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First results of DELPREIC study international validation of PREDELIRIC-model Mark van den Boogaard RN, CCRN, PhD Radboud University Nijmegen Medical Centre.

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Presentation on theme: "First results of DELPREIC study international validation of PREDELIRIC-model Mark van den Boogaard RN, CCRN, PhD Radboud University Nijmegen Medical Centre."— Presentation transcript:

1 First results of DELPREIC study international validation of PREDELIRIC-model Mark van den Boogaard RN, CCRN, PhD Radboud University Nijmegen Medical Centre Dep. Intensive Care.

2 Background • PREdiction DELIRium in ICu patients consists of 10 predictors to predict delirium within 24 hours after ICU admission • High predictive value in 3,054 patients (development, internal and external validation) of 0.85 (AUROC)

3 Aim of study -International validation of PREDELIRIC-model -Development of E-PREDELIRIC-model

4 Participants 1. Austriala-Princess Alexandra Hospital, Woolloongabba; Leanne Aitken 2. Austriala-Canberra Hospital, Canberra; Frank van Haren 3. Belgium-Academisch ziekenhuis Antwerpen; Philippe Jorens 4. Germany-Charité – Universitaetsmedizin Berlin, Claudia Spies, Lütz Alawi 5. Spain- Hospital Universitario La Paz, Madrid; Emilio Maseda 6. Sweden-Karolinska University Hospital Solna, Stockholm; Anna Schandl 7. UK-Medway Maritime Hospital, Kent ; Catherine Plowright and Nuno Pinto 8. UK-Whiston Hospital, Prescot; Christina Jones

5 Inclusion and exclusion Total : 2852 patients Excluded: 1028 patients Included: 1824 patients

6

7 Results Delirium/non-deliriumAUROC95% CI Belgium86/4800.790.74-0.84 Germany60/1630.850.80-0.91 Spain23/1050.880.81-0.94 Sweden30/470.710.60-0.83 Australia Brisbane42/2870.810.75-0.88 Australia Canberra23/1720.800.72-0.89 Australia overall65/4590.810.76-0.86 UK_Prescot73/1620.650.57-0.73 UK_Kent26/450.760.65-0.88 UK_overall99/2070.680.62-0.74 PREDELIRIC overall363/14610.770.74-0.79

8 Graphical view

9 Plan • October: re-calibration of predictors→ Statistician • November: writing manuscript • November-December: sending to co-authors • December-January: submitting to Critical Care Medicine • January-March: starting analyzing data for E-PREDELIRIC by new PhD-student

10 Many thanks in advance for all your effort in the DELPREIC study


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