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4/2/2017 Navigating the NIH Funding Process Barbara Gerratana, Ph.D. National Institute of General Medical Sciences Division of Pharmacology, Physiology.

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Presentation on theme: "4/2/2017 Navigating the NIH Funding Process Barbara Gerratana, Ph.D. National Institute of General Medical Sciences Division of Pharmacology, Physiology."— Presentation transcript:

1 4/2/2017 Navigating the NIH Funding Process Barbara Gerratana, Ph.D. National Institute of General Medical Sciences Division of Pharmacology, Physiology & Biological Chemistry

2 Outline NIH organization Some resources The funding cycle
NIGMS funding opportunity Diversity funding opportunities Outline

3 NIH Mission & Budget Annual Budget $29.1 Billion
NIH is the steward of medical and behavioral research for the Nation. Its mission is science in pursuit of fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to extend healthy life and reduce the burdens of illness and disability. Intramural Research R&D Contracts Research Centers Other Research Grants All Other Training Mgmt & Support 3% 5% 6% Research Project Grants (RPG) 53% 10% 11% Annual Budget $29.1 Billion Fiscal Year 2013 1.7 Billion less than FY2012 NIH organization

4 Translational Sciences
4/2/2017 27 Institutes & Centers Office of the Director National Institute on Alcohol Abuse and Alcoholism National Institute on Drug Abuse National Institute on Aging National Institute of Arthritis and Musculoskeletal and Skin Diseases National Cancer Institute National Institute of Child Health and Human Development National Institute on Deafness and Other Communication Disorders National Institute of Dental and Craniofacial Research National Institute of Diabetes and Digestive and Kidney Diseases National Institute of Allergy and Infectious Diseases National Institute of Environmental Health Sciences National Eye Institute National Institute of General Medical Sciences National Heart, Lung, and Blood Institute National Human Genome Research Institute National Institute of Mental Health National Institute of Neurological Disorders and Stroke National Institute of Nursing Research National Center for Advancing Translational Sciences National Center for Research Resources NIH is large and complex. 24 Institutes and Centers (ICs) fund grants Each Institute has different mission, responsibilities, constituencies and mode of operandi ICs autonomous – policies and practices vary Center for Scientific Review (CSR) runs most peer review for ICs via study sections and special emphasis panels (SEPs) CSR (and thus study section) does not fund – ICs make funding decisions Congress mandated separation between review and management of grants. National Center for Complementary and Alternative Medicine Fogarty International Center National Library of Medicine National Institute of Biomedical Imaging and Bioengineering National Center on Minority Health and Health Disparities Clinical Center Center for Information Technology Center for Scientific Review no funding authority NIH organization

5 4/2/2017 NIGMS Mission The general purpose of the National Institute of General Medical Sciences is the conduct and support of research, training, and as appropriate, health information dissemination, and other programs with respect to general or basic medical sciences and related natural or behavioral sciences which have significance for two or more national research institutes or are outside the general area of responsibility of any other national research institute. 5 Divisions: Biomedical Technology, Bioinformatics, and Computational Biology Cell Biology and Biophysics Training, Workforce Development, and Diversity Genetics and Developmental Biology Pharmacology, Physiology, and Biological Chemistry NIH organization

6 NIH Institute Funding $29.1 Billion Fiscal Year 2013 4/2/2017 $0
Cancer 4,779 Allergy, Infectious 4,231 Heart, Lung, Blood 2,901 General Medical Sciences 2,291 Diabetes, Kidney 1,693 Neurology 1,532 Office of the Director 1,435 Mental Health 1,394 Child Health 1,245 Aging 1,039 Drug Abuse 1,059 Eye 662 Environmental Health 645 Fiscal Year 2013 NCATS 542 Arthritis 504 $29.1 Billion Genome 483 Alcohol Abuse 432 Deafness 392 Dental 387 Library 318 Bio Imaging 318 Minority Health 260 Nursing 136 Comp. Med. 120 Buildings & Facilities 118 Fogarty International 65 $0 $1,000 $2,000 $3,000 $4,000 $5,000 (Dollars in millions) NIH organization

