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Supplementary Figure 1 EA: 0B: 1+ C: 2+D: 3+ E: Normal bronchial epithelium A C B D.

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Presentation on theme: "Supplementary Figure 1 EA: 0B: 1+ C: 2+D: 3+ E: Normal bronchial epithelium A C B D."— Presentation transcript:

1 Supplementary Figure 1 EA: 0B: 1+ C: 2+D: 3+ E: Normal bronchial epithelium A C B D

2 IDGenderHistological Type$EGFR Mutation StatusTreatmentBOR*HGFT790MMET Amplification NC-1MAdL858RGefitinibSD 0-- NC-2MAdL858RGefitinibSD160-- NC-3MAdL858RGefitinibPD160-- NC-4MAdL858RErlotinibSD110-- NC-6FAdG719SGefitinibSD120-- NC7MAdExon 19 delGefitinibSD150-- NC-9MAdL858RGefitinibPD180-- NC-10MNSCLCL858RGefitinibPD 90-- NC-11FAdL858RGefitinibSD200-- NC-12FAdL858RGefitinibPD120-- AC1FAdExon 19 delGefitinibSD 50-- AC2MAdExon 19 delGefitinibSD 100 #-- AC4MAdExon 19 delGefitinibSD190-- AC8FAdL858RGefitinibSD140-- AC10FAdL858RGefitinibPD150-- AC11MAdL858RGefitinibPD130-- AC12FAdL858RGefitinibPD120-+ OF-1MAdExon 19 delGefitinibSD 0 #-- OF-2FAdL858RGefitinibPD 0-- OF-3FAdL858RGefitinibPD 40-- OF-4MAdL858RGefitinibSD110-- KG-1FAdL858RGefitinibSD 0-- KG-10MAdExon 19 delGefitinibSD195-- KG-15MAdSqL858RGefitinibSD110-- KG-21FAdL858RGefitinibSD230-- KG-26MAdL858RGefitinibSD 0-- OC-1MSqExon 19 delGefitinibSD140-- OC-2MAdExon 19 delErlotinibSD 0-- OC-3FAdExon 19 delErlotinibSD210-- OC-4MAdG719AErlotinibPD160-- OC-6MAdExon 19 delGefitinibPD 20-- OC-7MSqL858RErlotinibSD170-- OC-10FAdL858RErlotinibSD180-- OC-15MAdL858RErlotinibPD140-- OC-16FAdL858R+Exon 19 delGefitinibSD150-- OC-18MAdExon 19 delGefitinibSD200-+ OK-2-1FAdL858RGefitinibSD270 - (D761Y+)- OK (D761Y+)- OK3MAdExon 19 delVandetanibSD280-- OK5MAdL858RGefitinibSD170-- OK6MAdL858RGefitinibPD200-- OK7FLaExon 19 delGefitinibPD270-- AC21MAdL858RGefitinibPD230-- AC22FAdL858RGefitinibPD200-- TB3FAdL858RGefitinibPD240-- Supplementary Table 1. Summary of Tumors with Intrinsic Resistance $ Ad: adeno; AdSq: adenosquamous; Sq squamous; La: large; *BOR: best overall response; # High-level HGF expression was detected in stromal cells.

3 IDGenderHistological Type$EGFR Mutation StatusTreatmentBOR*HGFT790MMET Amplification KG-2MAdExon 19 delGefitinibPR 80-- KG-3FAdL858RGefitinibPR 50-- KG-4MAdExon 19 delGefitinibPR150-- KG-5MAdL858RGefitinibPR200-- KG-7MAdL858RGefitinibPR150-- KG-8FAdL858RGefitinibPR140-- KG-9FAdExon 19 delGefitinibPR 80-- KG-11FAdExon 19 delGefitinibPR180-- KG-12FAdExon 19 delGefitinibPR160-- KG-13MAdExon 19 delGefitinibPR150-- KG-14MAdL858RGefitinibPR 80-- KG-16FAdL858RGefitinibPR 60-- KG-17FAdExon 19 delGefitinibPR220-- KG-18MAdL858RGefitinibPR 80-- KG-19FAdL858RGefitinibPR 10-- KG-20FAdL858RGefitinibPR120-- KG-22FAdL858RGefitinibPR 0#-- KG-23FAdExon 19 delGefitinibPR 75-- KG-24FAdL858RGefitinibPR100-- KG-25FAdExon 19 delGefitinibPR 0-- KG-27MAdExon 19 delGefitinibPR150-- OC-5MAdL858RGefitinibPR190-- OC-8FAdL858RErlotinibPR180-- OC-9FAdExon 19 delErlotinibPR160-- OC-11FAdL858RGefitinibPR100-- OC-12FAd Exon 19 del L858R ErlotinibPR 80-- OC-13FAdExon 19 delErlotinibPR130-- OC-14FAdExon 19 delGefitinibPR120-- OC-17MAdL858RGefitinibPR 80-- Supplementary Table 2. Summary of Sensitive Tumors $ Ad: adeno; *BOR: best overall response; # High-level HGF expression was detected in the stroma.


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