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Protein turnover. Biosynthesis of a mino acids Léránt István
Biosynthesis of amino acids N – NH 4 + C – glycolysis, PPP, citric acid cycle L-amino acid / D –amino acid Proteinog e n amino acids 20 (22) Essential amino acids Non essential amino acids
NADPH – L-Glutam a t e
Synthesis of amino acids Origin of C Intermedier of glycolysis Intermedier of PPP I ntermedier of citric acid cycle
BIOSYNTHESIS OF AMINO ACIDS al ph a-keto acid al ph a-amino acid Asp Ala Glu
SYNTHESIS OF AMINO ACIDS Asp Ala Glu
SYNTHESIS OF AMINO ACIDS Transamination Deamination Decarboxylation Glycogen-glucose PLP – Vitamin B 6
SYNTHESIS OF AMINO ACIDS ProlineArginine Glutamate Glutamate- -semialdehyde Proline Arginine
SYNTHESIS OF AMINO ACIDS ProlinArginin Glutamate Glutamate- -semialdehyde Proline Ornitine Arginine
SYNTHESIS OF AMINO ACIDS Ser Glycolysis intermedier: 3-P-glycerate Transamination Dephosphorylation Ser: precursor of Gly & Cys
SYNTHESIS OF AMINO ACIDS Ser Ser: precursor of Gly & Cys SerGly
SYNTHESIS OF AMINO ACIDS Ser Ser: precursor of Gly & Cys Ser + homocysteine (Met) Cystationine Alpha-ketobutyrate + cysteine
FOLIC ACID – C1 Folium Spinach 15 mg / adults Mainly - liver Vitamin B9, Vitamin M Vitamin B9 deficiency megaloblastic anaemia – Neurological symptoms peripherial neuropathy myelopathy – vegetative disturbance psychiatric disturbance – depression – insomnia – irritability – forgetfulness
February 14 Chapter 26 Amino Acid Metabolism
Amino Acid biosynthesis Amino acids are derived from intermediates in glycolysis, citric acid cycle, and PPP pathway Ten of the amino acids have relatively.
Amino acid metabolism IV. Biosynthesis of nonessential amino acids Figures: Lehninger-4ed; fejezet: 22 (Stryer-5ed; fejezet: 24)
Fates of the Carbon Atoms from Amino Acids Synthesis of Amino Acids Chapter 25 Metabolic Pathways for Lipids and Amino Acids.
Protein turnover Catabolism of amino acids II
Learning Targets “I Can...” -State how many nucleotides make up a codon. -Use a codon chart to find the corresponding amino acid.
Section M Nitrogen metabolism
Proteins: Structure reflects function….. Fig. 5-UN1 Amino group Carboxyl group carbon.
Chapter 26 Amino Acids Metabolism.
Methionine amino acid: Essential amino acid
Amino Acid Catabolism Amino Acids
Biosynthesis of monomers Glucose synthesis from organic compounds –Process is called gluconeogenesis –Most cells can carry out gluconeogenesis from phosphoenolpyruvate.
Chemistry: An Introduction to General, Organic, and Biological Chemistry, Eleventh Edition Copyright © 2012 by Pearson Education, Inc. Chapter 18 Metabolic.
Chapt. 39 Ch. 39 Student Learning Outcomes : Explain basic synthesis of nonessential amino acids Uses glucose derivatives (glycolysis, TCA) N sources often.
Role of Amino Acids Protein monomeric units Energy source Precursors of other biological molecules Protein monomeric units Energy source Precursors of.
Methionine amino acid: Essential amino acid Glucogenic: as it gives succinyl CoA It is used as methyl donor. The active form of methionine as methyl donor.
Amino Acid Synthesis Essential Amino Acids : amino acids that cannot be synthesized by the organism at a rate sufficient to meet the normal requirements.
Amino acid metabolism · Nitrogen balance protein catabolism, synthesis biosynthesis normal N balance: N ingested = N excreted negative N balance: N ingested.
The Big Picture of Protein Metabolism Gladys Kaba.
Amino Acid Metabolism. Essential Amino Acids Essential amino acids must be consumed in the diet. Mammalian cells lack enzymes to synthesize their carbon.
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