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Fructose. 2 FRUKTOSE (LEVULOSE) Blood Blood – Glucose – Galactose – Fructose Food Food – Honey – Fruits – Potato – Onion + glucose + glucose + sucrose.

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Presentation on theme: "Fructose. 2 FRUKTOSE (LEVULOSE) Blood Blood – Glucose – Galactose – Fructose Food Food – Honey – Fruits – Potato – Onion + glucose + glucose + sucrose."— Presentation transcript:

1 Fructose

2 2 FRUKTOSE (LEVULOSE) Blood Blood – Glucose – Galactose – Fructose Food Food – Honey – Fruits – Potato – Onion + glucose + glucose + sucrose + sucrose Degradation of sucrose Degradation of sucrose Diabetes mellitus Diabetes mellitus Influence on lipid metabolism Influence on lipid metabolism

3 3 Effect of fructose Ingestion results in Ingestion results in – Obesity – [LDL]  – [TRIGLYCERID]  – Metabolic syndroms Chelating effect Chelating effect – Cu – Zn – Cr Insulin resistence (DM Type II. típus) Insulin resistence (DM Type II. típus) Glycation of proteins Glycation of proteins

4 4 FRUCTOSE

5 5 Absorption of monosaccharides Transporters: – GLUT-5 – GLUT-2 – Glucose

6 6 Absorption of carbohydrates Gal Glu Fru Extracellular space Entherocytes Intestinalis lumen Lactose Starch Sucrose 2Na + K+K+ SGLT1 GluT5 GluT2 K + Na + ATP-ase Lactase Amylase  -glucosidase ATP ADPADP Sucrase Na + K+K+

7 7 0 FRUCTOSE GLUCOSE

8 8 D-fructose in liquor and in seminal plasma Peripherial neurons. Diabetic hyperglycaemia Accumulation of Sorbitol  periferial neuropathy

9 9 Degradation of fructose in muscleliver 0

10 10 Formation of methylglyoxal

11 11 Catabolism of methylglyoxal

12 12 Deficiency of liver fructokinase Benign disease Benign disease Fructoseuria Fructoseuria

13 13 FRUCTOSE 0 GLUCOSE

14 14 Deficiency of Fructose-1-phosphate aldolase (Fructose intolerance) Hereditery fructose intolerance (HFI) Hereditery fructose intolerance (HFI) fruktosemy fruktosemy Deficiency of fructose 1,6- bisphosphate aldolase B Deficiency of fructose 1,6- bisphosphate aldolase B Def, of aldolase B Def, of aldolase B vomiting hypoglycaemia Cachexy hepatomegaly jaundice coagulopathy Metabolic acidosis Coma renal Fanconi syndrome

15 15 0 FRUCTOSE GLUCOSE

16 16

17 17 Nakagawa T et al. (2005) Hypothesis: fructose-induced hyperuricemia as a causal mechanism for the epidemic of the metabolic syndrome Nat Clin Pract Neprol 1: 80–86 doi: /ncpneph0019 Figure 1 Fructose-induced production of uric acid in the hepatocyte

18 18 0 FRUKTÓZ GLUKÓZ [Fruktóz-1-P]  Foszfát-hiány A hipoglikémia kialakulásának valószín ű oka

19 19 0 FRUKTÓZ GLUKÓZ


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