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Last Updated 2013-11-06. Company Profile Rapid membrane test – Dipstick - MethodologyRapid membrane test –Dipstick - Methodology Human Rapid Tests - Dipstick:

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Presentation on theme: "Last Updated 2013-11-06. Company Profile Rapid membrane test – Dipstick - MethodologyRapid membrane test –Dipstick - Methodology Human Rapid Tests - Dipstick:"— Presentation transcript:

1 Last Updated

2 Company Profile Rapid membrane test – Dipstick - MethodologyRapid membrane test –Dipstick - Methodology Human Rapid Tests - Dipstick: Enteric products Enteric products – Respiratory products – Gastric products – Drug RangeRespiratory products Gastric productsDrug Range Uni-Strip Range Rapid membrane test – Cassette – MethodologyRapid membrane test Cassette – Methodology Human Rapid Tests - Cassette: Enteric products Enteric products – Respiratory products – Gastric products - OtherRespiratory products Gastric productsOther V-TesT Gravity – V-TesT Gravity – Methodology - ProductMethodology Product Oligochromatography Oligochromatography – Methodology - ProductsMethodology Products Veterinary Rapid Tests Summary

3 Coris BioConcept was founded in 1996 by 2 biologists and 2 investors. It is a biotechnology company offering innovative, rapid solutions to biomedical and research laboratories. The achievement of « Quality » is a consideration in all CORIS activities. Coris BioConcept produces and markets diagnostic kits for the rapid detection of pathogens involved in infectious diseases. 24 persons presently work in the company. Coris BioConcept is present in more than 80 countries in the 5 continents. To meet the demands of its customers, Coris BioConcept works in a QC/QA frame. The Quality Policy has been certified ISO 9001:2008 and ISO 13485:2003 by SGS.ISO 9001:2008 ISO 13485:2003 Moreover all Coris BioConcepts products fulfil the CE marking requirements.CE Company Profile

4 Coris BioConcept has developed mainly rapid kits to detect human enteric and respiratory pathogens. Tests are suitable for single sample analysis, require minimal sample manipulation and give unequivocal diagnostic within 5 to 15 minutes for positive samples. No sophisticated extra material is required to perform the test. Rapid membrane test Test are performed on coated nitrocellulose strips and results are observed with colloidal gold particles or latex microspheres. Once the strip is dipped into diluted sample, liquid samples and conjugate(s) migrate by capillary movement. At the end of the migration process, one or two coloured lines appear indicating either a negative or a positive result respectively.

5 Dipstick - Methodology

6 Human Rapid Tests: Enteric Products Rota-Strip > Rota-Strip > Rota-Strip > Rota-Strip > Rapid test to detect ROTAVIRUS in stool (C-1001) Adeno-Strip > Adeno-Strip > Adeno-Strip > Adeno-Strip > Rapid test to detect ADENOVIRUS group A to F in stool (C-1002) 40/41 Adeno-Strip > 40/41 Adeno-Strip > 40/41 Adeno-Strip > 40/41 Adeno-Strip > Rapid test to detect ADENOVIRUS group F (40/41) in stool (C-1003) Combi-Strip > Combi-Strip > Combi-Strip > Combi-Strip > Rapid test to detect both ROTAVIRUS and ADENOVIRUS group A to F in stool (C-1004) Crypto-Strip > Crypto-Strip > Crypto-Strip > Crypto-Strip > Rapid test to detect CRYPTOSPORIDIUM in stool (C-1005)

7 Human Rapid Tests: Enteric Products (2) O157 Coli-Strip > O157 Coli-Strip > O157 Coli-Strip > O157 Coli-Strip > Rapid test to detect ESCHERICHIA COLI O157 after broth enrichment (C-1011) Giardia-Strip > Giardia-Strip > Giardia-Strip > Giardia-Strip > Rapid test to detect GIARDIA in stool (C-1013) GastroVir-Strip > GastroVir-Strip > GastroVir-Strip > GastroVir-Strip > Rapid test to detect both ROTAVIRUS and ADENOVIRUS group F (40/41) in stool (C-1016) Crypto/Giardia Duo-Strip > Crypto/Giardia Duo-Strip > Crypto/Giardia Duo-Strip > Crypto/Giardia Duo-Strip > Rapid test to detect both CRYPTOSPORIDIUM and GIARDIA in stool (C-1018) C. diff-Strip > C. diff-Strip > C. diff-Strip > C. diff-Strip > Rapid test to detect CLOSTRIDIUM DIFFICILE in stool (C-1020)

