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Understanding Soy Soy has been consumed by Asian cultures for thousands of years. Soy has been consumed by Asian cultures for thousands of years. Soy is.

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Presentation on theme: "Understanding Soy Soy has been consumed by Asian cultures for thousands of years. Soy has been consumed by Asian cultures for thousands of years. Soy is."— Presentation transcript:

1 Understanding Soy Soy has been consumed by Asian cultures for thousands of years. Soy has been consumed by Asian cultures for thousands of years. Soy is a legume that is so nutritionally complete that it sustained Eastern populations through drought and famine. Soy is a legume that is so nutritionally complete that it sustained Eastern populations through drought and famine. Composed of: Composed of: Protein - Carbohydrate Protein - Carbohydrate Fat - Fiber Fat - Fiber Phytonutrients - Isoflavones Phytonutrients - Isoflavones Other isoflavone rich foods include garbanzo beans and sprouts (Red Clover) Other isoflavone rich foods include garbanzo beans and sprouts (Red Clover)

2 The forms of soy Soy has been used and studied in various forms: Soy has been used and studied in various forms: Whole soybeans-raw and cooked Whole soybeans-raw and cooked Protein isolates-with balanced and unbalanced isoflavone content Protein isolates-with balanced and unbalanced isoflavone content Balanced isoflavone isolates Balanced isoflavone isolates Single isoflavone isolates Single isoflavone isolates The more imbalanced the isoflavones the greater the chance for negative affects. The more imbalanced the isoflavones the greater the chance for negative affects.

3 Why is their confusion around soy? Negative articles regarding soy typically focus on only one particular study. Negative articles regarding soy typically focus on only one particular study. Thorough evaluation of existing research will reveal the positive health benefits of soy. Thorough evaluation of existing research will reveal the positive health benefits of soy. Also, certain companies and/or individuals are exploiting negative research as a marketing tactic. Also, certain companies and/or individuals are exploiting negative research as a marketing tactic.

4 Frequently Asked Questions about Soy Is GMO soy is used in Metagenics products? Is GMO soy is used in Metagenics products? Do Metagenics soy products have the proper balance of isoflavones? Do Metagenics soy products have the proper balance of isoflavones? Is soy beneficial for tissue health? Menopause? Bone health? Is soy beneficial for tissue health? Menopause? Bone health? Do you think people are eating too much soy? Do you think people are eating too much soy? Do soy products compromise male reproduction? Do soy products compromise male reproduction? Isnt it better to use a more complete protein? Isnt it better to use a more complete protein? Do I have to use fermented soy products to achieve therapeutic benefits? Do I have to use fermented soy products to achieve therapeutic benefits? Does soy inhibit thyroid function? Does soy inhibit thyroid function? How common is soy allergy? How common is soy allergy?

5 Is GMO soy is used in Metagenics products? NO. We use only DNA identified soy to guarantee the purity of our ingredients. NO. We use only DNA identified soy to guarantee the purity of our ingredients. We test every batch to ensure we are using only the purest soy protein. We test every batch to ensure we are using only the purest soy protein. Our Identity Preserved soy allows us to trace the source of the raw material and ensure it is not genetically modified. Our Identity Preserved soy allows us to trace the source of the raw material and ensure it is not genetically modified. Being certified by regulatory agencies of NNFA, NSF and TGA shows how seriously we take the quality of all of our products. Being certified by regulatory agencies of NNFA, NSF and TGA shows how seriously we take the quality of all of our products. Over $2 million spent in 2005 on QC/QA Over $2 million spent in 2005 on QC/QA

6 Do Metagenics soy products have a natural balance of isoflavones? Yes. Our soy products are evaluated to verify they have natural ratios of the isoflavones Genistein and Daidzein. Yes. Our soy products are evaluated to verify they have natural ratios of the isoflavones Genistein and Daidzein. Isoflavones from soy are 100 to 1000 times weaker than estradiol. Isoflavones from soy are 100 to 1000 times weaker than estradiol. Collins. Steroids 1997;62:365 Collins. Steroids 1997;62:365 Our soy products carry a 1:1 ratio of these isoflavones which is identical to what is found in tofu. Our soy products carry a 1:1 ratio of these isoflavones which is identical to what is found in tofu. Our 35 full-time scientists led by Dr. Jeffrey Bland are involved in every aspect of product formulation, research and testing. Our 35 full-time scientists led by Dr. Jeffrey Bland are involved in every aspect of product formulation, research and testing. Over $5 million spent in Over $5 million spent in 2005.

