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O.I.V. 2010/10 Intergovernmental organisation International Organisation of Vine and Wine Jean-Claude RUF OIV Scientific Coordinator Seminar: Health benefits.

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Presentation on theme: "O.I.V. 2010/10 Intergovernmental organisation International Organisation of Vine and Wine Jean-Claude RUF OIV Scientific Coordinator Seminar: Health benefits."— Presentation transcript:

1 O.I.V. 2010/10 Intergovernmental organisation International Organisation of Vine and Wine Jean-Claude RUF OIV Scientific Coordinator Seminar: Health benefits of moderate wine consumption – April 9, 2011 Limassol -Cyprus Scientific facts regarding the healthful benefits and nutritive properties of wine

2 O.I.V. 2010/10 Municipality of Yantai (China)* Algeria, Argentina, Australia, Austria, Belgium, Brazil, Bulgaria, Chile, Cyprus, Croatia, Slovakia, Slovenia, Spain, Finland, France, Georgia, Hungary, Israel, Italy, Ireland, Greece, Lebanon, Luxembourg, Morocco, Moldova, Portugal, FYR Macedonia, Malta, Montenegro, Norway, New Zealand, Netherlands, Peru, Czech Republic, Romania, Russia, Serbia, South Africa, Sweden, Switzerland, Turkey, Uruguay, Municipality of Yantai (China)* OIV Member States

3 O.I.V. 2010/10 i) by specialist scientific monitoring, making it possible to assess the specific characteristics of vine products, (ii) by promoting and guiding research into appropriate nutritional and health aspects, (iii)by extending the dissemination of information resulting from such research, beyond the recipients referred to in Article 2, paragraph n, to the medical and healthcare professions; to help protect the health of consumers and to contribute to food safety: Safety & Health Objectives

4 O.I.V. 2010/10 DISCUSSION PAPER ON APPROPRIATE PATTERNS OF WINE CONSUMPTION FOR HUMAN HEALTH 1.- Drinking patterns Risky and harmful drinking patterns including the regular consumption of high amounts of alcohol, as well as high amounts of alcohol consumed on single occasion (binge drinking), should be discouraged 2.- Information and education on appropriate wine consumption It is important to provide individuals with relevant, balanced and accurate information by appropriate, effective and proportionate means to allow them to make informed decisions. A) Harmful effects of abusive consumption As alcohol consumption can be a direct or additional detrimental risk factor in many diseases including cancer, other individual risk factors (such as dietary habits, genetic predisposition, obesity, smoking and physical activity) should be taken into account

5 O.I.V. 2010/10 - What does low risk moderate consumption means? Based on the results of numerous epidemiological and interventional studies, it can be generally considered that daily intake of up to 300 ml of an average wine for men (approximately 30 g ethanol), and up to 200 ml for women (approximately 20 g),. DISCUSSION PAPER ON APPROPRIATE PATTERNS OF WINE CONSUMPTION FOR HUMAN HEALTH

6 O.I.V. 2010/10 -Certain situations when wine consumption should be avoided: i) Pregnancy and breastfeeding : ii) BAC and driving iii) Underage people : iv) People with an increased risk of harm: people with a family history of alcohol dependence people with mental health problems people who use certain medications or recreational drugs people with specific diseases, especially of the liver and pancreas DISCUSSION PAPER ON APPROPRIATE PATTERNS OF WINE CONSUMPTION FOR HUMAN HEALTH

7 O.I.V. 2010/10 People who should seek professional advice about their drinking habits u Specific groups of people may need to seek professional advice about their drinking habits, because of the possibility of adverse interactions and associated harmful effects. These includes: –people using medications, either over-the-counter or prescription –people with alcohol-related, mental health or physical conditions that can be made worse or affected by alcohol –people who are concerned about their drinking habits. DISCUSSION PAPER ON APPROPRIATE PATTERNS OF WINE CONSUMPTION FOR HUMAN HEALTH

