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Presents The Canine Thyroid Epidemic with Dr Jean Dodds, D.V.M. In support of Hemopet.

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Presentation on theme: "Presents The Canine Thyroid Epidemic with Dr Jean Dodds, D.V.M. In support of Hemopet."— Presentation transcript:

1 presents The Canine Thyroid Epidemic with Dr Jean Dodds, D.V.M. In support of Hemopet

2 Since 1994

3 Dr Jean Dodds, D.V.M. WELCOME

4 4

5 www.hemopet.org

6 Welcome to the Canine Thyroid Epidemic with Dr Jean Dodds, D.V.M. In support of Hemopet

7 7 by W. Jean Dodds, DVM Hemopet/Hemolife

8 8 Puppies have higher basal thyroid levels than adults Geriatrics have lower basal thyroid levels than adults Large/giant breeds have lower basal thyroid levels Sight hounds have much lower basal thyroid levels

9 9 Dividing the daily dose q 12 hrs avoids peak and valley effect of once daily dosing Achieves better steady state over 24 hrs; half-life =12-16 hrs Dosing should be given directly by mouth rather than in food bowl Thyroxine binds to calcium and soy; should be given apart from meals (1 hr before or 3 hrs after)

10 10 Complete thyroid antibody profile preferred cTSH poorly predictive (~ 70%) compared to humans Basal levels affected (up to 25%) by certain drugs (steroids, Pb, sulfonamides, excess iodine) Basal levels lowered by estrogen; raised by progesterone [sex hormonal cycle effects] Rabies vaccine in prior 45 days can raise TgAA by ~ 25 %

11 11 Complete thyroid antibody profile required Test intact bitches during anestrus Need T3AA, T4AA, TgAA; not just freeT4, TSH, TgAA OFA Thyroid Registry is limited panel Some cases (~8%) are T3AA and/or T4AA +, but TGAA -

12 12 Treat all cases + for T3AA and/or T4AA, or TgAA Dont wait until dog gets ill or has aberrant behavior If only low-grade TgAA +, retest profile in 2-4 mos Treat with thyroxine BID; retest profile in 2-4 mos Always monitor with thyroid antibody profile

13 13 Screen relatives annually from puberty Consider for breeding, if negative, after age three Heritable trait, regardless of clinical status

14 14 1.Classical clinical hypothyroidism & low thyroid values occur after =/> 70% thyroid tissue destroyed 2.Other clinical / behavioral changes (especially aggression) seen during early phase 3.T4 alone gives misleading results; over- diagnose hypothyroidism with non- thyroidal illness or certain drugs; under- diagnose hyperthyroidism in cats or from thyroxine overdosage; inaccurately assesses thyroxine therapy; and fails to detect autoimmune thyroiditis

15 15 4.Even T4 plus freeT4 and TSH = inadequate, if thyroiditis present 5.Age-and breed-specific norms essential for accurate diagnosis; reference lab ranges not based on age and breed type 6.Sight hounds all have lower basal thyroid activity than other breeds 7.Thyroxine binds to calcium & soy; must be given apart from meals; BID therapy preferred

16 16 8.Dispensing thyroxine by human pharmacist often under-dosed [animal doses 10 x higher] 9.Stopping thyroxine to retest basal capacity needs 6 weeks or more 10.Thyroid Support or Thytrophin inadequate alone to fully correct true hypothyroidism or thyroiditis

17 17 cTSH poorly predictable for 1 o hypothyroidism in dogs [~ 70%] vs. people [95%] Dog has second regulatory pathway via growth hormone False negatives and false positives (i.e. discordant) occur in ~ 30% of cases

18 18 Blood samples should be drawn 4-6 hrs post-pill for BID Rx. Blood samples drawn 8-10 hrs post-pill for SID Rx (horses) Minimum testing needed is T4 and freeT4 Thyroid antibody profile preferred; a must for thyroiditis cases

19 19 Because the body can increase thyroxine turnover rate ~ 50 % and excrete it faster to avoid thyrotoxicosis

20 20 Principal reason for pet euthanasia is undesirable behavior Association between behavioral / psychologic changes and thyroid dysfunction long recognized in humans 66% of people with ADHD found to be hypothyroid; thyroxine largely curative

