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Neuronal ATM level is reduced in mouse models of AD

Published byWouter van der Berg Modified over 5 years ago

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Presentation on theme: "Neuronal ATM level is reduced in mouse models of AD"— Presentation transcript:

1 Neuronal ATM level is reduced in mouse models of AD
Neuronal ATM level is reduced in mouse models of AD. Sagittal brain sections from three AD mouse models and wild-type controls (age, months) were double immunostained for HDAC4 (red) and Map2 (green). Neuronal ATM level is reduced in mouse models of AD. Sagittal brain sections from three AD mouse models and wild-type controls (age, months) were double immunostained for HDAC4 (red) and Map2 (green). Scale bar, 50 μm. A–D, Wild-type mice (Wt; A), R1.40 APP transgenic mouse (B), PS/APP double-transgenic mouse (C), and 3xTg triple-transgenic mouse (D). E, Quantification of the percentage of neurons with HDAC4N found in the frontal cortex and hippocampus of each model examined. Difference determined by t test, *p < 0.05, **p < 0.01, ***p < (n = 3-4). Xuting Shen et al. eneuro 2016;3:ENEURO ©2016 by Society for Neuroscience

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