7 Is soy beneficial for tissue health? Yes. Soy contains various beneficial agents for tissue health Yes. Soy contains various beneficial agents for tissue health Kennedy AR. The evidence for soybean products as cancer preventive agents. J Nutr 1995;125(3 Suppl):733S-43S. Kennedy AR. The evidence for soybean products as cancer preventive agents. J Nutr 1995;125(3 Suppl):733S-43S. Cultures that eat soy have shown an improvement in colon and specific hormone-related tissue health issues. Cultures that eat soy have shown an improvement in colon and specific hormone-related tissue health issues. Shu XO, Jin F, Dai Q, et al. Soyfood intake during adolescence and subsequent risk of breast cancer among Chinese women. Cancer Epidemiol Biomarkers Prev 2001;10(5): Shu XO, Jin F, Dai Q, et al. Soyfood intake during adolescence and subsequent risk of breast cancer among Chinese women. Cancer Epidemiol Biomarkers Prev 2001;10(5): Lamartiniere CA, Moore JB, Brown NM, Thompson R, Hardin MJ, Barnes S. Genistein suppresses mammary cancer in rats. Carcinogenesis 1995;16(11): Lamartiniere CA, Moore JB, Brown NM, Thompson R, Hardin MJ, Barnes S. Genistein suppresses mammary cancer in rats. Carcinogenesis 1995;16(11): Human trials involving post-menopausal women demonstrate a significant shift in healthy estrogen metabolism. Human trials involving post-menopausal women demonstrate a significant shift in healthy estrogen metabolism. Xu X, Duncan AM, Merz BE, Kurzer MS. Effects of soy isoflavones on estrogen and phytoestrogen metabolism in premenopausal women. Cancer Epidemiol Biomarkers Prev 1998;7(12): Xu X, Duncan AM, Merz BE, Kurzer MS. Effects of soy isoflavones on estrogen and phytoestrogen metabolism in premenopausal women. Cancer Epidemiol Biomarkers Prev 1998;7(12): Xu X, Duncan AM, Wangen KE, Kurzer MS. Soy consumption alters endogenous estrogen metabolism in postmenopausal women. Cancer Epidemiol Biomarkers Prev 2000;9(8): Xu X, Duncan AM, Wangen KE, Kurzer MS. Soy consumption alters endogenous estrogen metabolism in postmenopausal women. Cancer Epidemiol Biomarkers Prev 2000;9(8):

8 Is soy beneficial for breast health? Research is far from conclusive on this issue and researchers are urging caution for women Research is far from conclusive on this issue and researchers are urging caution for women However, a distinction should be made between the clear benefit of soy protein for cardiovascular health and the inconclusive role of isoflavones for breast tissue health. However, a distinction should be made between the clear benefit of soy protein for cardiovascular health and the inconclusive role of isoflavones for breast tissue health. Henkel J. U.S. Food and Drug Administration. Soy: Health claims for soy protein, questions about other components. Available at: Accessed August 4, Henkel J. U.S. Food and Drug Administration. Soy: Health claims for soy protein, questions about other components. Available at: Accessed August 4, Messina M, Erdman J Jr, Setchell KD. Introduction to and perspectives from the Fifth International Symposium on the Role of Soy in Preventing and Treating Chronic Disease. J Nutr 2004;134(5):1205S-06S. Messina M, Erdman J Jr, Setchell KD. Introduction to and perspectives from the Fifth International Symposium on the Role of Soy in Preventing and Treating Chronic Disease. J Nutr 2004;134(5):1205S-06S. Xu X, Duncan AM, Merz BE, Kurzer MS. Effects of soy isoflavones on estrogen and phytoestrogen metabolism in premenopausal women. Cancer Epidemiol Biomarkers Prev 1998;7(12): Xu X, Duncan AM, Merz BE, Kurzer MS. Effects of soy isoflavones on estrogen and phytoestrogen metabolism in premenopausal women. Cancer Epidemiol Biomarkers Prev 1998;7(12): Xu X, Duncan AM, Wangen KE, Kurzer MS. Soy consumption alters endogenous estrogen metabolism in postmenopausal women. Cancer Epidemiol Biomarkers Prev 2000;9(8): Xu X, Duncan AM, Wangen KE, Kurzer MS. Soy consumption alters endogenous estrogen metabolism in postmenopausal women. Cancer Epidemiol Biomarkers Prev 2000;9(8):

