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CardioSense3D Introduction H. Delingette

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Presentation on theme: "CardioSense3D Introduction H. Delingette"— Presentation transcript:

1 CardioSense3D Introduction H. Delingette
Intermediate Evaluation of the CardioSense3D Research Action

2 Agenda of the day Start End Topic Speaker 9h30 9h55
Introduction of CardioSense3D ( with 5mn questions) Hervé Delingette 10h25 Research Activity of the Asclepios Team within CardioSense3D ( with 5mn questions) Hervé Delingette Maxime Sermesant 10h55 Research Activity of the Sisyphe Team within CardioSense3D ( with 5mn questions) Michel Sorine 11h10 Coffee Break 11h40 Research Activity of the Macs Team within CardioSense3D ( with 5mn questions) Dominique Chapelle 12h10 Research Activity of the Reo Team within CardioSense3D ( with 5mn questions) Jean-Frédéric Gerbeau 12h30 Perspectives of CardioSense3D ( with 5mn questions) Miguel Fernandez 13h45 Lunch Break 16h00 Discussion with the evaluation committee All 17h00 Discussion within the evaluation committee

3 Introduction to CardioSense3D
Scientific Objectives and Positioning Partnership and organization

4 What is CardioSense3D ? An INRIA Large Initiative Action on cardiac modeling : Started (officially) in May 2005 4 ans duration (evaluated after 2 years) Transversal to 4 INRIA project teams : ASCLEPIOS (Medical Image Analysis and Simulation) N. Ayache MACS (Biomechanics and Numerical Analysis) : D. Chapelle REO (Fluid Mechanics) : J-F. Gerbeau SISYPHE (Contrôle and Modeling) : M. Sorine Supervisor : H. Delingette, Co-Supervisor : M. Fernandez

5 CardioSense3D Research Topics
Cardiac data solid mechanics Clinical applications Diagnosis Therapy planning blood flow Personalization electro-physiology perfusion & metabolism anatomy Cardiac modeling

6 Propose models having a low number of parameters
Objectives Build a patient specific heart simulator Estimate the parameters of this model from observations of the cardiac function, Develop clinical applications (Cardiac Resynchronisation Therapy, radiofrequency ablation,..) . Propose models having a low number of parameters

7 State of the art Computational Cardiac Models
anatomy electro-physiology solid mechanics blood flow perfusion & metabolism Cardiac modeling Computational Cardiac Models ElectroPhysiology : Noble et al. (Oxford), S. Panfilov et al. , O. Dössel (Karlsruhe), Y. Rudy et al. (Wash. Univ. St Louis), Colli-Franzone (Univ. Pavia) Flow-Biomechanics : C. Peskin (NYU), Quarteroni (EPFL),… Electro-mechanics : Peter Hunter et al. (Physiome project; Auckland); Andrew McCulloch et al. (UCSD)

8 State of the art Cardiac Image Analysis (Geometrical approaches)
Cardiac data Cardiac Image Analysis (Geometrical approaches) Elliott McVeigh et al. (JHU+NIH) D. Rueckert et al. (Imperial College) and R. Razavi et al. (KCL + Guy’s hospital) Magnin et al (Creatis), Duncan et al (Yale), Axel and Metaxas (Rutgers & NYU), Frangi et al. (Univ. Pompeu Fabra), P. Shi (Hongkong Univ.)

9 Clinical applications
State of the art Therapy planning (Generic Models) D. Noble (Oxford) A. Mc Culloch (UCSD) O. Dössel (U. Karlsruhe) & F. Sasche (U. Utah) Therapy planning Diagnosis Clinical applications

10 Positioning of CardioSense3D
Integrate/Couple 4 physiological phenomena : Electrophysiology, Contraction/Relaxation Mechanics, Arterial Circulation, Perfusion To propose models having a low number of parameters in order to estimate them from clinical data. Develop clinical applications (CRT, RF Ablation) based on personalized models

