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Instructions for using this template. Remember this is Jeopardy, so where I have written Answer this is the prompt the students will see, and where I.

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Presentation on theme: "Instructions for using this template. Remember this is Jeopardy, so where I have written Answer this is the prompt the students will see, and where I."— Presentation transcript:

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2 Instructions for using this template. Remember this is Jeopardy, so where I have written Answer this is the prompt the students will see, and where I have Question should be the students response. To enter your questions and answers, click once on the text on the slide, then highlight and just type over whats there to replace it. If you hit Delete or Backspace, it sometimes makes the text box disappear. When clicking on the slide to move to the next appropriate slide, be sure you see the hand, not the arrow. (If you put your cursor over a text box, it will be an arrow and WILL NOT take you to the right location.)

3 Choose a category. You will be given the answer. You must give the correct question. Click to begin.

4 Click here for Final Jeopardy

5 My, oh, myloid Worth 1000 words? V, for Vignette 10 Point 20 Points 30 Points 40 Points 50 Points 10 Point 20 Point 20 Points 40 Points 30 Points 40 Points 50 Points 30 Points 60 Points 40 Points 80 Points 50 Points 100 Points Lymph and let lymph Translocate me up, Sharad

6 When this translocation is present in CML, it correlates with good prognosis, but when present in ALL correlates with relatively poor prognosis.

7 t(9; 22)

8 A patient with this translocation always has cellular features shown below, and should be treated with a specific therapy to avoid complications of DIC

9 t(15;17)

10 A child with rapidly progressing lymphocytosis and high blast count might have this favorable translocation associated with his/her blasts

11 t(12;21)

12 These two translocations might be called the twins, because not only are they both associated with favorable disease prognosis, they also both disturb a twin set of proteins needed for normal granulocyte maturation.

13 t(16;16) and t(8;21)

14 These are all three of the translocations we have learned that are associated with the IgH promoter, and the diseases they are found in.

15 t(8; 14): Burkitts lymphoma t(11; 14): Mantle cell lymphoma t(14; 18): Follicular lymphoma

16 This uncommon neoplasm is probably one of the only times treatment with leeches would still work, if your patient let you try them.

17 Polycythemia vera (normally phlebotomy, not leeches)

18 This mutation underlies the pathology in no fewer than 3 myeloproliferative disorders.

19 JAK2 mutation

20 In this disease, peripheral smear shows red blood cells leaving their home to in a trail of tears, accompanied by myelocytes and nucleated reds which fill up the spleen.

21 Primary myelofibrosis (or spent phase of other myeloproliferative disorder)

22 You might not be able to eat that whole Philly cheesesteak if you have absolute basophilia, eosinophila, and leukocytosis in the disease derived from this cellular precursor (give stage/proliferative potential).

23 Pluripotent stem cell (CML has the ability to convert to ALL or AML)

24 Erythromelalgia, a throbbing and burning of hands and feet caused by occlusion of small arterioles, is a rather characteristic symptom of this relatively indolent neoplasm – just dont try bloodletting.

25 Essential thrombocytosis

26 This common neoplasm can show up almost anywhere in the body; its aggressive neoplastic cells dwarf ordinary lymphocytes.

27 Diffuse large B-cell lymphoma

28 You might be careful how crazy you get on that Caribbean cruise – you just might catch the virus that causes this rapidly fatal cancer, although youd be safe for a good 40-60 year latency period.

29 Adult T cell lymphoma

30 A person with this test result could have these three diseases, among others:

31 MGUS, multiple myeloma, Waldenstrom macroglobulinemia, primary amyloidosis, heavy chain disease (monoclonal gammopathy)

32 Your diagnosis is a ringer if you see large, ugly horseshoe-shaped nuclei in this neoplasm, which is frequently produced by a translocation involving chromosomes numbered the same as its CD-markers.

33 Anaplastic large (T) cell lymphoma

34 You should be sure to keep this histopathological feature in mind when diagnosing a heterogenous group of memory B-cell neoplasms, all of which typically occur in the setting of chronic inflammation.