8 Human Rapid Tests: Respiratory Products RSV Respi-Strip > RSV Respi-Strip > RSV Respi-Strip > RSV Respi-Strip > Rapid test to detect RESPIRATORY SYNCYTIAL VIRUS in nasopharyngeal specimens (C-1006) Adeno Respi-Strip > Adeno Respi-Strip > Adeno Respi-Strip > Adeno Respi-Strip > Rapid test to detect RESPIRATORY ADENOVIRUS in nasopharyngeal secretions and/or culture supernatants (C-1009) Influ-A&B Respi-Strip > Influ-A&B Respi-Strip > Influ-A&B Respi-Strip > Influ-A&B Respi-Strip > Rapid test to detect INFLUENZA A and INFLUENZA B VIRUS in swabs, washings or aspirates of nasopharyngeal secretions (C-1012)

9 Human Rapid Tests: Gastric Products Pylori-Strip > Pylori-Strip > Pylori-Strip > Pylori-Strip > Rapid test to detect HELICOBACTER PYLORI in stool (C-1019)

10 Human Rapid Tests: Drug Range Mefloquine-Strip> Mefloquine-Strip> Mefloquine-Strip> In vitro rapid test for detection of Mefloquine in urine Mefloquine-Strip> Proguanil-Strip> Proguanil-Strip> Proguanil-Strip > In vitro rapid test for detection of Proguanil in urine Proguanil-Strip >

11 Enteric Products Rota-Strip: General Information Product File Advantages of the kit Instructions for use Rota Uni-Strip a quick solution for small laboratories, emergency centres, doctors offices, paediatricians, … A quick and reliable answer for diagnostic labs

12 Enteric Products Adeno-Strip: General Information Product File Advantages of the kit Instructions for use Adeno Uni-Strip a quick solution for small laboratories, emergency centres, doctors offices, paediatricians, … A quick and reliable answer for diagnostic labs

13 Enteric Products 40/41 Adeno-Strip: General Information Product File Advantages of the kit Instructions for use 40/41 Adeno Uni-Strip a quick solution for small laboratories, emergency centres, doctors offices, paediatricians, … A quick and reliable answer for diagnostic labs

14 Enteric Products Combi-Strip: General Information Product File Advantages of the kit Instructions for use A quick and reliable answer for diagnostic labs

15 Enteric Products Crypto-Strip: General Information Product File Advantages of the kit Instructions for use Crypto Uni-Strip a quick solution for small laboratories, emergency centres, doctors offices, paediatricians, … A quick and reliable answer for diagnostic labs

16 Enteric Products O157 Coli-Strip: General Information Product File Advantages of the kit Instructions for use O157 Coli Uni-Strip a quick solution for small laboratories, emergency centres, doctors offices, paediatricians, … A quick and reliable answer for diagnostic labs

17 Enteric Products Giardia-Strip: General Information Product File Advantages of the kit Instructions for use A quick and reliable answer for diagnostic labs

18 Enteric Products GastroVir-Strip: General Information Product File Advantages of the kit Instructions for use A quick and reliable answer for diagnostic labs

19 Enteric Products Crypto/Giardia Duo-Strip: a quick solution for small laboratories, emergency centres, doctors offices, paediatricians, … General Information Product File Advantages of the kit Instructions for use Crypto/Giardia Uni-Strip A quick and reliable answer for diagnostic labs

20 Enteric Products C. diff-Strip: General Information Product File Advantages of the kit Instructions for use A quick and reliable answer for diagnostic labs

21 Respiratory Products RSV Respi-Strip: General Information Product File Advantages of the kit Instructions for use A quick and reliable answer for diagnostic labs

22 Respiratory Products Adeno Respi-Strip: General Information Product File Advantages of the kit Instructions for use A quick and reliable answer for diagnostic labs

23 Respiratory Products Influ-A & B Respi-Strip: General Information Product File Advantages of the kit Instructions for use Influ-A & B Uni-Strip a quick solution for small laboratories, emergency centres, doctors offices, paediatricians, … A quick and reliable answer for diagnostic labs

24 Gastric Products Pylori-Strip: General Information Product File Advantages of the kit Instructions for use A quick and reliable answer for diagnostic labs

25 Drug Range Mefloquine-Strip: General Information Product File Advantages of the kit Instructions for use A quick and reliable answer for diagnostic labs

26 Drug Range Proguanil-Strip: General Information Product File Advantages of the kit Instructions for use A quick and reliable answer for diagnostic labs

27 Advantages of dipstick kits SENSITIVE SPECIFIC SIMPLE EASY TO USE EASY TO READ RELIABLE RAPID FORMAT CONVENIENT MINIMAL SAMPLE MANIPULATION NO SPECIAL TRAINING NEEDED NO SPECIAL EQUIPMENT REQUIRED RESULTS OBTAINED WITHIN 15 MINUTES