7 Outline NIH organization Some resources The funding cycle
NIGMS Funding opportunity Diversity funding opportunities Outline

8 NIGMS Feedback Loop http://www.nigms.nih.gov/News/FeedbackLoop.htm
4/2/2017 NIGMS Feedback Loop August 5th, 2013 Get NIGMS news as it happens! Regular updates on funding opportunities Post your comments Ask questions Sign up for updates or RSS feed Application resources

9 RePORTER projectreporter.nih.gov
Application resources

10 NIH Grant Writing Resources
NIH Central Resource Site grants.nih.gov/grants/grant_tips.htm New Investigators NIGMS NCI deainfo.nci.nih.gov/extra/extdocs/gntapp.pdf NIAID* funding.niaid.nih.gov/researchfunding/grant/pages/aag.aspx NINDS Application resources

11 Grant Writer’s Handbook
“The Grant Application Writer’s Workbook” available at GrantCentral.com “Writing the NIH Grant Proposal: A Step-by Step Guide” by William Gerin “Grant Application Writers Handbook” by Liane Reif-Lehrer “Guide to Effective Grant Writing: How to Write a Successful NIH Grant Application” by Otto O. Yang “How to Succeed in Academics” by Edward R. B. McCabe and Linda McCabe HHMI “Making the Right Moves” Application resources

12 NIGMS Mentoring Workshop for New Bio/Chemistry Faculty Since 2005
Mentoring is more than teaching someone to be just like you! 2013 Mentors Phil Cole (The Johns Hopkins), Jon Ellman (Yale), Barbara Imperiali (MIT), Jeff Johnson (University of North Carolina), Hening Lin (Cornell University), and Lisa McElwee-White (University of Florida). Next workshop 06/30-07/02/2013! Help PIs to convey significance/impact of proposed research Provide advice on key non-technical career skills Stress the value of mentoring and being mentoring Introduce junior faculty to NIH procedures and NIH staff Promote networking among young scientists and with senior role models 30 Junior faculty participants in organic chemistry and chemical biology 6-8 Senior faculty mentors plus NIH staff 3 Days of discussions, presentations, and networking NIGMS Application resources

13 Outline NIH organization Some info on preparing an application
The funding cycle NIGMS funding opportunity Diversity funding opportunities Outline

14 Funding Opportunity Announcements (FOAs)
4/2/2017 Funding Opportunity Announcements (FOAs) Parent Announcements or Unsolicited Applications Investigator initiated applications Fit of mission of one of the NIH institutes Mechanism of the grant should be supported by the Institute of programmatic relevance Funding Opportunity Announcement (FOA) A publicly available document by which a Federal agency makes known its intentions to award discretionary grants or cooperative agreements, usually as a result of competition for funds. Funding opportunity announcements may be known as program announcements, requests for applications, notices of funding availability, solicitations, or other names depending on the agency and type of program. Funding opportunity announcements can be found at Grants.gov/FIND and in the NIH Guide for Grants and Contracts. In addition, NIH and other HHS Agencies have developed omnibus Parent Announcements for common grant mechanisms that have transitioned to electronic submission, for use by applicants who wish to submit what were formerly termed “unsolicited” or "investigator-initiated" applications. Program Announcement (PA) Identifies areas of increased priority and/or emphasis on particular funding mechanisms for a specific area of science Usually accepted on standard receipt (postmarked) dates on an on-going basis Remains active for three years from date of release unless the announcement indicates a specific expiration date or the NIH Institute/Center (I/C) inactivates sooner (see January 13, 2005 NIH Guide Notice for more information on Expiration Dates) Special Types PAR: A PA with special receipt, referral and/or review considerations, as described in the PAR announcement PAS: A PA that includes specific set-aside funds as described in the PAS announcement Request for Application (RFA) Identifies a more narrowly defined area for which one or more NIH institutes have set aside funds for awarding grants Usually has a single receipt (received on or before) date specified in the RFA announcement Usually reviewed by a Scientific Review Group convened by the issuing awarding component Request for Proposal (RFP) Solicits contract proposals. An RFP usually has one receipt date, as specified in RFP solicitation Notice (NOT) Announces policy and procedures, changes to RFA or PA announcements, RFPs and other general information items Inquiries about specific Notices, PAs, and RFAs published in the NIH Guide, should be directed to the NIH staff member(s) identified in each announcement. Numbering System PA Numbering (e.g. PA ): Indicates a PA issued in 2006 or for funding in 2006 (06) with an associated serial number (008). RFA Numbering (e.g. RFA-HL ): Indicates an RFA issued by NHLBI (HL) in 2006 or for funding in 2006 (06) with an associated serial number (004). Notice Numbering (e.g. NOT-OD ): Indicates a Notice issued by the Office of the Director (OD) in Fiscal Year 2006 (06) with an associated serial number (025). Funding cycle

