1. Glia CNS Glia Mikroglia Makroglia Asztroglia Oligodendroglia
Rezidens nyugvó makrofág
Makroglia
Neuroepitél eredet
Asztroglia
Oligodendroglia
PNS Glia: Schwann sejt; „szatellita” sejtek
Glia
GFAP
(S100 b)
(Gln-synth)
(GLT-1)
MBP, Po, MOgp, O4
(Szénsav-anhidráz)
Átmeneti, fejlődő glia-alakok:
PNS szatellita sejtek;
CNS radiális glia, parenchyma-progenitorok (?)

2. „Asztroglia”-GFAP-pozitív központi idegrendszeri sejtek
In vitro:
radiális glia
I. típusú asztroglia
II. típusú asztroglia
reaktív asztroglia
Idegi őssejtek/gliális progenitorok (?)
In vivo:
plazmás asztrocita
rostos asztrocita
II.típusú asztroglia
reaktív asztroglia
tanycita
ependyma (?)
Müller-glia
Begman-glia
radiális glia
felnőttkori őssejtek
I.típusú

3. Aszimmetrikus mitózis+
Aszimmetrikus mitózis
G.C. Schoenwolf , 2001
kamra
Pia - ECM
Radiális glia
Radiális neuroepithel sejt
ECM
Idegsejt-előalak
Laterális
indukció / gátlás
Szimmetrikus aszimmetrikus
mitózisok
Notch
Hes
ErbB2
BLBP
Delta-1
Mash/Ngn1,2
NRG-1

4. Bordey
DV Hansen et al. Nature 000, 1-8 (2010) doi: /nature08845

5. Csökkent neuron differenciáció, megemelkedett asztroglia képzés az Fbxw7(Notch-ubikvitinálásért felelős ligáz)-deficiens agyban.
Matsumoto A et al. J. Biol. Chem. 2011;286:
Impairment of neuronal differentiation and enhanced astroglial differentiation in the Fbxw7-deficient brain. A, immunofluorescence analysis of βIII-tubulin (green) and GFAP (red) in primary cultured cells from the cerebrum of Nestin-Cre/Fbxw7+/F (Control) and Nestin-Cre/Fbxw7F/F (Fbxw7 CKO) mice at P0.5. Nuclei were stained blue with Hoechst Scale bars = 40 μm. B, quantitative analysis of cells positive for βIII-tubulin, GFAP, or MBP in experiments similar to that in A. Data are mean ± S.D. from three independent experiments. **, p < 0.01; ***, p < 0.005; N.S., not significant. C, immunofluorescence analysis of BrdU (green) and Ki67 (red) in the brain of Nestin-Cre/Fbxw7+/F (Control) and Fbxw7 CKO mice at 30 h after labeling with a single pulse of BrdU at E More BrdU-positive cells had migrated into the Ki67-negative differentiated mantle zone (MZ) of control mice than into that of Fbxw7 CKO mice. Scale bars = 100 μm (left panels) and 50 μm (right panels). D, quantitative analysis of cells positive for BrdU in the mantle zone in experiments similar to that in C. Data are mean ± S.D. from three independent experiments. ***, p < E, immunofluorescence analysis of GFAP in the posterior midbrain of Nestin-Cre/Fbxw7+/F (Control) and Fbxw7 CKO mice at P0.5. Scale bars = 100 μm.
Impairment of neuronal differentiation and enhanced astroglial differentiation in the Fbxw7-deficient brain.
A, B immunofluorescence analysis of βIII-tubulin (green) and GFAP (red) in primary cultured cells from the cerebrum of Nestin-Cre/Fbxw7+/F (Control) and Nestin-Cre/Fbxw7F/F (Fbxw7 CKO) mice at P0.5. Nuclei were stained blue with Hoechst Scale bars = 40 μm., **, p < 0.01; ***, p < 0.005; N.S., not significant.
C, immunofluorescence analysis of BrdU (green) and Ki67 (red) in the brain of Nestin-Cre/Fbxw7+/F (Control) and Fbxw7 CKO mice at 30 h after labeling with a single pulse of BrdU at E More BrdU-positive cells had migrated into the Ki67-negative differentiated mantle zone (MZ) of control mice than into that of Fbxw7 CKO mice. Scale bars = 100 μm (left panels) and 50 μm (right panels). D, quantitative analysis of cells positive for BrdU in the mantle zone in experiments similar to that in C. Data are mean ± S.D. from three independent experiments. ***, p <
E, immunofluorescence analysis of GFAP in the posterior midbrain of Nestin-Cre/Fbxw7+/F (Control) and Fbxw7 CKO mice at P0.5. Scale bars = 100 μm.

6. deAzevedo et al., 2003. J.Neurobiol.

7. II. Típusú asztrociták, in vitro