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Joint Hospital Grand Round Topic: Intraductal papillary mucinous neoplasm (IPMN) of Pancreas Dr. Chui Lap Bun Prince of Wales Hospital 16 th January, 2010.

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Presentation on theme: "Joint Hospital Grand Round Topic: Intraductal papillary mucinous neoplasm (IPMN) of Pancreas Dr. Chui Lap Bun Prince of Wales Hospital 16 th January, 2010."— Presentation transcript:

1 Joint Hospital Grand Round Topic: Intraductal papillary mucinous neoplasm (IPMN) of Pancreas Dr. Chui Lap Bun Prince of Wales Hospital 16 th January, 2010

2 Introduction More pancreatic cystic lesions are being detected. Evolution from small benign cystic neoplasms may be very slow and some had high malignant potential and therefore allow selective treatment according to morphological characteristics.

3 Classification Non-neoplastic lesionsNeoplastic lesions PseudocystSerous cystic tumour Retention cystMucinous cystic neoplasm Congenital cystIntraductal papillary mucinous neoplasm (IPMN) Lymphoepithelial cystSolid pseudopapillary neoplasm

4 Intraductal papillary mucinous neoplasm (IPMN) First described in 1982, it is characterized by papillary proliferation of mucin-producing epithelial cells with excessive mucus production and cystic dilatation of main or branch pancreatic ducts. Two-third of IPMN are men. Peak age :

5 Intraductal papillary mucinous neoplasm (IPMN) Main duct type: – characterised by marked dilatation of the MPD, diffuse or segmental. Together with atrophy of the pancreas. Branch duct type – Multi- focal cysts in clusters with mild or no dilatation of MPD.

6 CT Branch duct IPMN

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8 Main duct IPMN

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10 Investigation CT scan MRI + MRCP ERCP- mucin protruding from a widely open papilla. EUS- Detect communication with pancreatic duct and detect mural nodules. Sample cystic fluid and biopsy Cyst fluid for cytology, amylase, mucin and CEA

11 Malignancy in main duct IPMNs (including mixed type IPMN) Reference (author) Year published PatientsMalignant including CIS (%) Invasive malignancy (%) Kobari %23% Terris %37% Doi %- Mastsumoto %- Choi %- Kitagawa %54% Sugiyama %57% Sohn % Salvia %42% Mean70%43%

12 Malignancy in branch duct IPMNs Reference (author) Year published PatientsMalignant including CIS (%) Invasive malignancy (%) Kobari %6% Terris %0% Doi %- Mastsumoto %- Choi %- Kitagawa %31% Sugiyama %9% Sohn % Mean25%15%

13 Indication for surgery International Consensus guideline for Management of IPMN and MCN of Pancreas [Pancreatology 2006; 6: 17-32] Main duct and mixed variant IPMN Resection Branch-duct IPMN 1. symptomatic (30% malignancy), 2. > 3cm in size 3. mural nodules

14 Extent of surgery For invasive IPMN, recurrence after partial pancreatectomy vs total pancreatectomy 67% vs 62% suggested no oncologic advantage of total pancreatecomy. [ Study of recurrence after surgical resection of IPMN of the pancreas. Gastroenterology Nov; 123(5): ] The extent of pancreatic resection remain controversial.

15 Extent of surgery Risk of recurrence Vs. the morbidity of total pancreatectomy. Routine total pancreatectomy for IPMN is not recommended. Total pancreatectomy should only be reserved for patients with resectable but extensive IPMN which involves the whole pancreas.

16 Frozen section Microscopic extension of neoplastic cells beyond visible boundaries of the main lesion is common. IPMNs can be multifocal and the margin frequently involved at the time of resection Positive Margin (LD, MD, HD, invasive) Resect more??

17 Frozen section Clinical Significance of Frozen Section Analysis During Resection of Intraductal Papillary Mucinous Neoplasm: Should a Positive Pancreatic Margin for Adenoma or Borderline Lesion Be Resected Additionally? [J. Am Coll Surg 2009; 209: IPMN with CIS or invasive carcinoma: complete resection if possible. IPM adenoma or borderline lesion: might not need further resection

18 Clinical Significance of Frozen Section Analysis During Resection of Intraductal Papillary Mucinous Neoplasm: Should a Positive Pancreatic Margin for Adenoma or Borderline Lesion Be Resected Additionally? [J. Am Coll Surg 2009; 209: DiagnosisInitial IOFSAAdditional resection Recurrence Negative83017 LD or MD26121 HD (CIS)10 0 Invasive cancer661

19 Follow up plan Slow growing Residual tumour may develop into carcinoma New IPMN arise from ramnant Time of recurrence ranged from 8-62 months Need regular FU imaging

20 Synchronous and metachronous malignancy 23.6 – 32% IPMNs associated with extrapancreatic malignant neoplasm, including gastric, biliary, colorectal and lung malignancy. [ Yamaguchi et, al. Osanai et al., Augiyama et al.] Mayo clinic: IPMN patients with more benign and malignant neoplasms compared with controls– screening colonoscopy should be considered in all patients with IPMN. [Ann Surg 2010; 251: 64-69]

21 Conclusion IPMN of the pancreas is uncommon but important because it is slow growing with significant malignant potential. Main duct type should be resected. Branch duct type with tumour > 3cm, mural nodule or positive symptoms warrants surgical resection. High incidence of extrapancreatic malignancies and pancreatic ductal carcinoma.

22 ~Thank you~ Q&A

23 2 Frequency of Extrapancreatic Neoplasms in Intraductal Papillary Mucinous Neoplasm of the Pancreas: Implications for Management. Reid-Lombardo, Kaye; Mathis, Kellie; Wood, Christina; Harmsen, William; Sarr, Michael Annals of Surgery. 251(1):64-69, January DOI: /SLA.0b013e3181b5ad1e


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