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Heterochromatin protein 1 is recruited to various types of DNA damage Martijn S. Luijsterburg, Christoffel Dinant, Hannes Lans, Jan Stap, Elzbieta Wiernasz,

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Presentation on theme: "Heterochromatin protein 1 is recruited to various types of DNA damage Martijn S. Luijsterburg, Christoffel Dinant, Hannes Lans, Jan Stap, Elzbieta Wiernasz,"— Presentation transcript:

1 Heterochromatin protein 1 is recruited to various types of DNA damage Martijn S. Luijsterburg, Christoffel Dinant, Hannes Lans, Jan Stap, Elzbieta Wiernasz, Saskia Lagerwerf, Daniël O. Warmerdam, Michael Lindh, Maartje C. Brink, Jurek W. Dobrucki, Jacob A. Aten, Maria I. Fousteri, Gert Jansen, Nico P. Dantuma, Wim Vermeulen, Leon H.F. Mullenders, Adriaan B. Houtsmuller, Pernette J. Verschure, and Roel van Driel J. Cell Biol. Volume 185(4): May 2, 2009 © 2009 Luijsterburg et.al.

2 Figure 1. Recruitment of HP1s to UV damage depends on the CSD Luijsterburg et al. J. Cell Biol. 2009:185: © 2009 Luijsterburg et.al.

3 Figure 2. Recruitment of HP1 in NER-deficient cells Luijsterburg et al. J. Cell Biol. 2009:185: © 2009 Luijsterburg et.al.

4 Figure 3. Long-term accumulation of HP1-β in repair-proficient and repair-deficient cells Luijsterburg et al. J. Cell Biol. 2009:185: © 2009 Luijsterburg et.al.

5 Figure 4. Recruitment of HP1-β to DSBs Luijsterburg et al. J. Cell Biol. 2009:185: © 2009 Luijsterburg et.al.

6 Figure 5. Survival of C. elegans HP1 knockout worms upon UV irradiation and IR Luijsterburg et al. J. Cell Biol. 2009:185: © 2009 Luijsterburg et.al.


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