28 Intended for small labs, emergency centres, doctors offices, paediatricians, … Contains the necessary material to easily perform the test: - ten single strips - ten tubes - one dilution buffer - ten sampling systems - one tube rack - instructions for use Uni-Strip Range Influ-A & B Uni-Strip Legionella 10 V-TesT Enteric Range: Respiratory Range: Rota Uni-Strip Adeno Uni-Strip 40/41 Adeno Uni-Strip Crypto Uni-Strip O157 Coli Uni-Strip Crypto/Giardia Uni-Strip

29 Cassette - Methodology

30 Human Rapid Tests: Enteric Products Combi K-SeT > Combi K-SeT > Combi K-SeT > Combi K-SeT > Rapid test to detect both ROTAVIRUS and ADENOVIRUS group A to F in stool (K-1204 & K-1504) Giardia K-SeT> Giardia K-SeT> Giardia K-SeT> Giardia K-SeT> Rapid test to detect GIARDIA in stool (K-1213 & K-1513) GastroVir K-SeT> GastroVir K-SeT> GastroVir K-SeT> GastroVir K-SeT> Rapid test to detect both ROTAVIRUS and ADENOVIRUS group F (40/41) in stool (K-1216 & K-1516) Clostridium K-SeT> Clostridium K-SeT> Clostridium K-SeT> Clostridium K-SeT> Rapid test to detect CLOSTRIDIUM DIFFICILE antigen in human stool samples (K-1220 & K-1520)

31 Human Rapid Tests: Respiratory Products RSV K-SeT > RSV K-SeT > RSV K-SeT > RSV K-SeT > Rapid test to detect RESPIRATORY SYNCYTIAL VIRUS in nasopharyngeal specimens (K-1206 & K-1506) Adeno Respi K-SeT > Adeno Respi K-SeT > Adeno Respi K-SeT > Adeno Respi K-SeT > Rapid test to detect RESPIRATORY ADENOVIRUS in nasopharyngeal secretions and/or culture supernatants (K-1209 & K-1509)

32 Human Rapid Tests: Gastric Products Pylori K-SeT > Pylori K-SeT > Pylori K-SeT > Pylori K-SeT > Rapid test to detect HELICOBACTER PYLORI in stool (K-1219 & K-1519)

33 Human Rapid Tests: Other HAT Sero K-SeT > HAT Sero K-SeT > HAT Sero K-SeT > HAT Sero K-SeT > Rapid test to detect antibodies specific to TRYPANOSOMA BRUCEI GAMBIENSE in human whole blood, serum or plasma (K-12S2 & K-15S2)

34 Enteric Products Combi K-SeT: General Information Product File Advantages of the kit Instructions for use A quick and reliable answer for diagnostic labs

35 Enteric Products Giardia K-SeT: General Information Product File Advantages of the kit Instructions for use A quick and reliable answer for diagnostic labs

36 Enteric Products GastroVir K-SeT: General Information Product File Advantages of the kit Instructions for use A quick and reliable answer for diagnostic labs

37 Enteric Products Clostridium K-SeT: General Information Product File Advantages of the kit Instructions for use A quick and reliable answer for diagnostic labs

38 Respiratory Products RSV K-SeT: General Information Product File Advantages of the kit Instructions for use A quick and reliable answer for diagnostic labs

39 Respiratory Products Adeno Respi K-SeT: General Information Product File Advantages of the kit Instructions for use A quick and reliable answer for diagnostic labs

40 Gastric Products Pylori K-SeT: General Information Product File Advantages of the kit Instructions for use A quick and reliable answer for diagnostic labs

41 Other HAT Sero K-SeT: General Information Product File Advantages of the kit Instructions for use A quick and reliable answer for diagnostic labs

42 Advantages of cassette kits SENSITIVE SPECIFIC SIMPLE EASY TO USE EASY TO INTERPRET RELIABLE RAPID FORMAT CONVENIENT MINIMAL SAMPLE MANIPULATION NO SPECIAL TRAINING NEEDED NO SPECIAL EQUIPMENT REQUIRED RESULTS OBTAINED WITHIN 15 MINUTES ACCURATE: same performances as dipsticks

43 Coris BioConcept has developed a new legionella antigen detection assay based on colloidal gold nanoparticles with antibodies directed against LPS of L. pneumophila serogroup 1. This proprietary sandwich-type assay, is a ready-to-use test that does not require dilution of urine with a reaction buffer. Liquid sample moves by gravity along the stick within a specific designed device. Freshly collected urine is simply deposited on the top of the device and result is observed after 15 minutes in the reading window, the upper purple line appearing in case of a positive test. A build-in control is used as migration control (lower purple line).

