2Table of Contents Section 1 – History of Coeus Technology Section 2 - Microbes in our environmentSection 3 – Antimicrobial TechnologiesSection 4 – Coeus Technology/ ProductsSection 5 - EPA and other Federal AgenciesSection 6 - Competitors and their products
3Section 1 History of the company CEO and co-founder of Coeus Technology Nate Richardson has a background that includes 15 years of physiology and biology as well as a military career in the Marines and Army. President and co-founder of Coeus Technology David Parker has a background that includes 15 years of sales for Pfizer and Cardinal Health as well as a military career in the Air Force.
6Section 2 - Germs/ Bacteria 1 Section 2 - Germs/ Bacteria 1. MRSA or Methicillin-Resistant Staphylococcus aureusMRSA is a type of bacteria that causes a variety of infections that belong to the Staphylococcus family. MRSA has evolved and is resistant to the most used antibiotics. Staphylococcus aureus is a leading cause of hospital-acquired infections. This is because people in the hospital have weak immune systems from being sick and or they have open wounds which allow the bacteria to get in their body. It is also a problem in other confined setting such as prisons, daycare centers, nurseries and also in athletes who share locker rooms and gyms. MRSA is highly contagious and can cause severe health problems and even death if not treated in time.Although the MRSA bacteria are resistant to most antibiotics , MonoFoil® has been studied and proven to defeat it and continue to defeat for an average of 30 days per application.
7Section 2 – MRSA (pg.2)MonoFoil® has been tested and proven to defeat 99.99% of MRSA bacteria.MRSA on the rise - From 1999 through 2005, the CDC has estimated MRSA-related hospitalizations more than doubledMRSA is responsible for perhaps the largest percentage of Hospital Acquired Infections.
8Germs/ Bacteria 2. Escheria coli (ecoli) and Klebsiella Pneumoniae This is a bacterium that is commonly found in the gut of endotherms (warm blooded organisms).Years ago, E Coli was mainly responsible for severe stomach aches and diarrhea; however, two strains of the bacteria have become drug and antibiotic resistant. These strains are causing severe health complications that can lead to death.Several types of E. coli exist as part of the normal flora of the human gut and have several beneficial functions, such as the production of vitamin K2. They also prevent harmful bacteria, known as pathogenic bacteria, from establishing themselves in the intestine.Healthy adults usually recover from infection with E. coli O157:H7 within a week, but young children and older adults can develop a life-threatening form of kidney failure called hemolytic uremic syndrome (HUS).
9E coli (pg2)Humans can become infected by: Ingesting contaminated water - even though tap water contains chlorine and has undergone ozone or ultraviolet treatment, some E. coli outbreaks have been caused by contaminated municipal water supplies. Private wells can be a source of infection, as can some lakes and swimming pools.Ingesting contaminated food - examples include ground beef, unpasteurized milk, or fresh vegetables. Infected people who work in restaurants and do not wash their hands properly after going to the toilet can spread the infection to customers and other members of staff.Having physical contact with an infected person, known as person-to-person contact. Good hand hygiene is important in stemming the spread of infection.Contact with animals - this may not only occur in farms, but also in petting zoos or country fairs.
10Section 2 - Germs/ Bacteria KPC Klebsiella Pneumoniae Carbapenemases (KPC)is considered a “superbug” and is antibiotic resistant.KPC can lead to Lung infections, pneumonia and eventual death.KPC causes pneumonia, urinary tract infections, and sepsis; the mortality rate from these infections is extremely high.MonoFoil® has been proven to defeat Klebsiella bacteria up to 99.99% .