21 21 Parallel findings in dogs with thyroiditis/hypothyroidism; & cats with hyperthyroidism Typical clinical signs: unprovoked aggression, sudden onset seizure disorder, disorientation, moodiness, erratic temperament, hyperactivity, hypoattentiveness, depression, fearfulness, phobias, anxiety, passivity, submissiveness, compulsiveness, and irritability

22 22 Individuals deficient in selenium show clinical signs of hypothyroidism because tissue levels of thyroid hormones are depleted, while blood thyroid levels rise Diagnosis could be overlooked on the basis that blood levels of thyroid hormones appear normal

23 23 Iodine excess causes alterations in thyroid activity, blocking both its characteristic functions and cell proliferation Feeding excessive amounts of iodine in foods and supplements (kelp, seaweed) reduces thyroid function Could contribute to the rising prevalence of hypothyroidism in young dogs Iodine increases auto-antigenic potency of thyroglobulin leading to induction of autoimmune thyroiditis

24 24 Multiple endocrine glands become involved in a systemic immune-mediated process Patients have underlying autoimmune thyroid disease and concurrent Addisons disease, diabetes, reproductive failure, skin disease, alopecia, and IBD Most commonly associated non- endocrinologic autoimmune disorders are: AIHA, ITP, chronic active hepatitis, and immune-complex glomerulonephritis (SLE)

25 25 Canine autoimmune thyroid disease similar to human Hashimotos Disease Affected humans & dogs have MHC gene profile which predispose to thyroiditis Unique DLA-DQA1*00101 genetic determinant of DLA class II haplotype found in Doberman Pinscher, English Setter and Rhodesian Ridgeback; doubles risk of hypothyroidism; 11 more breeds now under study Second genotype of the CTLA locus found in Boxer, Shih Tzu, Yorkshire Terrier, Irish Water Spaniel, and Siberian Husky affected with thyroiditis Holds promise for a genetic marker test to identify affected breeding stock and allow for selective breeding to reduce disease incidence

26 26 Soon to be released…

27 27

28 28 Thyroid 5 TM is composed of T4, Free T4, T3, Free T3 and TGAA The TGAA (thyroglobulin autoantibody) test is included for genetic screening of breeds and cross-breeds at risk for heritable autoimmune thyroiditis. The confirmatory TGAA method is preferred because it removes any non-specific binding that could falsely elevate the result NEW HEMOLIFE THYROID 5 TM PANEL

29 29 Also, since ~ 8% of thyroiditis cases have high circulating T3AA and/or T4AA but normal TGAA, T3AA and T4AA is measured IF warranted from initial results or when either of these tests were previously high As relatively few cases have high T3AA and/or T4AA, it will be more cost effective for clients to have the new Thyroid 5 TM profile run rather than our current D8T + TGAA combination Novel, green non-RIA technology never used before in veterinary medicine (patented) NEW HEMOLIFE THYROID 5 TM PANEL

30 30

31 31 To get your dogs thyroid accurately tested… Get your downloadable form at http://www.wisdomfordoglovers/get-the-wisdom

32 If you have questions… Susan at info@wisdomfordogs.com Dr. Jean at hemopet@hotmail.com

33 Available now at www.WisdomForDogLovers.com

34 SUPPLEMENTS… Are they Helping, Harming, or Just Wasting MY Money!?! SUPPLEMENTS… Are they Helping, Harming, or Just Wasting MY Money!?! presentspresents Monday, July 18, 2011 at 6pm PST with Dr Jean Dodds Monday, July 18, 2011 at 6pm PST with Dr Jean Dodds In support of Hemopet

35 Presents Vaccination protocols A Secret Many Vets Dont Want You to Know! Presents Vaccination protocols A Secret Many Vets Dont Want You to Know! In support of Hemopet Monday, May 9, 2011 at 6pm PST with Dr Jean Dodds Monday, May 9, 2011 at 6pm PST with Dr Jean Dodds

36 website: www.wisdomfordoglovers.com facebook: http://www.facebook.com/wisdomfordoglovers Delivering Leading Edge Science and Wisdom for Dog Owners

37 37 Spread the word Thanks a heap for paying it forward… tell your fur-friends about Wisdom for Dog Lovers

38 38 For the love of dogs… www.wisdomfordoglovers.com


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