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UPAYA PENCEGAHAN KARIES MELALUI PENELAAHAN BIOFILM

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Presentation on theme: "UPAYA PENCEGAHAN KARIES MELALUI PENELAAHAN BIOFILM"— Presentation transcript:

1 UPAYA PENCEGAHAN KARIES MELALUI PENELAAHAN BIOFILM
Mochamad Fahlevi Rizal

2 Infeksi akibat biofilm

3 Perkembangan teori biofilm

4 Skema biofilm

5 Properti biofilm General property Dental plaque example
Open architecture Presence of channels and voids Protection from host defences, desiccation etc. Production of extracellular polymers to form a functional matrix Enhanced resistance to antimicrobials Increased resistance to chlorhexidine and antibiotics Neutralization of inhibitors Β-lactamase production by neighbouring cells to protect sensitive organisms Novel gene expression Synthesis of novel proteins; up-regulation of gtfBC Co-ordinated gene responses Production of cell-cell signaling molecules (e.g. CSP, autoinducer 2) Spatial and environmental heterogeneity pH and O2 gradients; co-adhesion Broader habitat range Obligate anaerobes in an overtly aerobic environment More efficient metabolism Complete catabolism of complex host macromolecules (e.g. mucins) by consortia

6 Host Saliva Struktur Gigi dll Agent Bakteri

7 Fungsi komponen saliva

8 Jalur metabolik spesifik dan mekanisme transport S. mutans

9 deft Salivary Mucin MG2 16 14 12 10 8 6 4 2 -2 .5 .4 .3 .2 .1 0.0 -.1
-2 .5 .4 .3 .2 .1 0.0 -.1 Observed Cubic

10 Terima Kasih


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