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Navigating the NIH Funding Process Barbara Gerratana, Ph.D. National Institute of General Medical Sciences Division of Pharmacology, Physiology & Biological.

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Presentation on theme: "Navigating the NIH Funding Process Barbara Gerratana, Ph.D. National Institute of General Medical Sciences Division of Pharmacology, Physiology & Biological."— Presentation transcript:

1 Navigating the NIH Funding Process Barbara Gerratana, Ph.D. National Institute of General Medical Sciences Division of Pharmacology, Physiology & Biological Chemistry

2 Outline 2 Some resources The funding cycle NIGMS funding opportunity Diversity funding opportunities

3 NIH Mission & Budget 3. NIH is the steward of medical and behavioral research for the Nation. Its mission is science in pursuit of fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to extend healthy life and reduce the burdens of illness and disability. $29.1 Billion Fiscal Year 2013 Annual Budget 1.7 Billion less than FY2012 Intramural Research R&D Contracts Research Centers Other Research Grants All Other Training Mgmt & Support 3% 5% 6% Research Project Grants (RPG) 53% 10% 11% 10% NIH organization

4 27 Institutes & Centers 4 Office of the Director National Library of Medicine National Library of Medicine Center for Information Technology Center for Information Technology Center for Scientific Review Center for Scientific Review Fogarty International Center Fogarty International Center National Institute of Arthritis and Musculoskeletal and Skin Diseases National Institute of Arthritis and Musculoskeletal and Skin Diseases National Institute of Diabetes and Digestive and Kidney Diseases National Institute of Diabetes and Digestive and Kidney Diseases National Institute of Dental and Craniofacial Research National Institute of Dental and Craniofacial Research National Institute on Deafness and Other Communication Disorders National Institute on Deafness and Other Communication Disorders National Eye Institute National Eye Institute National Heart, Lung, and Blood Institute National Heart, Lung, and Blood Institute National Institute on Alcohol Abuse and Alcoholism National Institute on Alcohol Abuse and Alcoholism National Cancer Institute National Cancer Institute National Institute of Environmental Health Sciences National Institute of Environmental Health Sciences National Institute of Mental Health National Institute of Mental Health National Institute of Neurological Disorders and Stroke National Institute of Neurological Disorders and Stroke National Institute of Allergy and Infectious Diseases National Institute of Allergy and Infectious Diseases National Center on Minority Health and Health Disparities National Center on Minority Health and Health Disparities National Institute on Aging National Institute on Aging National Institute of Child Health and Human Development National Institute of Child Health and Human Development National Human Genome Research Institute National Human Genome Research Institute National Institute of General Medical Sciences National Institute of General Medical Sciences National Institute of Nursing Research National Institute of Nursing Research National Center for Complementary and Alternative Medicine National Center for Complementary and Alternative Medicine National Center for Research Resources National Center for Research Resources Clinical Center Clinical Center National Institute of Biomedical Imaging and Bioengineering National Institute of Biomedical Imaging and Bioengineering no funding authority National Institute on Drug Abuse National Institute on Drug Abuse National Center for Advancing Translational Sciences National Center for Advancing Translational Sciences NIH organization

5 NIGMS Mission 5 The general purpose of the National Institute of General Medical Sciences is the conduct and support of research, training, and as appropriate, health information dissemination, and other programs with respect to general or basic medical sciences and related natural or behavioral sciences which have significance for two or more national research institutes or are outside the general area of responsibility of any other national research institute. 5 Divisions: Biomedical Technology, Bioinformatics, and Computational Biology Cell Biology and Biophysics Training, Workforce Development, and Diversity Genetics and Developmental Biology Pharmacology, Physiology, and Biological Chemistry NIH organization