8 O.I.V. 2010/10 Relative risk of cardiovascular mortality

9 O.I.V. 2010/10 Alcohol/wine and CHD The most widely known relationship between moderate drinking and positive health effects relates to CHD A inverse association has been described by many different studies conducted in different countries since at least 30 years. Regular moderate drinking 30 grams of alcohol/day is associated with a large reduction in the risk of CHD Some studies have found that moderate wine drinkers have additionnal beneficial health effects

10 O.I.V. 2010/10 Evidence obtained from the meta-analysis or other studies indicates an average significant reduction of 30 -35 % of overall vascular risk associated with drinking wine. Beer drinking was also associated with a reduced risk of vascular events, although at an extent lower than that observed with wine. An average significant reduction of 20 % of overall vascular risk associated with drinking beer Wine and CHD

11 O.I.V. 2010/10 Relative risk of Cancer mortality

12 O.I.V. 2010/10 Alcohol/Wine and Cancer The main studies comparing wine and other alcoholic drinks indicate for cancer mortality: A positive association between alcohol consumption and the relative risk of several cancer for consumption of 3 or more drinks/day A relative risk of 0.75-0.8 - 20 to 25% of reduction compared to the abstainers for consumption of 2-3 glasses per day A significant benefit of wine compared to beer Importance to distinguish the various types of alcoholic drinks

13 O.I.V. 2010/10 Relative risk of Total mortality 0% Wine 100% Wine 1-30% wine >30% Wine

14 O.I.V. 2010/10 Evidence obtained from the main studies indicates an average significant reduction of 30 - 35 % of overall mortality associated with wine. Wine drinking seems to be also associated with a more favourable reduction than for other alcoholic beverages Alcohol/Wine and Total Mortality

15 O.I.V. 2010/10 0 1 2 3 4 5 0 3 6 9 Hours after dinner ROOH (µM) Decreased formation of lipid peroxides in post prandial by wine phenolics Rich fat diet Rich fat diet + 250 ml red wine Ursini F. et al © 2001 Circulation. Polyphenols and antioxidant capacity

16 O.I.V. 2010/10 Actions and inter-actions Lipidic effects Anti-thrombotic effects Antioxidant effects Nitric oxide effects

17 O.I.V. 2010/10 Polyphenols and atherosclerosis Bentzon et al. © Circulation 2001 Biological studies comparing wine and other alcoholic beverages show: No reduction of atherosclerotic events with wine consumption. When the disease is developed there is no difference in disease progression Action in prevention and not in reduction of the pathology

18 O.I.V. 2010/10 Polyphenols and vascular risk Inhibition of platelet aggregation Inhibition of proliferation of smooth muscle cells Increase of vasodilatation properties Inhibition of monocytes activation Inhibition of activation of adhesion proteins decrease of lipid oxidation

19 O.I.V. 2010/10 Favorable Changes in Risk Factors WINE Alcohol Phenolics HDL Fibrinogen Factor VII Thrombosis Platelet aggregation LDL oxidation Endothelial Function (NO) DNA damage Plasma lipid peroxides Antioxidant capacity Chemoprevention

20 O.I.V. 2010/10 Relationship betwen alcohol/wine consumption and diets Tjonneland A. © Am J. Clin. Nutr. 1999

21 O.I.V. 2010/10 Relationship betwen alcohol/wine consumption and diets Tjonneland A. © Am J. Clin. Nutr. 1999

22 O.I.V. 2010/10

23 WHO Global strategy to reduce the harmful use of alcohol Delegations from all 193 Member States of (WHO) have adopted during the 63rd World Health Assembly from 17 to 21 May 2010, a resolution to reduce the harmful use of alcohol. According to the WHO for 2004, every year, the harmful use of alcohol would kill 2.5 million people, including 320 000 young people between 15 and 29 years of age. It is the eighth leading risk factor for deaths globally, harmful use of alcohol would be responsible for almost 4% of all deaths in the world.