15 RFA vs PA RFA = request for Applications PA = program announcement
4/2/2017 RFA vs PA RFA = request for Applications PA = program announcement PAR = program announcement reviewed in an Institute PAS = program announcement with set-aside funds Announcements Focus Set-aside funds Special review criteria and panel Length of announcement Receipt dates RFA Narrowly defined YES n/a One date PAR Specific scientific area but broadly defined Usually not 3 years Usually standard dates PAS Depends Funding cycle

16 Most Common Grant Mechanisms
4/2/2017 Most Common Grant Mechanisms Mechanism To support Length Budget Common goals Receipt dates R01:Research project single Pi or multi-PIs Discrete and specified research project in area of expertise Up to 5 years $250,000 DC/year but it can be higher New: Feb 5, June 5 and October 5 Renewal: March 5, July 5 and Nov. 5 R21:Exploratory/developmental grants Development of a new research activities Up to 2 years $ DC for 2 years Exploratory, novel studies High risk high reward studies Projects should be distinct from those supported through the traditional R01 mechanism New: Feb 16, June 16 and October 16 Renewal: March 16, July 16 and Nov. 16 R03:Small research grants Short-term projects with amount $50,000 DC/year Pilot or feasibility studies Secondary analysis of existing data Small, self-contained research projects Development of research methodology Development of new research technology R15:Academic research enhancement awards (AREA) Small research scale projects at educational institutions that have not been major recipients of NIH support. Up to 3 years $300,000 DC for 3 years Support meritorious research Expose students to research Strengthen the research environment of the institution New and renewal: Feb 25, June 25 and October 25 DP2 New Innovator awards highly innovative research projects by new investigators $300,000 DC/year Individual early stage investigators of exceptional creativity proposing research of uncommonly high potential impact Not announced yet for 2014 usually end of Summer or beginning of Fall Not all ICs carry all the mechanisms. Need to verify Funding cycle

17 Funding Cycle Review of Scientific Merit Funding Decision
Assign to Institute and Study Section Peer Review University Submits Electronically the Application 1st NIH Study Section 1946 Applicant Initiates Research Idea Review of Scientific Merit Conducts Research Leaders in the biological and medical sciences, education, health care, and public affairs. Allocation of Funds Institute Program staff Advisory Council of the Assigned Institute Funding Decision Second Review Funding Cycle

18 Cover Letter & Referral
The cover letter is important to: Suggest institute assignment Suggest study section assignment Identify individuals in conflict Identify areas of expertise needed to evaluate the application The cover letter is NOT appropriate to suggest specific reviewers! Assign to Institute and Study Section Is it possible to change the IC and/or study section assignment(s)? YES When? BEFORE the review of the application (after it is almost impossible) How? Contact the assigned SRO and PO and provide in writing a justification for the desired change If my application has a secondary Institute assignment, does the 2ary Institute consider automatically my application if the 1ary Institute does not fund it? NO Only if the Program Officer of the 2ary Institute has interest in your application it may be considered. This is an extremely rare case and usually applications are transferred before review. Funding Cycle