35 Lymphocytic infiltrate/attack of glands or other epithelial structures surrounding the MALT. (maltoma)

36 This CD marker is present on the neoplastic cells which give rise to this syndrome.

37 CD4 (accept other pan T-cell markers: CD2, 3, 5, 7; NOT 8)

38 This highly unique laboratory (CBC) abnormality may be the fur-st sign of the disease pictured.

39 Monocytopenia (Hairy cell leukemia)

40 This is the general age group in which you would see a patient with this peripheral smear and immunophenotype of CD2+, CD3+, CD4+, CD5+, CD7+, CD8+, CD 13- CD19-, CD20-, CD33-, CD34-, CD117-

41 Adolescents (Acute T cell leukemia)

42 The neoplastic disease pictured, which is historically very difficult to treat, is frequently mistaken for this non- neoplastic, troublesome disorder.

43 Pernicious (macrocytic) anemia (Myelodysplastic syndrome)

44 These are 3 of many signs / symptoms that may accompany this disease:

45 Roleaux formation: due to high Ig in serum. Most commonly: - Plasma cell neoplasm (esp MM): Bone pain, lytic lesions in axial skeleton, hypercalcemia, vertebral fractures, plasma cells in bone marrow, Bence-Jones proteins in urine, serum protein electrophoresis - Also accept features of other disease with high Ig in serum: ie malar rash (lupus), fatigue (autoimmune hemolytic anemia), etc; if justified

46 1. Kyle comes to Dr. Kennedy because he has been losing weight, feeling fatigued, sweating at night, and running fever for over a week. He blames his symptoms on burnout from not being in clinics and seeing patients. Dr. Kennedy finds a 3 cm LN in Kyles armpit and biopsies it. Dr. Alderson looks at the slide and sees this: Which of the following is true? a.He has poor prognosis b.His spleen is enlarged due to mets c.The cancer displays a typical B- cell immunophenotype d.He should have a CXR and CT to look for mets e.Tyrosine kinase mutation drives this tumors proliferation

47 HODGKIN LYMPHOMA a.He has poor prognosis - Prognosis for HL is good regardless of age group, even in advanced disease b.His spleen is enlarged due to mets HL is rarely extranodal in primary presentation c.The cancer displays a typical B-cell immunophenotype Though these cells are B cell derived, they have a highly atypical immunophenotype; CD15+, CD30+, sIg-, CD20+/- d.He should have a CXR and CT to look for mets – reasonable since HL spreads contiguously e.Tyrosine kinase mutation drives this tumors proliferation Unknown etiology, but EBV-associated and involves NF-kB upregulation

48 2. Caitlin, a 63 year old woman, makes an appointment to see you about a lump on her neck. She feels fine. You find a 4 cm submandibular node, which you biopsy. Here is what it looks like: What would be most useful to make the diagnosis? a.Flow cytometry of CD19 and CD20 b.Translocation analysis by FISH c.Bcl-2 cytochemical stain d.Serum protein electrophoresis e.Flow cytometry of CD11c, CD25, and CD103

49 What would be most useful to make the diagnosis? a.Flow cytometry of CD19 and CD20 All this would tell you is that it is a B cell neoplasm, which is probably what it is anyway (85% of the time) b.Translocation analysis by FISH Things that have small cells and grow diffusely are: CLL, mantle cell lymphoma, Burkitt lymphoma. This clinical picture most resembles either of the former, but regardless a translocation analysis would nicely stratify them: CLL – no translocation; Burkitt: t(8; 14), mantle cell: t(11; 14). c.Bcl-2 cytochemical stain - follicular lymphoma does not show diffuse growth d.Serum protein electrophoresis this is not a plasma cell neoplasm e.Flow cytometry of CD11c, CD25, and CD103 this is characteristic of hairy cell leukemia; those arent hairy cells