9 Does soy benefit menopausal women? Yes. The research shows a great correlation with reducing hot flashes and other menopausal issues by consuming soy products. Yes. The research shows a great correlation with reducing hot flashes and other menopausal issues by consuming soy products. Consumption of soy protein containing isoflavones decreased the intensity of hot flashes. Consumption of soy protein containing isoflavones decreased the intensity of hot flashes. Washburn S, Burke GL, Morgan T, Anthony M. Effect of soy protein supplementation on serum lipoproteins, blood pressure, and menopausal symptoms in perimenopausal women. Menopause 1999;6(1):7-13. Washburn S, Burke GL, Morgan T, Anthony M. Effect of soy protein supplementation on serum lipoproteins, blood pressure, and menopausal symptoms in perimenopausal women. Menopause 1999;6(1):7-13. The majority of studies in menopausal women have shown improvement of hot flashes following soy consumption. The majority of studies in menopausal women have shown improvement of hot flashes following soy consumption. The role of isoflavones in menopausal health: consensus opinion of The North American Menopause Society. Menopause 2000;7(4): The role of isoflavones in menopausal health: consensus opinion of The North American Menopause Society. Menopause 2000;7(4): Eden J. Phytoestrogens and the menopause. Baillieres Clin Endocrinol Metab 1998;12(4): Eden J. Phytoestrogens and the menopause. Baillieres Clin Endocrinol Metab 1998;12(4): Dalais FS, Rice GE, Wahlqvist ML, et al. Effects of dietary phytoestrogens in postmenopausal women. Climacteric 1998;1(2): Dalais FS, Rice GE, Wahlqvist ML, et al. Effects of dietary phytoestrogens in postmenopausal women. Climacteric 1998;1(2):

10 Is soy beneficial for bone health? Yes. Studies have shown that the isoflavones that are found in soy stimulate bone formation and reduce bone breakdown. Yes. Studies have shown that the isoflavones that are found in soy stimulate bone formation and reduce bone breakdown. Soy isoflavones have been found to have a positive effect on bone health. Soy isoflavones have been found to have a positive effect on bone health. Migliaccio S, Anderson JJ. Isoflavones and skeletal health: are these molecules ready for clinical application? Osteoporos Int 2003;14(5): Migliaccio S, Anderson JJ. Isoflavones and skeletal health: are these molecules ready for clinical application? Osteoporos Int 2003;14(5): Isoflavones stimulate osteoblastic bone formation and inhibit osteoclastic bone breakdown. Isoflavones stimulate osteoblastic bone formation and inhibit osteoclastic bone breakdown. Brynin R. Soy and its isoflavones: a review of their effects on bone density. Altern Med Rev 2002;7(4): Brynin R. Soy and its isoflavones: a review of their effects on bone density. Altern Med Rev 2002;7(4):

