Presentation is loading. Please wait.

Presentation is loading. Please wait.

Local Treatment of Rectal Tumour

Similar presentations


Presentation on theme: "Local Treatment of Rectal Tumour"— Presentation transcript:

1 Local Treatment of Rectal Tumour
Joint Hospital Surgical Grand Round Tsui Tsun Miu NDH

2 Rectum

3 Rectum

4 Rectal tumour Type Histologic Diagnosis Neoplastic Adenoma
  Tubular adenoma (adenomatous polyp)   Tubulovillous adenoma (villoglandular adenoma)   Villous adenoma (villous papilloma) Carcinoma Hamartomas Juvenile polyp Peutz-Jeghers polyp Inflammatory Inflammatory polyp (pseudopolyp) Benign lymphoid polyp Unclassified Hyperplastic polyp Miscellaneous Lipoma, leiomyoma, carcinoid, lymphoma Chang George J, Shelton Andrew A, Welton Mark L, "Chapter 30. Large Intestine" (Chapter). Doherty Gerard M.: CURRENT Diagnosis & Treatment: Surgery, 13th Edition:

5 Transanal local excision: Parks’ method
Treatment Rectal Tumour Benign Malignant Early Cancer? Fit for Surgery Local Treatment: Colonoscopic polypectomy Endoscopic Mucosal Rescion Endoscopic Submucosal Dissection Transanal local excision: Parks’ method Transanal Endoscopic Microsurgery Desiccation Procedure: Nd-Yag Laser Argon Plasma Coagulation Radical Surgery: Anterior Resection Low Anterior Resection Abdominal Perineal Resection Transanal local excision: Parks’ method Transanal Endoscopic Microsurgery

6 Why do we need local treatment?

7 Morbidity of Radical Rectal Surgery
Review of 53 prospective cohort studies + 45 RCTs (36,315 patients with 24,845 patients had an anastomosis) Anastomotic leak rate – 11% Pelvic sepsis rate – 12% Postoperative death rate – 2% Fecal incontinence rates – 7% Prevalence of Sexual dysfunction Men – 69% Women – 62% Postoperative complications following surgery for rectal cancer. Paun BC. Cassie S. MacLean AR. Dixon E. Buie WD. Annals of Surgery. 251(5):807-18, 2010 May. Hendren SK, O'Connor BI, Liu M, et al. Prevalence of male and female sexual dysfunction is high following surgery for rectal cancer. Ann Surg. 2005;242:212–223.

8 Development of Local Treatment of Rectal Tumour
Avoidance of Stoma Avoidance of Major Post-op Complications

9 Morbidity Oncological Control

10 Limitation of Local Treatment
Cannot Clear Lymph Node Metastasis

11 T-stage and N-stage Chance of nodal metastases
T1 disease  0-12% T2 disease  12-28% T3 disease  36-79% Local excision as curative intent only limited to T1 lesion Taylor RH, Hay JH, Larsson SN: Transanal local excision of selected low rectal cancers. Am J Surg 1998; 175: 360–363 Bleday R, Breen E, Jessup M, et al.: Prospective evaluation of local excision for small rectal cancers. Dis Colon Rectum 1997; 40: 388–392 Saclarides TJ, Bhattacharyya AK, Britton-Kuzel C, et al.: Predicting lymph node metastases in rectal cancer. Dis Colon Rectum 1994; 37: 52–57 Pre-op / post-op investigation for ?lymph node metastasis

12 Indication of Curative Local Excision
Endorectal Ultrasound T1N0 lesion Moderately to well differentiated carcinomas No evidence of perineural or lymphovascular invasion No mucinous component Size  no strict criteria

13 Transanal Excision

14 Conventioanl Transanal Excision (TAE)
First reported by Parks Excision of rectal polyps of any dimension <6 cm from the anal verge Anal retractors i.e. Park’s Retractor Use of snare Limited to small pedunculated lesion Use of resectoscope Piecemeal resection Difficult for complete excision Add Lone start retractor Parks AG, Rob C, Smith R, Morgan CN. Benign tumours of the rectum. In: Rob C, Smith R, Morgan CN, eds. Clinical Surgery. Vol 10. England, London: Butterworths, 1966: 541

15 Conventional Transanal Excision Outcome
Retrospective Comparative study 149 Local excision vs 169 Radical Surgery 5 year local recurrence rate Trananal Local Excision Radical Surgery Chi-Square T1 Tumors 18% 0% p=0.03 T2 Tumors 47% 6% p=0.001 Mellgren A, Sirivongs P, Rothenberger DA, Madoff RD, García-Aguilar J. Is local excision adequate therapy for early rectal cancer? Dis Colon Rectum 2000; 43: 1064–74.