19 Study Section and Institute, which one?
Colleagues, Reporter and web sites of ICs are the first source of information. Program director for confirmation. STUDY SECTION Standing Study Sections review most investigator-initiated research applications (R01, R03, R21, R15, and Ks). Standing study sections are those with both permanent members and temporary members, and are organized by CSR. Special Emphasis Panels one-time or recurring Special Emphasis Panels (SEPs) are held to review applications on special topics and members conflict applications. They include only temporary members. P01, SBIR/STRR…. review by SEPs. SEPs can be organized by CSR or by the review office of an institute. 24 INSTITUTES/CENTERS with funding authority Not all ICs participate in all mechanisms. For example/ NIGMS does not support investigated initiated R21 and R03. Not all ICs participate in all RFA , PAR and PAS. A standing study section reviews applications assigned to a variety of ICs Funding Cycle

20 Funding Opportunity Announcement (FOA)
4/2/2017 Funding Opportunity Announcement (FOA) Funding Opportunity Announcement Funding Cycle

21 Submission http://grants.nih.gov/grants/funding/submissionschedule.htm
University Submits Application Electronic Submission NIH Applicant Initiates Research Idea Conducts Research January 25 May 25 September 25 All Program Project and Center Grants February 5 June 5 October 5 New Research Grants (R type) February 12 June 12 October 12 New Career Development Awards (K type) March 5 July 5 November 5 Research Grant Renewal, Resubmission, and Revision Applications Funding Cycle

22 Only ONE resubmission allowed! Do not waste it by rushing!
4/2/2017 Due Dates for R01 Only ONE resubmission allowed! Do not waste it by rushing! NIH allows a shorten review cycle for New Investigator R01 Applications: Submission Review Council Funding A0 June 5th October January April ? Normal A1 March 5th June ?????? Shorten A1 December 10th February May July? NOT RECOMMENDED You have 37 months from the A0 application date to resubmit. Any applications submitted after the 37 month will be considered a new application. Funding Cycle

23 Funding Cycle Review of Scientific Merit Funding Decision
Assign to Institute and Study Section Peer Review University Submits Electronically the Application 1st NIH Study Section 1946 Applicant Initiates Research Idea Review of Scientific Merit Conducts Research Leaders in the biological and medical sciences, education, health care, and public affairs. Allocation of Funds Institute Program staff Advisory Council of the Assigned Institute Funding Decision Second Review Funding Cycle

24 Criteria Selection for Review Panel Memberships
Mandatory criteria: Scientific expertise is the most important criterium and it depends on the science covered by the pool of applications considered in a specific round of review Geographical distribution: 25% of Central, South, East, West Gender and minorities representation: at least 10% for each Limits in # of reviewers from: No 2 people from the same Department For each 10 reviewers 2 can be from the same University (up to 3 for 30 reviewers subjected to higher level approval) Optional criteria: age distribution one Assistant Professor SEP specific criterium: the making of the panel will reflect the community – SBIR will have industry people; R15 will have reviewers from qualifying institutions…. Funding Cycle

25 Early Career Reviewer (ECR) Program
ECR program was developed to: train qualified scientists without prior CSR review experience so that they may become effective reviewers, help emerging researchers advance their careers by exposing them to peer review, and enrich the existing pool of NIH reviewers by including scientists from less research-intensive institutions as well as those from traditionally research- intensive institutions Eligibility for the ECR program includes: Full-time faculty members or researchers in similar roles. Evidence of an active independent program of research Recent publications in peer-reviewed research journals Has not served on a CSR study section in a role other than a mail reviewer Prior NIH funding is NOT a requirement How to apply: First, send your CV and contact the SRO of the study section of interest Then, follow the official procedure described at What will you do: receive training from SRO on review procedures and how to write critiques you will have a lighter workload (2-4 applications) Attend panel and participate in discussion and voting Funding Cycle