11AspergillusAspergillus is a fungus whose spores are present in the air we breathe, but does not normally cause illness. However an individual with a weakened immune status may be susceptible to Aspergillus infection. Aspergillus can cause pulmonary respiratory infections as well as blood infections which can lead to death.It also occurs commonly in cancer patients and patients with other diseases. This bacterial mold is most often found in air conditioning systems where it is then spread through the air ducts. This bacterium is hard to diagnose due to the people who have it generally having illness symptoms due to major diseases like cancer, leukemia, and HIV. Some people with asthma have the illness because of the bacteria.; however, this is one bacterium that is hard to avoid because is found practically everywhere.Once it gets loose in the bloodstream, Aspergillus kills 50% of the time or more--and that's with the best new antifungal drugs that have been developed in recent years. Experts complain that drug companies are choosing to test their medicines on other, easier-to-treat fungal infections.The best way to treat an Aspergillus infection is prevention. MonoFoil® has been proven to defeat and give long lasting preventive protection against Aspergillis.
12Acinetobacter baumannii (MDR) This pathogenic bacterium, like many of the other deadly bacteria has become resistant to most antibiotics and causes thousands of deaths every year.It has been nicknamed the “Iraqibacter” due to the number of soldiers in Iraq who have contracted it after being wounded through open sores, wounds, catheters in war. The bacteria are able to enter the body and other openings into the body. This bacterium is not new but the prevalence of its outbreaks is increasing in number. The only way to lower the incidence of this bacterial infection is to increase and monitor hand washing. It is also an increasingly common cause of pneumonia, now accounting for 7% of hospital-acquired cases. There are few existing drugs to treat it, and no medicines in development targeted at this bug.MonoFoil® applied to surfaces will assist dramatically in reducing the populations of MDR bacteria.
13Vancomycin-resistant Enterococcus faecium (VRE) Enterococci (VRE) are part of the normal intestinal flora of humans and animals but are also important pathogens responsible for serious infections. The genus Enterococcus includes more than 17 species, but only a few cause clinical infections in humans. With increasing antibiotic resistance, enterococci are recognized as feared nosocomial pathogens that can be challenging to treat.Enterococci are a group of gram-negative, round-shaped bacteria that commonly live in the gut, although they can cause infection anywhere in the body. They are resistant to several antibiotics, but in the past, physicians could rely on the drug vancomycin to effectively treat VRE infections. In recent decades, however, some enterococci have become resistant to vancomycin VRE is a major cause of infection of the heart, brain and the abdomen.VRE is typically acquired in the U.S. thru consumption of intensively farmed chicken thru Hospital Acquired Infections.
14Section 2 - Germs/ Bacteria in the Home Top (5) most contaminated areas in the home:1. Kitchen sponges and clothsThe problem: Food particles from last night’s dinner cleanup are still clinging to your sponge or dishrag, but that’s not the main problem. It’s the moist environment that makes it a playground for bacteria to grow and multiply.2. Cutting boardsThe problem: Cutting boards are used to prepare a variety of foods, including raw meat which can contain dangerous, make-you-sick bacteria such as salmonella. Also, if you’re not washing your produce thoroughly before cutting, the bacteria clinging to your broccoli or strawberries get transferred to your board.3. ToothbrushesThe problem: Our mouths are full of bacteria, which can transfer to our brushes after a cleaning. Brushes are also often sitting out on a shelf our counter, so if you’re washing your toddler’s hands post-play date, for example, splashes can hit your toothbrush.4. Computers and cell phonesThe problem: Bacteria left over from handling food, suppressing a cough or changing the cat litter can all get deposited on these common household devices. Cell phones, hand held organizers and TV remotes are in this same category.5. PetsThe problem: Pets carry bacteria from playing, walking and eating outside, notes Mail. If your kitty creates an outdoor litter box, for example, or your dog investigates something dead and rotten, all kinds of bacteria gets tracked into your home on paws and fur.
