find a cure for cancer!
Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 96 96 96 96

97 So Many Careers To Choose!
--what’s hot what’s not -PM is a good career --most will go into DR and move around, most people will find that your interests change over time and you will want to explore new career areas --business interest? --interested in writing? Having children? Whatever your passion, there is hopefully something for you Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 97 97


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