Presentation on theme: "A effervescent tablet disinfectant Good Effervescent ! Long Lasting ! High Effectiveness ! Very Convenient ! Varied Application ! SUNGIL PHARMA A concern."— Presentation transcript:
A effervescent tablet disinfectant Good Effervescent ! Long Lasting ! High Effectiveness ! Very Convenient ! Varied Application ! SUNGIL PHARMA A concern of
Features of Aquagard-T Good Effervescent ! Long Lasting ! High Effectiveness ! Very Convenient ! Varied Application !
Aquagard-T… Aquagard-T is a effervescent tablet disinfectant. Aquagard-T is a very powerful disinfectant containing sodium dichloroisocyanurate (NaDCC) widely applied for the sterilization of drinking water, or fighting against infectious diseases, or act as disinfectant in raising livestock, poultry and fish.
Aquagard-T… Aquagard-T is an oxidising compound which releases chlorine to produce hypochlorous acid and hypochlorite ion in the presence of water. It is generally considered that the lethal action on organism is due to chlorination of cell protein or enzyme systems by nonionised hypochlorous acid, causing hydrolysis of peptidic chains of cellular membranes of pathogenic germs. Chlorine-releasing substances are bactericidal to most gram-positive and gram-negative bacteria, bacterial spores and viruses.
NaDCC (Sodium Dichloroisocyanurate) (Structural formula of NaDCC)
NaDCC (Sodium Dichloroisocyanurate) (Hydrolysis of NaDCC) + 2H 2 O germicidal activity + 2HOCl Hypochlorous acid H + + OCl - Hypochlorite ion
The germicidal activity of hypochlorous acid is 80 times higher than hypochlorite ion. The presence of HOCl in solution of chlorine containing compound Aquagard-T : NaDCC (Sodium Dichloroisocyanurate) pH of Aquagard-T solutions pH of NaOCl solutions
Chlorine containing compound Chlorine used widely as a disinfectant and bleaching agent Inorganic compound Sodium hypochlorite (NaOCl) Calcium hypochlorite (CaOCl) Chloline dioxide (ClO 2 ) unstable, less germicidal activity Organic compound Sodium dichloroisocyanurate (NaDCC) very stable, predominantly germicidal activity
Features of Aquagard-T Good effervescent high technique for making effervescent tablets Long lasting free available chlorine is present for 5 days in Aquagard-T solutions High effectiveness broad spectrum disinfectant (active to spore forming bacteria, naked virus) Very convenient easy to handle and safe Varied application used widely for disinfection of poultry, pig, cattle and sheep, livestock houses and facilities, drinking water
MicrobialsNaDCC* (ppm) Staphylococcus aureus1.12 Escherichia coli0.83 Salmonella typhi0.83 Klebsiella pneumoniae2.36 Serratia marcescens1.14 Yersinia enterocolitica0.72 Pseudomonas aeruginosa2.00 Saccharomyces cerevisiae72.0 Candida albicans45.9 Microbiocidal activity of Aquagard-T * Total available chlorine
Test strainsPhenol coefficiency Staphylococcus aureus 209P28.5 Salmonella pullorum Erysipelothrix rhusiopathiae16.3 Erysipelothrix rhusiopathiae fujisawa16.3 Bactericidal activity of Aquagard-T Phenol coefficiency of Aquagard-T against bacteria
Disinfectants Spore Bacillus subtilis ATCC9372 Bacillus (natto) BN strain B. Cereus RIMD Cl. Perfringens Type B NCTC3182 Aspergillus oryzae Aquagard-T 1:152(5)1:57(15) 1:380(5) 1:950(15) 1:3,800(15)1:3,420(15) Iodine 1:10(30)<1:10(30)1:10(15)<1:101:1,000(15) Benzalkonium chloride 1:150(5)1:100(5) 1:50(5) 1:100(5) <1:101:1,500(15) Amphoteric surfactant 1:50(15) 1:20(5) 1:25(15) 1:10(5) <1:50(15) <1:101:1,000(15) Chlorhexidine 1:200(5) 1:300(15) 1:100(15) 1:10(5) <1:50(15) <1:101:1,200(15) Bactericidal activity of Aquagard-T Effectiveness of Aquagard-T against spore forming bacteria Effective dilution rate, ( ) : Exposure time
Test strainsNaDCCNaOClRemarks Bacillus cereus17.21,060>62 times Bacillus subtilis30.91,510>49 times Bactericidal activity of Aquagard-T The sporicidal activity of disinfectants
AdenovirusIBD virus ILT virus ND virus NaDCC Iodine× Benzalkonium chloride ×× Virucidal activity of Aquagard-T Virucidal activity against poultry viruses : inactivated, × : not inactivated
FMD virus Adeno virus JE virus TGE virus Aujeszkys disease virus Rota virus HC virus NaDCC Iodine ××× × Virucidal activity of Aquagard-T Virucidal activity against pig viruses : inactivated, × : not inactivated
Test fungiMIC (mcg/ml) of Aquagard-T Candida albicans2.6 Candida krusei26.3 Aspergillus niger263.2 Aspergillus fumigatus263.2 Penicillium citrinum263.2 Trichophyton verrucosum263.2 Microsporum canis263.2 Trichophyton mentagrophytes263.2 Fungicidal activity of Aquagard-T
Disinfectants Chlorine contents or dilution rate Elapsed days (day) 0135 Aquagard-T418ppm---2.0×10 3 NaOCl418ppm--2.4× ×10 5 Quaternary ammonium chloride 1: × ×10 5 Iodine1: × ×10 3 Orthodichlorobenzene1: × × ×10 3 Control--5.0× × ×10 7 The efficacy test scope Total bacterial colony counts on foot bath in entrance of farm Unit : CFU/ml, - : <1 ×10 1 CFU/ml
Bactericidal activity Method : According to regulation of NVRQS Experiment : Research Institute for Veterinary Science in Konkuk Univ. Results : Disease Condition Light water Organic substance Salmonella spp.1:7,2001:540 Brucella spp.1:3,5001:400 Streptococcus spp.1:8,0001:720
