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Sildenafil suppresses polyp formation in the AOM/DSS model of colon cancer. Sildenafil suppresses polyp formation in the AOM/DSS model of colon cancer.

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Presentation on theme: "Sildenafil suppresses polyp formation in the AOM/DSS model of colon cancer. Sildenafil suppresses polyp formation in the AOM/DSS model of colon cancer."— Presentation transcript:

1 Sildenafil suppresses polyp formation in the AOM/DSS model of colon cancer.
Sildenafil suppresses polyp formation in the AOM/DSS model of colon cancer. A, Experimental scheme for the AOM/DSS-induced colon carcinogenesis model. C57Bl/6J mice provided water (Control) or water containing sildenafil (5.7 mg/kg/day). B, Change in body weight from the initial weight. AOM was administered on day 0, and gray panels depict DSS treatment cycles. C, Representative colons from AOM/DSS treated mice, top-bottom orientation is proximal-rectal and representative polyps are indicated in the first panels by arrows. D, Plot shows the effect of sildenafil on median polyp number per animal (n = 14 per group). Asterisks show difference between weight loss between treated and control groups at each day, P < ; D, P value generated with Mann–Whitney test. Bianca N. Islam et al. Cancer Prev Res 2017;10: ©2017 by American Association for Cancer Research

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