11 Do you think people are eating too much soy? Americans eat very little soy products when compared to Asian populations. Americans eat very little soy products when compared to Asian populations. While Asian populations consume an average of 10 to 50 grams of soy per day, Americans generally consume only 1 to 3 grams daily. While Asian populations consume an average of 10 to 50 grams of soy per day, Americans generally consume only 1 to 3 grams daily. Limer JL, Speirs V. Phyto-oestrogens and breast cancer chemoprevention. Breast Cancer Res 2004;6(3): Limer JL, Speirs V. Phyto-oestrogens and breast cancer chemoprevention. Breast Cancer Res 2004;6(3): In fact, one-quarter of Americans reported consuming soy foods once a week or more, while 38% admitted to never consuming soy products. In fact, one-quarter of Americans reported consuming soy foods once a week or more, while 38% admitted to never consuming soy products. United Soybean Board. National Report, Consumer attitudes about nutrition – Insights into nutrition, health, and soyfoods. Available at: Accessed August 5, United Soybean Board. National Report, Consumer attitudes about nutrition – Insights into nutrition, health, and soyfoods. Available at: Accessed August 5, 2004.

12 Do soy products compromise male reproduction? NO. Studies done with balanced soy isoflavones do not show negative impact on male reproduction. NO. Studies done with balanced soy isoflavones do not show negative impact on male reproduction. These studies done with one isoflavone or by injecting isoflavones directly into the blood create much of the negative concern on soy. These studies done with one isoflavone or by injecting isoflavones directly into the blood create much of the negative concern on soy. Genistein was shown in cell cultures to negatively impact human sperm's ability to fertilize the female egg. Genistein was shown in cell cultures to negatively impact human sperm's ability to fertilize the female egg. Professor Lynn Fraser of King's College London, European Society for Human Reproduction and Embryology Professor Lynn Fraser of King's College London, European Society for Human Reproduction and Embryology Only when plant estrogens are injected, leading to high blood levels are adverse effects seen in research animals. Only when plant estrogens are injected, leading to high blood levels are adverse effects seen in research animals. US Center for the Evaluation of Risks to Human Reproduction (CERHR) or the National Institute of Environmental Health Services and National Toxicology Program; March 20, US Center for the Evaluation of Risks to Human Reproduction (CERHR) or the National Institute of Environmental Health Services and National Toxicology Program; March 20, 2006.

13 Do soy products compromise male reproduction? Four published clinical trials investigating the effects of soy isoflavone consumption in men and reported that there are no adverse effects of soy isoflavone consumption on sperm quality. Four published clinical trials investigating the effects of soy isoflavone consumption in men and reported that there are no adverse effects of soy isoflavone consumption on sperm quality. Persky VW, Turyk ME, Wang L, et al. Effect of soy protein on endogenous hormones in postmenopausal women. Am J Clin Nutr 2002;75(1): Persky VW, Turyk ME, Wang L, et al. Effect of soy protein on endogenous hormones in postmenopausal women. Am J Clin Nutr 2002;75(1): Consumption of isoflavone supplements at the level of 40 mg daily had no effect on semen quality. Consumption of isoflavone supplements at the level of 40 mg daily had no effect on semen quality. Mitchell JH, Cawood E, Kinniburgh D, Provan A, Collins AR, Irvine DS. Publication: Clin Sci (Lond) Jun;100(6): Mitchell JH, Cawood E, Kinniburgh D, Provan A, Collins AR, Irvine DS. Publication: Clin Sci (Lond) Jun;100(6): There is no evidence of increased rates of fertility disorders among the Asian population due to soy consumption. There is no evidence of increased rates of fertility disorders among the Asian population due to soy consumption. Medical foods with soy deliver 17mg of balanced isoflavones. Medical foods with soy deliver 17mg of balanced isoflavones.