16 TAE – High local recurrence rate?
Related to high chance of positive margins and piecemeal resection of specimen Transanal endoscopic microsurgery versus conventional transanal excision for patients with early rectal cancer. Christoforidis D. Cho HM. Dixon MR. Mellgren AF. Madoff RD. Finne CO. Annals of Surgery. 249(5):776-82, 2009 May.

17 Can We Do Better?

18 Transanal Endoscopic Microsurgery (TEM)
Originally designed by Buess et al. in 1980s 40-mm operating proctoscopy Insufflation of the rectum Magnified three-dimensional image Facilitates an extremely precise dissection Full thickness excisions 20cm from anal verge posteriorly 12cm from anal verge anteriorly Primary closure Remove submucosal tumours (i.e. leiomyoma, carcinoid tumour) by full thickness excision Add photo Buss G, Theiss R, Gunther M, et al. Endoscopic surgery in the rectum. Endoscopy. 1985;17:31-5

19 csite.clevelandclinic.org tropicalgastro.com

20 TEM technique 5mm margin of normal appearing mucosa for adenomas
1cm margin for cancers Full thickness Extrarectal fat as a landmark to signify transmural penetration Wound closed transversely with running sutures

21 TEM outcome – Rectal Adenoma
Residual adenoma in the Surgical Margin 11% Recurrence Rate 6.3% Surgical resection of rectal adenoma: a rapid review. Casadesus D. World Journal of Gastroenterology. 15(31):3851-4, 2009 Aug 21

22 TEM outcome – Rectal T1 Cancer
For pathology T1 lesions: Recurrence rates from 0% % Saclarides TJ. TEM/local excision: indications, techniques, outcomes, and the future. J Surg Oncol. 2007;96:644–650.

23 Outcome of TEM Significant increase in local recurrence rate in T2 and T3 rectal cancer Tsai BM, Finne CO, Nordenstam JF, et al. Transanal endoscopic microsurgery resection of rectal tumors: outcomes and recommendations. Dis Colon Rectum 2010; 53:16–23

24 Failed Local Excision, What should we do?

25 Immediate Salvage Surgery vs Delay Radical Surgery
If TEM specimen showed unfavourable histologic characteristics T2 or above Poor differentiated Lymphovascular invasion Mucinous component Disease-free survival rate Immediate APR for adverse pathological features 94% Salvage APR for local recurrence 56% Baron PL, EnkerWE, Zakowski MF, Urmacher C. Immediate vs salvage resection after local treatment for early rectal cancer. Dis Colon Rectum 1995; 38: 177–181.

26 TEM complication Entry into peritoneal cavity
Conversion to laparoscopy / laparotomy Bleeding Faecal Soilage Rectal Stenoses Wound dehiscence Urinary dysfunction Rectovaginal fistula

27 TEM Complications Inadvertent opening of the peritoneum (4.3%)
80% can be treated with direct suturing without conversion to major surgery Other post-op complications: Bleeding (3.7%) Suture dehiscence (1.7%) Rectovagina fistula (1.3%) Transanal endoscopic microsurgery for rectal neoplasms: experience of 300 consecutive cases. Allaix ME. Arezzo A. Caldart M. Festa F. Morino M. Diseases of the Colon & Rectum. 52(11):1831-6, 2009 Nov.

28 TEM Complications Risk factor for Post-op bleeding:
Localization of the tumour on the lateral wall of the rectum Tumour diameter > 2cm Kreissler-Haag D, Schuld J, Lindemann W, Konig J, Hildebrandt U, Schilling M. Complications after transanal endoscopic microsurgical resection correlate with location of rectal neoplasms. Surg Endosc 2008; 22: 612–6.

29 How good is TEM comparing other treatment modalities?

30 TEM vs Park’s Transanal Excision
Retrospective study 42 TEM vs 126 TAE TEM over TAE by: Increased likelihood of clear margins Less specimen fragmentation Lower recurrence rates More proximal tumours can be accessed Moore JS, Cataldo PA, Osler T, Hyman NH. Transanal endoscopic microsurgery is more effective than traditional transanal excision for resection of rectal masses. Dis Colon Rectum. 2008;51:1026–31

31 TEM vs Park’s Transanal Excision
Possible reasons: Carbon dioxide insufflation and distension of the rectum Superior optics that provide a magnified image Simultaneously evacuate smoke, blood, and liquid while cutting and sewing Complete resection specimen photo of TEM Can orientate much better

32 Comparison of TEM with Radical Surgery
Randomized controlled trial Rectal adenocarcinoma (GI/II) + ERUS uT1 N0 Transanal endoscopic microsurgery (TEM; n=24) Anterior resection (AR; n=26) Local recurrence and five-year survival rates similar Early postoperative mortality was zero Significant differences in Time of hospitalization Loss of blood Operation time Opiate analgesia Surgical cure for early rectal carcinomas (T1). Transanal endoscopic microsurgery vs. anterior resection. Winde G. Nottberg H. Keller R. Schmid KW. Bunte H. Diseases of the Colon & Rectum. 39(9):969-76, 1996 Sep.

