1. WP 6.4 Genomics & colon cancer 9 th Consortie Meeing Rome September 2006 Pilot WP 6.4 Genomics & colon cancer

2. WP 6.4 Genomics & colon cancer 9 th Consortie Meeing Rome September 2006 4 genetic dept. 4 laboratories 50 surg.dept. >20 gyn.dept. HNPCC-register Today: Paper based Future Aims: Interoperability Communication Further IT-support Web-reporting of data

3. WP 6.4 Genomics & colon cancer 9 th Consortie Meeing Rome September 2006 HNPCC-register Today: Paper based Future Aims: Interoperability Communication Further IT-support Web-reporting of data

4. WP 6.4 Genomics & colon cancer 9 th Consortie Meeing Rome September 2006 Danish Health Data Network Web Server Laboratory / Surgery Dep. / Genetic Dep. Web Service Provider Front end HNPCC DB HTML Web ServiceNot part of InfoBioMed Web Page ClientWeb Service Client Vali- dation

5. WP 6.4 Genomics & colon cancer 9 th Consortie Meeing Rome September 2006 Invited departments Genetic Department Århus Odense Vejle Hvidovre Surgical Department Herning Ålborg Odense Hvidovre Århus Laboratory Ålborg Copenhagen Hvidovre Århus 100% functioning IP-addresses

6. WP 6.4 Genomics & colon cancer 9 th Consortie Meeing Rome September 2006

7. WP 6.4 Genomics & colon cancer 9 th Consortie Meeing Rome September 2006

8. WP 6.4 Genomics & colon cancer 9 th Consortie Meeing Rome September 2006 Herning Ålborg Odense Genetic Department Surgical Department Laboratory Ålborg Copenhagen Århus Vejle Hvidovre Odense Århus Hvidovre

9. WP 6.4 Genomics & colon cancer 9 th Consortie Meeing Rome September 2006

10. WP 6.4 Genomics & colon cancer 9 th Consortie Meeing Rome September 2006

11. WP 6.4 Genomics & colon cancer 9 th Consortie Meeing Rome September 2006 Herning Ålborg Odense Genetic Department Surgical Department Laboratory Ålborg Copenhagen Århus Vejle Hvidovre Odense Århus Hvidovre II:1 Max Bergren

12. WP 6.4 Genomics & colon cancer 9 th Consortie Meeing Rome September 2006 Herning Ålborg Odense Genetic Department Surgical Department Laboratory Ålborg Copenhagen Århus Vejle Hvidovre Odense Århus Hvidovre

13. WP 6.4 Genomics & colon cancer 9 th Consortie Meeing Rome September 2006

14. WP 6.4 Genomics & colon cancer 9 th Consortie Meeing Rome September 2006

15. WP 6.4 Genomics & colon cancer 9 th Consortie Meeing Rome September 2006 Herning Ålborg Odense Laboratory Ålborg Copenhagen Århus Vejle Hvidovre Odense Århus Hvidovre MLH1, exon4, c.350C>T, p.T117M Genetic Department Surgical Department

16. WP 6.4 Genomics & colon cancer 9 th Consortie Meeing Rome September 2006 HHUD – evaluation

17. WP 6.4 Genomics & colon cancer 9 th Consortie Meeing Rome September 2006 International HL7 Interoperability Conference IHIC 2006 August 24-25, 2006, Cologne, Germany

18. WP 6.4 Genomics & colon cancer 9 th Consortie Meeing Rome September 2006

19. WP 6.4 Genomics & colon cancer 9 th Consortie Meeing Rome September 2006 FORTH Family Information HL7v3 model

20. WP 6.4 Genomics & colon cancer 9 th Consortie Meeing Rome September 2006 FORTH Individual Information HL7v3 model

21. WP 6.4 Genomics & colon cancer 9 th Consortie Meeing Rome September 2006 Example: CDA for Surveillance messages

22. WP 6.4 Genomics & colon cancer 9 th Consortie Meeing Rome September 2006 Overview •INFOBIOMED European Network of Excellence •Danish Hereditary Non-polyposis Colon Cancer (HNPCC) Registry •Data flows that involve the Registry –XML models –web-reporting •HL7 v3 approaches investigated for interoperability –Developing a bottom-up HL7 v3 solution –Utilizing Genomics SIG: Family History Model –Extending the Family History Model –Employing CDA Release 2 •Summary & Conclusions

23. WP 6.4 Genomics & colon cancer 9 th Consortie Meeing Rome September 2006 Summary •HL7 interoperability can eliminate heterogeneity and speed-up reporting of laboratories, surgery, and genetic counseling departments to the Danish HNPCC registry. •In the long run it can also facilitate cooperation among HNPCC registries in Europe. •We have experimented with the HL7 v3 tools, Family History Model of the Clinical Genomics SIG and CDA release 2 to facilitate information exchange and promote interoperability.

24. WP 6.4 Genomics & colon cancer 9 th Consortie Meeing Rome September 2006 Conclusions HL7 v3 tools are useful but require a long time of work. Interoperability of the result is limited. •Family History topic is the most promising solution in the long term. –collaboration with the Clinical Genomics SIG is envisioned to share understanding and reach consensus. •CDA release 2 currently provides early feedback and max flexibility among the solutions we investigated. •Implementation guides should be developed and shared with the community for the CDA and the Family History model. –they are the key to interoperability!

25. 20052006 WEB XML/HL7 SNP2005 Leicester SNP2005 Leicester FORTHUPM Implementation FUNEN HNPCC 2007 HHUD Evaluation CustodixAveiro ISCIII

26. WP 6.4 Genomics & colon cancer 9 th Consortie Meeing Rome September 2006 Specific output WP 6.4 •Current status data exchange HNPCC •4 XML standards on clinical content •Design of XML documents •WEB service client •Implementation & evaluation of WEB-client •Ethical, legal and security issues •Early HL7 and CDA experience •Dissemination experience

27. WP 6.4 Genomics & colon cancer 9 th Consortie Meeing Rome September 2006 Experience ??