26 Review Process of a Standing Study Section
SRO assigns your application to 3 primary reviewers Reviewers submit preliminary criterion scores (from 1 exceptional to 9 poor) with comments for Significance, Investigator(s), Innovation, Approach and Environment SRO determines Review Order Best scoring application first New investigators (best-to-worst) are reviewed separately from others Everyone else (best-to-worst) Persons with conflicts of interest excused Primary reviewers (3) give preliminary scores (1-9) Discussion of application’s scientific and technical merit Other panel members join discussion Primary reviewers give final scores (1-9) All panel members (except those in conflict) score privately Assignment of codes for animals and human subjects protection Budget recommendations. About 50% applications will be discussed, remainder unscored (ND, not discussed) Mock study section video: Funding Cycle

27 Feedback from Review Priority Score & Percentile eRA Commons
1-4 days after meeting Impact/Priority score is average reviewer score (1-9) times ten (10-90) Percentile: relative ranking of application with last 3 meetings of study panel Not all applications get percentiled (e.g. R15, for GM F32s and K99s are not percentiled) Summary Statement eRA Commons SRO prepares and releases 10 (New PIs) – 30 (all others) days after meeting for R01s Summary of discussion written by SRO Criteria scores from assigned reviewers Critiques from assigned reviewers Budget recommendations Administrative notes Codes for Animal Vertebrates and Human Subjects Assigned Program Officer Typically present at review meeting Interpret comments Advice on resubmission Final scores of primary reviewers are NOT an average of the criteria scores! Funding Cycle

28 Funding Cycle Review of Scientific Merit Funding Decision
Assign to Institute and Study Section Peer Review University Submits Electronically the Application 1st NIH Study Section 1946 Applicant Initiates Research Idea Review of Scientific Merit Conducts Research Leaders in the biological and medical sciences, education, health care, and public affairs. Allocation of Funds Institute Program staff Advisory Council of the Assigned Institute Funding Decision Second Review Funding Cycle

29 Second Level of Review: Advisory Council
Provides oversight to insure initial review was fair and in compliance with NIH policy Most applications are voted en bloc by Council Council usually discuss specific applications if there are appeal, program projects, Merit award,. etc. Council does not make funding decisions Funding Cycle

30 Funding Cycle Review of Scientific Merit Funding Decision
Assign to Institute and Study Section Peer Review University Submits Electronically the Application 1st NIH Study Section 1946 Applicant Initiates Research Idea Review of Scientific Merit Conducts Research Leaders in the biological and medical sciences, education, health care, and public affairs. Allocation of Funds Institute Program staff Advisory Council of the Assigned Institute Funding Decision Second Review Funding Cycle

31 Funding Decision by IC Program Staff
Unofficial but updated and comprehensive source of paylines of all ICs: Institutes with set paylines (NIAID, NCI*..) Applications are ranked based on Priority Score (Fs, Ks) or Percentile ranking (R01s) Paylines are decided based on availability of funds Paylines vary from different types of grants Paylines may be more liberal for New (or ESI) investigators Institutes without set paylines: NIGMS example Applications are ranked based on Priority Score (Fs, Ks) or Percentile ranking (R01s) Top-scoring applications are given the highest priority for funding A “grey area” of applications is identified based on available funds just after the top scoring applications. Not all the applications in the grey area will be funded. Applications in the “grey area” are ranked for funding consideration based on: Percentile, Programmatic needs, Other support of applicant, ESI or New investigator, If council has recommendations Funding Cycle

32 When and Who to Contact WHEN WHO
Before and as you prepare your application Mentors/colleagues Institute Program Officer When you register for eRA Commons eRA Commons Help Desk Submission Grants.gov Help Desk Receipt & Referral Scientific Review Offcier (SRO) and Program Officer Before Review SRO After and about the review Program Officer Funding decision Award Program Officer and Grants Management Specialist Funding Cycle