33 Can we extend the indication of local excision?
Combined therapy

34 Can we extend the Indication?
Randomized controlled trial T2 tumour  neoadjuvant chemoradiation TEM vs Laparoscopic Resection (35 vs 35) Median follow-up period : 84 months (range, 72–96 ) TEM Laparoscopic Resection Local recurrence 5.7% 2.9% Distant metastasis 5-year Disease-Free Survival 94% Lezoche G, Baldarelli M, Guerrieri M, Paganini AM, De Sanctis A, Bartolacci S, et al. A prospective randomized study with a 5-year minimum follow-up evaluation of transanal endoscopic microsurgery versus laparoscopic total mesorectal excision after neoadjuvant therapy. Surg Endosc 2008;22:352-8

35 Pathological T0 after neoadjuvant chemoradiation
570 patients : the rate of lymph node involvement was 5%. Kundel Y; Brenner R; Purim O; Peled N; Idelevich E; Fenig E; Sulkes A; Brenner B Is local excision after complete pathological response to neoadjuvant chemoradiation for rectal cancer an acceptable treatment option?. Diseases of the Colon & Rectum. 53(12): , 2010 Dec.

36 Local exicison on pT0 after neoadjuvant therapy
Retrospective comparative study Subjects: clinical stage T3 to 4Nx, TxN+ Neoadjuvant chemoradiation Radical Surgery or Local Excision Final Pathology – pT0 Radical Surgery (n=37) Local excision (n=14) 5 year disease free survival 88% 100% Pelvic recurrence free survival 92% Overall survival 97% Kundel Y; Brenner R; Purim O; Peled N; Idelevich E; Fenig E; Sulkes A; Brenner B Is local excision after complete pathological response to neoadjuvant chemoradiation for rectal cancer an acceptable treatment option?. Diseases of the Colon & Rectum. 53(12): , 2010 Dec.

37 We can spare this particular group of patients from Radical Surgery!
Pathology T0 after neoadjuvant chemoradiation

38 Local exicison + Post-op radiotherapy
Post-excision pathology T2 disease Not fit for Salvage Radical Surgery A Case Series: Significantly lower disease recurrence in T2 disease with radiotherapy 18% (with adj. RT) vs 66% (without adj. RT) Han SL. Zeng QQ. Shen X. Zheng XF. Guo SC. Yan JY. The indication and surgical results of local excision following radiotherapy for low rectal cancer. Colorectal Disease. 12(11):1094-8, 2010 Nov

39 Endoscopic local treatment
Colonoscopic polypectomy Suitable in 90% of rectal polyps Complete resection difficult if tumour in submucosal area i.e. carcinoid tumors / malignant rectal tumour Suitable for pedunculated polyp Endoscopic mucosal resection Removal of mucosal lesion of < 1cm Special device needed if tumour suspected to be in submucosal area i.e. 2 channel EMR

40 Endoscopic Submucosal Dissection
Indicated when one−piece resection by conventional procedures is impossible: Large−sized lesions Lesions with biopsy−induced scars Lesions on haustra Rate of one-piece resection with ESD: 70-88% Rate of perforation: 5% Mean size : 26.2 mm (8 ± 60) 32.8 mm (9 - 91) Colorectal endoscopic submucosal dissection: present status and future perspective, including its differentiation from endoscopic mucosal resection. [Review] [47 refs] Tanaka S. Oka S. Chayama K. Journal of Gastroenterology. 43(9):641-51, 2008 Onozato Y, Kakizaki S, Ishihara H, et al. Endoscopic submucosal dissection for rectal tumors. Endoscopy. 2007;39:423– 427 Fujishiro M, Yahagi N, Nakamura M et al. Endoscopic submucosal dissection for rectal epithelial neoplasia. Endoscopy 2006; 38: 493±497

41 Other Local Treatment Modalities
Endoscopic Nd-Yag Laser Ablation Palliate bleeding, mucinous discharge, impending obstruction Success in 8 out of 11 patients Argon Plasma Coagulation Palliate tumour bleeding Debulking Endoscopic laser ablation of advanced rectal carcinoma--a DGH experience. Rao VS. Al-Mukhtar A. Rayan F. Stojkovic S. Moore PJ. Ahmad SM. Colorectal Disease. 7(1):58-60, 2005 Jan Prospective nonrandomized comparison of two modes of argon beamer (APC) tumor desobstruction: effectiveness of the new pulsed APC versus forced APC. Eickhoff A. Jakobs R. Schilling D. Hartmann D. Weickert U. Enderle MD. Eickhoff JC. Riemann JF. Endoscopy. 39(7):637-42, 2007 Jul.

