Presentation on theme: "FOLLOW UP IN THALASSEMIA CLINIC"— Presentation transcript:
1 FOLLOW UP IN THALASSEMIA CLINIC Presented by:Dr. Afsana Jahan (PGT)Dr. Aditi Baruah (MD); Dr. P. Bishwanath (MD)Department of PaediatricsAssam Medical College & Hospital, Dibrugarh
2 IntroductionThalassemia is the commonest chronic haematological disease needing repeated blood transfusion.North-East specially Assam is a reservoir of abnormal haemoglobins & also thalassemia because of ethnic diversity of the inhabitants.Present thalassemia clinic was established in April’2005, AMCH, Dibrugarh where regular follow-up of thalassemia pateints are done.
3 Aim of the StudyTo study the follow-up cases of haemo- globinopathy with special reference to thalassemia in thalassemia clinic
4 Materials & Methods Place of Study : Thalassemia clinic, AMCH Period of Study : May’2005 to Oct’2007Study universe : 50 diagnosed and registered cases of HaemoglobinopathySelection criteria : Cases of Haemoglobinopathy diagnosed by HPLC.
12 Effect of chelation on Serum Ferritin No. of patientsDrug and dosemg/kg/dayLength of studyS. Ferritin level (μg/L)InitialFinal16Deferiprone50 – 1001yr326114204Desferoxamine35 – 55319013923Combined9months52611276
13 Effect of use of filter on transfusion reaction
14 Hb E trait - β – thalassemia trait Parental HPLC studyDIAGNOSISCASE NO.MOTHERFATHERβ – thalassemia major49β – thalassemia traitHb E - thalassemia1Hb E trait2Not done3Hb E trait - β – thalassemia trait678134048Hb A A
16 Problems in Thalassemia clinic Family study and convincing parents and relatives for necessity of the test.Irregular follow-up visits.Irregular blood transfusionLack of voluntary blood donation.Cost of filters and chelation therapy limits their use.Cost of different laboratory tests.
17 Need of the HOUR! Public awareness. Education of health professional. Antenatal diagnosis.Emphasis on conventional treatment in particular chelation in view of its high efficacy.Cure of the disease with increasing possibility of bone marrow transplantation and gene therapy.Concrete support for achieving high standard for management of thalassemia in this part of Country.
18 ConclusionThalassemia clinic is playing an important role in making thalassemia a preventable, manageable and curable disease in prospect of high incidence in this region.