14 Should soy be used for prostate health? Yes. Research shows overwhelming evidence of the positive benefits in supporting prostate health without adverse effects. Yes. Research shows overwhelming evidence of the positive benefits in supporting prostate health without adverse effects. Peterson G, Barnes S. Genistein and biochanin A inhibit the growth of human prostate cancer cells but not epidermal growth factor receptor tyrosine autophosphorylation. Prostate 1993;22(4): Peterson G, Barnes S. Genistein and biochanin A inhibit the growth of human prostate cancer cells but not epidermal growth factor receptor tyrosine autophosphorylation. Prostate 1993;22(4): Geller J, Sionit L, Partido C, et al. Genistein inhibits the growth of human-patient BPH and prostate cancer in histoculture. Prostate 1998;34(2): Geller J, Sionit L, Partido C, et al. Genistein inhibits the growth of human-patient BPH and prostate cancer in histoculture. Prostate 1998;34(2): Barnes S. Effect of genistein on in vitro and in vivo models of cancer. J Nutr 1995;125(Suppl):777S-83S. Barnes S. Effect of genistein on in vitro and in vivo models of cancer. J Nutr 1995;125(Suppl):777S-83S. Adlercreutz CH, Goldin BR, Gorbach SL, et al. Soybean phytoestrogen intake and cancer risk. J Nutr 1995;125(3 Suppl):757S-70S. Adlercreutz CH, Goldin BR, Gorbach SL, et al. Soybean phytoestrogen intake and cancer risk. J Nutr 1995;125(3 Suppl):757S-70S. Nagata C, Takatsuka N, Shimizu H, Hayashi H, Akamatsu T, Murase K. Effect of soymilk consumption on serum estrogen and androgen concentrations in Japanese men. Cancer Epidemiol Biomarkers Prev 2001;10(3): Nagata C, Takatsuka N, Shimizu H, Hayashi H, Akamatsu T, Murase K. Effect of soymilk consumption on serum estrogen and androgen concentrations in Japanese men. Cancer Epidemiol Biomarkers Prev 2001;10(3): Habito RC, Montalto J, Leslie E, Ball MJ. Effects of replacing meat with soyabean in the diet on sex hormone concentrations in healthy adult males. Br J Nutr 2000;84(4): Habito RC, Montalto J, Leslie E, Ball MJ. Effects of replacing meat with soyabean in the diet on sex hormone concentrations in healthy adult males. Br J Nutr 2000;84(4): Mitchell JH, Cawood E, Kinniburgh D, Provan A, Collins AR, Irvine DS. Effect of a phytoestrogen food supplement on reproductive health in normal males. Clin Sci 2001;100(6): Mitchell JH, Cawood E, Kinniburgh D, Provan A, Collins AR, Irvine DS. Effect of a phytoestrogen food supplement on reproductive health in normal males. Clin Sci 2001;100(6): Hussain M et al. Soy isoflavones in the treatment of prostate cancer Nutr Cancer 2003;47(2): Hussain M et al. Soy isoflavones in the treatment of prostate cancer Nutr Cancer 2003;47(2):111-7.

15 Isnt it better to use a more complete protein? Early studies suggested that soy was not a complete protein source. These early findings have been shown to be inaccurate. Early studies suggested that soy was not a complete protein source. These early findings have been shown to be inaccurate. Soy has the same score as egg white and milk protein. Soy has the same score as egg white and milk protein. Protein Digestibility Corrected Amino Acid Score (PDCAAS), which has been adopted by both the FDA and World Health Organization (WHO) Protein Digestibility Corrected Amino Acid Score (PDCAAS), which has been adopted by both the FDA and World Health Organization (WHO) Sarwar G, McDonough FE. Evaluation of protein digestibility-corrected amino acid score method for assessing protein quality of foods. J Assoc Off Anal Chem 1990;73(3): Sarwar G, McDonough FE. Evaluation of protein digestibility-corrected amino acid score method for assessing protein quality of foods. J Assoc Off Anal Chem 1990;73(3): FAO/WHO/UNU Expert Consultation. Energy and Protein Requirements. Geneva: World Health Organization; 1985 (WHO technical report, series 724). FAO/WHO/UNU Expert Consultation. Energy and Protein Requirements. Geneva: World Health Organization; 1985 (WHO technical report, series 724). U.S. Food and Drug Administration. Federal Register. 21 CFR, Part 101, et al. Part III. Food Labeling, U.S. Food and Drug Administration. Federal Register. 21 CFR, Part 101, et al. Part III. Food Labeling, 1991.