6 NIH Institute Funding 6 Buildings & Facilities 1,059 1,039 Drug Abuse Aging ,245 1,435 1,532 4,231 4,779 2,901 1,693 2,291 $0$1,000$2,000$3,000$4,000$5,000 Fogarty International Comp. Med. Nursing Minority Health Bio Imaging Library Dental Deafness Alcohol Abuse Genome Arthritis Environmental Health Eye Child Health Mental Health Neurology Diabetes, Kidney General Medical Sciences Heart, Lung, Blood Allergy, Infectious Cancer $29.1 Billion Fiscal Year 2013 Office of the Director 1,394 NCATS 542 (Dollars in millions) NIH organization

7 Outline 7 Some resources The funding cycle NIGMS Funding opportunity Diversity funding opportunities

8 NIGMS Feedback Loop 8 Get NIGMS news as it happens! Regular updates on funding opportunities Post your comments Ask questions Sign up for updates or RSS feed Get NIGMS news as it happens! Regular updates on funding opportunities Post your comments Ask questions Sign up for updates or RSS feed Application resources August 5 th, 2013

9 RePORTER projectreporter.nih.gov 9 Application resources

10 NIH Grant Writing Resources 10 Application resources grants.nih.gov/grants/grant_tips.htm NIH Central Resource Site New Investigators NIGMS NCI deainfo.nci.nih.gov/extra/extdocs/gntapp.pdf NIAID* funding.niaid.nih.gov/researchfunding/grant/pages/aag.aspx NINDS

11 Grant Writers Handbook 11 Application resources HHMI Making the Right Moves Writing the NIH Grant Proposal: A Step-by Step Guide by William Gerin Grant Application Writers Handbook by Liane Reif-Lehrer Guide to Effective Grant Writing: How to Write a Successful NIH Grant Application Successful NIH Grant Application by Otto O. Yang How to Succeed in Academics by Edward R. B. McCabe and Linda McCabe The Grant Application Writers Workbook available at GrantCentral.com

12 NIGMS Mentoring Workshop for New Bio/Chemistry Faculty Since Application resources Mentoring is more than teaching someone to be just like you! Help PIs to convey significance/impact of proposed research Provide advice on key non-technical career skills Stress the value of mentoring and being mentoring Introduce junior faculty to NIH procedures and NIH staff Promote networking among young scientists and with senior role models 30 Junior faculty participants in organic chemistry and chemical biology 6-8 Senior faculty mentors plus NIH staff 3 Days of discussions, presentations, and networking Help PIs to convey significance/impact of proposed research Provide advice on key non-technical career skills Stress the value of mentoring and being mentoring Introduce junior faculty to NIH procedures and NIH staff Promote networking among young scientists and with senior role models 30 Junior faculty participants in organic chemistry and chemical biology 6-8 Senior faculty mentors plus NIH staff 3 Days of discussions, presentations, and networking 2013 Mentors Phil Cole (The Johns Hopkins), Jon Ellman (Yale), Barbara Imperiali (MIT), Jeff Johnson (University of North Carolina), Hening Lin (Cornell University), and Lisa McElwee-White (University of Florida). Next workshop 06/30-07/02/2013!

13 Outline 13 Outline

14 Funding Opportunity Announcements (FOAs) 14 Parent Announcements or Unsolicited Applications Investigator initiated applications Investigator initiated applications Fit of mission of one of the NIH institutes Fit of mission of one of the NIH institutes Mechanism of the grant should be supported by the Institute of programmatic relevance Mechanism of the grant should be supported by the Institute of programmatic relevance Funding cycle

15 RFA vs PA 15 Funding cycle AnnouncementsFocusSet-aside funds Special review criteria and panel Length of announcement Receipt dates RFANarrowly definedYES n/aOne date PARSpecific scientific area but broadly defined Usually not YES3 yearsUsually standard dates PASSpecific scientific area but broadly defined YESDepends3 yearsUsually standard dates RFA = request for Applications PA = program announcement PAR = program announcement reviewed in an Institute PAS = program announcement with set-aside funds