33 Only ONE resubmission allowed! Do not waste it by rushing!
4/2/2017 Resubmission Only ONE resubmission allowed! Do not waste it by rushing! NIH allows a shorten review cycle for New Investigator R01 Applications: Submission Review Council A0 June 5th October January Normal A1 March 5th June Shorten A1 December 10th February May NOT RECOMMENDED You have 37 months from the A0 application date to resubmit. Any applications submitted after the 37 month will be considered a new application. Funding Cycle

34 Outline NIH organization Some info on preparing an application
The funding cycle NIGMS funding opportunity Diversity funding opportunities Outline

35 NIGMS Collaborative Supplement http://www. nigms. nih
Main eligibility criteria: New collaborations i.e. no publications or collaboration in the last 3 years and  no mention in the parent grant Collaborative research should be within the scope of the grant All members should have financial support (not necessarily NIH support other is fine) Collaborators may be foreign PIs funded by an NIGMS R01, R37 or SC1 grant with at least 18 months of active funding on the parent grant at the time of the receipt date deadline are eligible to apply Main facts: Deadlines January 15th and May15th $90,000 direct cost/year up to 3 years for the PI and one collaborating group. An additional $45,000  direct cost/year up to 3 years for a second collaborating group No $ for PI salary Proposed work could not have been foreseen/planned at the time of the parent grant application Strong rational for collaboration Intellectual involvement of all the PIs Reviewed internally by NIGMS committee NIGMS Funding opportunity

36 NIGMS RFAs http://search. nigms. nih. gov/funding/funding. asp
NIGMS Funding opportunity

37 Outline NIH organization Some info on preparing an application
The funding cycle NIGMS funding opportunity Diversity funding opportunities Outline

38 NIGMS Diversity Supplement http://www. nigms. nih
To support an US citizen on a grant at the high school, undergraduate, post-baccalaureate, graduate student or postdoctoral fellow levels. Main eligibility criteria and philosophy: There should be at least 2 years or more of support remaining at the time of the supplement on the parent grant Individuals (proposed for support) should not have been funded by the parent grant prior to the application To support individuals in early stages of their training (generally first 1 or 2 years) with the expectation that individuals will transition to traditional means of support Up to $75,000 direct cost/year No deadlines For additional information on diversity supplements, see the NIH Guide for Grants and Contracts, July 2, 2008 (PA ), or contact Dr. Marion Zatz at Diversity funding opportunity

39 Score Program http://www. nigms. nih
Three Score programs fund investigator initiated research applications fitting an IC mission: SC1 (Research Advancement Award) research support for research project in advanced stage planning to transition to non-Score support SC2 (Pilot Project Award) research support for early stages of development of a research plan. It allows to test new idea or gather preliminary data in a new line of research. SC3 (Research Continuance Award) research support for research project in an intermediate stage of development Institution eligibility 4-years colleges, MS or Ph.D. granting Universities serving underrepresented minority students Institutions receiving less than 6 million dollars from NIH R01 support in the last two fiscal years PI eligibility Full time regular faculty appointment Faculty with a track record of external support (other than MBRS) and publications are ineligible Faculty currently receiving other individual or institutional developmental research support are ineligible Diversity funding opportunity

40 Score Program http://www. nigms. nih
SC1 Research Advancement Award SC2 Pilot Project Award SC3 Research Continuance Award Programmatic Goal Foster the transition to major non-SCORE support Allows beginning PIs to generate preliminary data to establish a new line of research Allows PIs conduct projects of limited scope and publish Max Direct Costs (Modular Budgets) Up to $250K/yr Up to $100K/yr Not to exceed $300K for entire project period Up to $75K Duration New PIs, who have not had SCORE support- 5 years Previous SCORE PIs- 4 years Renewable once 3 years Not renewable 4 years Renewable Common Requirement PIs developmental objectives and plan to achieve them must be provided No MPI grant Other Requirements No other research support PIs must have a mentor and a mentoring plan Other external research support of less than $75K is allowed NIGMS contact: Dr. Hinda Zlotnik, Tel , Diversity funding opportunity

41 4/2/2017 NIGMS: Investing in Discovery Barbara Gerratana


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