16 Does soy inhibit thyroid function? Well-designed human clinical studies have demonstrated that soy has a minimal effect on overall thyroid function in healthy individuals. Well-designed human clinical studies have demonstrated that soy has a minimal effect on overall thyroid function in healthy individuals. Duncan AM, Underhill KE, Xu X, Lavalleur J, Phipps WR, Kurzer MS. Modest hormonal effects of soy isoflavones in postmenopausal women. J Clin Endocrinol Metab 1999;84(10): Duncan AM, Underhill KE, Xu X, Lavalleur J, Phipps WR, Kurzer MS. Modest hormonal effects of soy isoflavones in postmenopausal women. J Clin Endocrinol Metab 1999;84(10): Persky VW, Turyk ME, Wang L, et al. Effect of soy protein on endogenous hormones in postmenopausal women. Am J Clin Nutr 2002;75(1): Persky VW, Turyk ME, Wang L, et al. Effect of soy protein on endogenous hormones in postmenopausal women. Am J Clin Nutr 2002;75(1): UltraMeal Medical Food Program: Containing soy protein (15 grams) with a comprehensive vitamin/mineral blend UltraMeal Medical Food Program: Containing soy protein (15 grams) with a comprehensive vitamin/mineral blend Patients using the UltraMeal product had no change in their TSH levels after 10 weeks. Patients using the popular retail product showed a significant elevation (150% above baseline) in their TSH levels. Patients using the UltraMeal product had no change in their TSH levels after 10 weeks. Patients using the popular retail product showed a significant elevation (150% above baseline) in their TSH levels. Bland JS, DiBase F, Ronzio R. Physiological effects of a doctor-supervised versus and unsupervised over-the-counter weight-loss program. J Nutr Med 1992;3: Bland JS, DiBase F, Ronzio R. Physiological effects of a doctor-supervised versus and unsupervised over-the-counter weight-loss program. J Nutr Med 1992;3:285-93

17 Does soy inhibit thyroid function? Amounts greater than 200 mg of isoflavones per day may inhibit thyroid hormone synthesis in susceptible people. (thyroid issues/low iodine) Amounts greater than 200 mg of isoflavones per day may inhibit thyroid hormone synthesis in susceptible people. (thyroid issues/low iodine) Certain studies suggest that soy and soy isoflavones inhibit the production of thyroid hormones in individuals with thyroid issues. Certain studies suggest that soy and soy isoflavones inhibit the production of thyroid hormones in individuals with thyroid issues. Chang HC, Doerge DR. Dietary genistein inactivates rat thyroid peroxidase in vivo without an apparent hypothyroid effect. Toxicol Appl Pharmacol 2000;168(3): Chang HC, Doerge DR. Dietary genistein inactivates rat thyroid peroxidase in vivo without an apparent hypothyroid effect. Toxicol Appl Pharmacol 2000;168(3): Approximately 10 million Americans or 3% of the population have thyroid issues. Approximately 10 million Americans or 3% of the population have thyroid issues. Alternatives to soy based medical foods are available for these individuals. Alternatives to soy based medical foods are available for these individuals.

18 Isnt soy more allergenic than other proteins? Soy proteins tend to be less reactive than many other food proteins. In fact, soy has been used as an alternative for infants with allergies to cows milk. Soy proteins tend to be less reactive than many other food proteins. In fact, soy has been used as an alternative for infants with allergies to cows milk. Cordle CT. Soy protein allergy: incidence and relative severity. J Nutr 2004;134(5):1213S-19S. Cordle CT. Soy protein allergy: incidence and relative severity. J Nutr 2004;134(5):1213S-19S. A meta-analysis of 17 studies of allergy patterns of high-risk infants revealed soy allergy occurring in 3% to 4% of subjects versus 25% for cows milk. A meta-analysis of 17 studies of allergy patterns of high-risk infants revealed soy allergy occurring in 3% to 4% of subjects versus 25% for cows milk. Cantani A, Lucenti P. Natural history of soy allergy and/or intolerance in children, and clinical use of soy-protein formulas. Pediatr Allergy Immunol 1997;8(2): Cantani A, Lucenti P. Natural history of soy allergy and/or intolerance in children, and clinical use of soy-protein formulas. Pediatr Allergy Immunol 1997;8(2):59-74.