Virucidal activity Method : According to regulation of NVRQS Experiment : Research Institute for Veterinary Science in Gyeongsang National Univ. and Cheonbuk National Univ. Results : Disease Condition Light waterOrganic substance Hog cholera virus1:12,0001:1,000 PRRS virus1:12,5001:750 New castle virus1:9,0001:1,000 Avian Influenza Virus1:15,0001:500 Avian Pneumovirus1:7001:50 Inclusion Hepatitis virus1:5001:100
Each tablet (13g) contains 5g of Sodium dichloroisocyanurate (= 3g of available chlorine) and Component A (effervescent agent) Component B (pH controlling agent) Composition of Aquagard-T
Disinfection of virus and bacteria in livestock housing, farms (floor, wall), facilities and equipment, the animal body Drinking water treatment Teat dip or spray (mastitis prevention) Disinfection of pathogen –General bacteria (Salmonella spp.), Brucella spp., Streptococcus spp. and so on. –Foot and Mouth Disease virus, Hog Cholera virus, PRRS virus, Newcastle Disease virus, Avian Influenza Virus, Avian Pneumovirus, Inclusion Body Hepatitis virus and so on Application of Aquagard-T
Use of Aquagard-T (Bacteria) Recommended Dilution Rate Disinfection Target Low Contamination Group High Contamination Group Livestock building, the surface of the animal's body, equipment, General automobiles The Floor of the Livestock building, Manure, the body of the animal (dead or alive), Automobiles/Vehicles General Bacteria (Salmonella spp.) 1:7,200 (1tablet per 93L of water) 1:540 (1tablet per 7L of water) Brucella spp. 1:3,500 (1tablet per 45L of water) 1:400 (1tablet per 5L of water) Streptococcus spp. 1:8,000 (1tablet per 104L of water) 1:720 (1tablet per 9.3L of water) * Dilution rate is the most effective dilution rate of results of determination of the efficacy of disinfectant against general bacteria and specific pathogen.
Use of Aquagard-T (Virus) Recommended Dilution Rate Disinfection Target Low Contamination GroupHigh Contamination Group Livestock building, the surface of the animal's body, equipment, General automobiles The Floor of the Livestock building, Manure, the body of the animal (dead or alive), Automobiles/Vehicles Hog Cholera virus 1:12,000 (1 tablet per 156L of water) 1:1,000 (1 tablet per 13L of water) PRRS virus 1:12,500 (1 tablet per 163L of water) 1:750 (1 tablet per 9.7L of water) ND virus 1:9,000 (1 tablet per 117L of water) 1:1,000 (1 tablet per 13L of water) Avian Influenza Virus 1:15,000 (1 tablet per 195L of water) 1:500 (1 tablet per 6.5L of water) Avian Pneumovirus 1:700 (1 tablet per 9L of water) 1:50 (1 tablet per 650ml of water) Inclusion body hepatitis virus 1:500 (1 tablet per 6.5L of water) 1:100 (1 tablet per 1.3L of water) * Dilution rate is the most effective dilution rate of results of determination of the efficacy of disinfectant against general bacteria and specific pathogen.
Use of Aquagard-T (Water Treatment) Dissolve Aquagard-T in water tank every other day or every day if necessary. Dilute 1 tablet per 500 ~ 750 L of drinking water according to water quality and farm condition.
Use program for poultry Poultry houses and facilities - Thorough cleaning with water - Spray Aquagard-T solution not less than 2 times before placement of chicks. - Spray Aquagard-T solution during growing period if necessary.
Use program for poultry Foot bath - For disinfect boots by dipping before entering each house, replace the Aquagard-T solutions every 5 days or sooner when soiled by heavy use. Transport - For prevention of disease transmission through trucks and crates by disinfecting them with Aquagard-T. - Use in wheel baths and renew every 5 days or according to volume of traffic.
Use program for dairy Dairy houses and facilities - Thorough cleaning with water - Spray Aquagard-T solution, eliminate all bacteria, viruses and fungi.
Use program for dairy to prevent Mastitis Preparation of disinfection –Dissolve 1 Aquagard-T tablet per 1L of water and move to dipping cup or sprayer for disinfection. Prior to milking - Clean milk starts with clean teats. - Teat and udder spraying will remove all bacteria, viruses and fungi. After milking - Teat dip or spraying will decontaminate the teats and prevent mastitis
Use program for Milking 1) Disinfection prior to milking - Removal of contaminant on teat Dipping methodSpray method 2) Removal of disinfectant - With clean and disinfected towel 3) Prior to milking - More than 5 times 4) Massage and final cleaning - With clean and disinfected towel 5) Attaching the milking mashing - Vacuum-blocking 6) Disinfection after milking - Prevention of teat canal
Storage and shelf-life of Aquagard-T Storage Keep under cool and dry conditions and protect from light Shelf-life 24 months after manufacturing
Efficacy Test Report
Effect of Aquagard-T on E. Coli in Water
Precautions of Aquagard-T Keep out of reach of children. Do not dissolve in strong alkali (over pH 10) or acidic (below pH 3) solution. Do not exceed the recommended dosage. For 5 days, from before 2 days to after 2 days of vaccination, do not disinfect drinking water. Do not place near fire or strong inflammables. Do not place in metallic vessel more than 2 hours. In case of drink diluted solution, immediately seek for medical advice.