16 Most Common Grant Mechanisms 16 Funding cycle MechanismTo supportLengthBudgetCommon goalsReceipt dates R01:Research project single Pi or multi-PIs grants/funding/ac_se arch_results.htm Discrete and specified research project in area of expertise Up to 5 years $250,000 DC/year but it can be higher New: Feb 5, June 5 and October 5 Renewal: March 5, July 5 and Nov. 5 R21:Exploratory/devel opmental grants grants/funding/r21.ht m Development of a new research activities Up to 2 years $ DC for 2 years Exploratory, novel studies High risk high reward studies Projects should be distinct from those supported through the traditional R01 mechanism New: Feb 16, June 16 and October 16 Renewal: March 16, July 16 and Nov. 16 R03:Small research grants grants/funding/r03.ht m Short-term projects with amount Up to 2 years $50,000 DC/year Pilot or feasibility studies Secondary analysis of existing data Small, self-contained research projects Development of research methodology Development of new research technology New: Feb 16, June 16 and October 16 Renewal: March 16, July 16 and Nov. 16 R15:Academic research enhancement awards (AREA) grants/funding/area.h tm Small research scale projects at educational institutions that have not been major recipients of NIH support. Up to 3 years $300,000 DC for 3 years Support meritorious research Expose students to research Strengthen the research environment of the institution New and renewal: Feb 25, June 25 and October 25 DP2 New Innovator awards h.gov/newinnovator/ highly innovative research projects by new investigators Up to 5 years $300,000 DC/year Individual early stage investigators of exceptional creativity proposing research of uncommonly high potential impact Not announced yet for 2014 usually end of Summer or beginning of Fall

17 Funding Cycle 17 Applicant Initiates Research Idea University Submits Electronically the Application Assign to Institute and Study Section Peer Review Leaders in the biological and medical sciences, education, health care, and public affairs. Advisory Council of the Assigned Institute Allocation of Funds Review of Scientific Merit Second Review Conducts Research Institute Program staff 1 st NIH Study Section 1946 Funding Decision Funding Cycle

18 Cover Letter & Referral 18 Funding Cycle Assign to Institute and Study Section The cover letter is important to: Suggest institute assignment Suggest study section assignment Identify individuals in conflict Identify areas of expertise needed to evaluate the application The cover letter is NOT appropriate to suggest specific reviewers! Is it possible to change the IC and/or study section assignment(s)? Is it possible to change the IC and/or study section assignment(s)? YES When? BEFORE the review of the application (after it is almost impossible) How? Contact the assigned SRO and PO and provide in writing a justification for the desired change If my application has a secondary Institute assignment, does the 2ary Institute consider automatically my application if the 1ary Institute does not fund it? NO Only if the Program Officer of the 2ary Institute has interest in your application it may be considered. This is an extremely rare case and usually applications are transferred before review.

19 Study Section and Institute, which one? 19 Funding Cycle Colleagues, Reporter and web sites of ICs are the first source of information. Program director for confirmation. STUDY SECTION Standing Study Sections review most investigator-initiated research applications (R01, R03, R21, R15, and Ks). Standing study sections are those with both permanent members and temporary members, and are organized by CSR. Special Emphasis Panels one-time or recurring Special Emphasis Panels (SEPs) are held to review applications on special topics and members conflict applications. They include only temporary members. P01, SBIR/STRR…. review by SEPs. SEPs can be organized by CSR or by the review office of an institute. 24 INSTITUTES/CENTERS with funding authority Not all ICs participate in all mechanisms. For example/ NIGMS does not support investigated initiated R21 and R03. Not all ICs participate in all RFA, PAR and PAS. A standing study section reviews applications assigned to a variety of ICs

20 20 Funding Opportunity Announcement (FOA) Funding Cycle

21 Submission 21 Funding Cycle Applicant Initiates Research Idea University Submits Application Electronic Submission NIH Conducts Research February 5 June 5 October 5 New Research Grants (R type) January 25 May 25 September 25 All Program Project and Center Grants February 12 June 12 October 12 New Career Development Awards (K type) March 5 July 5 November 5 Research Grant Renewal, Resubmission, and Revision Applications