15Section 2 - Microbes Fungi (Molds)- Fungi can cause a wide array of Any of a large group of plant-like living organisms which do not contain chlorophyll, including yeasts, molds, and mushrooms.Fungi can cause a wide array ofdeadly infections including:1) Aspergillosis- Sinuses, Lungs, Pulmonary problems2) Yeast infections3) Hair, nail and skin diseases4) Athlete’s foot5) Jock itch
16Section 2 - MicrobesALGAE –A large group of simple non-flowering plants containing chlorophyll but lacking true stems, roots, leaves, and vascular tissueSome algal blooms are dangerous and produce toxins. Toxic algal blooms occur in both salt and fresh water, are known to kill fish, marine mammals, and birds; they can contaminate shellfish with toxins sometimes resulting in human fatalities. Algae is often responsible for sidelining fishermen and detouring tourists from resorts. Researchers have estimated that Algae costs coastal communities nearly $100 million annually.Algal blooms can also cause hypoxia where oxygen is stripped from the water resulting in so-called "dead zones". Like humans, most animals and plants need oxygen for survival and typically perish in areas such as the "dead zone" in the Gulf of Mexico, which averages 6,000 square miles in size.
17Section 2 (Microbes Quiz) 1) What it one of the leading causes of Hospital Acquired Infections (HAI’s)?a) E Coli b) MRSA c) Influenza d) Diarrhea2) Where are e coli bacteria typically found?a) Digestive system of most animals b) in the mouths of most animals c) from human ears d) bird poop3) Which is NOT a way to become infected with e coli?a) Drinking contaminated water b) eating contaminated food c) contact with a contaminated person d) none of the above.4) The KPC “superbug” can lead to: a) pneumonia b) sepsis c) urinary tract infections d) all of the above5) Aspergillus is: a) a bacterium b) a green vegetable c) a fungus d) the by- product of asparagus.
18Section 2 (Quiz)Aspergillus is difficult to avoid because; a) it is virtually everywhere b) It “clings” onto clothing c) It has a positive charge d) all of the above.The best way to treat Aspergillus is to: a) use prevention by applying MonoFoil® to surfaces in the home and office b) apply MonoFoil® to the open sore c) create a MonoFoil® bath and soak your body d) Rinse your mouth out with MonoFoil® once per dayMDR is typically contracted through: a) open wounds b) mouth to mouth contact c) unprotected sex d) all of the aboveVRE is most closely resembled to: a) Protozoa b) gram negative bacteria c) Hodgkin's disease d) e coliWhich type of infection is Fungi typically NOT responsible for: a) Common cold b) yeast infections c) toe nail infections d) athlete’s foot
19Section 3 Antimicrobial Technologies Antimicrobials: An antimicrobial is a substance that is capable of destroying or inhibiting the growth of disease-causing microorganisms. Antimicrobials either poison microbes (microbiocidal) or prevents the growth of microbes (microbiostatic).
20Section 3 Antimicrobial Technologies Triclosan Triclosan - Triclosan is considered a microbiocidal antimicrobialToxic chemicalOutlawed in most developed nationsAs of the end of 2010, triclosan could be found in everything up to approximately 50 percent of all consumer soaps to deodorant, cutting boards and clothing; basically most products labeled "anti-bacterial" or "anti-microbial“Unknown to most consumers, triclosan poses serious public health and environmental concerns. It is an endocrine disruptor which research has linked to increased allergies, cancer and reproductive effects. Doctors worry its increased use is also breeding bacteria with increased resistance to medical antibiotics.Triclosan is banned in many countries in Europe, in Canada and in Japan.
21Section 3 - Antimicrobial Technologies Silver/ Copper Silver/ Copper - Metal based microbiocidal antimicrobialsSilver- Silver ions have been shown inhibit a microbe’s oxidative enzymes. Silver ions have also been shown to interact with DNA to possibly prevent DNA replication. Silver acts similar to a virus and attaches itself to the cell and slowly poisons thru the cell membrane.Copper- Elevated copper levels inside a cell causes oxidative stress and the generation of hydrogen peroxide. This causes a chemical reaction resulting in oxidative damage to cells. Excess copper causes a decline in the membrane integrity of microbes, leading to leakage of specific essential cell nutrients, such as potassium and glutamate. This leads to slow and subsequent cell death.
