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Diffusion of Technology BIOE 301 Lecture 20. Review of Last Time: Artificial Heart First artificial heart implanted in 1969 No more human trials until.

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Presentation on theme: "Diffusion of Technology BIOE 301 Lecture 20. Review of Last Time: Artificial Heart First artificial heart implanted in 1969 No more human trials until."— Presentation transcript:

1 Diffusion of Technology BIOE 301 Lecture 20

2 Review of Last Time: Artificial Heart First artificial heart implanted in 1969 No more human trials until the 1980s AbioCOR – 1 st fully implantable artificial heart

3 Review of Last Lecture: Study Design Type I Error: (False Positive) Mistakenly conclude there is a difference between the two groups, when in reality there is no difference p-value = probability of making type I error Type II Error: (False Negative) Mistakenly conclude that there is not a difference between the two, when in reality there is a difference Beta = probability of making type II error

4 Review of Last Time: Optimal Sample Size Sample size calculations Ensure differences between treatment & control group are real Choose our sample size: Acceptable likelihood of Type I or II error Enough $$ to carry out the trial

5 Drug Eluting Stent – Sample Size Treatment group: Receive stent Control group: Get angioplasty Primary Outcome: 1 year restenosis rate Expected Outcomes: Stent: 10% Angioplasty: 45% Error rates: p =.05 Beta = patients required

6 Science of Understanding Disease Emerging Health Technologies Preclinical Testing Clinical Trials Adoption & Diffusion Abandoned due to: poor performance safety concerns ethical concerns legal issues social issues economic issues Bioengineering Ethics of research Cost-Effectiveness

7 Introduction Sharing of Technology isnt as simple as merely transplanting Technology from place to place Technology is a system- many components required to make it work, resources vary from country to country Technology needs support of human beings who understand its workings; may vary from country to country

8 Diffusion is historically slow…. 1497: Vasco Da Gama lost 100 out of 160 crew members to scurvy sailing around Cape of Good Hope 1601: British Navy Captain James Lancaster was in command of 4 ships traveling from England to India Required sailors to take 3 tsp of lemon juice daily on 1 ship The other 3 ships served as the control Results: 110/278 sailors died in control group 0 deaths in the experimental group 1747: British Navy Physician James Lind repeated study with similar results 1865: British Navy finally adopted innovation, 264 years after first recorded evidence Berwick, Donald M., Disseminating Innovations in Health Care. JAMA April 16, 2003 – Vol 289, No. 15

9 Characteristics of people who adopt change Innovators Mavericks, willing to leave the village, weird, incautious, socially disconnected, risk takers Early Adopters Well connected, social opinion leaders, watched by communities Early Majority Local in perspective, follow the lead of the early adopters Late Majority Watch for local proof Laggards Traditional, prefer the tried and true, archivists Berwick, Donald M., Disseminating Innovations in Health Care. JAMA April 16, 2003 – Vol 289, No. 15 Tipping Point – often between 15% - 20% adoption; spread becomes difficult to stop.

10 A Case Study Cholecystectomy: Removal of the Gall Bladder

11 The Gall Bladder iary%20anatomy%20- %20hsk.jpg

12 The Gall Bladder Function: Stores bile made by liver After eating: Gall bladder contracts Secretes bile into duct which empties into small intestine Aids in digestion Gallstones: Liquid bile may precipitate into solid stones Common: 1/5 of North Americans and ¼ Europeans develop gallstones at some point

13 Gallstones Symptoms If gallstones block outflow of bile: Abdominal discomfort Pain Heartburn Indigestion Acute inflammation

14 Treatment of Gallstones Before 1990: Open surgery to remove the gall bladder Effective Low mortality rate ( %) 7 day hospital stay 30 days lost time from work Most common non-obstetric surgical procedure in many countries

15 A Case Study: Laparoscopic Cholecystectomy Most significant major surgical advance of the 1980s Allows shorter hospitalization Rapid recovery Early return to work Significant financial savings Forerunner of new era of minimally invasive surgery

16 Laparoscopic Removal of Gall Bladder Patient receives general anesthesia Small incision is made at navel and thin tube carrying video camera is inserted Surgeon inflates abdomen with carbon dioxide Two needle-like instruments inserted; serve as tiny hands. Pick up gallbladder & move intestines around. Several instruments inserted to clip gallbladder artery & bile duct, to safely dissect & remove gallbladder & stones Gallbladder is teased out of tiny navel incision. Entire procedure normally takes 30 to 60 minutes. Three puncture wounds require no stitches; may leave very slight blemishes. Navel incision is barely visible

17 Laparoscopic Cholecystectomy html html

18 Advantages/Disadvantages Benefits: Ease of recovery No incision pain as occurs with standard abdominal surgery Up to 90% of patients go home the same day Within several days, normal activities can be resumed No scar on the abdomen Complications: Complication rate is about the same for this procedure as for standard gallbladder surgery: Nausea and vomiting may occur after the surgery Injury to the bile ducts, blood vessels, or intestine can occur, requiring corrective surgery 5 to 10% of cases, the gallbladder cannot be safely removed by laparoscopy. Standard open abdominal surgery is then immediately performed.

