Presentation on theme: "Deputy Executive Director"— Presentation transcript:
1 Deputy Executive Director Top HIV diagnostics for small labs in AfricaPhilippe DunetonDeputy Executive Director17 June 2013
2 Long term goal of the Global Health Community HIV/AIDSGOAL: Reaching 15 million people with ARVs by 2015WHO New 2013 GuidelinesCD4: 500 cells/mm3 from 350FDCs – 1 pill a day (Tenofovir based)Patient monitoring
3 Low access to HIV treatment: Only 9 million of 25 million people in need are now on ART 1Previous target of Universal access set up in 2011 (and defined as 80% of those in need), was to reach 15 Million by year 2015.The number of people considered eligible for ART will increase approx. to 25 million with revised criteria (CD4 Threshold) for ART initiation and the addition of the groups already considered independent of CD4 such as all pregnant women and breastfeeding women (previously called Option B plus), children under five years old, HIV-positive partners in serodiscordant couples, and people with HIV and active TB disease or severe chronic liver disease and Hepatitis B ).The challenge of reaching an additional 16 million people in need of treatment is compounded by the fact that a proportion of those currently on ART are receiving suboptimal treatment including d4T-containing regimens (estimates up to 20-30% of those on 1st line ART) .
4 Monitoring diagnostics CD4 Viral Load Early Infant Diagnostics Large modern laboratoriesSophisticated equipmentHighly trained staffBenefit: High volume4,500 tests a monthsSamples need to be transportedResult returned to patientNyumbani, Karen, KenyaPediatric University Hospital, Lusaka, Zambia
5 The reality of low resource settings Limitation in health infrastructureCrowded facilitiesBasic laboratory facilitiesIrregular power and water supplyLimitation in human resourcesFew doctorsHealth workers with limited training carry out most consultationsDistrict Hospital, Meconta, MozambiqueQuality, simple to usediagnostic and medicines are needed to assure rapid effective treatmentKiboga Referral Hospital, Uganda
6 Point of care testing Small devices Easy to use outside central laboratoriesRapid resultsBack up power supplyHIV patient monitoringCD4Viral LoadEarly Infant Diagnosis1er maio, MaputoMozambique
7 Benefits to Patients Ideal for resource limited settings – both urban and ruralDecreases turn-around time – results available on same dayImproves patient outcomes – prompt treatmentReduces loss to follow up – no need to return for resultsReduces workload of the central laboratoryPhebe Hospital, Liberia
8 UNITAID's new Point of Care Projects CHAI/UNICEFMedecin Sans FrontiereFEI –OPP-ERALondon School of Hygiene and Tropical MedicinesAIM: Increase CD4 testing to 80% and Viral load testing to 50% in low income countriesGood monitoring of patients =better care and treatment
9 PointCare Technologies CD4 Product Pipeline*BD FACSPresto™BD BiosciencesPima™ AnalyserAlerePointCount NOW™PointCare TechnologiesVisitect® CD4Omega/BurnetZyomyxCD4 TestMBio CD4 SystemCyFlow® CD4 miniPOCPartecDaktari™CD4 Counter2009201020132014DisposableDisposableInstrumentsInstruments*Estimated as of March timeline and sequence may change.9
10 EOSCAPE HIV™ Rapid RNA Assay System LYNX Viral Load Platform Viral Load and EID Product Pipeline*Liat™ AnalyserIQuumAlere QAlereEOSCAPE HIV™ Rapid RNA Assay SystemWave 80 BiosciencesRT CPA HIV-1 Viral Load UstarLYNX Viral Load PlatformNWGHFMicronicsGene-RADAR®NanobiosymSAMBA VLDDU/CambridgeALLCavidi AMPGene Xpert® SystemCepheidLYNX HIV p24 AntigenNWGHFTruelab™ PCRMolbio/bigTecViral Load Assay with BART LumoraBioHelixSAMBA EIDDDU/Cambridge2013201420152016*Estimated as of March timeline and sequence may change No market launch date set by company.10
11 Call for LOIsUNITAID is pleased to announce the first Call for Letters of Intent (LOI) of its new strategic periodDeadline: 22 Sep 2013
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