11 Positioning of CardioSense3D
Space 1 m CS0D 10-1 m CS3D 10-2 m 10-3 m 10-4 m 1s 1h 24h time

12 CardioSense3D : Academic / Clinical / Industrial Partnership
Physiology/Control Sisyphe/Sosso, INRIA Numerical Analysis Macs, INRIA Reo, INRIA Geometrica, INRIA Gamma, INRIA Univ. de Nantes Pzlen Univ. (Czech Rep.) LIRMM (Montpellier) Imaging/Simulation Asclepios, INRIA UCL / King’s College (London) Creatis, CNRS Clinical Sites Guy’s Hospital (London) NIH (Washington) HEGP, U678 (Paris) Hopital Henri Mondor (Créteil) Sunnybrook Health Sciences Center InParys, Clinique George Bizet Hopital Bicêtre + Paris XI U. +INSERM (Paris) Industrial Partners Philips Research France ELA Medical (Siemens)

13 First Circle Members of CS3D
Two different INRIA Research Units : Sophia-Antipolis Rocquencourt

14 INRIA Support Recruitment of :
P. Moireau (Détachement X-Corps des Telecoms) in 2005 4 Phd Thesis : R. Chabiniok MD (Macs) from Sep bourse Cordi M. Astorino (Reo) from Janvier bourse Cordi F. Billet (Asclepios) from Oct 2006 R. Djafri (Sisyphe) from 2007 3 Engineers : M. Alba (Macs) Ingénieur Associé E. Phe (Macs-REO) Ingénieur Associé N. Toussaint (Asclepios) : Ingénieur Associé

15 External Support National Scholarship :
PhD of N. Zemzemi Philips Medical Systems Paris (Suresnes): PhD of D. Lepiller (Asclepios) ELA Medical : Post-doc of M. Boulakia (Reo) and Post-doc of G. Ebrard Siemens Corporate Research PhD of JM Peyrat European Health eChild PhD of T. Mansi European RTN HaeModel Phd of N. Diniz Dos Santos Industrial contracts PhD of M. Laleg and K. Djabella

16 Software Current Development based on 3 software packages :
LifeV (Reo) (www.lifev.org) for CFD and electrophysiology OpenFEM (Macs) (www-rocq.inria.fr/OpenFEM/ ) for FEM continuum mechanics Mips and MedInria (Asclepios) for medical image analysis + simple models for electrophysiology and soft tissue deformation (migration on SOFA) (www-sop.inria.fr/asclepios/software/MedINRIA/) Software developed within CardioSense3D : CardioViz3D (Asclepios) Heartlab (Macs)

17 Dissemination Activity
“Digital Heart” DVD (20mn) Auteurs scientifiques : Dominique Chapelle, Hervé Delingette, Miguel Fernandez, Philippe Moireau, Maxime Sermesant

18 Dissemination Activity
“Digital Heart” Movie Public release of Software (CardioViz3D) and database (DTI atlas) Involvements in Conferences (NIH-INRIA workshop) General Audience Articles (La Recherche, Ercim News)

19 Dissemination Activity
“Digital Heart” DVD Public release of Software (CardioViz3D) and database (DTI atlas) Involvements in Conferences (ISBI’07, NIH-INRIA workshop) General Audience Articles (La Recherche, Ercim News) CardioSense3D seminars with Paris V university

20 Dissemination Activity
“Digital Heart” DVD Public release of Software (CardioViz3D) and database (DTI atlas) Involvements in Conferences (ISBI’07, NIH-INRIA workshop) General Audience Articles (La Recherche, Ercim News) CardioSense3D seminars with Paris V university Organisation of workshops (summer school) and conferences (FIMH’09 in Nice) Apple ARTS Award

21 Agenda of the day Start End Topic Speaker 9h30 9h55
Introduction of CardioSense3D ( with 5mn questions) Hervé Delingette 10h25 Research Activity of the Asclepios Team within CardioSense3D ( with 5mn questions) Hervé Delingette Maxime Sermesant 10h55 Research Activity of the Sisyphe Team within CardioSense3D ( with 5mn questions) Michel Sorine 11h10 Coffee Break 11h40 Research Activity of the Macs Team within CardioSense3D ( with 5mn questions) Dominique Chapelle 12h10 Research Activity of the Reo Team within CardioSense3D ( with 5mn questions) Jean-Frédéric Gerbeau 12h30 Perspectives of CardioSense3D ( with 5mn questions) Miguel Fernandez 13h45 Lunch Break 16h00 Discussion with the evaluation committee All 17h00 Discussion within the evaluation committee

22 CardioSense3D Research Topics
Cardiac data solid mechanics Clinical applications Diagnosis Therapy planning blood flow Personalization electro-physiology perfusion & metabolism anatomy Cardiac modeling


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