25 HPA 1a peptide presented by HLA DR B3 0101 positive APC’s Integrin β3HPA 1aHLA class IIDR alpha chain HLA class IIDRB3-1 beta chainEach MHC molecule can bind a limited set of peptides determined by “anchor residues”The strong association of HLA-DRB3*0101 with NAIT, and the allogeneic differences between the maternal and fetal platelet antigen, suggests that anti-HPA-1a antibody responses depend on T cells that recognize HPA 1a derived peptide presented by this MHC molecule.The ability of HPA 1a peptide to associate with this MHC strengthens this notion.Parry, C.S. et al., J. Mol. Biol. (2007), 371(2):435-46
26 T cells bind antigenic peptide associated with MHC molecules.Antigen-presentingcellT cellCD28B72.CD41.CD3TCRMHC class II
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