22 Due Dates for R01 22 Only ONE resubmission allowed! Do not waste it by rushing! NIH allows a shorten review cycle for New Investigator R01 Applications:shorten review cycle SubmissionReviewCouncilFunding A0June 5 th OctoberJanuaryApril ? Normal A1March 5 th JuneOctober?????? Shorten A1December 10 th FebruaryMayJuly? NOT RECOMMENDED You have 37 months from the A0 application date to resubmit. Any applications submitted after the 37 month will be considered a new application. Funding Cycle

23 23 Applicant Initiates Research Idea University Submits Electronically the Application Assign to Institute and Study Section Peer Review Leaders in the biological and medical sciences, education, health care, and public affairs. Advisory Council of the Assigned Institute Allocation of Funds Review of Scientific Merit Second Review Conducts Research Institute Program staff 1 st NIH Study Section 1946 Funding Decision Funding Cycle

24 Criteria Selection for Review Panel Memberships 24 Funding Cycle Mandatory criteria: Scientific expertise is the most important criterium and it depends on the science covered by the pool of applications considered in a specific round of review Geographical distribution: 25% of Central, South, East, West Gender and minorities representation: at least 10% for each Limits in # of reviewers from: No 2 people from the same Department For each 10 reviewers 2 can be from the same University (up to 3 for 30 reviewers subjected to higher level approval) Optional criteria: age distribution one Assistant Professor SEP specific criterium: the making of the panel will reflect the community – SBIR will have industry people; R15 will have reviewers from qualifying institutions….

25 Early Career Reviewer (ECR) Program 25 Funding Cycle ECR program was developed to: train qualified scientists without prior CSR review experience so that they may become effective reviewers, help emerging researchers advance their careers by exposing them to peer review, and enrich the existing pool of NIH reviewers by including scientists from less research-intensive institutions as well as those from traditionally research- intensive institutions Eligibility for the ECR program includes: Full-time faculty members or researchers in similar roles. Evidence of an active independent program of research Recent publications in peer-reviewed research journals Has not served on a CSR study section in a role other than a mail reviewer Prior NIH funding is NOT a requirement How to apply: First, send your CV and contact the SRO of the study section of interest Then, follow the official procedure described at What will you do: receive training from SRO on review procedures and how to write critiques you will have a lighter workload (2-4 applications) Attend panel and participate in discussion and voting

26 Review Process of a Standing Study Section 26 Funding Cycle SRO assigns your application to 3 primary reviewers Reviewers submit preliminary criterion scores (from 1 exceptional to 9 poor) with comments for Significance, Investigator(s), Innovation, Approach and Environment SRO determines Review Order SRO assigns your application to 3 primary reviewers Reviewers submit preliminary criterion scores (from 1 exceptional to 9 poor) with comments for Significance, Investigator(s), Innovation, Approach and Environment SRO determines Review Order Persons with conflicts of interest excused Primary reviewers (3) give preliminary scores (1-9) Discussion of applications scientific and technical merit Other panel members join discussion Primary reviewers give final scores (1-9) All panel members (except those in conflict) score privately Assignment of codes for animals and human subjects protection Budget recommendations. Best scoring application first New investigators (best-to-worst) are reviewed separately from others Everyone else (best-to-worst) About 50% applications will be discussed, remainder unscored (ND, not discussed) Mock study section videoMock study section video: About 50% applications will be discussed, remainder unscored (ND, not discussed) Mock study section videoMock study section video:

27 Feedback from Review 27 Funding Cycle Priority Score & Percentile Priority Score & Percentile eRA Commons 1-4 days after meeting Impact/Priority score is average reviewer score (1-9) times ten (10-90) Percentile: relative ranking of application with last 3 meetings of study panel Not all applications get percentiled (e.g. R15, for GM F32s and K99s are not percentiled) Summary Statement Summary Statement eRA Commons SRO prepares and releases 10 (New PIs) – 30 (all others) days after meeting for R01s Summary of discussion written by SRO Criteria scores from assigned reviewers Critiques from assigned reviewers Budget recommendations Administrative notes Codes for Animal Vertebrates and Human Subjects Assigned Program Officer Assigned Program Officer Typically present at review meeting Interpret comments Advice on resubmission Final scores of primary reviewers are NOT an average of the criteria scores!