22Section 3 - Antimicrobial Technologies Quaternary Ammonium compounds Quaternary Ammonium Compounds- A compound derived from ammonium with hydrogen atoms replaced by organic groups; used as surface-active agents, disinfectants, and in drugs.The quaternary ammonium compound 3-(Trimethoxysilyl) –propyl dimethyl octa decyl ammonium chloride (Si-QAC) has been found to have antimicrobial activity when the molecule covalently bonds to a surface. Once bonded to the surface, the molecule ruptures the cell membrane.Key components-Carbon chain- acts like a “blade” and punctures or impales the cell membraneSilane base – anchors the molecule and bonds it to the surface. The base allows the carbon chain to “stand straight up”Positive charge – creates a “magnetism” effect and attracts the microbe to the carbon chain.Microbiostatic – does not leach
23Section 3 - MonoFoil® Technology MonoFoil® is a Microbiostatic Quaternary Ammonium Compound used on non-living objects and outside of the human body.Unique attributes of MonoFoil®:“Bonds” to the surface and does not “leach” off into our environment (rivers and streams) and into humans like triclosan or silver.Carries a “Positive charge” that attracts “negatively charged” microbes that includes (99.9%) of all bacteria, molds, fungi, and algae.Acts like a “sword” or “blade” that pierces the cell membrane and electrocutes offending microbes. NO microbes are allowed to adapt and develop an immunity resulting in potential “superbugs”.MonoFoil® lasts for an average of 30 days per application onto a surface after it dries and for over 25 washes once properly applied to textiles.Coeus Technology formulates MonoFoil™ and has developed a “trade-secret” process that is, by far, the cleanest and most versatile in the world giving MonoFoil™ the ability to “bond” to virtually any surface.MonoFoil® has no surfactants. Surfactants are “chemicals” to ease surface tension. In addition, MonoFoil® unlike competing products, is the world’s cleanest formulation (no surfactants). MonoFoil® up to 50% more effective than any other competing Microbiostatic Quaternary Ammonium Compound technology allowing it to bond to nearly all surfaces.
24Actual photo from a Mass-spectrometer of MonoFoil™ applied to a surface.
25Technology Comparisons MonoFoil® Silver/ Copper Based TriclosanMode of action: Pierces and electrocutes Releases silver ions Releases toxins into cells to poisoncell membranes to poison cells resulting in slow death of cellsLeaching: NO Yes YesDurability: days per application minutes minutesCost: Economical Expensive Medium CostEffectiveness: Effective against wide array of Limited spectrum of microbes Limited spectrum of microbesbacteria, molds, fungi, algaeDistribution: Worldwide Varies by company Banned in most developed countriesincluding the European Union, Japan,and Canada
26Section 3 QuizWhich is not an Antimicrobial technology? a) Silver/ Copper b) Pine Solc) Triclosan d) Quaternary Ammonium compoundsTriclosan and metal technologies typically a) poison a microbe b) leach into the environment c) lasts for a limited amount of time d) all of the aboveTriclosan is banned in all of the following countries EXCEPT: a) USA b) Germanyc) Japan d) FranceQuaternary Compounds are: a) microbiostatic b) Microbiocidal c) Micro-mono static d) illegal in most developed nationsOnce MonoFoil® is applied to a surface; a) it creates a magnetic attraction for microbes b) will “stab” and “electrocute” microbes c) last for an average of 30 days per application d) all of the above
27Section 3 - QuizMonoFoil® will defeat 99.99% of: a) Bacteria and germs b) Fungi and molds c) Algae d) all of the aboveMonoFoil® bonds to : a) textiles b) drywall c) concrete d) most all surfacesSilver and Copper technologies: a) are toxic b) will “poison” a microbe and slowly defeat it c) are expensive d) all of the above
28Section 4 Coeus Technology Antimicrobial Products/ Formulations MonoFoil®Coeus Technology’s primary and premium brandThe most versatile of all Coeus brands against bacteria, molds, fungi, algae.One point three percent (1.3%) active formulation.HypoallergenicCoeus Technology is the only company that makes this technology in “wipe” form.