24 O.I.V. 2010/10 (a)raise global awareness of the magnitude and nature of the health, social and economic problems caused by harmful use of alcohol, (b)Stimulate knowledge base on the magnitude and determinants of alcohol-related harm and on effective interventions to reduce and prevent such harm; (c)increase technical support to, and enhanced capacity of, Member States for preventing the harmful use of alcohol (d)Stimulate partnerships and better coordination among stakeholders and increased mobilization of resources required for appropriate and concerted action to prevent the harmful use of alcohol; (e)improve systems for monitoring and surveillance at different levels, and more effective dissemination and application of information for advocacy, policy development and evaluation purposes. WHO Global strategy: Objectives

25 O.I.V. 2010/10 Leadership, awareness, and commitment Health servicesresponse Community action Drink-drivind policies and countermeasures Availability of alcohol Marketing of alcoholic beverages Pricing policies Reducing the negative consequences of drinking and alcohol intoxication Reducing the public health impact of illicit alcohol and informally produced alcohol Monitoring and surveillance WHO Global strategy: 10 Areas of action

26 O.I.V. 2010/10 WHO Global Strategy : Other strategies, and programmes This global strategy builds upon regional initiatives WHO European Region (resolution EUR/RC55/R1), Western Pacific Region (resolution WPR/RC57.R5), South-East Asia Region (resolution SEA/RC59/R8), Eastern Mediterranean Region (resolution EM/RC53/R.5) African Region (document AFR/RC58/3).

27 O.I.V. 2010/10 UE Alcohol Strategy Adopted by the Commission in October 2006 Endorsed by Council Conclusions November 2007 EP Report August 2007 Priorities : 1) Protect young people, children and the unborn child 2) Reduce injuries and deaths from alcohol-related road traffic accidents 3) Prevent alcohol-related harm among adults and reduce the negative impact on the workplace 4) Inform, educate and raise awareness on the impact of harmful and hazardous alcohol consumption, and on appropriate consumption patterns 5) Develop, support and maintain a common evidence base

28 O.I.V. 2010/10 This strategy will be put into practice through: A Committee on National Policy and Action The main objective of this group will be to further coordinate government-driven policies aimed at reducing alcohol-related harm at national and local level A European Alcohol and Health Forum The creation of a European Alcohol and Health Forum is hoped to become one of the cornerstones in the work to reduce alcohol- related harm. The overall objective is to provide a common platform for all interested stakeholders at EU level that are willing to step up actions aimed at reducing alcohol harm, notably in different areas: UE Alcohol Strategy

29 O.I.V. 2010/10 Strategies aiming to curb under-age drinking; Information and education programmes on the effect of harmful drinking and on responsible patterns of consumption; Possible development of efficient common approaches throughout the Community to provide adequate consumer information; Actions to better enforce age limits for selling and serving alcohol; Interventions promoting effective behavioural change among children and adolescents; Cooperation to promote responsibility in, and prevent irresponsible, commercial communication and sales. European Alcohol and Health Forum

30 O.I.V. 2010/10 NOTES: that the level of alcohol-related harm, especially among vulnerable people, on roads and at workplaces, is still high in the Member States, 15 % of the EU adult population is estimated to drink at harmful levels on a regular basis between five and nine million children in families in the EU are adversely affected by alcohol harmful and hazardous use of alcohol is a causal factor in approximately 16 % of cases of child abuse, an estimated 60 000 underweightbirths each year are attributable to harmful and hazardous use of alcohol,

31 O.I.V. 2010/10 Recommendations on alcohol/wine and health Dont recommend alcohol as medicine Inform patients that beneficial effects are achieved at moderate consumption Dont discourage moderate drinking, but consider individual circumstances Always discourage binge drinking Inform of harmful effects of abusive consumption Dont recommend alcohol as medicine Inform patients that beneficial effects are achieved at moderate consumption Dont discourage moderate drinking, but consider individual circumstances Always discourage binge drinking Inform of harmful effects of abusive consumption

32 O.I.V. 2010/10 Thank you for your attention Ευχαριστούμε


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