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Published byAntoine Ogles
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RECURRENT PREGNANCY LOSS
1. Anatomic 2. Infectious 3. Endocrine 4. Immunologic 5. Genetic 6. Male factor 7. Environment al _________
Congenital Uterine Septum T-Shaped Uterus - DES ? Cervical Incompetence Acquired Fibroid Synechiae Polyps Deformities/Cervical Incompetence _________
Systemic Infections Endometritis Cervicitis Bacterial Vaginosis _________
Ovulatory Defects Luteal Phase Defects Thyroid Dysfunction Diabetes/Insulin Resistance _________
Balanced Translocations Random Chromosomal Abnormalities Thrombophilias Various Other Genetic Derangements _________
Autoimmune Phospholipid Antibodies Lupus Anticoagulant Thyroid Antibodies Other Autoimmune Antibodies Alloimmune Host Response Antibodies Others _________
DNA fragmentation Aneuploidy Specific gene abnormalities
Chemical Thermal Radiation Traumatic Infectious Other _________
Examination Ultrasound Hysterosalpingogram Sonohysterogram Hysteroscopy Other Imagining Modalities _________
Cultures – Cervical – Other Blood Tests – Hepatitis A, B, C, ?? – Toxoplasmosis – STS – Rubella – CMV – Chlamydial Antibodies Endometrial Biopsy _________
Follicle Development US/Estradiol Luteal Phase Progesterone/Endometrial Biopsy Thyroid TSH (T 3, T 4 ) Thyroid Antibodies (http://www.medscape.com/viewarticle/747914?src= mp&spon=16)http://www.medscape.com/viewarticle/747914?src= mp&spon=16) Other _________
aPTT Lupus Anticoagulant Phospholipid Antibody Panel See next slide ± Thyroid Antibodies ±EmbryoToxic Antibodies ± Natural Killer Cells _________
1. Phospholipid isotypes of: -aCA, aPI, aPS, aPE, aPC 2. Lupus anti-coagulant 3. Anti-Beta-2-Glycoprotein 1 antibodies
History Tissue Culture (POC) Other Genetic Markers (thrombophilias) See next slide Sperm DNA Fragmentation Assay Karyotyping of Husband and Wife CVS Amniocentesis _________
Anti-Thrombin III APTT Factor V Leiden MTHFR PAI-I Protein C Protein S Prothrombin
The Diagnostic Evaluation and Treatment of Recurrent Pregnancy Loss Ashim Kumar, M.D. Reproductive Endocrinology and Infertility Clinical Assistant Professor,
RECURRENT PREGNANCY LOSS Rukset Attar, MD, PhD Obstetrics and Gynecology Department.
Early Fetal Wastage “ Miscarriage” Professor Hassan Nasrat.
Max Brinsmead MB BS PhD May A summary of... RCOG Green-top Guideline number 17 April 2011 “The Investigation and Treatment of Couples with Recurrent.
Bleeding causes in the first trimester pregnancy Threatened abortion Ectopic pregnancy Cervical polyps Hydatidiform mole Cervicitis.
RECURRENT MISCARRIAGE GUIDELINES RECURRENT MISCARRIAGE GUIDELINES MAJ DR AMINA AKBAR MBBS, MCPS, FCPS.
FERTILITY TESTING Sana Javed Amnah Mahroo Sidrah Naseem Fatima Darakhshan Tehreem Tanveer Misha Mazhar.
RECURRENT PREGNANCY LOSS. INTRODUCTION Emotionally traumatic, similar to stillbirth or neonatal death Etiology is often unknown Primary or secondary.
ABORTIONS. Definition Termination of pregnancy before the period of viability.
RECURRENT MISCARRIAGE & SEPTIC ABORTION DR. ROBINA TARIQ Associate PROF. OBS / GYNAE SERVICES INSTITUTE OF MEDICAL SCIENCES /
RECURRENT AND MID- TRIMESTER PREGNANCY LOSS David L. Berry, M.D. Austin Perinatal Associates Seton Medical Center OB Grand Rounds September 19, 2011.
Miscarriage ( abortion Early pregnancy loss Dr. R. EL-Gantri Associated Professor Obst. & Gyne. Department.
Second trimester pregnancy loss Tehran university of medical sciences
Dr.Suresh Babu Chaduvula Professor Dept. of OBGyn, College of Medicine, KKU, Abha, KSA.
Recurrent Miscarriage, Investigation and Treatment of Couples Dr Chro Najmaddin Fattah MBChB, DGO, MRCOG, MRCPI, MD.