42 Local Recurrences (range%)
Discussion Radical Surgery Outcome: Multicenter Dutch study: for T1-T2,N0 lesions, the local recurrence rate in 244 total mesorectal excisions = 0.7% Local Excision Outcome 968 patients in 22 studies Kapitejn E, Marijnen C, Nagtegaal ID, et al. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med 2001;345:638–46. T-staging Local Recurrences (range%) T1 9.7% (0-24%) T2 25% (0-50%) Overall 13.7% Sengupta S, Tjandra JJ. Local excision of rectal cancer: What is the evidence? Dis Colon Rectum 2001;44:1345–61.

43 Summary Rectal Tumour Endorectal Ultrasound Assessment
Pedunculated polyp Complete polypectomy not feasible, i.e. broad base Endorectal Ultrasound Assessment Colonoscopic Polypectomy Submucosal tumour Mucosal tumour uT1N0 uT2N0 uT3/4Nx EMR ESD Parks TAE TEM (level 1b) Neoadjuvant ChemoRT + TEM (level 1b) Neoadjuvant ChemoRT + TEM (level 3b) if final pathology T0 If Unfavourable factor present Cure (level 3b) Immediate Radical Surgery (level 3b) EMR ESD Parks TAE TEM

44 Thank You

45 Rectal Carcinoid ~10% to 17% of all carcinoid tumors
Middle-aged adults Small, solitary, submucosal nodules Midrectum between 4 and 8 cm from the anorectal junction Tendency for metastasis: Low if tumour size < 1cm Local excision is adequate if tumour size < 1cm Onozato Y. Kakizaki S. Iizuka H. Sohara N. Mori M. Itoh H Endoscopic Treatment of Rectal Carcinoid Tumors Diseases of the Colon & Rectum. 53(2):169-76, 2010 Feb

46 Rectal Carcinoid Located in submucosal layer To be removed by
Endoscopic submucosal resection with a ligation device 2 channel EMR Endoscopic submucosal dissection Ono A, Fujii T, Saito Y, Matsuda T et al. Endoscopic submucosal resection of rectal carcinoid tumors with a ligation device. Gastrointest Endosc 2003; 57: 583±587

47 Palliative local treamtent

48 Palliative Radiotherapy
Overall Mobile Partially fixed Fixed Number of patients 271 103(38%) 51(19%) 92(34%) Complete response (CR) 80(30%) 50(49%) 11(22%) 8(9%) <0.01 Local relapse after CR 62(78%) 36(72%) 8(73%) 8(100%) <0.05 5 year survival 27% 48% 26% 6% Five (1.8%) patients developed grade 3 or 4 acute toxicity. Four patients had acute bowel toxicity and one patient had acute skin toxicity. All patients with acute toxicity recovered after treatment with intravenous rehydration or medications. Another four patients (1.5%) developed grade 3 or higher late toxicity. Three patients developed skin ulcers. One recovered after treatment with topical medication, the second patient was treated with rotation flap surgery, and the third patient died of osteomyelitis and sepsis secondary to skin ulcer infection. One patient developed ureteric stenosis, and recovered after ureteric stenting. Wang Y, Cummings B, Catton P, Dawson L, Kim J, Ringash J, Wong R, Yi QL, Brierley J. Primary radical external beam radiotherapy of rectal adenocarcinoma: long term outcome of 271 patients. Radiother Oncol 77:126–132

49 Palliative chemoradiation
Complete Response (no tumour clinically) Median progression-free survival = 65 months Partial Response (shrunken tumour) Median progression-free survival = 15 months T1/2 group Median PFS = 64 months T3 Median PFS = 28 months Lim L, Chao M, Shapiro J, et al. Long-term outcomes of patients with localized rectal cancer treated with chemoradiation or radiotherapy alone because of medical inoperability or patient refusal. Dis Colon Rectum 2007;50:

50 Other Local Treatment Modalities
Endoscopic Nd-Yag Laser Ablation Palliate bleeding, mucinous discharge, impending obstruction Success in 8 out of 11 patients Argon Plasma Coagulation Palliate tumour bleeding Debulking Endoscopic laser ablation of advanced rectal carcinoma--a DGH experience. Rao VS. Al-Mukhtar A. Rayan F. Stojkovic S. Moore PJ. Ahmad SM. Colorectal Disease. 7(1):58-60, 2005 Jan Prospective nonrandomized comparison of two modes of argon beamer (APC) tumor desobstruction: effectiveness of the new pulsed APC versus forced APC. Eickhoff A. Jakobs R. Schilling D. Hartmann D. Weickert U. Enderle MD. Eickhoff JC. Riemann JF. Endoscopy. 39(7):637-42, 2007 Jul.

