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1 Complejidad Dia 8 Ecología Biologí a Psicologia Meteorología MacroEconomía Geofisica UBA, Junio 21, 2012.

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Presentation on theme: "1 Complejidad Dia 8 Ecología Biologí a Psicologia Meteorología MacroEconomía Geofisica UBA, Junio 21, 2012."— Presentation transcript:

1 1 Complejidad Dia 8 Ecología Biologí a Psicologia Meteorología MacroEconomía Geofisica UBA, Junio 21, 2012.

2 1era parte Generalidades de brain imaging Brain imaging for hackers 2da Parte Fisica y fisiología de la señal BOLD.

3 Brain imaging: whole brain Magnetic Resonance Imaging (MRI) MRI estructural (MRI) Funcional MRI (fMRI) Functional connectivity MRI (fcMRI) Computed tomography (CT) Positron emission tomography (PET) EEG, MEG, SPECT, DTI,…etc

4 Essential in clinical care. Radiologists perform qualitative lightbox reads. Most psychiatric and neurological disorders are invisible to reading radiologists. MRI estructural

5 Brain volume declines with age Marcus et al., 2007

6 fMRI: where and when (in response). rfMRI: at rest fcMRI: functional connectivity Functional MRI f MRI

7 fMRI Algo de lo que se viene en Tecnologias emergentes Amazon.com

8 1.Patient visits doctor. Doctor orders fcMRI. 2.fcMRI brain scan. 3.Quantitative analysis 4.Doctor receives report. 5.Doctor makes dx. and plans treatment. Quantitative report provides diagnostic measures, guides treatment, assesses response. Tecnologias Emergentes: quantitative neuroradiology India, Rafaela, Los Angeles

9 Tecnologias Emergentes: digital lab on the clouds Input: Raw MRI scans Output: Quantitative reports Amazon.com

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11 Aun mas: Tecnologias Emergentes: Patient-driven care Microsoft HealthVault

12 Google Health (prototype) Otro ejemplo: Tecnologias Emergentes: patient-driven care

13 Habrá algo, alguna vez, realmente nuevo?

14 Veber den Kreislauf des Blutes in Menschlichen Gehirn (Concerning the circulation of the blood in the human brain) Verlag von Viet & Company: Leipzig, 1881 La primera coneccion entre flujo sanguineo y actividad mental Angelo Mosso Inventor del primer ergografo para medir la fuerza muscular

15 Resting quietly Forearm Brain Arrow: room clock strikes 12 noon and of church bells heard Brain Forearm Arrow: Mosso asked Bertino if the Ave Maria should have been said Brain Forearm What is 8 x 12? ω: response Brain Forearm Monday noon, September 23, 1878 From: Angelo Mosso (1881)

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17 Brain imaging for hackers* Get yourself some brain images Get yourself some brain analysis tools Discover something, invent something *From : Daniel Marcus, PhD Director, Neuroinformatics Research Washington University School of Medicine

18 Get your own brain scanned Buy a scanner and install it in your basement

19 Get your own brain scanned Buy a scanner and install it in your basement Inflict severe brain injury

20 Get your own brain scanned Buy a scanner and install it in your basement Inflict severe brain injury Volunteer for a study Contact local research centers Ask for your scans (Ive brought a blank CD with me. Will you please copy the DICOM files of my scans onto it?)

21 Use open access data Neuron: Neuron Yale Sense Lab Gene expression: Allen Brain Atlas Structural MRI: Open Access Structural Imaging Series (OASIS), mBIRN Data Repository Functional MRI: fMRI Data Center, fBIRN Data Repository Functional connectivity MRI: Brainscape

22 oasis-brains.org

23 brainscape.org

24 Neuron Network Whole brain Genesis Neuron Slicer, Caret, AFNI, Freesurfer, SPM, FSL, ImageJ Get yourself some tools See also NITRC (http://www.nitrc.org/)http://www.nitrc.org/

25 Some unsolved problems Automated brain extraction How many networks are in the brain Methods for distinguishing differences between populations Predicting disease and aptitude Data sharing Individual differences in performance (gifted, savant) Neuroethics Deidentifying images Bridging the spatial divide Security and privacy Data mining

26 Start hacking.


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