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Protein turnover. Biosynthesis of a mino acids Léránt István
Biosynthesis of amino acids N – NH 4 + C – glycolysis, PPP, citric acid cycle L-amino acid / D –amino acid Proteinog e n amino acids 20 (22) Essential amino acids Non essential amino acids
NADPH – L-Glutam a t e
Synthesis of amino acids Origin of C Intermedier of glycolysis Intermedier of PPP I ntermedier of citric acid cycle
BIOSYNTHESIS OF AMINO ACIDS al ph a-keto acid al ph a-amino acid Asp Ala Glu
SYNTHESIS OF AMINO ACIDS Asp Ala Glu
SYNTHESIS OF AMINO ACIDS Transamination Deamination Decarboxylation Glycogen-glucose PLP – Vitamin B 6
SYNTHESIS OF AMINO ACIDS ProlineArginine Glutamate Glutamate- -semialdehyde Proline Arginine
SYNTHESIS OF AMINO ACIDS ProlinArginin Glutamate Glutamate- -semialdehyde Proline Ornitine Arginine
SYNTHESIS OF AMINO ACIDS Ser Glycolysis intermedier: 3-P-glycerate Transamination Dephosphorylation Ser: precursor of Gly & Cys
SYNTHESIS OF AMINO ACIDS Ser Ser: precursor of Gly & Cys SerGly
SYNTHESIS OF AMINO ACIDS Ser Ser: precursor of Gly & Cys Ser + homocysteine (Met) Cystationine Alpha-ketobutyrate + cysteine
FOLIC ACID – C1 Folium Spinach 15 mg / adults Mainly - liver Vitamin B9, Vitamin M Vitamin B9 deficiency megaloblastic anaemia – Neurological symptoms peripherial neuropathy myelopathy – vegetative disturbance psychiatric disturbance – depression – insomnia – irritability – forgetfulness
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The Big Picture of Protein Metabolism Gladys Kaba.
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Nitrogen Metabolism Pratt and Cornely Chapter 18.
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TUMS Dr. Azin Nowrouzi Tehran University of Medical Sciences Dr. Azin Nowrouzi Tehran University of Medical Sciences.
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Protein Catabolism. Overview of Protein Catabolism Proteases are zymogens Excess amino acids are not stored Normal protein turnover 1-2% of body protein.
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AMINO ACID METABOLISMS. Amino acid structure Essential amimo acids Val, Leu Ile Phe Met, Thr, Lys, Arg *, Hys *, Trp Non essential amino acids Gly,
FCH 532 Lecture 26 Chapter 26: Essential amino acids Quiz Monday: Translation factors Quiz Wed: NIH Shift Quiz Fri: Essential amino acids Exam 3: Next.
The Nitrogen Cycle nitrogenase Nitrite reductase Nitrate reductase.
Metabolism of amino acids - exercise - Vladimíra Kvasnicová.
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Amino Acids ©CMBI 2001 “ When you understand the amino acids, you understand everything ”
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