51 Ultrasound Staging Bianchi PP, Ceriani C, Rottoli M, et al.: Endoscopic ultrasonography and magnetic resonance in preoperative staging of rectal cancer: Comparison with histologic findings. J Gastrointest Surg 2005; 9: 1222–1228

52 Deal with Complication
Ramirez et al.22 concluded from a randomized trial that intraoperative results and outcome were not affected according to whether or not the defect was sutured. The defect was left open in the majority of patients in the present study (72·0 per cent) to minimize the risk of rectal stenosis, although it was closed in patients with a high tumour. Ramirez JM, Aguilella V, Arribas D, Martinez M. Transanal full-thickness excision of rectal tumours: should the defect be sutured? A randomized controlled study. Colorectal Dis 2002; 4: 51–55.

53 Local treatment modalities
Colonoscopy Snare Submucosal dissection Transanal excision Parks (Direct transanal approach) Transanal Endoscopic Microsurgery Others Radiotherapy Laser / Argon Plasma Coagulation

54 Colonoscopic procedures

55 Endoscopic local treatment
Colonoscopic polypectomy Suitable in 90% of rectal polyps Complete resection difficult if tumour in submucosal area i.e. carcinoid tumors / malignant rectal tumour Suitable for pedunculated polyp Endoscopic mucosal resection Removal of mucosal lesion of < 1cm Special device needed if tumour suspected to be in submucosal area i.e. 2 channel EMR

56 2 channel EMR Ono A, Fujii T, Saito Y, Matsuda T et al.
Endoscopic submucosal resection of rectal carcinoid tumors with a ligation device. Gastrointest Endosc 2003; 57: 583±587

57 Endoscopic Submucosal Dissection
Indicated when one−piece resection by conventional procedures is impossible: Large−sized lesions Lesions with biopsy−induced scars Lesions on haustra Rate of one-piece resection with ESD: 70-88% Rate of perforation: 5% Mean size : 26.2 mm (8 ± 60) 32.8 mm (9 - 91) Colorectal endoscopic submucosal dissection: present status and future perspective, including its differentiation from endoscopic mucosal resection. [Review] [47 refs] Tanaka S. Oka S. Chayama K. Journal of Gastroenterology. 43(9):641-51, 2008 Onozato Y, Kakizaki S, Ishihara H, et al. Endoscopic submucosal dissection for rectal tumors. Endoscopy. 2007;39:423– 427 Fujishiro M, Yahagi N, Nakamura M et al. Endoscopic submucosal dissection for rectal epithelial neoplasia. Endoscopy 2006; 38: 493±497

58 ESD Ono A, Fujii T, Saito Y, Matsuda T et al.
Endoscopic submucosal resection of rectal carcinoid tumors with a ligation device. Gastrointest Endosc 2003; 57: 583±587

59 ESD in Rectal Cancer Limited to: Involvement only to SM1 or less
Kikuchi Classification of Adenocarcinoma in Sessile Polyp

60

61 Rectum The junction between the sigmoid colon and the rectum has been variously described: A point opposite the left sacroiliac joint Level of the 3rd sacral vertebra Level at which the sigmoid mesentery disappears Level at which sacculations and epiploic appendages disappear and taeniae broaden to form a complete muscle layer (long transition) Level at which the superior rectal artery divides into right and left branches Construction with anterior angulation (proctoscopy) Level of superior rectal fold (inconstant) Transition between rugose mucosa of colon and smooth mucosa of rectum (cadaver) Skandalakis John E, Colborn Gene L, Weidman Thomas A, Kingsnorth Andrew N, Skandalakis Lee J, Skandalakis Panajiotis N, Shafik Followed b, "Chapter 18. Large Intestine and Anorectum" (Chapter). Skandalakis JE, Colburn GL, Weidman TA, Foster RS Jr, Kingsworth AN, Skandalakis LJ, Skandalakis PN, Mirilas PS: Skandalakis' Surgical Anatomy:


Download ppt "Local Treatment of Rectal Tumour"

Similar presentations


Ads by Google