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Mochamad Fahlevi Rizal. Infeksi akibat biofilm Perkembangan teori biofilm.

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Presentation on theme: "Mochamad Fahlevi Rizal. Infeksi akibat biofilm Perkembangan teori biofilm."— Presentation transcript:

1 Mochamad Fahlevi Rizal

2 Infeksi akibat biofilm

3 Perkembangan teori biofilm

4 Skema biofilm

5 Properti biofilm General propertyDental plaque example Open architecturePresence of channels and voids Protection from host defences, desiccation etc. Production of extracellular polymers to form a functional matrix Enhanced resistance to antimicrobials Increased resistance to chlorhexidine and antibiotics Neutralization of inhibitorsΒ-lactamase production by neighbouring cells to protect sensitive organisms Novel gene expressionSynthesis of novel proteins; up-regulation of gtfBC Co-ordinated gene responsesProduction of cell-cell signaling molecules (e.g. CSP, autoinducer 2) Spatial and environmental heterogeneity pH and O2 gradients; co-adhesion Broader habitat rangeObligate anaerobes in an overtly aerobic environment More efficient metabolismComplete catabolism of complex host macromolecules (e.g. mucins) by consortia

6 •Saliva •Struktur Gigi •dll Host •Bakteri Agent

7 Fungsi komponen saliva

8 Jalur metabolik spesifik dan mekanisme transport S. mutans

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