19 Do I have to use fermented soy products to achieve therapeutic benefits? No. The majority of studies around the world show beneficial effects of soy. No. The majority of studies around the world show beneficial effects of soy. Our research studies confirm those findings for areas including: Our research studies confirm those findings for areas including: Blood Sugar Blood Sugar Body composition Body composition Preserving muscle mass during weight loss Preserving muscle mass during weight loss Cardiovascular risk reduction Cardiovascular risk reduction

20 The Functional Medicine Research Center We are the only company in the professional market to operate a patient clinic. We are the only company in the professional market to operate a patient clinic. In the FMRC conducted over 5,000 patient visits. In the FMRC conducted over 5,000 patient visits. It allows us to test our products for safety and efficacy before they reach your patients. It allows us to test our products for safety and efficacy before they reach your patients. Many companies use your patients to test their products. Many companies use your patients to test their products.

21 UltraGlycemX medical food positively affects blood sugar UltraGlycemX Medical Food UltraGlycemX Medical Food Contains soy protein (15 grams) with a comprehensive vitamin/mineral blend Contains soy protein (15 grams) with a comprehensive vitamin/mineral blend Clinically Shown to: Clinically Shown to: Significantly improve Significantly improve fasting and 2-hour postprandial insulin fasting and 2-hour postprandial insulin Triglycerides and cholesterol levels Triglycerides and cholesterol levels Body composition Body composition Study lasted 8 weeks and 37 insulin resistant patients participated Study lasted 8 weeks and 37 insulin resistant patients participated

22 UltraMeal medical food positively affects body composition UltraMeal Medical Food UltraMeal Medical Food Contains soy protein (15 grams) with a comprehensive vitamin/mineral blend Contains soy protein (15 grams) with a comprehensive vitamin/mineral blend Published Peer Review Study: Published Peer Review Study: A 10 week study with 34 patients showed Patients on UltraMeal lost an average of 13 lbs with zero muscle lost. A 10 week study with 34 patients showed Patients on UltraMeal lost an average of 13 lbs with zero muscle lost. Compared to a popular retail product in which patients lost similar weight but lost 85% of it as muscle. Compared to a popular retail product in which patients lost similar weight but lost 85% of it as muscle. Bland JS, DiBase F, Ronzio R. Physiological effects of a doctor-supervised versus and unsupervised over-the-counter weight-loss program. J Nutr Med 1992;3: Bland JS, DiBase F, Ronzio R. Physiological effects of a doctor-supervised versus and unsupervised over-the-counter weight-loss program. J Nutr Med 1992;3:285-93

23 UltraMeal medical food positively affects body composition UltraMeal Medical Food UltraMeal Medical Food Published Peer Reviewed Study: Published Peer Reviewed Study: A University of Oregon study showed significant change in body composition over 7 weeks. A University of Oregon study showed significant change in body composition over 7 weeks. 34 patients lost an average of 14.1 lbs of fat while gaining 0.9 lbs of muscle. 34 patients lost an average of 14.1 lbs of fat while gaining 0.9 lbs of muscle. Hackman RM, Ellis BK, Brown RL. Phosphorous magnetic resonance spectra and changes in body composition during weight loss. J Am Coll Nutr 1994; 13(3) Hackman RM, Ellis BK, Brown RL. Phosphorous magnetic resonance spectra and changes in body composition during weight loss. J Am Coll Nutr 1994; 13(3)