28 Funding Cycle 28 Applicant Initiates Research Idea University Submits Electronically the Application Assign to Institute and Study Section Peer Review Leaders in the biological and medical sciences, education, health care, and public affairs. Advisory Council of the Assigned Institute Allocation of Funds Review of Scientific Merit Second Review Conducts Research Institute Program staff 1 st NIH Study Section 1946 Funding Decision Funding Cycle

29 Second Level of Review: Advisory Council 29 Funding Cycle Provides oversight to insure initial review was fair and in compliance with NIH policy Most applications are voted en bloc by Council Council usually discuss specific applications if there are appeal, program projects, Merit award,. etc. Council does not make funding decisions

30 Funding Cycle 30 Applicant Initiates Research Idea University Submits Electronically the Application Assign to Institute and Study Section Peer Review Leaders in the biological and medical sciences, education, health care, and public affairs. Advisory Council of the Assigned Institute Allocation of Funds Review of Scientific Merit Second Review Conducts Research Institute Program staff 1 st NIH Study Section 1946 Funding Decision Funding Cycle

31 Funding Decision by IC Program Staff 31 Funding Cycle Applications are ranked based on Priority Score (Fs, Ks) or Percentile ranking (R01s) Paylines are decided based on availability of funds Paylines vary from different types of grants Paylines may be more liberal for New (or ESI) investigators Unofficial but updated and comprehensive source of paylines of all ICs: Institutes with set paylines (NIAID, NCI*..) Unofficial but updated and comprehensive source of paylines of all ICs: Institutes with set paylines (NIAID, NCI*..) Institutes without set paylines: NIGMS exampleNIGMS example Institutes without set paylines: NIGMS exampleNIGMS example Applications are ranked based on Priority Score (Fs, Ks) or Percentile ranking (R01s) Top-scoring applications are given the highest priority for funding A grey area of applications is identified based on available funds just after the top scoring applications. Not all the applications in the grey area will be funded. Applications in the grey area are ranked for funding consideration based on: Percentile, Programmatic needs, Other support of applicant, ESI or New investigator, If council has recommendations

32 When and Who to Contact 32 Funding Cycle WHENWHO Before and as you prepare your applicationMentors/colleagues Institute Program Officer When you register for eRA CommonseRA Commons Help Desk SubmissionGrants.gov Help Desk Receipt & ReferralScientific Review Offcier (SRO) and Program Officer Before Review SRO After and about the reviewProgram Officer Funding decisionProgram Officer AwardProgram Officer and Grants Management Specialist

33 Resubmission 33 Funding Cycle Only ONE resubmission allowed! Do not waste it by rushing! NIH allows a shorten review cycle for New Investigator R01 Applications:shorten review cycle SubmissionReviewCouncil A0June 5 th OctoberJanuary Normal A1March 5 th JuneOctober Shorten A1December 10 th FebruaryMay NOT RECOMMENDED You have 37 months from the A0 application date to resubmit. Any applications submitted after the 37 month will be considered a new application.

34 Outline 34 Outline

35 NIGMS Collaborative Supplement NIGMS Funding opportunity Main eligibility criteria: New collaborations i.e. no publications or collaboration in the last 3 years and no mention in the parent grant Collaborative research should be within the scope of the grant All members should have financial support (not necessarily NIH support other is fine) Collaborators may be foreign PIs funded by an NIGMS R01, R37 or SC1 grant with at least 18 months of active funding on the parent grant at the time of the receipt date deadline are eligible to apply Main facts: Deadlines January 15 th and May15th $90,000 direct cost/year up to 3 years for the PI and one collaborating group. An additional $45,000 direct cost/year up to 3 years for a second collaborating group No $ for PI salary Proposed work could not have been foreseen/planned at the time of the parent grant application Strong rational for collaboration Intellectual involvement of all the PIs Reviewed internally by NIGMS committee Main eligibility criteria: New collaborations i.e. no publications or collaboration in the last 3 years and no mention in the parent grant Collaborative research should be within the scope of the grant All members should have financial support (not necessarily NIH support other is fine) Collaborators may be foreign PIs funded by an NIGMS R01, R37 or SC1 grant with at least 18 months of active funding on the parent grant at the time of the receipt date deadline are eligible to apply Main facts: Deadlines January 15 th and May15th $90,000 direct cost/year up to 3 years for the PI and one collaborating group. An additional $45,000 direct cost/year up to 3 years for a second collaborating group No $ for PI salary Proposed work could not have been foreseen/planned at the time of the parent grant application Strong rational for collaboration Intellectual involvement of all the PIs Reviewed internally by NIGMS committee