29Section 4 (pg. 2) Coeus Technology Formulations (pg.2) General Purpose Formulation – MonoFoil® is a 1.3% active formulation that is the best all around defense against bacteria, germs, molds, fungi, and algae.Mold Formulation – Specifically formulated for defeating molds (fungi). Current brand is Ultra 7 and being sold in Home Depot.Laundry Formulation – Formulated specifically for textiles with easy treatment method. Proven to last for a minimum of 25 washes.Consumer Electronic Formulation- specifically blended for cell phone and other electronic devicesCustom Formulation - Coeus Technology is an EPA registered formulator and has the flexibility to make custom formulations for our customers.
30Market SegmentsAgriculture, Airlines, Air Filtration, Athletics, Automotive, Bandages, Band-Aids, Casinos, Child Care Centers, Construction, Contact lens cases, Cruise Lines, Doctors Offices, Dental Offices, Drywall, Embalming, Epidemiology, Furnace Filters, Flooring – Carpet, Flooring - hardwoods, Flooring Composites, Supermarkets, Food packaging, Air Filtration, Food Preparation, Gauze, Healthcare, Homes, Hospitals, Hotels, Hunting Industry, Janitorial, Long Term Care, Maritime/Boating, Mass Transit, Nursing Homes, Offices, Paint, Petroleum, Water filtration, Cosemeceuticals, Plastics, Pet Industry, Powder Coating, Prisons, Restaurants, Schools, Stadiums, Supermarkets, Textiles…
31Section 5 Regulating Federal Agencies Environmental Protection Agency-Originally, EPA acted as the nation’s environmental watchdog making sure that industries met legal requirements to control pollution. In subsequent years, EPA began to develop theory, tools, and practices that enabled it to move from controlling pollution to preventing it with additional power to enforce lawsMonoFoil ® is registered and regulated by the Environmental Protection Agency or EPA.MonoFoil® is currently categorized as an “Antimicrobial”. All Antimicrobials within the EPA are considered “pesticides”. Coeus Technology is currently in the process of “re-registering “ MonoFoil®
32Section 5 Regulating Federal Agencies (pg.2) MSDS – Material Data Safety Sheet1) describes ingredients and hazards associated with any product2) provides remedies for any potential dangers3) MSDS review on the following slideEPA Registration Number-The EPA requires the establishment of an EPA Registration Number. The purpose of an Identification Number is to provide a unique product number for regular registrations, distributor registrations, Special Local Needs registrations, and Experimental Use Permits.The EPA Registration Number indicates which company holds the registration for the pesticide product, and in which sequence the product was submitted to EPA by the company.
33Section 5 Regulating Federal agencies United States Department of Agriculture –The primary purpose of the USDA is to make sure that all American food that is manufactured and consumed is safe, nutritious and sustainableThey set guidelines by which manufacturers and producers are required to safely operate. By exceeding these safety guidelines, a product like MonoFoil is deemed safe and ready to be used by the consumer
34Section 5 -Food and Drug Administration (FDA) United States Food and Drug Administration –The FDA is responsible for protecting and promoting public health through the regulation and supervision of food safety, tobacco products, dietary supplements, prescription and over-the-counter pharmaceutical drugs (medications), vaccines, biopharmaceuticals, blood transfusions, medical devices, electromagnetic radiation emitting devices (ERED), veterinary products, and cosmetics.MonoFoil® may not be used for health care purposes. However, any use outside of the human body for surface protection is permissible.
35MonoFoil MSDSAll Product MSDS sheets are located on the Partners Page of our website.
36Section 6 What separates MonoFoil® from the Competition All competitors have a “conditional registration” with the EPA if they are registered at all. MonoFoil® has an “unconditional registration”.Coeus Technology is the only manufacturer of Quaternary Ammonium compounds that has the technology in a Pad or “Wipe” form.This is specifically because MonoFoil is the only product of its kind capable of being transferred from a non-woven to another surface while at the same time maintaining a durability profile3) MonoFoil® is a one-step process that includes an instant defeat of microbes while simultaneously applying the base molecule to the surface for long-lasting 24/7 protection on that surface. Keeps microbe populations down.Coeus Technology is an EPA registered formulator and has the ability tocreate a “custom blend” for our customers.