24 UltraMeal Plus program affects body composition and cardiovascular health UltraMeal Plus Medical Food UltraMeal Plus Medical Food Incorporates soy protein and phytosterols with a comprehensive vitamin and mineral blend Incorporates soy protein and phytosterols with a comprehensive vitamin and mineral blend Published Peer Reviewed Study: Published Peer Reviewed Study: 42 post-menopausal women were studied for 12 weeks and the results showed statistically significant improvement in 14 independent cardiovascular risk markers 42 post-menopausal women were studied for 12 weeks and the results showed statistically significant improvement in 14 independent cardiovascular risk markers Lukaczer D, Liska DJ, Lerman RH. et al. Effect of a low glycemic index diet with soy protein and phytosterols on CVD risk factors in postmenopausal women. Nutrition Lukaczer D, Liska DJ, Lerman RH. et al. Effect of a low glycemic index diet with soy protein and phytosterols on CVD risk factors in postmenopausal women. Nutrition

25 UltraMeal Plus shows significant changes in key cardiovascular markers Weight-14.8 lbs Weight-14.8 lbs Lean Muscle+2.28 lbs Lean Muscle+2.28 lbs Total Cholesterol-16% Total Cholesterol-16% LDL Cholesterol-15% LDL Cholesterol-15% HDL Cholesterol+6% HDL Cholesterol+6% tChol/HDL-20% tChol/HDL-20% TG/HDL-56% TG/HDL-56% hsCRP -34% hsCRP -34% HA1C -3.4% HA1C -3.4% Insulin-26% Insulin-26%

26 We support the use of soy Due to the large amount of reported safety and efficacy studies. Its long history of safe consumption by Asian populations. The FDA health claim regarding soy protein and its potential to reduce the risk of heart disease. Substantial data regarding the benefits of soy in cardiovascular health, prostate health, menopausal symptom relief, and osteoporosis prevention as well as other important areas.

27 We have options to benefit every type of patient Many companies just say why one protein or ingredient is better than another. Many companies just say why one protein or ingredient is better than another. Thyriod issues and soy allergy patients Thyriod issues and soy allergy patients UltraMeal Whey UltraMeal Whey UltraMeal Rice UltraMeal Rice UltraClear Medical Food UltraClear Medical Food UltraClear Plus Medical Food UltraClear Plus Medical Food UltraInflamX Medical Food UltraInflamX Medical Food Breast tissue health options Breast tissue health options Estrium Medical Food Estrium Medical Food UltraMeal Whey UltraMeal Whey UltraMeal Rice UltraMeal Rice UltraClear Medical Food UltraClear Medical Food UltraClear Plus Medical Food UltraClear Plus Medical Food UltraInflamX Medical Food UltraInflamX Medical Food

28 Decisions must be based on a balanced review of research Metagenics will always select the best ingredients and method of delivery to meet the needs of your patients Metagenics will always select the best ingredients and method of delivery to meet the needs of your patients Variety of proteins in our medical foods Variety of proteins in our medical foods Use of powders, tablets, capsules and liquids in different products to ensure effectiveness as well as improved compliance. Use of powders, tablets, capsules and liquids in different products to ensure effectiveness as well as improved compliance.

29 At Metagenics, we're in the health business - Not the pill business In the health business, safety and effectiveness are top priority because there is a lot riding on the quality of the products we make: In the health business, safety and effectiveness are top priority because there is a lot riding on the quality of the products we make: 1.Your patients health. 2.The success of the nutritional therapy you recommend. 3.Your credibility as a health professional.

30 Genetic Potential Through Nutrition We invest more in research and quality than anyone else in our industry. We invest more in research and quality than anyone else in our industry. Our medical foods are just one example of how we distinguish ourselves in this industry. Our medical foods are just one example of how we distinguish ourselves in this industry. Always True to Our Mission Since our inception in 1983, we have never deviated from our founding idea - "the patient's best interests must be served." Always True to Our Mission Since our inception in 1983, we have never deviated from our founding idea - "the patient's best interests must be served."


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