44 Methodology Gravity Driven Test is a new technology aimed at the development of rapid membrane diagnostic test in urine samples with improved performances such as speed, detectability and safety

45 Human Rapid Tests: Respiratory Products Legionella V-TesT > Legionella V-TesT > Legionella V-TesT > Legionella V-TesT > Rapid test to detect LEGIONELLA PNEUMOPHILA antigen in urine (C-1815 & C-1915)

46 Respiratory Products Legionella V-TesT: General Information Product File Advantages of the kit Instructions for use Legionella 10 V-TesT a quick solution for small laboratories, emergency centres, doctors offices, paediatricians, … A quick and reliable answer for diagnostic labs

47 Oligochromatography Oligochromatography is a proprietary technique aimed at the specific detection of amplified products after molecular amplification. The test is completed without need of specific extra material within 5 minutes. A positive result means that : polymerisation process was performed without any inhibitors interference (genuine control probe) polymerisation process produces amplicons specific for the organism to be detected (specific probe) Oligochromatography takes advantage of two classical known techniques : 1. Molecular amplification (PCR) 2. Membrane chromatography (MC) Side A Side B

48 Methodology - Oligochromatography OligoC-TesT consists of a DNA amplification mix and an oligochromatographic strip detecting specifically the pathogen amplified DNA. The ready-to-use PCR mix contains an internal control (IC) template which allows verifying that the PCR occurs properly in each sample tube without any effect of PCR inhibitors. After PCR, amplified products are allowed to migrate by passive diffusion in the oligochromatographic strip. They hybridize with the target specific and internal control gold-probes, and accumulate on the capture reagent areas. Pink/Purple lines develop at these sites if corresponding amplicons are present. Excess gold-probes hybridize on their complementary sequence at the sites of migration control lines to confirm proper migration.

49 Oligochromatographic Products T.cruzi OligoC-TesT > T.cruzi OligoC-TesT > T.cruzi OligoC-TesT > T.cruzi OligoC-TesT > Rapid Diagnostic of Trypanosoma cruzi by amplification followed by oligochromatographic detection (C-3404) Leishmania OligoC-TesT> Leishmania OligoC-TesT > Leishmania OligoC-TesT> Leishmania OligoC-TesT > Rapid Diagnostic of Leishmania by amplification and oligochromatographic detection (C-3405) mex Q-TesT>mex Q-TesT> mex Q-TesT > In vitro mexAB-oprM and meXY-oprM efflux detection in P. aeruginosa by Real Time mex Q-TesT > PCR (C-3806)

50 Oligochromatographic Products T.cruzi OligoC-TesT: Product File Instructions for use HIGH SENSITIVITY HIGH SPECIFICITY SINGLE SAMPLE ANALYSIS CARRY-OVER CONTAMINATION PROOF SAFETY (NO ETHIDIUM BROMIDE) RAPID GENUINE PCR INTERNAL CONTROL QUALITY GUARANTEED PRODUCT Advantages of the kit: A quick and reliable answer for diagnostic labs

51 Oligochromatographic Products Leishmania OligoC-TesT: Product File Instructions for use HIGH SENSITIVITY HIGH SPECIFICITY SINGLE SAMPLE ANALYSIS CARRY-OVER CONTAMINATION PROOF SAFETY (NO ETHIDIUM BROMIDE) RAPID GENUINE PCR INTERNAL CONTROL QUALITY GUARANTEED PRODUCT Advantages of the kit: A quick and reliable answer for diagnostic labs

52 Oligochromatographic Products mex Q-TesT: Product File Instructions for use Determination of the status of the efflux pump expression Two housekeeping genes for standardization Validation of the PCR product specificity Relative and absolute quantifications Certified IVD primers RNA purity check PCR efficiency Advantages of the kit: A quick and reliable answer for diagnostic labs

53 Veterinary Rapid Tests Quatro Vet Uni-Strip > Quatro Vet Uni-Strip > Quatro Vet Uni-Strip > Quatro Vet Uni-Strip > Kit to detect ROTAVIRUS, CRYPTOSPORIDIUM PARVUM, CORONAVIRUS and E. COLI K99 in bovine stool specimen (C-1540) Surra Sero K-SeT> Surra Sero K-SeT > Surra Sero K-SeT> Surra Sero K-SeT > Rapid test to detect antibodies specific to TRYPANOSOMA EVANSI in animal whole blood or plasma (K-12S1)

54 Veterinary Rapid Tests Product File Instruction for Use Quatro Vet Uni-Strip: A quick and reliable answer for diagnostic labs

55 Veterinary Rapid Tests Product File Instruction for Use Surra Sero K-SeT: A quick and reliable answer for diagnostic labs

56 Thank you for your collaboration and the confidence you place in Coris BioConcept Coris BioConcept – Science Park CREALYS Rue Jean Sonet 4A – 5032 Gembloux – BELGIUM Ph.: +32 (0) – Fax: +32 (0)


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