50 3. Jordan, a 67 year old man, goes to the hospital for a nosebleed that just wont stop. Once he is within 10 miles of the hospital, a CBC is run on him and shows a moderate lymphocytosis and thrombocytopenia. Bone marrow biopsy shows an interstitial growth pattern of small lymphocytes, CD5+ CD23+. The lymphocytes are shown to be a clonal B-lineage proliferation with > 2% of the IgHv region differing from that of genetic libraries. Which of the following is true concerning James disease? a.Prognosis is poor compared to other forms b.It is associated with a characteristic translocation c.It is derived from a naïve B cell d.It is likely to transform into a more malignant subtype e.It may be associated with a paraprotein

51 a.Prognosis is poor compared to other forms U-CLL has worse prognosis b/c of potential for transformation b.It is associated with a characteristic translocation CLL is not associated with a chromosomal translocation c.It is derived from a naïve B cell – true of U-CLL d.It is likely to transform into a more malignant subtype – transformation is more characteristic of U-CLL e.It may be associated with a paraprotein – Hyper or hypogammaglobulinemia may be associated with CLL, resulting in immune dysfunction that can be responsible for platelet or RBC destruction and anemia and thrombocytopenia.

52 4. Joe is a 65 year old white male who notices that he is fatigued and bleeds for a long time when he cuts himself while shaving. This has been going on for about 6 months. His CBC reveals a moderate absolute lymphocytosis with absolute thrombocytopenia and anemia. Smudge cells and spherocytes are seen in the peripheral smear. Which of the following immunophenotypes is most likely? a. CD10+, CD19+, TdT+, sIg- b. CD2+, CD3+, CD5+, CD7+, TdT+, CD4+ & CD8+ c. CD19+, CD20+, CD5+, CD10-, sIg+, CD23+, cyclin D1- d. CD19+, CD20+, CD5-, CD10-, sIg+, CD11c+, CD25+, CD103+ e. CD19+, CD20+, CD10+, CD5-, sIg+, Bcl2+ f. CD19+, CD20+, CD10+/-, CD5-, sIg+ g. CD19-, CD20-, sIg- h. CD19+, CD20+, CD10+, CD5-, sIg+, TdT- i. CD19+, CD20+, CD10-, CD5+, sIg+, CD23-, cyclin D1+

53 B- ALLB-ALL: CD10+, CD19+, TdT+, sIg- T-ALLCD2+, CD3+, CD5+, CD7+, TdT+, CD4+ & CD8+ CLL CD19+, CD20+, CD5+, CD10-, sIg+, CD23+, cyclin D1- Hairy cell CD19+, CD20+, CD5-, CD10-, sIg+, CD11c+, CD25+, CD103+ FollicularCD19+, CD20+, CD10+, CD5-, sIg+, Bcl2+ DLBCL*CD19+, CD20+, CD10+/-, CD5-, sIg+ Plasma cell*CD19-, CD20-, sIg- Burkitt*CD19+, CD20+, CD10+, CD5-, sIg+, TdT- Mantle cell CD19+, CD20+, CD10-, CD5+, sIg+, CD23-, cyclin D1+ Any T-cell-derived** CD2+, CD3+, CD5+, TCR+ ( αβ or γδ), CD4+/-, CD8+/- Classic HLCD15+, CD30+, CD20+/-, negative for most others Lymph-pred. HLCD19+, CD20+, CD15-, CD30-

54 5. Sam, a 4 year old boy presents to your clinic with a painful lump on the top of his head which has been growing for several months. Your exam reveals exophthalmus and an overal lumpy, funny-shaped head with a 7 cm immobile, tender mass in the right upper parietal region. During the visit, he asks to leave to get a drink of water several times, and also leaves to run pee twice. Which picture portrays the histopathology of the disease?

55 Hans-Christian-Schuller triad (Langerhans cell histiocytosis)

56 Make your wager

57 When you consider the terrible two: infection with this virus and mutation of this class of proteins, you have the etiology of the majority of leukocyte neoplasms.

58 Epstein-Barr Virus Tyrosine kinases


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