Bleeding in early pregnancy Dr. Abdalla H. Alsadig MD.
RECURRENT MISCARRIAGE Dr.F Mardanian MD. CASE CASE 35 Y G5L1Ab4 G1=L1 G2=16weeks G3=8weeks G4=12weeks G5=16weeks BW=105kg 35 Y G5L1Ab4 G1=L1 G2=16weeks.
CONGENITAL ANOMALIES (Birth defects). A congenital anomaly is a structural abnormality of any type that is present at birth. A congenital anomaly is a.
Thrombophilia Barry White National Haemophilia Director Director, National Centre for Hereditary Coagulation Disorders, St James’s Hospital.
Hypercoagulable States. Acquired versus inherited Acquired versus inherited “Provoked” vs idiopathic VTE “Provoked” vs idiopathic VTE Who should be tested.
Dr Uma.T Department of Obstetrics and Gynecology SAT Hospital,Government Medical College Trivandrum.
Thrombophilia. Definition –Tendency to develop clots due to predisposing factors that may be genetically determined.
definition A process of expulsion or extraction of embryo / fetus from womb before it reaches to viability period (or less than 500gm in weight), is called.
DR MANAL IDRIS menorrhagia. Introduction Menorrhagia is one of the commenest gynaecological complaints seen in practice and accounts for approximately.
Early pregnancy problems Dr. Mohamed Khalil MD, MRCOG. Diploma in Fetal Medicine RCOG/RCR Consultant Obst & Gyn Security Forces Hospital.
Genetics and Infertility By Salwa Hassan Teama M.D. N.C.I.Cairo University, Egypt.
INFERTILITY *Infertility affects 15% of reproductive age couples. *Infertility is defined as a couple’s failure to conceive following 1 year of unprotected.
Dr. HANA OMER Abnormal Uterine Bleeding (AUB) 2014.
Lesson 2. Review of the Female reproductive system.
Abnormal uterine bleeding King Khalid University Hospital Department of Obstetrics & Gynecology Course 481 Tutorials.
Congenital Heart Disease Child Heart Center Delhi
Abortion (miscarriage) طیبه غریبی عضو هیئت علمی دانشکده پرستاری و مامایی.
SPONTANEOUS ABORTION ASSOCIATE PROFESSOR IOLANDA BLIDARU MD, PhD.
Abortion (miscarriage) Dongzi Yang 杨冬梓 The Second Affiliated Hospital Sun Yat-Sen University.
Infertility Clare Blake N.D. Fertility Massage Therapy & Training.
GENETIC DISEASES. Define disease abnormal condition affecting the body of an organism – may be caused by external factors or it may be caused by internal.
Infertility. Fertility Sub fertility Sterility Infertility:Diminished capacity to conceive and bear a child Sterility:Absolute and irreversible inability.
INFERTILITY. DEFINITION of Infertility What is Infertility? Infertility is defined two years of unprotected intercourse without pregnancy. (WHO, one year)
Dr. Shiuli Mukherjee MD, Fellow in Reproductive Medicine Institute of Reproductive Medicine, Kolkata, India.
CASE #2 32 year old woman who has had one first trimester pregnancy loss presents with secondary infertility of three years duration. She has periods every.
Pregnancy Wastage l Human reproduction is an inefficient enterprise l Incidence of abortions: 15-20% of clinical pregnancies 50-75% of conceptions.
The Challenge of the Miracle of Life - Infertility Jennifer McDonald DO.
Male & Female Investigations Workup Routine / Prior to IVF.
15 Chapter Health and Wellness How Genes Affect Health.
Exams and tests for vaginal bleeding. 1.Your health care provider will take a careful medical history. You will be asked questions about the following.
Defined as proliferation and degeneration of the chorion A benign neoplasm of the chorion The embryo fails to develop in most cases Occurs in.
The Immune System and Endocrine Disorders Immunology Unit College of Medicine King Saud University.
RECURRENT PREGNANCY LOSS (RPL) AND ITS RELATION TO COMBINED PARENTAL THROMBOPHILIC GENE MUTATIONS DOÇ. DR. A. GONCA İ M İ R YEN İ CESU CUMHUR İ YET ÜN.
Lecture Outline 1.Normal menstrual cycle 2.Amenorrhea 3.Dysfunctional uterine bleeding (DUB)
Thrombophilic states. Thrombophilic state is characterized by a shift in the coagulation balance in favour of hypercoagulability – i.e. easier and oftener.
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