19 Did this technology diffuse slowly or rapidly?

20 An Important Innovator Kurt Semm ( ) Gynecologist 80 medical device inventions Electronic insufflator Thermocoagulation Loop ligator Laparoscopic suturing Brother and father owned a medical instrument company which rapidly produced instruments for him Allowed more complex procedures to be performed endoscopically Gynecology General surgery

21 Laparoscopic Appendectomy 1985: Semms techniques used to perform the worlds first laparoscopic appendectomy Said to reduce problem of adhesions formed during opens surgeries

22 Public Response Hes gone absolutely crazy. Was asked to undergo a brain scan by his colleagues Lectures were initially greeted with laughter and derision Technique was initially viewed as too expensive and too dangerous Semm exaggerated problems of adhesions Surgeons saw no reason to change a well established working method into a complex technical manner

23 Public Response Semm: Both surgeons and gynecologists were angry with me. All my initial attempts to publish on laparoscopic appendectomy were refused with the comment that such nonsense does not and will never belong to general surgery. Gynecologists have surgeon envy Semm is trying to enter into general surgery to bolster his operation ego

24 Did this technology diffuse slowly or rapidly?

25 Diffusion of Lap Choly cponline.org/j ournals/ecp/ marapr99/diff us.pdf

26 Diffusion of Lap Choly line.org/journals/e cp/marapr99/diffu s.pdf

27 Diffusion No technique in modern times has become so popular as rapidly as laparoscopic cholecystectomy Semm Displayed an ability to push his ideas through despite skepticism and suspicion Without Semm, the laparoscopic revolution may have been postponed by many years

28 Diffusion of Lap Choly Diffusion of laparoscopic cholecystectomy in health care is unprecedented Since its introduction in 1989: the laparoscopic procedure has rapidly become the most widely used treatment for gallstone disease By 1992: laparoscopic cholecystectomy accounted for 50% of all cholecystectomies in Medicare populations 75% to 80% of all cholecystectomies in younger populations Increased overall rate of cholecystectomy

29 Take Home Messages In most settings: Rate of cholecystectomy increased dramatically after introduction of the laparoscopic procedure Financial incentives for physicians and hospitals to use the procedure influenced the rate of diffusion Introduction of laparoscopic cholecystectomy: Associated with a 22% decrease in the operative mortality rate for cholecystectomy

30 Using Gold to Detect Cancer NormalAbnormal How long do you think it will be before we can test this in patients?

31 Using Gold to Feel Better offbeat.blue.candidate/ offbeat.blue.candidate/ How long do you think it will be before we can test this in patients? ndom/stanjones.jpg

32 International Diffusion of Technology Myth Technology is largely result of ones own people --> Technological Nativism No Technologically dynamic nation is autonomous from Technologies of other nations 1500's China produced most Technology 's Europe leads world in Technological advances Many of these Technologies were the continuation of earlier advances in technology from China and elsewhere

33 U.S.: Diffusion of Technology United States heavily dependent on Technologies of other countries since its inception Even advances that originated in U.S. are often owed to immigrants Bakelite- (Leo Baekeland- Belgium) BakeliteLeo Baekeland Television Camera- (Vladimir Zworykin- Russia)Vladimir Zworykin

34 "A country (or an individual firm) that draws on technologies developed elsewhere is spared the expense of reinventing the wheel. But making effective use of imported technologies even if only direct copying is required often requires a stock of indigenous skill that cannot always be easily found."

35 Sharing of Technology Technologies shared between countries can be used for very different purposes China Gun Powder used medicinally for centuries passed on to EuropeGun Powder Europe within short time using it for cannons and firearms

36 Technology Transfer When Technology is transferred from one country to another, modifications are most likely required for Technology to work; Thus it isnt the exact same Technology Japan and Steel Production Japanese tried to apply Dutch steel production but had to make many modifications. The special characteristics of Japanese coal and iron ore required special modifications

37 Rate of Technology Usage Equal use of Technologies can have devastating impact U.S. (pop. 290 million)-- one car/ 1.5 people China (pop. 1.5 billion)-- one car/ 500 people

38 Technology brings economic empowerment? Not all countries have equal resources (human and material) Even if Technologies can be transferred the results are not always desirable Pakistan introduction of tractor replaces worker 40% unemployment rate Workers migrate to cities dire poverty results per acre crop yields hardly increased at all.

39 Lab to Diffusion It often takes a long time for Technology to move from lab. Feasibility to commercial value: Freon refrigerants 1 year Freon zipper 27 years zipper Fluorescent lamp--79 years Fluorescent lamp

40 Summary: The Not Invented Here (NIH) Syndrome Risky nature of Technological innovation blocks the diffusion of new Technologies "The status quo is a hell of a lot easier than making changes." Henry Ford

41 Summary: Factors Relative advantages over existing Technology Compatibility w/ existing values of country Ease/difficulty of understanding and applying new Technology Ease of experimentation with new Technology Extent to which positive results appear People with knowledge of Technology are KEY to diffusion of Technology

42 Read and Reflect …Experts are in a position to influence the course of technological change, but at the same time, they face many difficulties in converting their knowledge into power. Having the correct technical answers isnt enough; wielding power requires the mobilization of a constituency and the ability to create a broad base of support."


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