Download presentation

Presentation is loading. Please wait.

Published byHayden Schultz Modified over 3 years ago

1
This is how the simplified structure of the non-covalent complex between CYCLO (blue baskets) and Cholesterol looks like. In the ideal complex structure two CYCLO baskets bind one molecule of cholesterol. This is the form of a supramolecular complex where CYCLO is the shuttle that transports cholesterol in the body and replaces the role of the missing protein transporter. Note that my calculations were (for some mathematical reasons) made only when one basket binds one cholesterol, but tendencies obtained are valid.

2
Preliminary in vitro based calculations Percentage of CYCLO-bound cholesterol calculations were made with average molecular mass of HPBCD = 1400 under in vitro model conditions in slowly stirred 37oC solutions Applied doseIn pure waterIn simulated human serum 250 mg HPBCD Per body weight kg 22 % of the total cholesterol about 14 % of the total cholesterol 500 mg HPBCD Per body weight kg 34 % of the total cholesterol about 26 % of the total cholesterol

3
This graph only shows that UNDER IN VITRO CONDITIONS among many other types of CYLOs the HPBCD (orange bar) exhibits a really modest, but useful cholesterol binding. Note that other strong cholesterol binders (RAME, DIMEB etc) WILL NOT EASILY RELEASE the entrapped and transported cholesterol. We need to bind gently then to transport and finally have it released. This is why HPBCD is the right choice!!.

Similar presentations

Presentation is loading. Please wait....

OK

Ions in aqueous Solutions And Colligative Properties

Ions in aqueous Solutions And Colligative Properties

© 2017 SlidePlayer.com Inc.

All rights reserved.

Ads by Google

Ppt on lateral thinking Ppt on restaurant business plan Ppt on effective business communication skills Ppt on plant cell wall Ppt on economic order quantity method Ppt on water activity center Ppt on isobars and isotopes of helium Ppt on bluetooth hacking software Ppt on generation of electricity from wastewater Ppt on rulers and buildings class 7