36 NIGMS RFAs gov/funding/funding.asp? tab=All ants/oer.htm gov/funding/funding.asp? tab=All ants/oer.htm 36 NIGMS Funding opportunity

37 Outline 37 Outline Some info on preparing an application The funding cycle NIGMS funding opportunity Diversity funding opportunities

38 NIGMS Diversity Supplement html html 38 Diversity funding opportunity To support an US citizen on a grant at the high school, undergraduate, post-baccalaureate, graduate student or postdoctoral fellow levels. Main eligibility criteria and philosophy: There should be at least 2 years or more of support remaining at the time of the supplement on the parent grant Individuals (proposed for support) should not have been funded by the parent grant prior to the application To support individuals in early stages of their training (generally first 1 or 2 years) with the expectation that individuals will transition to traditional means of support Up to $75,000 direct cost/year No deadlines For additional information on diversity supplements, see the NIH Guide for Grants and Contracts, July 2, 2008 (PA ), or contact Dr. Marion Zatz at To support an US citizen on a grant at the high school, undergraduate, post-baccalaureate, graduate student or postdoctoral fellow levels. Main eligibility criteria and philosophy: There should be at least 2 years or more of support remaining at the time of the supplement on the parent grant Individuals (proposed for support) should not have been funded by the parent grant prior to the application To support individuals in early stages of their training (generally first 1 or 2 years) with the expectation that individuals will transition to traditional means of support Up to $75,000 direct cost/year No deadlines For additional information on diversity supplements, see the NIH Guide for Grants and Contracts, July 2, 2008 (PA ), or contact Dr. Marion Zatz at

39 Score Program 39 Diversity funding opportunity Three Score programs fund investigator initiated research applications fitting an IC mission: SC1 (Research Advancement Award) research support for research project in advanced stage planning to transition to non-Score support SC1 SC2 (Pilot Project Award) research support for early stages of development of a research plan. It allows to test new idea or gather preliminary data in a new line of research. SC2 SC3 (Research Continuance Award) research support for research project in an intermediate stage of development SC3 Institution eligibility 4-years colleges, MS or Ph.D. granting Universities serving underrepresented minority students Institutions receiving less than 6 million dollars from NIH R01 support in the last two fiscal years PI eligibility Full time regular faculty appointment Faculty with a track record of external support (other than MBRS) and publications are ineligible Faculty currently receiving other individual or institutional developmental research support are ineligible

40 Score Program 40 Diversity funding opportunity SC1 Research Advancement Award SC2 Pilot Project Award SC3 Research Continuance Award Programmatic Goal Foster the transition to major non-SCORE support Allows beginning PIs to generate preliminary data to establish a new line of research Allows PIs conduct projects of limited scope and publish Max Direct Costs (Modular Budgets) Up to $250K/yrUp to $100K/yr Not to exceed $300K for entire project period Up to $75K Not to exceed $300K for entire project period Duration New PIs, who have not had SCORE support- 5 years Previous SCORE PIs- 4 years Renewable once 3 years Not renewable 4 years Renewable Common Requirement PIs developmental objectives and plan to achieve them must be provided No MPI grant Other Requirements No other research supportPIs must have a mentor and a mentoring plan No other research support Other external research support of less than $75K is allowed NIGMS contact: Dr. Hinda Zlotnik, Tel ,

41 NIGMS: Investing in Discovery Barbara Gerratana


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